Article
Developmental Biology
Peter K. Nicholls, David C. Page
Summary: Germ cells commit to gametogenesis after colonizing the gonads, and germ cell tumors may originate from cells that failed to undergo germ cell determination. The diversity of cell types in these tumors reflects the developmental potential of migratory PGCs.
Article
Biology
Astrid S. Jorgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Masa Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Hjorto, Sara Rankin, Jon Vabeno, Mette M. Rosenkilde
Summary: Plerixafor exhibits biased action by reversing the CXCL12 gradient across the bone marrow endothelium and showing superior therapeutic effect in HSC mobilization. In contrast, AMD11070, despite having superior antagonism, does not perform as effectively in HSC mobilization in vivo.
COMMUNICATIONS BIOLOGY
(2021)
Article
Hematology
Alexis Leonard, Akshay Sharma, Naoya Uchida, David Stroncek, Sandhya R. Panch, Kamille West, Eoghan Molloy, Thomas E. Hughes, Sara Hauffe, Tiffani Taylor, Courtney Fitzhugh, Jane S. Hankins, Megan Wilson, Shengdar Q. Tsai, Mitchell J. Weiss, Matthew Hsieh, John F. Tisdale
Summary: Recent studies have shown that plerixafor mobilization and apheresis in patients with sickle cell disease can safely collect sufficient CD34(+) hematopoietic stem cells for clinical gene therapy applications. The quantity of CD34(+) cells mobilized by plerixafor varies among SCD patients for unknown reasons, and factors influencing this yield include age, baseline and pre-apheresis CD34(+) cell counts, and disease severity markers unique to SCD.
Article
Oncology
Nianyu Xue, Guoyao Wang, Shengmin Zhang, Yijun Lu
Summary: Unlike younger patients, seminoma is not common in patients with primary testicular tumors over the age of 50. The diagnostic value of conventional ultrasonography and contrast-enhanced ultrasonography (CEUS) in these patients was compared. The CEUS method showed higher accuracy in distinguishing between germ cell tumors and non-germ cell tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Kira Kirchner, Christoph Seidel, Finn-Ole Paulsen, Bianca Sievers, Carsten Bokemeyer, Davor Lessel
Summary: The CHEK2 gene is associated with susceptibility to testicular germ cell tumors (TGCT) and has moderate penetrance. The frequency of CHEK2 gene variants was found to be significantly higher in TGCT cases compared to the control group, and patients with CHEK2 variants developed TGCT at a younger age. Additionally, another CHEK2 variant related to TGCT susceptibility was identified.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marco De Martino, Paolo Chieffi, Francesco Esposito
Summary: Testicular germ cell tumors are the leading form of solid cancer and death among males aged 20 to 40. The deregulation of miRNAs plays a key role in TGCTs, making them potential diagnostic and prognostic markers for testicular tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Omar Abughanimeh, Benjamin A. Teply
Summary: The management of refractory/relapsed GCTs is challenging, with treatments such as high-dose chemotherapy, conventional chemotherapy, and surgery being effective options. More research is needed to determine the optimal chemotherapy approach for refractory diseases. Immunotherapy is also being investigated as a potential treatment option in this setting.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Dennis M. Timmerman, Thomas F. Eleveld, Ad J. M. Gillis, Carlijn C. Friedrichs, Sanne Hillenius, Tessa L. Remmers, Sruthi Sriram, Leendert H. J. Looijenga
Summary: Germ cell tumors (GCTs) have varying responses to platinum-based chemotherapy depending on their anatomical origin, with mediastinal GCTs showing resistance compared to testicular GCTs. TP53 mutations may play a role in causing cisplatin resistance in mediastinal GCTs, suggesting a potential target for treatment. The study provides insights into the underlying mechanisms of TP53 mutant and mediastinal GCTs for alternative treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Weigang Xiu, Jiyun Pang, Yang Hu, Huashan Shi
Summary: In this review, the current research progress on the pathogenesis, diagnosis, and treatment of extragonadal germ cell tumors (EGCTs) from an immunology perspective are summarized. EGCTs have a histological origin related to gonads but are located outside. They can occur in various areas and have great morphological variation. The unclear pathogenesis and extensive differential diagnosis of EGCTs pose challenges. This review provides ideas for applying immunology in combating these diseases, which is currently a hot topic.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zuzana Orszaghova, Katarina Kalavska, Michal Mego, Michal Chovanec
Summary: Testicular germ cell tumors (GCTs) are highly sensitive to cisplatin-based chemotherapy, but some patients develop cisplatin resistance. Multiple potential therapeutic targets have been identified, but their effectiveness in clinical trials remains limited.
Article
Surgery
Raul Caso, Gregory D. Jones, Manjit S. Bains, Meier Hsu, Kay See Tan, Darren R. Feldman, Samuel A. Funt, Victor E. Reuter, George J. Bosl, Deaglan McHugh, James Huang, Daniela Molena, David Amar, Gregory Fischer, Valerie W. Rusch, David R. Jones
Summary: This study found that in patients with PMNSGCT undergoing resection, completeness of resection, postoperative pathology, and postoperative serum tumor markers were associated with progression-free survival. Patients undergoing second-line chemotherapy followed by resection had a poor prognosis, with a long-term survival rate of 22%.
Article
Cell Biology
Ruijing Sun, Eun Joo Lee, Seonock Lee, Gamin Kim, Jungho Kim
Summary: This study demonstrates that the Pin1 inhibitor KPT6566 has significant antiproliferative and antitumor effects in TGCT cells, suggesting its potential as a therapeutic approach for TGCTs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Developmental Biology
Nicholas J. Webster, Rebecca L. Maywald, Susan M. Benton, Emily P. Dawson, Oscar D. Murillo, Emily L. LaPlante, Aleksandar Milosavljevic, Denise G. Lanza, Jason D. Heaney
Summary: NANOS2 plays a crucial role in coordinating the differentiation of germ cells, and its absence may increase susceptibility to tumors. Developmental phenotypes necessary for tumorigenesis typically occur in germ cells failing to express NANOS2.
Article
Oncology
Apostolia-Maria Tsimberidou, Henry Hiep Vo, Vivek Subbiah, Filip Janku, Sarina Piha-Paul, Bulent Yilmaz, Jing Gong, Mohammad Faraz Naqvi, Shi-Ming Tu, Matthew Campbell, Funda Meric-Bernstam, Aung Naing
Summary: Lessons learned from the study show that advanced germ cell tumors have poor prognosis, and pembrolizumab, while well tolerated, has limited antitumor activity in these patients. Resistance to immunotherapy in germ cell tumors may be partially attributed to tumor biology and other poor-risk features. Therefore, tumor profiling and innovative clinical trials to identify effective combination regimens are warranted for advanced germ cell tumors.
Article
Oncology
Ying L. Liu, Beryl L. Manning-Geist, Andrea Knezevic, Luxue Deng, Maria Bromberg, Samuel A. Funt, Jane L. Meisel, Oliver Zivanovic, Kara Long Roche, Yukio Sonoda, Ginger J. Gardner, Rachel N. Grisham, Roisin E. O'Cearbhaill, William P. Tew, Nadeem R. Abu-Rustum, Dennis S. Chi, Carol Aghajanian, Darren R. Feldman
Summary: The objective of this study was to validate the modified international male IGCCCG prognostic model in female patients with germ cell tumors (GCTs). The results demonstrated that the modified IGCCCG model accurately assessed the prognostic risk in female GCTs patients and was associated with clinical outcomes.
GYNECOLOGIC ONCOLOGY
(2023)