Article
Public, Environmental & Occupational Health
Niyousha Hosseinichimeh, Rod MacDonald, Kaigang Li, James C. Fell, Denise L. Haynie, Bruce Simons-Morton, Barbara C. Banz, Deepa R. Camenga, Ronald J. Iannotti, Leslie A. Curry, James Dziura, Linda C. Mayes, David F. Andersen, Federico E. Vaca
Summary: This study applies the system dynamics approach to understand and analyze the problem of alcohol-impaired driving among adolescents and young adults. The causal loop diagram developed in this study depicts diverse influences on youth impaired driving, such as parents, peers, policies, law enforcement, and the alcohol industry.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rany Vorn, Maiko Suarez, Jacob C. White, Carina A. Martin, Hyung-Suk Kim, Chen Lai, Si-Jung Yun, Jessica M. Gill, Hyunhwa Lee
Summary: In chronic mild traumatic brain injury (mTBI), dysregulation of exosomal microRNAs in plasma may indicate long-lasting neuronal inflammation, resulting in persistent post-injury symptoms.
Article
Cell Biology
Drew R. Nannini, Brian T. Joyce, Yinan Zheng, Tao Gao, Jun Wang, Lei Liu, David R. Jacobs Jr, Pamela J. Schreiner, Chunyu Liu, Qi Dai, Steve Horvath, Ake T. Lu, Kristine Yaffe, Philip Greenland, Donald M. Lloyd-Jones, Lifang Hou
Summary: This study found that long-term alcohol consumption and recent binge drinking in young adults may affect age-related epigenetic changes, particularly those related to DNA methylation changes. These findings have important implications for improving dietary habits and promoting healthy aging.
Article
Psychology, Multidisciplinary
Lauren A. Monds, Matthew R. Singleton, Alex M. T. Russell
Summary: This study investigated the relationship between binge drinking and attention performance in young adults, testing the moderating role of sex and the influence of earlier age of binge drinking onset. The results showed that binge drinking, sex, and age of first binge drinking session did not predict attention impairment, and sex did not moderate the relationship.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Substance Abuse
Jesus Chavarria, Daniel J. Fridberg, Elisabeth Obst, Ulrich S. Zimmermann, Andrea C. King
Summary: High-risk adolescent drinkers exhibit heightened sensitivity to alcohol-induced stimulation and tonic high levels of wanting compared with low-risk adolescent drinkers.
Article
Substance Abuse
Robert J. Wellman, Erika N. Dugas, Erin K. O'Loughlin, Marie-Pierre Sylvestre, Annie Pelekanakis, Jennifer O'Loughlin
Summary: The study revealed a time-varying trend in co-use of alcohol and cannabis in adolescents and young adults, highlighting the need for continuous monitoring. As age increased, the proportion of co-use decreased, frequent binge drinking decreased, and frequent cannabis use slightly increased.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2022)
Article
Psychology, Clinical
Helena C. Kaltenegger, Sabrina Doering, Christopher Gillberg, Peter Wennberg, Sebastian Lundstrom
Summary: This study aimed to assess the prevalence of risk drinking in individuals with autism spectrum disorder (ASD) and found that the prevalence of risk drinking was lower in individuals with ASD compared to those without, but increased with age. Individuals with co-existing attention-deficit/hyperactivity disorder (ADHD) or learning disorder (LD) were more likely to engage in risk drinking.
ADDICTIVE BEHAVIORS
(2021)
Article
Medicine, General & Internal
Wiebke Kaeckenmester, Claas Guethoff, Dana Mross, Gertrud Wietholt, Kristina Zappel, Ingo Schmehl
Summary: This study evaluates post-hospital care of children and adolescents after mild traumatic brain injury (TBI) through a physician survey. The results show that a significant proportion of general practitioners are not familiar with TBI severity assessment scales and have difficulties assessing the symptoms correctly. Pediatricians demonstrate better knowledge on the treatment and outpatient care of TBI compared to general practitioners.
Article
Clinical Neurology
Soo Ji Kim, Yoon-Kyum Shin, Eomhyeong Jeong, Sung-Rae Cho
Summary: This study examines the effects of movement-specific keyboard playing on improving hand function in patients with acquired brain injury (ABI). The results show that keyboard playing can enhance functional independence, key-pressing force, and most hand function tests. Additionally, keyboard playing can motivate young patients with ABI and optimize intervention effects.
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychology, Clinical
Melissa A. Lewis, Zhengyang Zhou, Anne M. Fairlie, Dana M. Litt, Emma Kannard, Raul Resendiz, Travis Walker, Morgan Seamster, Tracey Garcia, Christine M. Lee
Summary: The present study examines the association between cognitions and situational factors with playing drinking games among adolescents and young adults. The study finds that higher willingness, higher descriptive norms, and less familiarity with people are associated with playing drinking games. Furthermore, playing drinking games is associated with consuming more drinks, but not directly associated with experiencing more negative consequences and riding in a vehicle with a driver who had been drinking.
ADDICTIVE BEHAVIORS
(2023)
Article
Psychiatry
Vanessa Le, Dylan E. Kirsch, Valeria Tretyak, Wade Weber, Stephen M. Strakowski, Elizabeth T. C. Lippard
Summary: This study found that perceived stress in youth with bipolar disorder is associated with increased right amygdala activation, which is not significant in typically developing youth. Furthermore, greater amygdala reactivity to acute stress is correlated with quantity and frequency of alcohol use and frequency of cannabis use in bipolar disorder.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Markus Karlander, Johan Ljungqvist, Johan Zelano
Summary: The risk of post-traumatic epilepsy is considerable, with higher risks for focal cerebral injuries and diffuse cerebral injuries compared to mild TBI. The risk of epilepsy after any TBI was 4.0%, significantly higher than the control group's risk of 0.9%. Risk of epilepsy increased with severity of injury.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Oliver Lasry, Nandini Dendukuri, Judith Marcoux, David L. Buckeridge
Summary: This study evaluated the accuracy of administrative health data surveillance case definitions for recurrent traumatic brain injury (rTBI) and estimated the adjusted 1-year rTBI incidence. Results showed an incidence of 4.48 per 100 person-years across all age groups, with higher severity index TBI patients having a significantly higher incidence of rTBI. The study demonstrates the feasibility of conducting accurate surveillance and epidemiological research for rTBI using administrative health data.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Jason-Alexander Hoerauf, Christoph Nau, Nils Muehlenfeld, Rene D. Verboket, Ingo Marzi, Philipp Stoermann
Summary: This retrospective study analyzed the injury patterns of severe trauma patients who fell down a flight of stairs, and found that the likelihood of traumatic brain injury and intracranial hemorrhage increased with the number of stairs fallen. There was also a high correlation between staircase falls and alcohol intake. Therefore, it is important to consider the impact of brain injury and alcohol intake in these cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Andrea R. Molino, Judith Jerry-Fluker, Meredith A. Atkinson, Susan L. Furth, Bradley A. Warady, Derek K. Ng
Summary: The study found that substance use was less common among adolescents and young adults with chronic kidney disease compared to the general population. Factors such as gender, race, and age had an impact on substance use, and prevention efforts should be focused on the age group of 12-14 years.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Mari Leppavouri, Eveliina Lammentausta, Arttu Peuna, Michaela K. Bode, Jari Jokelainen, Juha Ojala, Miika T. Nieminen
Summary: This study used magnetic resonance imaging to examine vocal tract dimensions in four vocal modes from Complete Vocal Technique. The results showed significant differences in vocal tract dimensions between different vocal modes, indicating the importance of vocal tract adjustments in producing these modes. Additionally, differences in vocal tract dimensions were also found between samples sung with different vowels.
Article
Clinical Neurology
Brian J. Miller, Karl-Heinz Herzig, Jari Jokelainen, Toni Karhu, Sirkka Keinanen-Kiukaanniemi, Marjo-Riitta Jarvelin, Juha Veijola, Heimo Viinamaki, Paivikki Tanskanen, Erika Jaaskelainen, Matti Isohanni, Markku Timonen
Summary: Elevated blood interleukin-6 (IL-6) levels in midlife schizophrenia patients are associated with smaller hippocampal volumes. The study suggests a potential role of IL-6 in the pathophysiology of schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Letter
Dermatology
Saana Kauppi, Jari Jokelainen, Markku Timonen, Kaisa Tasanen, Laura Huilaja
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Endocrinology & Metabolism
Maria Hagnas, Henry Sundqvist, Jari Jokelainen, Andrea Tumminia, Federica Vinciguerra, Carla Loreto, Lucia Frittitta, Giuseppina T. Russo, Ilona Mikkola
PRIMARY CARE DIABETES
(2020)
Article
Dentistry, Oral Surgery & Medicine
Paula Tegelberg, Tellervo Tervonen, Matti Knuuttila, Jari Jokelainen, Sirkka Keinanen-Kiukaanniemi, Juha Auvinen, Pekka Ylostalo
Summary: The study indicates that impairment in glucose control in non-diabetic individuals is associated with deterioration in periodontal status, suggesting a correlation between blood sugar levels at age 46 and periodontal conditions.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jukka Kiiskila, Jari Jokelainen, Laura Kytovuori, Ilona Mikkola, Pirjo Harkonen, Sirkka Keinanen-Kiukaanniemi, Kari Majamaa
Summary: Following a standard-dose training period, subjects with mtDNA haplogroups J or K showed less excellence in endurance performance compared to subjects with non-JK haplogroups, with this difference being more pronounced among the best-performing individuals.
Article
Hematology
Hanna Ventola, Aino Vesikansa, Jari Jokelainen, Timo Siitonen, Pia Ettala, Outi Laine, Elina Lehtinen, Aino Lepantalo, Maria Patronen, Anu Partanen, Miika Linna, Tero Ylisaukko-oja, Riitta Lassila
Summary: Characterisation of outcomes and costs of haemophilia care in common practice settings is important for evaluating new treatment options and clinical practices. In Finland, adult inhibitor-negative haemophilia patients managed in University Hospitals mainly receive factor replacement therapy, with low annual bleeding rates and costs. Centralising care management to University Hospital Treatment Centres has shown successful outcomes in Finland, with lower treatment costs compared to other high-income European populations.
Article
Education & Educational Research
Elina Paloniemi, Ilona Mikkola, Ritva Vatjus, Jari Jokelainen, Markku Timonen, Maria Hagnaes
Summary: The study found that male dental students had lower levels of empathy compared to male medical students, while also demonstrating a positive correlation between empathy and self-reflection among both groups and genders. Further research in this field is recommended.
BMC MEDICAL EDUCATION
(2021)
Article
Multidisciplinary Sciences
Anna Karoliina Haarala, Suvi-Paivikki Sinikumpu, Eeva Vaaramo, Jari Jokelainen, Markku Timonen, Juha Auvinen, Juha Pekkanen, Jussi Lampi, Laura Huilaja
Summary: The study found that sensitization to aeroallergens in adult populations can change over time, with men being more prone to developing allergies and polysensitization. New sensitization reactions can still occur in middle age and should be considered when managing allergic manifestations in adults, as sensitization is considered the first step in developing clinical allergies.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Kari A. Makela, Jari Jokelainen, Ville Stenback, Juha Auvinen, Marjo-Riitta Jarvelin, Mikko Tulppo, Juhani Leppaluoto, Sirkka Keinanen-Kiukaanniemi, Karl-Heinz Herzig
Summary: The study examined the effects of PCSK9 in patients with alterations of glucose metabolism and statin therapy, showing that in subjects with abnormal glucose metabolism and statin treatment, the significant PCSK9-mediated effects on lipid metabolites are diminished compared to those with normal glucose tolerance (NGT) subjects, although statins can reduce LDL-C and VLDL-C levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Dermatology
S-P Sinikumpu, H. Vahanikkila, J. Jokelainen, K. Tasanen, L. Huilaja
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Letter
Dermatology
Outi Varpuluoma, Jari Jokelainen, Laura Huilaja, Kaisa Tasanen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Environmental Sciences
Anna Karoliina Haarala, Suvi-Paivikki Sinikumpu, Eeva Vaaramo, Jari Jokelainen, Markku Timonen, Juha Auvinen, Juha Pekkanen, Laura Huilaja
Summary: The study found that living on a farm or in a rural environment in childhood had a protective effect on sensitization even in middle age, but did not protect from new-onset sensitization in adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Reeta Rintamaki, Nina Rautio, Markku Peltonen, Jari Jokelainen, Sirkka Keinanen-Kiukaanniemi, Heikki Oksa, Timo Saaristo, Hannu Puolijoki, Juha Saltevo, Jaakko Tuomilehto, Matti Uusitupa, Leena Moilanen
Summary: The Finnish National Diabetes Prevention Program (FIN-D2D) showed that a one-year weight loss intervention in high-risk individuals can significantly reduce the incidence of drug-treated type 2 diabetes in the long term, but did not have a significant impact on cardiovascular events or all-cause mortality.
PRIMARY CARE DIABETES
(2021)
Article
Dermatology
Suvi-Paivikki Sinikumpu, Jari Jokelainen, Kaisa Tasanen, Laura Huilaja
Summary: This study aimed to investigate the prevalence and clinical characteristics of adult acne at the population level, as well as its association with cardiovascular and metabolic profiles. The results showed that adult acne is common in middle-aged individuals, with slight differences in clinical picture between females and males. Male subjects with acne may have a higher risk of metabolic disturbances, highlighting the need for comprehensive evaluation of adult acne patients.
ACTA DERMATO-VENEREOLOGICA
(2023)
