Dysfunctional mitochondrial maintenance: what breaks the circle of life?

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

(2011) Brendan A I Payne et al.   NATURE GENETICS

Subclinical multisystem neurologic disease in "pure" OPA1 autosomal dominant optic atrophy

(2011) M. R. Baker et al.   NEUROLOGY

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Multi-system neurological disease is common in patients with OPA1 mutations

(2010) P. Yu-Wai-Man et al.   BRAIN

Subtle neurological and metabolic abnormalities in an Opa1 mouse model of autosomal dominant optic atrophy

(2009) Marcel V. Alavi et al.   EXPERIMENTAL NEUROLOGY

Detection of cytochrome c oxidase activity and mitochondrial proteins in single cells

(2009) D.J. Mahad et al.   JOURNAL OF NEUROSCIENCE METHODS

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

(2007) P. Amati-Bonneau et al.   BRAIN