Article
Cell Biology
Severine Ledoux, Nathalie Boulet, Chloe Belles, Alexia Zakaroff-Girard, Arnaud Bernard, Alberic Germain, Pauline Decaunes, Anais Briot, Jean Galitzky, Anne Bouloumie
Summary: This study analyzed the characteristics of unhealthy expansion of subcutaneous and visceral adipose tissue in obesity and weight loss surgery outcomes. It found that adipogenesis and adipocyte hypertrophy are important factors in metabolic alterations related to obesity and response to bariatric surgery. These findings contribute to a better understanding and prediction of individual responses to changes in energy balance.
Review
Biotechnology & Applied Microbiology
Xiaoshen Hu, Weiyang Zhang, Xiang Li, Dongling Zhong, Yuxi Li, Juan Li, Rongjiang Jin
Summary: Studies have shown that chondrocytes tend to dedifferentiate during cell amplification, losing their physiological properties, but recent research has made progress in redifferentiation control. By modulating various factors in cell culture, similar physiological characteristics and functions to human cartilage tissue have been achieved, offering hope for future cartilage repair and treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhe Cheng, Xinyu Xiong, Yi Zhou, Fan Wu, Qingqing Shao, Ruolan Dong, Qiong Liu, Lingli Li, Guang Chen
Summary: The study demonstrated that 6-gingerol can alleviate obesity by regulating adipocytokines and the TLR3/IL-6/JAK1/STAT3 axis, inhibiting excessive hyperplasia and hypertrophy of adipocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Multidisciplinary
Gao-Peng Dang, Wen Qin, Qian-Qian Wan, Jun-Ting Gu, Kai-Yan Wang, Zhao Mu, Bo Gao, Kai Jiao, Franklin R. Tay, Li-Na Niu
Summary: This review discusses the gradient composition of the tendon-bone interface, revealing the regulatory mechanisms and applications, with the aim of creating a mise en scene for future research in interface tissue engineering.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Hosung Bae, Katie Lam, Cholsoon Jang
Summary: This article reviews the historical development of arteriovenous measurements and discusses their advantages and limitations. Through example studies, we gain insights into the exchange flux of metabolites between organs in diverse pathophysiological contexts.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Paula Alejandra Sacca, Juan Carlos Calvo
Summary: PPAT plays an important role in PCa, with its metabolic profile potentially related to tumor energy requirements and 5 pathways related to energy balance. Patients at different stages of PPAT have different metabolic profiles, and an in-depth understanding of the key components could have a positive impact on disease treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Longfei Li, Tong Wang, Kelly Van, Xiaodi Zhang, Xindan Zhang, Jian Song, Rui Shi, Liqun Zhang, Jiajia Xue
Summary: This study reports a general method for generating dual gradients of bioactive components to mimic the in vivo microenvironment and promote tissue regeneration on scaffolds. The method involves layer-by-layer self-assembly of collagen and chondroitin sulfate on electrospun nanofibers, resulting in dual gradients of COL and CS along the fiber alignment.
MATERIALS TODAY ADVANCES
(2022)
Review
Immunology
Dehong Cao, Ruonan Sun, Lei Peng, Jinze Li, Yin Huang, Zeyu Chen, Bo Chen, Jin Li, Jianzhong Ai, Lu Yang, Liangren Liu, Qiang Wei
Summary: This article provides a comprehensive review of the role of inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH). Inflammation plays a significant role in the occurrence and development of BPH, and its mechanisms include tissue damage, autoimmunity, and interaction with androgens. Early intervention in prostate tissue inflammation during treatment can slow down the progression of BPH, and combining standard therapies with anti-inflammatory measures may offer new insights for BPH treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Czajka, Krzysztof Sawicki, Magdalena Matysiak-Kucharek, Marcin Kruszewski, Jacek Kurzepa, Paulina Wojtyla-Buciora, Lucyna Kapka-Skrzypczak
Summary: Chlorpyrifos, a representative of organophosphorus pesticides, has effects on the viability, proliferation, differentiation, and fatty acid uptake in 3T3-L1 cells. Exposure to chlorpyrifos decreases cell viability but increases it at low concentrations. It inhibits proliferation and differentiation of preadipocytes, reduces lipid accumulation, and down-regulates key transcription factors. In fully differentiated adipocytes, chlorpyrifos increases basal free fatty acid uptake. These findings suggest that chlorpyrifos may play a role in the development of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Rosa Spinelli, Ritesh Kumar Baboota, Silvia Gogg, Francesco Beguinot, Matthias Bluher, Annika Nerstedt, Ulf Smith
Summary: Cell senescence (CS) plays a crucial role in the connection between aging and chronic disorders, and CS is more prevalent in major metabolic tissues with aging. However, CS is also increased in adult obesity, type 2 diabetes (T2D), and nonalcoholic fatty liver disease, regardless of aging. Dysfunction and inflammation are common features of senescent tissues, affecting both progenitor cells and mature differentiated cells. Recent studies have found that hyperinsulinemia and insulin resistance (IR) can promote CS in human adipose and liver cells. Conversely, increased CS also promotes cellular IR, indicating their interdependence. Additionally, increased adipose CS in T2D is not solely determined by age, BMI, or hyperinsulinemia, suggesting premature aging. These findings suggest that senomorphic/senolytic therapy could be important for treating common metabolic disorders.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Thomas H. Boag, William Gearty, Richard G. Stockey
Summary: The latitudinal gradient of increasing marine biodiversity from the poles to the tropics is a noticeable pattern, but low-latitude regions are expected to be most affected by climate change. Fossil evidence suggests that biodiversity peaks may have occurred further away from the equator in the past, possibly due to transitions between climate states.
Review
Biochemistry & Molecular Biology
Sigita Malijauskaite, Sinead Connolly, David Newport, Kieran McGourty
Summary: Intestinal tissue, particularly its mucosal layer, is regulated by gradients of various factors and supports healthy homeostasis. Current in vitro intestinal tissue mimetic platforms face challenges in capturing the complexity of the tissue's physiology. This review outlines the microenvironment of intestinal tissue and discusses the design drawbacks of existing mimetic systems while presenting a framework for future development efforts.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Alexandra Madsen, Julia Krause, Grit Hoeppner, Marc N. Hirt, Wilson Lek Wen Tan, Ives Lim, Arne Hansen, Viacheslav O. Nikolaev, Roger S. Y. Foo, Thomas Eschenhagen, Justus Stenzig
Summary: The study demonstrates the important role of DNMT3A in human cardiomyocyte cell homeostasis and metabolism, as well as its protective effect in cardiac hypertrophy. These findings highlight the significance of DNA methylation in both normal cardiomyocyte physiology and cardiac disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Martina Tortorici, Erik Brauer, Mario Thiele, Georg N. Duda, Ansgar Petersen
Summary: The success of cell-free in situ tissue engineering approaches relies on the recruitment of autologous cells. This study presents a new method to quantify the extent and directionality of cell migration. By using cell spheroids, the limitations of 2D cell sources can be overcome. The method provides a better representation of the in vivo situation and allows for analysis of cell migration direction based on cellular density profiles within biomaterials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biology
Sanford P. Bishop, Jianyi Zhang, Lei Ye
Summary: Death from heart injury is a major cause of mortality worldwide, and the ability of cardiomyocytes to regenerate is limited. This review explores the developmental, structural, and functional changes of cardiomyocytes and their response to myocardial diseases or injuries, providing new insights into the cell cycle regulation of cardiomyocytes.
Article
Plant Sciences
Gracielle Pereira Pimenta Braganca, Bruno Garcia Ferreira, Rosy Mary dos Santos Isaias
Summary: The study tested three gall morphotypes induced by Cecidomyiidae on leaflets of Inga ingoides and found that different gall types exhibit differences in cytological and metabolic traits, as well as in the accumulation of primary metabolites. The presence of fungi influences the system but does not define exclusive features for specific gall types, with distinct cytological mechanisms identified for each gall type in terms of food resources availability.
Article
Ecology
Elaine C. Costa, Vitor C. Martini, Aline Souza-Silva, Jose P. Lemos-Filho, Denis C. Oliveira, Rosy M. S. Isaias
Summary: The success of galling insects in a shared microhabitat depends on the synchrony and asynchrony of their life cycles, as well as the availability of water potential and resources in the environment.
Article
Plant Sciences
Bruno G. Ferreira, Gilson R. P. Moreira, Rene G. S. Carneiro, Rosy M. S. Isaias
Summary: This study provides a detailed description of the morphogenetic changes induced by E. minutanus in the lateral buds of S. engleri. The stages of gall development are associated with the development of specific instars of E. minutanus.
AMERICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Elaine C. Costa, Gracielle P. P. Braganca, Igor A. Arriola, Mariana S. C. Freitas, Rosy M. S. Isaias
Summary: Gall structures and their associated host plants exhibit distinctive structural and histochemical adaptations to survive in the challenging environment of restingas. These adaptations include the presence of thick cuticles, the accumulation of polyphenols and lignified cell walls, and the reorganization of host tissues. Different gall development patterns and host tissue modifications facilitate water accumulation and protect the gall inducers against environmental stresses and enemies.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Larissa Quirino da Silva, Cristina Moll Huther, Natalia Fernandes Rodrigues, Julia Ramos de Oliveira, Daniela Marques Correia, Bruno Garcia Ferreira, Vitor Francisco Ferreira, Mariana de Oliveira Pereira, Bruna de Carvalho Assuncao, Gabriela Martins Correa, Filipe Rodrigues Valeriano, Leticia Ponticel Nobrega, Daiane Cecchin, Thelma Machado, Silvio Roberto de Lucena Tavares, Carlos Pereira
Summary: This study assessed the morphophysiological responses of comfrey to short-term severe water restriction and found that water deficit affected the growth and metabolism of comfrey plants. However, adjustments in photosynthetic apparatus and increased dry mass productivity indicated a possible adjustment to severe drought.
Article
Biology
Uiara Costa Rezende, Nina de Castro Jorge, Barbara Dolabela, Rosy Mary dos Santos Isaias, Paul Hanson, Denis Coelho de Oliveira
Summary: Piptocarpha macropoda is a plant species that can develop globoid galls induced by insects. These galls can be attacked by parasitoid insects, which have a positive impact on gall size and nutritive cell layers. However, the parasitoid insects do not affect the size of the host insects, indicating an overstimulation on plant cells and tissues by the parasitized insects.
Article
Plant Sciences
Ravena Malheiros Nogueira, Elaine Cotrim Costa, Juliana Santos Silva, Rosy Mary Santos Isaias
Summary: The Caatinga environment imposes constraints on the phenology and development of host plants and their associated galls. The study on the Mimosa tenuiflora-Lopesia mimosae system reveals that phenological synchronism and structural strategies are key for gall survivorship in Caatinga. Phenological strategies involve synchronizing young galls with leaf sprouting in the rainy season and reproducing during gall senescence in the dry season. Structural strategies include tissue reorganization and compartmentalization to adapt to environmental constraints, and the predominance of periclinal cell elongation determines the gall's bivalve shape.
Article
Plant Sciences
Nina de Castro Jorge, Heraldo Luis Vasconcelos, Mariana de Sousa Costa Freitas, Fernando Henrique Aguiar Vale, Rosy Mary dos Santos Isaias
Summary: Research focuses on how senescent globoid stem galls induced by Neolasioptera sp. on Eremanthus erythropappus can still interact with ants and fungi, forming unique ant-nest galls. The anatomical analyses showed that ant activity in the gall chamber may prevent the closing of the exit channel, allowing the invasion of opportunistic fungal hyphae. This interaction among the plant, fungi, and ants leads to tissue responses and the maintenance of the peculiar ant-nest galls.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
L. P. Nobrega, B. De Sa-Haiad, B. G. Ferreira
Summary: Intralaminar galls of Meunieriella are the result of ground tissue proliferation in leaves of Avicennia schaueriana, a typical halophytic mangrove. Preferred sites of gall induction were found to be the midribs and secondary veins (SV) at the basal leaf portion, where the galls were largest. The vascular system in galls and adjacent regions was altered to favor water supply in galls, thus increasing their growth.
Article
Plant Sciences
Rayssa Rosa Marquesine de Castro, Pedro Ernandez Ferreira Barbosa, Leonardo Guimaraes Sant'Anna, Caio Marcello da Silva Pereira, Bruno Garcia Ferreira
Summary: Gall-inducing insects stimulate host plants to form distinct structures, like the fusiform galls induced by Clinodiplosis profusa. Infestation rates of these galls are similar in sun and shade plants, but there are differences in cell size and epidermal features between sun and shade galls. In conclusion, gall formation is influenced by galling stimuli, while some developmental processes are influenced by light exposure.
Article
Plant Sciences
Vanessa Lino, Atiles Reis, Yve Canaveze, Murilo Sartarelli Farah, Lana da Silva Sylvestre, Bruno Garcia Ferreira
Summary: Ferns have two types of trichomes, hairs and scales, on their stems and leaves. The morphology and histochemistry of glandular scales in Asplenium spp. were investigated using different species under microscopes. The glandular scales had swollen cells with variable number stalks and secreted mucilage, pectins, phenolics, essential oils, and oleoresins. These secretions may provide resistance to desiccation, protection against herbivores and pathogens. Species and habits of the ferns influenced the secretory composition of the scales.
Article
Multidisciplinary Sciences
Leticia Ponticel Nobrega, Barbara de Sa Haiad, Bruno Garcia Ferreira
Summary: Leaf-galling Eriophyidae can cause simple or complex alterations in the host plants' organs. Hairy galls on Avicennia schaueriana were found to occur mostly at the apical portion of the leaves and leaf margins. The gall anatomy showed influence on epidermal features and complex changes in abaxial epidermal cells close to feeding sites of the inducer. The gall size was mainly influenced by the number of inducers per gall, rather than the position in the leaves.
Article
Biology
Vinicius Coelho Kuster, Joao Custodio Fernandes Cardoso, Ana Silvia Franco Pinheiro Moreira, Rosy Mary dos Santos Isaias, Denis Coelho de Oliveira
Summary: This study evaluated oxidative stress, photochemical parameters, and pigment contents in four leaf galls caused by different galling insects on Aspidosperma spp. It was found that different galling systems have underlying mechanisms that impact gall tissues.
Article
Microbiology
Joao C. M. Dornelas, Marliete C. Costa, Paulo H. F. Carmo, Vivian M. Paixao, Vanessa S. D. Carvalho, Leilane C. Barreto, Queila S. Garcia, Gracielle P. P. Braganca, Rosy M. S. Isaias, Julio C. M. Brito, Maria A. Resende-Stoianoff, Daniel A. Santos
Summary: This study developed a plant model to investigate the interaction between Cryptococcus gattii and plants. The results showed that C. gattii can grow in plants without causing pathological effects. N. benthamiana exhibited higher proliferation of C. gattii, accompanied by an increase in hydrogen peroxide content, antioxidant system activity, and indoleacetic acid production. Colonies of C. gattii recovered from N. benthamiana displayed altered composition and morphology, as well as increased resistance to antifungal drugs. These findings suggest that plants may serve as a potential reservoir and transmission route for C. gattii.
FEMS MICROBIOLOGY ECOLOGY
(2022)