Article
Psychology, Biological
Tal Ness, Aya Meltzer-Asscher
Summary: Ample evidence supports the pre-activation of lexical/semantic knowledge during sentence processing, with a recent study proposing an activation threshold mechanism to explain pre-updating. By analyzing electrophysiological data combined with a speeded cloze task, the study found evidence of pre-updating in high constraint sentences, even when participants predicted a low cloze word.
Article
Psychology, Multidisciplinary
Susan Sayehli, Marianne Gullberg, Aaron J. Newman, Annika Andersson
Summary: This study examines the processing of variation in basic word order in native Swedish speakers. The results show that the naturally occurring word order "violation" is processed differently depending on the specific adverbial used, and that these patterns are related to individuals' own production patterns.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Francesca Delogu, Harm Brouwer, Matthew W. Crocker
Summary: The issue of spatiotemporal overlap between ERP components in language research can affect the interpretation of experimental results. This study demonstrates how considering the effects of overlap between N400 and P600 using rERP analysis can reconcile inconsistencies in findings and provide clear conclusions about their functional interpretations. The findings emphasize the importance of carefully considering component overlap when interpreting ERP patterns in language research.
Article
Psychology, Multidisciplinary
Harm Brouwer, Francesca Delogu, Noortje J. Venhuizen, Matthew W. Crocker
Summary: Research has found that expectation-based theories of language comprehension, particularly Surprisal Theory, are effective in explaining the behavioral correlates of word-by-word processing difficulty. However, there is still uncertainty about which component(s) of the Event-Related brain Potential (ERP) signal reflects Surprisal and how these electrophysiological correlates are related to behavioral processing indices. By establishing a neurocomputational model and experimental design, a close link between Surprisal and the P600 component has been identified, providing an integrated explanation for processing difficulty in language comprehension.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Biological
Anne L. Beatty-Martinez, Michelle R. Bruni, Maria Teresa Bajo, Paola E. Dussias
Summary: Studies of Spanish grammatical gender have shown that native speakers utilize gender cues and are sensitive to gender mismatches during speech processing. Research suggests that masculine and feminine grammatical gender may elicit qualitatively different brain responses, with variations in response dominance linked to cognitive control and lexical knowledge.
Article
Multidisciplinary Sciences
Natasha Janzen Ulbricht
Summary: Research shows that using gestures as a teaching tool can help learners grasp grammatical morphemes. This study finds that using gestures to teach grammatical morphemes leads to a decrease in response time during task completion, suggesting that gestures can enhance learners' procedural learning.
Article
Clinical Neurology
Jennifer N. Bress, Faith M. Gunning, Lindsay Arader, Patricia A. Arean, George S. Alexopoulos
Summary: This study investigated the effects of reward-focused interventions on the Positive Valence Systems (PVS) in older adults with major depression. The results showed an increase in the late positive potential, indicating enhanced response to rewarding stimuli, while no significant changes were observed in the reward positivity. This study provides preliminary evidence for understanding the therapeutic mechanism of late-life depression in older adults.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Annika Andersson, Marianne Gullberg
Summary: This study explored how L2 learners process L2 verb semantics in the domain of caused motion and found that the similarity between L1 and L2 influences processing and judgments, with both offline and online tasks showing crosslinguistic influence.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Jasna Mikic Ljubi, Andraz Matkovic, Jurij Bon, Aleksandra Kanjuo Mrcela
Summary: The present study investigated the effects of grammatical gender on the mental representation of grammatical subject using the event-related potential method. The results showed that gender-balanced forms were more likely to be paired with feminine continuations compared to masculine generic forms. This is the first ERP study in Slovenian to address the effects of processing grammatical gender.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Biological
Eric C. Fields
Summary: This paper discusses the emotion-related late positive potential (LPP) of the event-related potential (ERP), and argues that the function of the LPP is still uncertain. By linking the LPP to the P300 component of the ERP and exploring its connections to memory and emotional memory research, the author suggests that the LPP may be related to memory processes.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Psychology, Experimental
Liyan Ji
Summary: This study investigated the interaction between politeness processing and local syntactic/semantic processing, revealing that the local syntactic/semantic processing takes functional primacy over politeness processing during language comprehension. The results support the blocking hypothesis from a politeness processing perspective.
Article
Audiology & Speech-Language Pathology
Mael Mauchand, Marc D. Pell
Summary: When complaining, the voice can convey a feeling of pain, even when describing harmless events. The processing of complaints is influenced by the emotional features of the voice, as shown by the N400 and P600 effects. Prosody and accent also play a role in the processing of spoken complaints, according to the parallel-constraint-satisfaction model proposed in this study.
BRAIN AND LANGUAGE
(2023)
Article
Neurosciences
Cristina Lopez-Rojas, Aniko Csilinko, M. Teresa Bajo, Alejandra Marful
Summary: Language influences how bilinguals process information and perform cognitive tasks, such as visual search, decision-making, or reading, in their first (L1) or second language (L2). However, few studies have investigated the impact of bilingual language processing on Prospective Memory (PM) abilities, which involve setting intentions for future actions. This novel study explored the neural and behavioral correlates of bilinguals during L1 and L2 processing in a PM task. The results revealed impaired prospective processing during L2 processing, indicating the influence of working in L2 contexts on PM.
Article
Geriatrics & Gerontology
Milica R. Prvulovic, Desanka J. Milanovic, Predrag Z. Vujovic, Milena S. Jovic, Selma D. Kanazir, Smilja T. Todorovic, Aleksandra N. Mladenovic
Summary: This study aims to determine the potential benefits of calorie restriction (CR) on cognitive performances in aging female rats. The results show that the effects of CR depend on the duration and onset of restriction. Life-long restriction with an early-onset is protective and beneficial, while short-term restriction introduced at a late age worsens behaviors and frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Dara E. Babinski, Samantha Pegg, Michael West, Kodi B. Arfer, Autumn Kujawa
Summary: The study aimed to examine how emerging adults with borderline personality features process social feedback. The findings indicate that individuals with higher levels of borderline personality features show heightened neural and behavioral responses to social acceptance, but struggle to modulate their behaviors adaptively to obtain more social rewards.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Andrea Schneider, Tri Indah Winarni, Ana Maria Cabal-Herrera, Susan Bacalman, Louise Gane, Paul Hagerman, Flora Tassone, Randi Hagerman
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Eleonora Napoli, Yingratana Amabel McLennan, Andrea Schneider, Flora Tassone, Randi J. Hagerman, Cecilia Giulivi
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Behavioral Sciences
David Hessl, Lauren Libero, Andrea Schneider, Connor Kerns, Breanna Winder-Patel, Brianna Heath, Joshua Lee, Cory Coleman, Natasha Sharma, Marjorie Solomon, Christine Wu Nordahl, David G. Amaral
Summary: The study found that the connection between fear conditioning and anxiety in children with autism spectrum disorder (ASD) depends on the size of the amygdala.
Review
Biotechnology & Applied Microbiology
Jill A. Morris, Chris H. Boshoff, Nina F. Schor, Ling M. Wong, Guangping Gao, Beverly L. Davidson
Summary: NINDS organized a workshop on gene-targeted therapies for CNS disorders, bringing together experts from various fields to identify challenges and propose solutions. Prior to the workshop, key obstacles and research gaps were identified through pre-meeting teleconferences, allowing for problem-solving discussions and strategy development at the workshop.
Article
Neurosciences
Maria Jimena Salcedo-Arellano, Desiree Sanchez, Jun Yi Wang, Yingratana A. McLennan, Courtney Jessica Clark, Pablo Juarez, Andrea Schneider, Flora Tassone, Randi J. Hagerman, Veronica Martinez-Cerdeno
Summary: This case report documents the co-occurrence of FXTAS and AD in a 71-year-old carrier with rapid cognitive decline and remarkable MRI changes.
FRONTIERS IN NEUROSCIENCE
(2021)
Letter
Biotechnology & Applied Microbiology
Nina F. Schor, Amir P. Tamiz, Walter J. Koroshetz, Ann-Marie Broome, Julia L. Bachman, Chris Boshoff, Janice Cordell, Neel T. Dhruv, Amelie Gubitz, Adam L. Hartman, Walter J. Koroshetz, Genevieve E. Lind, Codrin I. Lungu, Jill A. Morris, Glen H. Nuckolls, Shantadurga Rajaram, Ranga Rangarajan, Rebecca A. Roof, Nina F. Schor, Mario H. Skiadopoulos, Natalia Strunnikova, Amir P. Tamiz, Ling M. Wong, Clinton B. Wright
NATURE BIOTECHNOLOGY
(2021)
Article
Psychiatry
Melodie Proteau-Lemieux, Inga Sophia Knoth, Kristian Agbogba, Valerie Cote, Hazel Maridith Barlahan Biag, Angela John Thurman, Charles-Olivier Martin, Anne-Marie Belanger, Cory Rosenfelt, Flora Tassone, Leonard J. Abbeduto, Sebastien Jacquemont, Randi Hagerman, Francois Bolduc, David Hessl, Andrea Schneider, Sarah Lippe
Summary: Research compared brain signal features between FXS patients and neurotypical controls, revealing significant changes in signal complexity in FXS patients, indicating potential brain alterations.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Devon Johnson, Ellery Santos, Kyoungmi Kim, Matthew D. Ponzini, Yingratana A. McLennan, Andrea Schneider, Flora Tassone, Randi J. Hagerman
Summary: Individuals with the fragile X premutation often experience chronic pain symptoms, with women being more likely than men to experience pain, particularly allodynia, peripheral neuropathy pain, migraine, fibromyalgia, and back pain. Onset of peripheral neuropathy predicts the onset of ataxia and tremor, and women also report higher levels of anxiety.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Jessica Famula, Emilio Ferrer, Randi J. Hagerman, Flora Tassone, Andrea Schneider, Susan M. Rivera, David Hessl
Summary: Carriers of the FMR1 premutation have an increased risk of developing FXTAS, a neurodegenerative disease characterized by intention tremor, ataxia, and cognitive decline. Longitudinal study showed that FMR1 premutation carriers exhibited greater rates of decline in visual working memory, motor dexterity, inhibitory control, and manual movement speed. The findings suggest that executive function decline and subtle motor changes may precede and track with the emergence of FXTAS symptoms.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2022)
Correction
Psychiatry
Melodie Proteau-Lemieux, Inga Sophia Knoth, Kristian Agbogba, Valerie Cote, Hazel Maridith Barlahan Biag, Angela John Thurman, Charles-Olivier Martin, Anne-Marie Belanger, Cory Rosenfelt, Flora Tassone, Leonard J. Abbeduto, Sebastien Jacquemont, Randi Hagerman, Francois Bolduc, David Hessl, Andrea Schneider, Sarah Lippe
FRONTIERS IN PSYCHIATRY
(2022)
Article
Genetics & Heredity
Ramkumar Aishworiya, Dragana Protic, Si Jie Tang, Andrea Schneider, Flora Tassone, Randi Hagerman
Summary: This study identified a high prevalence of fragile X-associated neurodevelopmental disorders (FXAND) in a sample of young individuals with fragile X premutation carrier state (PM). The presence of FXAND and early recognition of associated symptoms may facilitate timely and appropriate care for PM individuals.
Article
Medicine, General & Internal
Si Jie Tang, Shanthi Giri, Nima Pahlavan, Sophia H. Han, Ellery R. Santos, Glenda Espinal, Ramkumar Aishworiya, Andrea Schneider, David Hessl, Susan M. Rivera, Randi J. Hagerman
Summary: In this case study, we report a 68-year-old male with FXTAS who presented with uncontrolled gout involving multiple sites, including a rare gouty tophus in the nasal region.
CLINICAL CASE REPORTS
(2022)
Article
Cell Biology
Ramkumar Aishworiya, Mei-Hung Chi, Marwa Zafarullah, Guadalupe Mendoza, Matthew Dominic Ponzini, Kyoungmi Kim, Hazel Maridith Barlahan Biag, Angela John Thurman, Leonard Abbeduto, David Hessl, Jamie Leah Randol, Francois V. Bolduc, Sebastien Jacquemont, Sarah Lippe, Paul Hagerman, Randi Hagerman, Andrea Schneider, Flora Tassone
Summary: This study provides insights into the use of molecular biomarkers to identify clinical phenotypes of fragile X syndrome (FXS). Findings show positive correlations between FMR1 mRNA expression levels and adaptive functioning, language, and specific NIH Toolbox measures. Other correlations include MMP-9 levels with obesity, CYFIP1 mRNA with mood and autistic symptoms, and FMR1 mRNA expression level with better cognitive, language, and adaptive functions. These potential biomarkers could guide future targeted treatments for FXS.
Meeting Abstract
Education, Special
R. Aishworiya, M. Zafarullah, M. J. Salcedo-Arellano, K. Kim, H. Biag, A. Schneider, D. Hessl, F. Tassone, R. Hagerman
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2022)
Review
Clinical Neurology
Akash Rajaratnam, Laura Axelrod Potter, Hazel Maridith Barlahan Biag, Andrea Schneider, Ignacio Cortina Petrasic, Randi Jenssen Hagerman
FRONTIERS IN NEUROLOGY
(2020)