Journal
BRAIN RESEARCH
Volume 1271, Issue -, Pages 103-113Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2009.03.022
Keywords
Metal ion; Apoptosis; Inflammation; Oxidative stress; CNS injury
Categories
Funding
- IMK Almene Fond
- Aase and Ejnar Danielsens Fond
- Copenhagen University Faculty Foundation
- Hede Nielsen Fonden
- Horslev Fonden
- Vera og Carl Michaelsens Legat
- Fonden til Laegevidenskabens Fremme
- Eva and Henry Fraenkels Mindefond
- Kathrine og Vigo Skovgaards Fond
- Kong Christian d. X's fond
- Th. Maigaard's Eftf. Fru Lily Benthine Lunds Fond [1/6 1978]
- Toyota Fonden
- Danish Medical Association
- Laegernes Forsikringsforening [1891]
- Karen A Tolstrups Fond
- Laererinde Karen Svankjaer Ydes Fond
- Direktor Kurt Bonnelyckes Fond
- Hotelejer Edvard Johnsen og hustrus fond
- Faculty of Health Sciences at Copenhagenand and Aarhus Universities
- Aarhus University Research Foundation
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Brain injury represents a major health problem and may result in chronic inflammation and neurodegeneration. Due to antiinflammatory effects of gold, we have investigated the cerebral effects of metallic gold particles following a focal brain injury (freeze-lesion) in mice. Gold particles 20-45 mu m in size or the vehicle (placebo) were implanted in the cortical tissue followed by a cortical freeze-lesioning. At 1-2 weeks post-injury, brains were analyzed by using immunohistochemistry and markers of inflammation, oxidative stress and apoptosis. This study shows that gold treatment significantly reduces the cerebral levels of tumor necrosis factor alpha (TNF alpha), oxidative DNA damage (as judged by 8-oxoguanine levels), and pro-apoptotic markers (cleaved caspase-3, cytochrome c leakage), when compared to those of controls. The data presented here points toward gold particles as a tool to modulate the cerebral response to injury. (C) 2009 Elsevier B.V. All rights reserved.
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