Chemotherapy-related cognitive dysfunction: current animal studies and future directions

Chemotherapy drug thioTEPA exacerbates stress-induced anhedonia and corticosteroid responses but not impairment of hippocampal cell proliferation in adult mice

(2012) Courtney L. Wilson et al.   BEHAVIOURAL BRAIN RESEARCH

The effect of 5-fluorouracil on the long term survival and proliferation of cells in the rat hippocampus

(2012) Maha ELBeltagy et al.   BRAIN RESEARCH BULLETIN

Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer

(2012) Miyoung Yang et al.   BRAIN RESEARCH BULLETIN

The Effects of Chemotherapy on Cognitive Function in a Mouse Model: A Prospective Study

(2012) G. Winocur et al.   CLINICAL CANCER RESEARCH

Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy

(2012) L.-A. Christie et al.   CLINICAL CANCER RESEARCH

Chemotherapy-Related Cognitive Dysfunction

(2012) Jeffrey S. Wefel et al.   Current Neurology and Neuroscience Reports

Neuropsychological Performance in Survivors of Breast Cancer More Than 20 Years After Adjuvant Chemotherapy

(2012) Vincent Koppelmans et al.   JOURNAL OF CLINICAL ONCOLOGY

Learning to Learn: Theta Oscillations Predict New Learning, which Enhances Related Learning and Neurogenesis

(2012) Miriam S. Nokia et al.   PLoS One

Fluoxetine Counteracts the Cognitive and Cellular Effects of 5-Fluorouracil in the Rat Hippocampus by a Mechanism of Prevention Rather than Recovery

(2012) Laura Lyons et al.   PLoS One

Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist

(2011) Veena Vijayanathan et al.   BEHAVIOURAL BRAIN RESEARCH

Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis

(2011) Michelle Monje et al.   BEHAVIOURAL BRAIN RESEARCH

Neurotoxicity of methotrexate to hippocampal cells in vivo and in vitro

(2011) Miyoung Yang et al.   BIOCHEMICAL PHARMACOLOGY

Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications

(2011) Teresita L Briones et al.   BMC NEUROSCIENCE

2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain

(2011) Christopher D. Aluise et al.   FREE RADICAL BIOLOGY AND MEDICINE

Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model

(2011) Gordon Winocur et al.   NEUROPHARMACOLOGY

Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats

(2011) Jeffrey M. Long et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Effects of Cyclophosphamide on Hippocampal Cell Proliferation and Spatial Working Memory in Rat

(2011) Laura Lyons et al.   PLoS One

Reversible modulations of neuronal plasticity by VEGF

(2011) T. Licht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice

(2010) Christopher M. Mondie et al.   BEHAVIOURAL BRAIN RESEARCH

Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer

(2010) Jeffrey S. Wefel et al.   CANCER

Mathematical and Experimental Approaches to Identify and Predict the Effects of Chemotherapy on Neuroglial Precursors

(2010) O. Hyrien et al.   CANCER RESEARCH

Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto (Bixa orellana) seeds

(2010) Ganiyu Oboh et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Longitudinal Assessment of Cognitive Changes Associated With Adjuvant Treatment for Breast Cancer: Impact of Age and Cognitive Reserve

(2010) Tim A. Ahles et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits

(2010) Miyoung Yang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain

(2010) G. Joshi et al.   NEUROSCIENCE

Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia Mangostana

(2010) J. Tangpong et al.   NEUROSCIENCE

Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research

(2010) Riejanne Seigers et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Metallothionein Induction Reduces Caspase-3 Activity and Tnfα Levels with Preservation of Cognitive Function and Intact Hippocampal Neurons in Carmustine-Treated Rats

(2010) Gouda K. Helal et al.   Oxidative Medicine and Cellular Longevity

Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine

(2010) Yan Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy

(2010) Laura Lyons et al.   PSYCHOPHARMACOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats

(2009) Riejanne Seigers et al.   BEHAVIOURAL BRAIN RESEARCH

Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release

(2009) Riejanne Seigers et al.   BEHAVIOURAL BRAIN RESEARCH

Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil

(2009) Maha ELBeltagy et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor

(2009) Riejanne Seigers et al.   BRAIN RESEARCH BULLETIN

IGF-1 Partially Restores Chemotherapy-Induced Reductions in Neural Cell Proliferation in Adult C57BL/6 Mice

(2009) Michelle C. Janelsins et al.   CANCER INVESTIGATION

Cyclophosphamide-induced oxidative stress in brain: Protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum)

(2009) Ganiyu Oboh et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption

(2009) Benson W.M. Lau et al.   NEUROREPORT

Systemic administration of doxorubicin impairs aversively motivated memory in rats

(2009) Pedro Emanuel Rubini Liedke et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats

(2009) Yan Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neurofilament isoform alterations in the rat cerebellum following cytosine arabinoside administration

(2009) Christos Koros et al.   TOXICOLOGY LETTERS

The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats

(2008) Juan P. Cata et al.   BRAIN RESEARCH

Cytosine arabinoside treatment impairs the remote spatial memory function and induces dendritic retraction in the anterior cingulate cortex of rats

(2008) Chang-Qi Li et al.   BRAIN RESEARCH BULLETIN

5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus

(2008) Sarah Mustafa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats

(2008) Gregory W. Konat et al.   METABOLIC BRAIN DISEASE

A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice

(2008) M.J. Gandal et al.   NEUROSCIENCE

Clinical Patterns and Biological Correlates of Cognitive Dysfunction Associated with Cancer Therapy

(2008) J. Dietrich et al.   ONCOLOGIST

Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat

(2007) R SEIGERS et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammation: A new candidate in modulating adult neurogenesis

(2007) Sulagna Das et al.   JOURNAL OF NEUROSCIENCE RESEARCH