Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Immunology
Carina Matos, Katrin Peter, Laura Weich, Alice Peuker, Gabriele Schoenhammer, Tobias Roider, Sakhila Ghimire, Nathalie Babl, Sonja Decking, Martina Guellstorf, Nicolaus Kroeger, Kathrin Hammon, Wolfgang Herr, Klaus Stark, Iris M. Heid, Kathrin Renner, Ernst Holler, Marina Kreutz
Summary: The study revealed a cooperative effect of ATG and vitamin D3 in regulating the production of 1,25-dihydroxyvitamin D3 in HSCT, especially important for patients receiving ATG for GvHD prophylaxis. High levels of 1,25-dihydroxyvitamin D3 early in HSCT have been shown to predict lower transplant-related mortality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Fatima A. H. Al-Jaberi, Martin Kongsbak-Wismann, Alejandro Aguayo-Orozco, Nicolai Krogh, Terkild B. Buus, Daniel V. Lopez, Anna K. O. Rode, Eva Gravesen, Klaus Olgaard, Soren Brunak, Anders Woetmann, Niels odum, Charlotte M. Bonefeld, Carsten Geisler
Summary: This study reveals the impact of a point mutation in the DNA-binding domain of VDR on 1,25(OH)(2)D-3 signaling, with effects on VDR subcellular localization and transcriptional activity. The study also demonstrates that the expression level of wild-type VDR determines the responsiveness of T cells to 1,25(OH)(2)D-3. Additionally, the study shows that vitamin A inhibits the translocation of VDR to the nucleus and upregulation of CYP24A1 induced by 1,25(OH)(2)D-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Rajiv Erasmus, Setjie Maepa, Ian Machingura, Saarah Davids, Shanel Raghubeer, Tandi Matsha
Summary: This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in a South African population. The results showed a high prevalence of vitamin D deficiency/insufficiency in this population, with decreased vitamin D levels observed in hyperglycaemic individuals. These findings can contribute to further research on the diagnosis and treatment of hyperglycaemia.
Article
Nutrition & Dietetics
Azza M. Kamel, Eman R. Radwan, Ashraf Zeidan, Amen Zaky, Abeer Ibrahim, Ahmed Refaat, Raafat Abdelfattah, Maged Abdelfattah
Summary: This study aimed to evaluate the impact of pre-transplant vitamin D level on the outcome of allogeneic hematopoietic stem cell transplantation (HSCT). The results showed that vitamin D level had no impact on the occurrence and severity of graft versus host disease (GVHD) and survival rate. This might be due to the majority of patients having relatively normal vitamin D levels, possibly because of the sunny weather in Egypt.
CLINICAL NUTRITION ESPEN
(2023)
Review
Immunology
Benjamin Watkins, Kirsten M. Williams
Summary: Severe acute and chronic graft versus host disease (GVHD) is a major cause of morbidity and mortality after hematopoietic cell transplantation. Certain drugs can reduce the risk of GVHD, but they come with potential risks of relapse, graft failure, infections, and delayed immune reconstitution. However, these drugs have expanded donor options, especially for non-Caucasian individuals who previously had limited transplant options.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Nutrition & Dietetics
Valentina Aristarco, Harriet Johansson, Sara Gandini, Debora Macis, Cristina Zanzottera, Gianluca Tolva, Irene Feroce, Chiara Accornero, Bernardo Bonanni, Aliana Guerrieri-Gonzaga, Davide Serrano
Summary: This study found that SNPs of VDR and GC genes may influence breast cancer recurrence and survival in patients, particularly with major alleles of BsmI and TaqI showing lower risk of relapse.
Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki
Summary: Vitamin D and VDR play critical roles in maintaining calcium homeostasis, bone formation, and immune response against cancer. Mutations in the VDR gene are associated with manifestations of type II rickets and abnormal bone formation. The unliganded VDR is crucial for maintaining the hair cycle and normal skin.
Article
Immunology
Daniel V. Lopez, Fatima A. H. Al-Jaberi, Nkerorema D. Damas, Brian T. Weinert, Urska Pus, Sara Torres-Rusillo, Anders Woetmann, Niels Odum, Charlotte M. Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Th22 cells are a CD4(+) T cell subset that produces interleukin (IL)-22 and primarily acts on epithelial cells, affecting keratinocyte proliferation, differentiation, and maturation. The regulation of IL-22 production in human T cells involves the transcription factors AhR and ROR gamma t, as well as the active form of vitamin D-3. The inhibition of IL-22 production by 1,25(OH)(2)D-3 through VDR and VDRE has been identified as a key mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: Inflammatory bowel diseases (IBD) are chronic conditions with unknown etiology and immunomediated pathogenesis. Research on the intestinal microbiome and the vitamin D/VDR pathway have shown promising potential for novel approaches to diagnosis and treatment of IBD. Probiotic bacteria have shown more exciting results in experimental models than in clinical practice, and understanding their properties and mechanisms of action may lead to new therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Sepideh Zununi Vahed, Elham Ahmadian, Peyman Foroughi, Soroush Mostafavi, Henning Madry, Mohammadreza Ardalan, Magali Cucchiarini
Summary: The study revealed a significant association between VDR and VDBP gene polymorphisms with renal allograft rejection and viral infection, showing differences in G allele frequencies among different groups.
Article
Biochemistry & Molecular Biology
Thomas Mueller, Lutz Lohse, Andreas Blodau, Katja Frommholz
Summary: The study investigated the impact of 25-hydroxy-vitamin D plasma concentrations on blood parameters, indicating that changes in blood parameters were affected by the variation in plasma levels of this form of vitamin D. Additionally, the elevation of vitamin D plasma levels was found to provide enhanced preconditions for better tissue oxygenation on a cellular level.
Article
Biochemistry & Molecular Biology
Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michal Chodynski, Ewa Marcinkowska, Enikoe Kallay, Martin Schepelmann
Summary: This study found that newly developed low calcemic vitamin D analogs (an1,25Ds) can be used as anticancer agents in ovarian cancer cells, with PRI-5202 showing the best efficacy. The potency of these analogs and their ability to increase CYP24A1 expression in HGSOC cell lines were dependent on the cell line and chemical structure, suggesting that further optimization of the analogs' structure may lead to new treatment options for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)