Journal
BRAIN RESEARCH
Volume 1527, Issue -, Pages 40-46Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2013.06.009
Keywords
Spinal cord injury; Edema; Epigallocatechin gallate; Aquaporin-4; Glial fibrillary acidic protein
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Recent studies indicated that epigallocatechin gallate (EGCG) had neuroprotective effects on spinal cord injury (SCI). The current study was performed to determine the anti-edema effect of EGCG after SCI in rats. EGCG (100 mg/kg, i.p.) was administered to rats immediately following SCI. It was found that EGCG (100 mg/kg) could significantly reduce spinal cord water content. In addition, EGCG (100 mg/kg) significantly reduced the expression of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) level at 24, 48 and 72 h after injury, but it did not have this effect at 12 h after injury. The changes of AQP4 and GFAP protein induced by EGCG (100 mg/kg) treatment were accompanied by a reduction of spinal cord edema. Our results indicated that EGCG (100 mg/kg) could reduce spinal cord edema after SCI, which could be correlated with the down-regulation the expression of AQP4 and GFAP protein level after SCI. (C) 2013 Elsevier B.V. All rights reserved.
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