Journal
BRAIN & DEVELOPMENT
Volume 32, Issue 6, Pages 435-439Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2009.07.004
Keywords
Acute encephalopathy; Tau protein; Axonal damage
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
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Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently clinicoradiologically-established encephalopathy syndrome. In the present study, we examined the levels of cerebrospinal fluid (CSF) tau protein, a marker of axonal damage, in 11 patients with AESD. CSF tau levels were normal on day I and increased from day 3 of the disease between the initial and the secondary seizures. Magnetic resonance imaging (MRI) reveals reduced diffusion in the subcortical white matter during days 3-7. Two patients showed elevated tau protein prior to the diffusion abnormality of subcortical white matter on MRI. Levels of CSF neuron specific enolase (NSE), a neuronal marker, were elevated in only two out of seven patients with AESD, and CSF tau levels were also increased in these patients. Our results indicated that tau protein is a more sensitive marker than NSE and axonal damage causes the conspicuous M RI findings in AESD patients. A therapeutic strategy for axonal protection should be developed to prevent severe neurological impairment of A ESD patients. (C) 2009 Elsevier B.V. All rights reserved.
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