Journal
BRAIN RESEARCH
Volume 1476, Issue -, Pages 132-153Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2012.03.035
Keywords
5-HT (serotonin); 5-HT2C receptors; 5-HT2C receptor ligands; Drugs of abuse; Behavioral studies; Dependence
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Funding
- Institute of Pharmacology (Krakow, Poland)
- Department of Toxicology, Faculty of Pharmacy, Jagiellonian University (Krakow, Poland)
- Institut National de la Recherche et de la Sante (INSERM)
- Bordeaux 2 University
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The present review provides an overview on serotonin (5-hydroxytryptamine; 5-HT)(2C) receptors and their relationship to drug dependence. We have focused our discussion on the impact of 5-HT2C receptors on the effects of different classes of addictive drugs, illustrated by reference to data using pharmacological and genetic tools. The neurochemical mechanism of the interaction between 5-T-2C receptors, with focus on the mesocorticolimbic dopaminergic system, and drugs of abuse (using cocaine as an example) is discussed. Finally, we integrate recent nonclinical and clinical research and information with marketed products possessing 5-HT2C receptor binding affinities. Accordingly, available nonclinical data and some clinical observations targeting 5-T-2C receptors may offer innovative translational strategies for combating drug dependence. This article is part of a Special Issue entitled: Brain Integration. (C) 2012 Elsevier B.V. All rights reserved.
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