Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Virology
Akeno Tsuneki-Tokunaga, Kyosuke Kanai, Asao Itagaki, Hideaki Tsuchie, Takayoshi Okada, Masaaki Kasagi, Kiyoshi Tanaka, Miho Aoki, Alfredo Jr A. Hinay, Seiji Kageyama
Summary: This study assessed the correlation between the growth capability of epidemic influenza A/H1N1, A/H3N2, and B viruses in cells and the viral load in nasopharyngeal swabs, revealing a positive correlation between growth capability and viral load. Additionally, a high positive correlation between growth capability and cell death was observed in the experiment. Therefore, the growth capability of viruses plays a significant role in disease prognosis.
ARCHIVES OF VIROLOGY
(2021)
Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Krystal Lau, Ilaria Dorigatti, Marisa Miraldo, Katharina Hauck
Summary: This study estimated hospitalization rates, severity rates, mortality rates, and time lags between infections and hospitalizations of H1N1 pandemic patients in England during and after the pandemic period. Results showed increased severity in the post-pandemic flu season, highlighting the importance of continued vigilance by policymakers and researchers. Analysis of administrative hospital data and epidemiological modeling estimates can provide valuable insights for responding to COVID-19 and future pandemics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biology
Michael Lutz, Jordana Schmierer, Toru Takimoto
Summary: Avian species are the main source of pandemic influenza A viruses that can infect humans. This study found that avian influenza A virus genes, including PA, PB1, and PB2, need to undergo host-adaptive mutations in order to replicate and transmit in humans. It was discovered that the PA gene from the 2009 pH1N1 strain had host-adaptive mutations that enhanced viral replication by increasing translation efficiency. This was achieved through increased cytosolic accumulation of viral mRNA, which depended on the host RNA binding protein GRSF1. Mutations to the GRSF1 binding site and knockdown of GRSF1 reduced viral mRNA accumulation and translation efficiency. These findings reveal a previously unrecognized mechanism by which host-adaptive mutations in PA regulate viral replication and host adaptation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Veronica A. Ferrando, Marcel E. Friedrich, Shrey Gandhi, Alexander Mellmann, Doerthe Masemann, Anmari Christersson, Darisuren Anhlan, Linda Brunotte, Monika Stoll, Timm Harder, Martin Beer, Yvonne Boergeling, Stephan Ludwig
Summary: Influenza A viruses, including the H1N1pdm09 virus, cause recurrent epidemics and occasional pandemics in humans. The reassortment of these viruses in swine and their ability to replicate in human lung tissue suggest a possible zoonotic potential. Reassortment frequently occurs in the PB1, PA, and NA segments, resulting in the generation of reassortants that can reach high titers in swine lung cells.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Veterinary Sciences
Darling Melany de C. Madrid, Weihong Gu, Bianca L. Artiaga, Guan Yang, Julia Loeb, Ian K. Hawkins, William L. Castleman, John A. Lednicky, Jurgen A. Richt, John P. Driver
Summary: Influenza virus infections are a major respiratory disease in humans, and the primary antiviral medication used, NAIs, are not always effective. The emergence of NAI-resistant virus strains and the risk of severe side effects are concerns. This study compared the efficacy of oseltamivir with the iNKT cell superagonist, alpha-GalCer, and found that alpha-GalCer had no impact on virus replication or transmission.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuka Iwaya, Jun Muneuchi, Yuka Inoue, Mamie Watanabe, Seigo Okada, Yoshie Ochiai
PEDIATRIC CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Yuji Ohnishi, Hiroki Yasudo, Yasuo Suzuki, Takashi Furuta, Chie Matsuguma, Yoshihiro Azuma, Akiko Miyake, Seigo Okada, Kiyoshi Ichihara, Shouichi Ohga, Shunji Hasegawa
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Clinical Neurology
Seigo Okada, Shinnosuke Fukunaga, Haruka Ohta, Takashi Furuta, Reiji Hirano, Takahiro Motonaga, Yuichi Ishikawa
Article
Pediatrics
Seigo Okada, Shintaro Hashimoto, Akiko Miyake, Yusuke Okada, Reiji Hirano, Shinnosuke Fukunaga, Yuichi Ishikawa
FRONTIERS IN PEDIATRICS
(2020)
Letter
Immunology
Takashi Furuta, Hiroki Yasudo, Yuji Ohnishi, Akiko Miyake, Seigo Okada, Yasuo Suzuki, Shouichi Ohga, Shunji Hasegawa
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2020)
Article
Pediatrics
Yoshihiro Azuma, Yasuo Suzuki, Seigo Okada, Chie Matsuguma, Hiroyuki Wakiguchi, Yuji Ohnishi, Takashi Furuta, Akiko Miyake, Hiroki Yasudo, Kiyoshi Ichihara, Shouichi Ohga, Shunji Hasegawa
FRONTIERS IN PEDIATRICS
(2020)
Article
Cardiac & Cardiovascular Systems
Yuji Ohnishi, Seigo Okada, Hiroki Yasudo, Sasagu Kimura, Yasuo Suzuki, Shunji Hasegawa
INTERNATIONAL HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Takahiro Motonaga, Takashi Furuta, Seigo Okada, Yuji Ohnishi, Yasuo Suzuki, Hiroki Yasudo, Shunji Hasegawa
INTERNATIONAL HEART JOURNAL
(2020)
Editorial Material
Medicine, General & Internal
Seigo Okada, Shunji Hasegawa
Summary: The passage describes a male infant delivered at 28 weeks of gestation who exhibited bilious vomiting, abdominal distention, and inability to pass meconium. Physical examination revealed intestinal peristalsis, as shown in a video, indicating a need for further evaluation and intervention.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Seigo Okada, Yuji Ohnishi, Takashi Furuta, Hirofumi Inoue, Shunji Hasegawa
CARDIOLOGY JOURNAL
(2021)
Editorial Material
Pediatrics
Chie Matsuguma, Kazumasa Takahashi, Seigo Okada, Shunji Hasegawa
PEDIATRICS AND NEONATOLOGY
(2022)
Letter
Pediatrics
Seigo Okada, Yuji Ohnishi, Takashi Furuta, Yasuo Suzuki, Akiko Kawakami-Miyake, Chie Matsuguma, Takako Waniishi, Hiroki Yasudo, Shunji Hasegawa
WORLD JOURNAL OF PEDIATRICS
(2021)
Review
Cardiac & Cardiovascular Systems
Takahiro Motonaga, Yuji Ohnishi, Seigo Okada, Yasuo Suzuki, Takashi Furuta, Mai Kawamura, Naoko Okayama, Yutaka Suehiro, Shunji Hasegawa
Summary: Marfan syndrome is a rare genetic disorder with poor prognosis, especially in neonatal cases. This case study presents the successful outcome of mitral valve replacement in an 11-year-old girl with neonatal Marfan syndrome, suggesting that early surgical intervention may lead to better outcomes for these patients.
INTERNATIONAL HEART JOURNAL
(2022)
Article
Dermatology
Hidenobu Kaneyasu, Kazumasa Takahashi, Naoki Ohta, Seigo Okada, Sasagu Kimura, Shuichiro Yasuno, Susumu Murata, Shunsaku Katsura, Naoyuki Yamada, Koji Shiraishi, Junko Tsuda, Shunsuke Miyai, Hiroki Kurahashi, Shunji Hasegawa, Yutaka Shimomura
Summary: This study reports a case of EB with pyloric atresia and identifies two novel compound heterozygous mutations in the plectin gene. The study highlights the crucial role of plectin in various organs and provides valuable information about the phenotype associated with mutations in the PLEC gene.
JOURNAL OF DERMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuji Ohnishi, Seigo Okada, Takashi Furuta, Yasuo Suzuki, Yuki Iwaya, Shunji Hasegawa, Jun Muneuchi
TEXAS HEART INSTITUTE JOURNAL
(2020)