Article
Clinical Neurology
Luis Octavio Tierradentro-Garcia, Alireza Zandifar, Jorge Du Ub Kim, Savvas Andronikou
Summary: This study retrospectively analyzed three cases of parechovirus encephalitis, including two newborns and one adolescent, and described their neuroimaging findings in detail. The typical findings in neonatal cases included restricted diffusion of subcortical and periventricular white matter, along with abnormal corpus callosum signal and bilateral swollen thalami. The adolescent case showed an additional pattern of white matter signal abnormality in the corona radiata in continuity with the corticospinal tracts.
PEDIATRIC NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Eero Hietanen, Lav Tripathi, Eeva-Christine Brockmann, Pirjo Merilahti, Urpo Lamminmaki, Petri Susi
Summary: This study successfully isolated phage display antibodies against human parechoviruses, which may have broad applications in diagnostic antibody development.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Pablo J. Sanchez, Reginald A. Woods, Huanyu Wang, Andrea Ronchi, Carlo Pietrasanta, Ian C. Michelow, Fabio Mosca, Lorenza Pugni, Amy Leber
Summary: In a study of 65 inborn infants evaluated for late-onset sepsis, no parechovirus or enterovirus RNA was detected in nasopharyngeal specimens during the sepsis evaluations.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Immunology
Danna Zhou, Shuangshuang Wang, Keli Yang, Xue Liu, Wei Liu, Rui Guo, Wan Liang, Fangyan Yuan, Zewen Liu, Ting Gao, Yong-xiang Tian
Summary: A new real-time nucleic acid sequence-based amplification (RT-NASBA) method was developed for rapid detection of Japanese encephalitis virus (JEV), showing high specificity and sensitivity.
MICROBIAL PATHOGENESIS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chi-Wei Robin Yang, Michael Mason, Paul M. Parizel, Richard Warne
Summary: Pediatric brain infections are relatively rare, but it is crucial for radiologists to be able to recognize the disease and provide accurate differential diagnoses. MRI plays a significant role in identifying the most probable causative pathogen in children with acute infectious encephalitis, as well as in assessing children for the consequences of past infections. The article presents a framework of six key MRI patterns commonly seen in pediatric brain infections, focusing on acute infectious encephalitis, to help guide differential diagnoses in clinical practice.
INSIGHTS INTO IMAGING
(2022)
Article
Medicine, General & Internal
Juan-Juan Liu, Li-Ping Teng, Chun-Zhen Hua, Yong-Ping Xie, Yan-Xiang Pan, Bo-Fei Hu, Wei-Lin Hu, Wei-Jian Wang
Summary: This study aimed to investigate the common pathogens of viral encephalitis (VE) in children, and found that enterovirus (EV) is the most common causative pathogen. The study also revealed that VE is more prevalent in the summer in Zhejiang province.
Review
Infectious Diseases
Thomas Pichl, Catherine J. Wedderburn, Chandrashekar Hoskote, Lance Turtle, Tehmina Bharucha
Summary: A systematic review of brain imaging findings in Japanese encephalitis (JE) and dengue virus (DENV) neurological infection revealed that thalamic lesions were commonly observed, but more frequent in JE. No radiological findings were found to be specific to either disease.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
German Tapia, Katerina Chuda, Christian R. Kahrs, Lars C. Stene, Lenka Kramna, Karl Marild, Trond Rasmussen, Kjersti S. Ronningen, Ondrej Cinek, Ketil Stordal
Summary: Parechovirus infections in early life are associated with the development of CD in genetically at-risk children, while anellovirus does not show significant differences. The results support the hypothesis.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pediatrics
Muayad Alali, Kiet Tat, Shannon Hamilton, Drew A. Streicher, James G. Carlucci
Summary: In July 2022, there was an increase in reported cases of PeV infections among infants in the USA. A retrospective cohort study examined the clinical characteristics and outcomes of PeV encephalitis in infants under 90 days old. Out of 2115 infants evaluated, 32 cases of PeV encephalitis were identified. The study found that PeV can cause encephalitis and sepsis-like syndrome in infants, even when cerebrospinal fluid (CSF) parameters are normal. Prospective studies are needed to understand PeV epidemiology and monitor outbreaks.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Virology
Sara Sanbonmatsu-Gamez, Irene Pedrosa-Corral, Jose Maria Navarro-Mari, Mercedes Perez-Ruiz
Summary: This study reports 107 cases of TOSV neurological infection identified in Andalusia, Spain, with the majority of cases located in the hyperendemic region of Granada province. The research highlights the potential underdiagnosis of TOSV neurological infection and introduces an automated method for detecting related viruses, aiming to improve diagnostic efficiency and speed for such syndromes.
Article
Virology
Xiujie Gao, Jindou Hao, Lin Yu, Yan Cao, Jianfang Liang, Juan Han, Rong Zou, Xike Zhou, Peihui Liu
Summary: The outbreak of the COVID-19 epidemic has emphasized the need for rapid and accurate detection methods for enterovirus. This study established an ultra-fast RT-PCR equipment to evaluate a testing method for enterovirus nucleic acids. The results showed that the method achieved fast and accurate detection within 24 minutes, with high sensitivity and good repeatability.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Neurosciences
Jessica Hui Yin Tan, Chew Thye Choong, Nancy Wen Sim Tee, Chia Yin Chong, Koh Cheng Thoon, Matthias Maiwald, Elis Yue Xian Lee, Melody Si Shan Tan, Natalie Woon Hui Tan
Summary: HPeV is a common cause of aseptic meningitis in children aged <= 1 year, with symptoms including poor feeding, tachycardia, and lethargy. Patients with HPeV meningitis typically lack CSF pleocytosis, and are less likely to have it compared to EV meningitis cases.
JOURNAL OF NEUROVIROLOGY
(2022)
Article
Virology
Mami Oba, Shiho Obinata, Hitoshi Takemae, Kei Kazama, Masashi Oguro, Kazuki Ito, Seiichi Kakinuma, Hiroho Ishida, Hironobu Murakami, Shoichi Sakaguchi, Tetsuya Mizutani, Makoto Nagai
Summary: In this study, bovine parechoviruses (Bo_ParVs) were detected in 10 out of 158 bovine fecal samples using real-time RT-PCR, with three samples yielding isolateable Bo_ParVs. Analysis of the P1 region revealed high amino acid sequence similarity (>= 95.7%) among Bo_ParVs, indicating antigenic similarity, while nucleotide sequence identity values (>= 84.8%) showed more variability. A recombination breakpoint was identified in the 2B region, suggesting its potential influence on the virus evolution.
ARCHIVES OF VIROLOGY
(2023)
Article
Pediatrics
Xueyuan Wang, Xianglong Liu, Meiying Cheng, Desheng Xuan, Xin Zhao, Xiaoan Zhang
Summary: This study used diffusion kurtosis imaging (DKI) to explore the changing patterns of white matter and gray matter during neonatal brain development. The DKI metrics were measured and analyzed, showing positive correlations with the age at the time of brain MRI acquisition. The DKI parameters showed potential advantages in detecting changes in brain microstructure during neonatal brain development.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Regan King, Selma Low, Nancy Gee, Roger Wood, Bonny Hadweh, Joanne Houghton, Lara M. Leijser
Summary: Magnetic resonance imaging (MRI) is commonly used for imaging newborn infant brains, but the challenge of infant movement affects image quality. A systematic approach, including the use of the feed-and-bundle technique, reduces infant motion and ensures high-quality images.
Article
Clinical Neurology
Ana Filipa Geraldo, Cesar Augusto P. F. Alves, Aysha Luis, Domenico Tortora, Joana Guimaraes, Daisy Abreu, Sofia Reimao, Marco Pavanello, Patrizia de Marco, Marcello Scala, Valeria Capra, Rui Vaz, Andrea Rossi, Erin Simon Schwartz, Kshitij Mankad, Mariasavina Severino
Summary: This study investigates the neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. It reveals that the incidence and risk factors of symptomatic hemorrhage in children with FCCM are comparable to those in adults. Imaging features at the first brain MRI may help predict future symptomatic hemorrhage.
Review
Pediatrics
Andrea Rossi, Maria Argyropoulou, Dora Zlatareva, Gregoire Boulouis, Francesca B. Pizzini, Luc van den Hauwe, Maria Raissaki, Jean-Pierre Pruvo, Karen Rosendahl, Chen Hoffmann, Pia C. Sundgren
Summary: This article discusses the importance of pediatric neuroradiology and the lack of standardized training programs in European countries. It provides recommendations and guidance for the safe practice of pediatric neuroradiology, including imaging techniques, facility requirements, and team requirements.
PEDIATRIC RADIOLOGY
(2023)
Review
Pediatrics
Clara Adriana Maria de Bruijn, Stefano Di Michele, Maria Luisa Tataranno, Luca Antonio Ramenghi, Andrea Rossi, Mariya Malova, Manon Benders, Agnes van den Hoogen, Jeroen Dudink
Summary: This study evaluated the influence of punctate white matter lesions (PWML) on long-term neurodevelopmental outcomes in preterm infants. The findings showed a correlation between PWML and motor delay, as well as between PWML and cognitive and behavioral outcomes. The severity and types of impairments were found to be related to the number and location of PWML.
PEDIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Vincenzo Daniele Boccia, Caterina Lapucci, Maria Cellerino, Francesco Tazza, Andrea Rossi, Simona Schiavi, Maria Margherita Mancardi, Matilde Inglese
Summary: The contribution of the central vein sign (CVS) to the diagnosis of multiple sclerosis (MS) was compared between pediatric-onset (POMS) and adult-onset (AOMS) patients. The study found that CVS had lower sensitivity in POMS patients, possibly due to the exclusion of a high proportion of periventricular confluent lesions from CVS assessment.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Silvia Boeri, Marina Martinez Popple, Thea Giacomini, Tommaso Bellini, Mariasavina Severino, Andrea Rossi, Carla Debbia, Silvana Ancona, Elena Aldera, Lino Nobili, Laura Siri
Summary: A 12-year-old boy developed central nervous system demyelinating lesions following SARS-CoV-2 infection. He experienced symptoms such as headache and orbital pain, but recovered well after treatment. This case contributes to expanding our understanding of possible complications of COVID-19 and serves as a reminder not to overlook mild neurological symptoms associated with the disease.
Article
Clinical Neurology
Gelsomina Aruta, Pietro Fiaschi, Marco Ceraudo, Gianluca Piatelli, Valeria Capra, Andrea Bianconi, Andrea Rossi, Francesca Secci, Marco Pavanello
Summary: This article examines the association between multisutural craniosynostosis with Chiari malformation (CM), venous hypertension, and hydrocephalus, and proposes a simple and effective therapeutic flow-chart for managing these rare pathologies.
PEDIATRIC NEUROSURGERY
(2023)
Article
Virology
Cristina Galli, Laura Pellegrinelli, Federica Giardina, Guglielmo Ferrari, Sara Colonia Uceda Renteria, Federica Novazzi, Elisa Masi, Elisabetta Pagani, Giulia Piccirilli, Maria Vittoria Mauro, Sandro Binda, Benedetta Corvaro, Claudia Tiberio, Eleonora Lalle, Fabrizio Maggi, Cristina Russo, Stefania Ranno, Elisa Vian, Elena Pariani, Fausto Baldanti, Antonio Piralla
Summary: This study aimed to assess the circulation and molecular evolution of influenza viruses (IVs), particularly A(H3N2), during the 2021-2022 season in Italy. Analysis of respiratory specimens collected from January 1, 2022 to May 31, 2022 showed that all confirmed IVs were type A, with a majority being H3N2. Phylogenetic analysis revealed genetic clusters and mutations in the HA gene sequences, suggesting the presence of drifted strains. The study highlights the importance of molecular surveillance in assessing vaccine effectiveness and detecting novel strains.
Article
Immunology
Filippo Bianchini, Virginia Crivelli, Morgan E. Abernathy, Concetta Guerra, Martin Palus, Jonathan Muri, Harold Marcotte, Antonio Piralla, Mattia Pedotti, Raoul De Gasparo, Luca Simonelli, Milos Matkovic, Chiara Toscano, Maira Biggiogero, Veronica Calvaruso, Pavel Svoboda, Tomas Cervantes Rincon, Tommaso Fava, Lucie Podesvova, Akanksha A. Shanbhag, Andrea Celoria, Jacopo Sgrignani, Michal Stefanik, Vaclav Honig, Veronika Pranclova, Tereza Michalcikova, Jan Prochazka, Giuditta Guerrini, Dora Mehn, Annalisa Clabbattini, Hassan Abolhassani, David Jarrossay, Mariagrazia Uguccioni, Donata Medaglini, Qiang Pan-Hammarstroem, Luigi Calzolai, Daniel Fernandez, Fausto Baldanti, Alessandra Franzetti-Pellanda, Christian Garzoni, Radislav Sedlacek, Daniel Ruzek, Luca Varani, Andrea Cavalli, Christopher O. Barnes, Davide F. Robbiani
Summary: Using coldspot-guided antibody discovery, neutralizing antibodies to highly conserved viral epitopes were identified. Antibody fp.006 binds the fusion peptide and cross-reacts against coronaviruses. Antibody hr2.016 targets the stem helix and neutralizes SARS-CoV-2 variants. Antibody sd1.040 binds to subdomain 1 and synergizes with antibody rbd.042 for neutralization.
SCIENCE IMMUNOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Rosella Tro, Monica Roascio, Gabriele Arnulfo, Domenico Tortora, Mariasavina Severino, Andrea Rossi, Antonio Napolitano, Marco M. Fato
Summary: Choosing the most appropriate denoising method is crucial for improving the quality of diagnostic images in the pre-processing of diffusion MRI images. This study compared two adaptive techniques, Patch2Self and Nlsam, and found that Patch2Self framework is specifically suitable for DKI data, demonstrating better performance at 7T.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Sara Uccella, Alessandro Parodi, Maria Grazia Calevo, Lino Nobili, Domenico Tortora, Mariasavina Severino, Chiara Andreato, Andrea Rossi, Luca Antonio Ramenghi
Summary: This study aimed to determine the impact of isolated low-grade germinal matrix-intraventricular haemorrhages (LG-GMH-IVH) and low-grade punctate cerebellar haemorrhages (LG-CBH) on the neurodevelopment of infants born preterm with very low birthweight (VLBW). The results showed that both the LG-GMH-IVH and LG-CBH groups scored lower on the GMDS-ER assessments compared to the no-lesion group at all ages. Early rehabilitation may have contributed to the development of infants with LG-GMH-IVH, while it may have had a greater impact on the development of infants with LG-CBH.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Review
Virology
Angioletta Lasagna, Antonio Piralla, Sabrina Borgetto, Mattia Quaccini, Fausto Baldanti, Paolo Pedrazzoli
Summary: Torque teno virus (TTV) can be detected in over 90% of healthy individuals. It can be detected in various samples such as blood, serum, breast milk, cerebrospinal fluid, and saliva, as well as in different tissues such as the vagina and hepatocytes. TTV DNAemia is stable in healthy infected individuals, while TTV viral load is inversely correlated with T lymphocyte numbers and functions in immunocompromised populations. The role of TTV in cancer pathogenesis and response to anticancer treatments is still not well-known.
Review
Acoustics
Nevena Fileva, Mariasavina Severino, Domenico Tortora, Antonia Ramaglia, Dario Paladini, Andrea Rossi
Summary: Fetal MRI is a crucial tool for diagnosing brain malformations during prenatal stages, especially when ultrasound indicates a potential abnormality. Despite the immature state of the fetal brain, early signs of brain malformations can still be recognized. Differentiating between normal brain growth and pathological conditions can be challenging and requires extensive knowledge of the central nervous system's development and corresponding neuroradiological stages. This article provides a review of common second-trimester brain malformations, focusing on helpful tips and subtle signs to aid in the diagnosis of conditions such as rhombencephalosynapsis, vermian rotation, molar tooth spectrum anomalies, diencephalic-mesencephalic junction dysplasia, ganglionic eminence anomalies, and common malformations of cortical development.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Public, Environmental & Occupational Health
Jose Camilla Sammartino, Marta Colaneri, Cecilia Bassoli, Mariaelena Ceresini, Antonio Piralla, Alessandro Ferrari, Elena Percivalle, Fausto Baldanti, Raffaele Bruno, Mario U. Mondelli
Summary: This study aimed to verify the presence of viable virus on different surfaces exposed to droplets released by coughing in SARS-CoV-2 RNA positive patients. The results showed that droplets on common inanimate surfaces did not contain viable virus, while laboratory-propagated viruses could survive and grow on the same surfaces.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
George Hadjidekov, Gleb Haynatzki, Petya Chaveeva, Miroslav Nikolov, Gabriele Masselli, Andrea Rossi
Summary: This study compared the 2D and 3D segmentation of fetal lateral ventricles and brain structures using ultrasound and MRI. The results showed that both ultrasound and MRI measurements were consistent and reliable, providing valuable information for clinical prognosis and patient counseling.
Article
Infectious Diseases
Irene Mileto, Greta Petazzoni, Marta Corbella, Stefano Gaiarsa, Cristina Merla, Angela Kuka, Marina Ramus, Cristina Terulla, Micaela Brandolini, Antonio Piralla, Patrizia Cambieri, Fausto Baldanti
Summary: This article describes a new NDM-producing Kp clone, ST6668, that rapidly spread across hospitals in the Pavia province of Italy. Genomic surveillance programs are shown to be useful for tracking the spread of new clones with reduced antibiotic susceptibility.
