Article
Fisheries
Yihua Chen, Yukuan Chen, Liang Tao, Xinxin Du, Zhiguo Dong, Donghong Niu, Jiale Li
Summary: This study investigates genotype by environment interactions of growth traits in razor clams reared in outdoor ponds and semi-natural environments. The results show significant genetic differences among families in different aquaculture environments. The heritabilities for growth traits are low to moderate, indicating that these traits can be effectively selected in both environments. This study provides guidance for breeding programs of razor clams in different aquaculture environments.
AQUACULTURE REPORTS
(2022)
Article
Multidisciplinary Sciences
Mi-Yeon Cha, Yu-Jin Hong, Ja-Eun Choi, Tae-Song Kwon, Ig-Jae Kim, Kyung-Won Hong
Summary: This study investigated the genetic basis of early age facial growth patterns and identified significant associations with horizontal and vertical phenotypes. It is the first study to classify and characterize facial growth patterns and related genetic polymorphisms.
SCIENTIFIC REPORTS
(2022)
Article
Fisheries
Priadi Setyawan, Muhammad Hunaina Fariduddin Aththar, Imron Imron, Bambang Gunadi, Joni Haryadi, John W. M. Bastiaansen, Mark D. Camara, Hans Komen
Summary: Recurrent farming failures caused by disease outbreaks have led Indonesian shrimp farmers to explore shrimp and tilapia co-culture. The Research Institute for Fish Breeding (RIFB) Indonesia is developing a fast-growing tilapia with good growth in brackish water ponds. This study aimed to investigate the genotype by environment interaction between brackish water and freshwater, as well as the impact of salinity on genetic parameters and gonadal development of tilapia. The results showed significant differences in growth, heritability, and gonadal development between brackish water and freshwater environments.
Article
Neurosciences
Marvin Petersen, Felix L. Naegele, Carola Mayer, Maximilian Schell, D. Leander Rimmele, Elina Petersen, Simone Kuehn, Juergen Gallinat, Uta Hanning, Jens Fiehler, Raphael Twerenbold, Christian Gerloff, Goetz Thomalla, Bastian Cheng
Summary: The study identified a pattern of age-related cortical thickness differences, particularly with pronounced age effects in sensorimotor areas, showing strong correlations with connectivity profiles of functional and structural brain networks. Additionally, the identified difference pattern significantly covaried with cognitive and motor performance.
Article
Agriculture, Dairy & Animal Science
Stavroula Oikonomou, Zoi Kazlari, Dimitrios Loukovitis, Arkadios Dimitroglou, Lefteris Kottaras, Konstantinos Tzokas, Dimitrios Barkas, Nikolaos Katribouzas, Leonidas Papaharisis, Dimitrios Chatziplis
Summary: The use of plant-based proteins as a substitute for fishmeal and fish oil in aquaculture feeds has gained attention due to the high cost of nutrition. This study found that using a standard commercial diet instead of a plant-based one can achieve higher genetic gain, although it may reduce the genetic gain per generation. Therefore, establishing a breeding strategy based on plant-based diets is feasible but requires balancing the reduction in feed cost and the decrease in genetic gain.
Article
Multidisciplinary Sciences
Marta Guindo-Martinez, Ramon Amela, Silvia Bonas-Guarch, Montserrat Puiggros, Cecilia Salvoro, Irene Miguel-Escalada, Caitlin E. Carey, Joanne B. Cole, Sina Rueger, Elizabeth Atkinson, Aaron Leong, Friman Sanchez, Cristian Ramon-Cortes, Jorge Ejarque, Duncan S. Palmer, Mitja Kurki, Krishna Aragam, Jose C. Florez, Rosa M. Badia, Josep M. Mercader, David Torrents
Summary: This study utilized an extensive GWAS strategy called GUIDANCE to improve genotype imputation by using multiple reference panels, including the X chromosome and non-additive models. By applying this methodology, 94 genome-wide associated loci were identified for 22 age-related diseases, with 26 previously unreported loci. The study also revealed that 27.7% of these loci would have been missed if standard imputation strategies with a single reference panel and only testing the additive model were used.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Hao Cheng, Mengyuan Ye, Tingting Wu, Hao Ma
Summary: High seed vigor is crucial for achieving high and stable soybean yield. However, seed vigor is currently not prioritized in soybean breeding programs in China, leading to unclear seed vigor status of soybean strains. This study measured the seed vigor of 131 soybean strains using the artificial accelerated aging method and found significant differences in seed vigor among the strains. Only 28.24% of the strains exhibited high seed vigor, indicating a generally low seed quality. Multiyear and multilocation experiments further showed that seed vigor of different vigor types varied under different environmental conditions. The results suggest that prioritizing high seed vigor in soybean breeding programs is necessary to ensure varieties with desirable seed quality in China.
Article
Substance Abuse
Christine Adjangba, Richard Border, Pamela N. Romero Villela, Marissa A. Ehringer, Luke M. Evans
Summary: The study failed to replicate the previously reported interaction effect between rs16969968 and age of onset of regular smoking on smoking quantity in a large, independent sample. It suggests that gene-moderator interactions may depend on the scale of measurement and current biobanks lack the power to detect significant genome-wide associations due to the expected minute effect sizes.
NICOTINE & TOBACCO RESEARCH
(2021)
Article
Agronomy
Sammy Larry Madahana, James Otieno Owuoche, Maurice Edwards Oyoo, Godwin Kamau Macharia, Mandeep Singh Randhawa
Summary: The study revealed significant differences in yield, yield components, and rust resistance among different wheat genotypes, highlighting certain genotypes with high yield and resistance to stem rust and yellow rust.
Article
Multidisciplinary Sciences
Kazuhide Seo, Ichiro Matunari, Toshimasa Yamamoto
Summary: Patients with older-onset Parkinson's disease (PD) have more severe motor symptoms, faster progression, and a worse prognosis due to thinning of the cerebral cortex, which is possibly caused by extended α-synuclein deposition in the cortical regions.
Article
Forestry
Guangjin Liu, Zuwei Tian, Hongyan Jia, Wenhui Shen, Zuhe Li, Li Tang, Hongpeng Zhao, Jianmin Xu
Summary: In this study, 20-year-old Castanopsis hystrix experimental forests in Yulin, Liuzhou, and Pingxiang, Guangxi Province, China were used to assess the genetic variations and estimate the genetic parameters of growth and morphological traits. The average values for tree height, diameter at breast height (DBH), volume, height to live crown base (HCB), crown width (CW), and branch angle were determined. The block and family were found to be the most important sources of variance for growth and morphological traits, and the genotype x environment interaction effects were significant. Family heritability was also calculated for each trait. Excellent families with strong adaptability and genetic stability were identified using BLUP-GGE biplots. The results of this study provide a theoretical basis for efficient cultivation of C. hystrix in South China.
Article
Fisheries
Honghui Hu, Chaohu Sun, Zhiyi Bai, Jiale Li
Summary: This study estimated the heritabilities and genotype by environment interactions on inner shell color and growth traits of Hyriopsis cumingii reared in different water depths and mud substrates. The results showed that under the same mud substrate condition, animals reared in shallower water depths exhibited better performance in shell color and growth, while animals reared with mussel pond mud substrate showed superior performance in shell color and growth traits under the same water depth condition.
Article
Geriatrics & Gerontology
Haakon R. Hol, Marianne M. Flak, Linda Chang, Gro Christine Christensen Lohaugen, Knut Jorgen Bjuland, Lars M. Rimol, Andreas Engvig, Jon Skranes, Thomas Ernst, Bengt-Ove Madsen, Susanne S. Hernes
Summary: In patients with MCI, both adaptive and non-adaptive WM training did not lead to improved cortical thickness. However, individuals with LMX1A-AA genotype showed increased cortical thickness trajectories or lack of decrease post-training.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Fisheries
Matthew G. Hamilton, Wagdy Mekkawy, Md Badrul Alam, Benoy K. Barman, Manjurul Karim, John A. H. Benzie
Summary: The study aims to quantify the genetic differences among founder populations in genetic improvement programs and estimate the genetic parameters for harvest weight under different culture systems. The study found that the interaction and main effects among genetic groups were not significant. Additive genetic variances were significantly different from zero in most ponds for both species. The narrow-sense heritability estimates for harvest weight ranged within a certain range for both catla and silver carp.
Article
Psychology, Developmental
Stine K. Krogsrud, Athanasia M. Mowinckel, Donatas Sederevicius, Didac Vidal-Pineiro, Inge K. Amlien, Yunpeng Wang, Oystein Sorensen, Kristine B. Walhovd, Anders M. Fjell
Summary: Working memory capacity changes significantly throughout life, with improvements during childhood and adolescence but decline in older age mainly attributed to reductions in passive storage capacity. Greater WM function during development is associated with apparent thinner cortex, a relationship also observed in young adults. These WM-thickness relationships cannot be explained by SNP-based co-heritability or socioeconomic status, suggesting the need for larger samples with genetic information to unravel true gene-environment effects.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Christienne G. Damatac, Roselyne J. M. Chauvin, Marcel P. Zwiers, Daan van Rooij, Sophie E. A. Akkermans, Jilly Naaijen, Pieter J. Hoekstra, Catharina A. Hartman, Jaap Oosterlaan, Barbara Franke, Jan K. Buitelaar, Christian F. Beckmann, Emma Sprooten
Summary: This study found that lower fractional anisotropy (FA) in the right cingulum angular bundle was associated with higher hyperactivity-impulsivity symptom severity in patients with attention-deficit/hyperactivity disorder (ADHD), however, no evidence was found for altered FA in association with ADHD diagnosis or impairment. The associations of FA with ADHD symptom severity were not uniformly distributed across white matter tracts.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Biochemistry & Molecular Biology
Emma Sprooten, Barbara Franke, Corina U. Greven
Summary: The article introduces three general dimensions to describe the covariance of psychopathology, including a general psychopathology factor, genetic and neural effects on behavior. A unified interpretation is proposed, suggesting that these general dimensions partly reflect a combination of heritable 'environmental' factors influenced by gene-environment correlations.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Joao P. O. F. T. Guimaraes, E. Sprooten, C. F. Beckmann, B. Franke, J. Bralten
Summary: This study used genomic structural equation modeling to analyze the genetic effects on brain resting state networks (RSNs) and identified the SNPs and genes driving the pleiotropy of RSNs. The results suggest that multivariate modeling is a powerful approach to investigate the biological mechanisms of brain function.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
John D. Lewis, Gleb Bezgin, Vladimir S. Fonov, D. Louis Collins, Alan C. Evans
Summary: The study focuses on mapping and parcellating the brain structures, facing challenges due to vast individual differences in morphology. The authors extend a surface-based approach to include both cortical and subcortical structures, resulting in a more uniform functional parcellation. Results show that this extended functional parcellation provides greater homogeneity in functional connectivity patterns, aligns with known cortical and subcortical architecture, and fits better to changes in white/gray contrast data over the lifespan, supporting its use with surface-based metrics.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemical Research Methods
Elizabeth DuPre, Chris Holdgraf, Agah Karakuzu, Loic Tetrel, Pierre Bellec, Nikola Stikov, Jean-Baptiste Poline
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biology
Andrew T. Reid, Julia A. Camilleri, Felix Hoffstaedter, Simon B. Eickhoff
Summary: This study presents a method for deriving tract-specific statistics based on diffusion-weighted MRI and predefined regions of interest. The results show both positive and negative associations between age and tract-specific anisotropy, as well as moderate sex differences and age-by-sex interactions.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Emily C. Merz, Jordan Strack, Hailee Hurtado, Uku Vainik, Michael Thomas, Alan Evans, Budhachandra Khundrakpam
Summary: Genome-wide polygenic scores for educational attainment (PGS-EA) and socioeconomic factors are associated with academic achievement and cognitive ability in children and adolescents. This study explores the independent contributions of PGS-EA and parental education to cortical structure and neurocognitive skills, as well as the associations between PGS-EA, cortical structure, and neurocognitive skills.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Budhachandra Khundrakpam, Neha Bhutani, Uku Vainik, Jinnan Gong, Noor Al-Sharif, Alain Dagher, Tonya White, Alan C. C. Evans
Summary: Studies have found cortical alterations in individuals with autism spectrum disorders (ASD) and those with high polygenic risk for ASD, and investigating the underlying brain network architecture is important in understanding the mechanisms of ASD. This study used clinical data and structural connectome-based network measures to assess ASD-related cortical alterations and cortical correlates of polygenic risk for ASD. The study highlighted the role of network architecture in ASD and the predictive value of structural connectomes in assessing polygenic risk for ASD.
MOLECULAR PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Sourena Soheili-Nezhad, Emma Sprooten, Indira Tendolkar, Marco Medici
Summary: There is an association between thyroid dysfunction and depression, bipolar disorder, and anxiety disorders, particularly with autoimmune hypothyroidism. Genetics play a significant role in this association, especially at the major histocompatibility complex locus on chromosome 6.
Article
Multidisciplinary Sciences
Qing Wang, Meshal Aljassar, Nikhil Bhagwat, Yashar Zeighami, Alan C. Evans, Alain Dagher, G. Bruce Pike, Abbas F. Sadikot, Jean-Baptiste Poline
Summary: This study analyzed the structural differences in the cerebellum in ET using a large dataset and found that the results varied with different methods, suggesting that the current estimation of cerebellar involvement in ET may be overemphasized in MRI studies. It highlights the importance of methods sensitivity analysis on results interpretation.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Kuaikuai Duan, Jiayu Chen, Vince D. D. Calhoun, Wenhao Jiang, Kelly Rootes-Murdy, Gido Schoenmacker, Rogers F. F. Silva, Barbara Franke, Jan K. K. Buitelaar, Martine Hoogman, Jaap Oosterlaan, Pieter J. J. Hoekstra, Dirk Heslenfeld, Catharina A. A. Hartman, Emma Sprooten, Alejandro Arias-Vasquez, Jessica A. A. Turner, Jingyu Liu
Summary: In this study, a genomic pattern underlying the gray matter variation in the frontal cortex related to working memory deficit in ADHD was revealed through a multivariate analysis. The identified genes are involved in modulating neuronal substrates underlying high-level cognition in ADHD, providing insights into the pathology of ADHD persistence.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Shima Rastegarnia, Marie St-Laurent, Elizabeth DuPre, Basile Pinsard, Pierre Bellec
Summary: This paper investigates the training and accuracy of brain decoding models at the individual level. The research trained multiple classifiers on an individual fMRI dataset and evaluated different decoding methods. The study found that GCN and MLP models trained at the individual level achieved higher prediction accuracies, approaching the best accuracy achieved by models trained at the group level.
Article
Neuroimaging
Christienne G. Damatac, Sourena Soheili-Nezhad, Guilherme Blazquez Freches, Marcel P. Zwiers, Sanne de Bruijn, Seyma Ikde, Christel M. Portengen, Amy C. Abelmann, Janneke T. Dammers, Daan van Rooij, Sophie E. A. Akkermans, Jilly Naaijen, Barbara Franke, Jan K. Buitelaar, Christian F. Beckmann, Emma Sprooten
Summary: This study used a more physiologically informative fixel-based analysis to investigate the relationship between longitudinal changes in symptoms of childhood ADHD and white matter microstructure. The results showed that clinical improvement in ADHD and hyperactivity/impulsivity symptoms over time was associated with increased fiber density and cross-section in specific brain regions.
NEUROIMAGE-CLINICAL
(2022)
Meeting Abstract
Neurosciences
Joao Guimaraes, Barbara Franke, Christian Beckmann, Janita Bralten, Emma Sprooten
BIOLOGICAL PSYCHIATRY
(2022)
