Article
Surgery
Jemma H. Larson, Sujeong Jin, Michael Loschi, Sara Bolivar Wagers, Govindarajan Thangavelu, Michael C. Zaiken, Cameron McDonald-Hyman, Asim Saha, Ethan G. Aguilar, Brent Koehn, Mark J. Osborn, Angela Panoskaltsis-Mortari, Kelli P. A. Macdonald, Geoffrey R. Hill, William J. Murphy, Jonathan S. Serody, Ivan Maillard, Leslie S. Kean, Sangwon Kim, Dan R. Littman, Bruce R. Blazar
Summary: Damage to the gastrointestinal tract plays a significant role in the severity and perpetuation of graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. In preclinical models and clinical trials, infusing high numbers of regulatory T cells has been shown to reduce the incidence of graft-versus-host disease. Transferring ex vivo expanded regulatory T cells overexpressing G protein-coupled receptor 15 or C-C motif chemokine receptor 9, specific homing receptors for colon or small intestine respectively, can lessen the severity of graft-versus-host disease in mice.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Mingyang Li, Haiyan Cheng, Dan Tian, Lu Yang, Xiaonan Du, Yuhualei Pan, Dong Zhang, Xueling Mei
Summary: This study characterized the phenotype of γδT cells and evaluated the impact of D-mannose on γδT cell-mediated psoriasis. The research found that γδT cells underwent proliferation and acquired an IL-17-producing phenotype during psoriasis. Treatment with D-mannose suppressed the reaction of γδT cells and alleviated the inflammation induced by imiquimod.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Cameron W. Paterson, Melissa B. Gutierrez, Craig M. Coopersmith, Mandy L. Ford
Summary: Chronic alcohol use leads to T cell dysregulation within the adaptive immune system. In this study, using a murine model, researchers compared rare splenic subpopulations in alcohol-exposed mice and water-fed controls. The results showed decreased naive T cell populations and alterations in effector regulatory T cell phenotypes in chronic alcohol-induced immune dysfunction.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Sara Bolivar-Wagers, Jemma H. Larson, Sujeong Jin, Bruce R. Blazar
Summary: Treg cells play a critical role in maintaining immune homeostasis and tolerance induction; however, the mechanisms responsible for their cytotoxicity and therapeutic potential have not been fully explored.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lyra Morina, Madalyn E. Jones, Cihan Oguz, Mariana J. Kaplan, Arunakumar Gangaplara, Courtney D. Fitzhugh, Christopher G. Kanakry, Ethan M. Shevach, Maja Buszko
Summary: Foxp3 is the major transcription factor for T regulatory (T-reg) cells, but its suitability as a T-reg marker in humans is doubted due to its expression in activated human CD4(+) T conventional (T-conv) cells. Helios, another marker, is expressed by the majority of human Foxp3(+) T-reg cells. The combined use of Foxp3 and Helios expression provides a more reliable approach for the characterization of T-reg in humans.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Tiago R. Matos, Masahiro Hirakawa, Ana C. Alho, Lars Neleman, Luis Graca, Jerome Ritz
Summary: CD4(+) Regulatory T cells play a critical role in immune homeostasis, but their heterogeneity in different populations including newborns, healthy adults, and patients after allogeneic hematopoietic stem cell transplantation with or without chronic graft-versus-host disease has been compared. The study found that Treg heterogeneity is higher in adults and gradually increases in the first two years post-transplant, while patients with chronic graft-versus-host disease have significantly fewer distinct Treg subpopulations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zohreh Amoozgar, Jonas Kloepper, Jun Ren, Rong En Tay, Samuel W. Kazer, Evgeny Kiner, Shanmugarajan Krishnan, Jessica M. Posada, Mitrajit Ghosh, Emilie Mamessier, Christina Wong, Gino B. Ferraro, Ana Batista, Nancy Wang, Mark Badeaux, Sylvie Roberge, Lei Xu, Peigen Huang, Alex K. Shalek, Dai Fukumura, Hye-Jung Kim, Rakesh K. Jain
Summary: In this study, researchers found that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.
NATURE COMMUNICATIONS
(2021)
Article
Critical Care Medicine
Timothy W. Phares, Vinayaka Kotraiah, Chun-Shiang Chung, Jacqueline Unsinger, Monty Mazer, Kenneth E. Remy, Cecille D. Browne, Peter Buontempo, Marc Mansour, James Pannucci, Alfred Ayala, Richard S. Hotchkiss, Gabriel M. Gutierrez
Summary: In a study using LD01 to treat CLP-induced sepsis in mice, it was found that LD01 significantly improved survival rates, reduced bacterial burden, and enhanced macrophage phagocytic activity and T-cell production of interferon-gamma. These results suggest that LD01 modulates host immunity and could be a viable therapeutic candidate for alleviating immunosuppression in sepsis and other infectious diseases.
Article
Cell & Tissue Engineering
Aaron Martin, Mark Daris, James A. Johnston, Jiajia Cui
Summary: The study demonstrates that genetically modified CD4+ T cells expressing CAR and FOXP3 can effectively suppress T cell proliferation and cytokine secretion in GvHD, showing superior suppression compared to polyclonal Tregs in experiments.
Article
Oncology
Ellis Tibbs, Rakhee Rathnam Kalari Kandy, Delong Jiao, Long Wu, Xuefang Cao
Summary: Regulatory T cells (Tregs) express Granzyme B (GzmB) and perforin, which were shown to inhibit tumor clearance. This study investigates the role of Treg-derived GzmB in tumor progression and metastasis, showing that it is important for spontaneous lung metastasis and increasing the metastatic burden.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Snigdha Majumder, Isabelle Jugovic, Domenica Saul, Luisa Bell, Nadine Hundhausen, Rishav Seal, Andreas Beilhack, Andreas Rosenwald, Dimitrios Mougiakakos, Friederike Berberich-Siebelt
Summary: Gene editing of primary T cells is challenging but important for research and clinical T-cell transfers. CRISPR/Cas9 is a powerful technique for precise editing, with nucleofection of guideRNA proving to be rapid and efficient. Transferring unstimulated human T cells during stem cell transplantation may be necessary for long-term protection from adverse effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Lachlan M. Moldenhauer, Min Jin, Jasmine J. Wilson, Ella S. Green, David J. Sharkey, Mark D. Salkeld, Thomas C. Bristow, M. Louise Hull, Gustaaf A. Dekker, Sarah A. Robertson
Summary: Research has shown that oral contraception use can impact the number and phenotype of Treg cells, leading to physiological changes and altered disease susceptibility.
Article
Surgery
Rongrong Gao, Ang Li, Sen Li, Xiangrong Li, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu
Summary: Induced regulatory T (iTreg) cells play a crucial role in immune tolerance and controlling chronic inflammation. A novel engineering strategy has been developed to generate stably induced regulatory T (SI T-reg) cells that maintain their regulatory properties and possess potent immunosuppressive functions even in unfavorable environments. These findings suggest that SI T-reg cells hold great promise for future clinical applications and provide a rational therapeutic approach for transplant rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Editorial Material
Hematology
Rick Kapur
Summary: Thrombopoietin receptor agonists have been found to increase the number of regulatory T cells in the spleen of patients with immune thrombocytopenia, indicating their potential immune modulatory role.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)