Article
Hematology
Caner Saygin, Gregory Roloff, Christopher N. Hahn, Rakchha Chhetri, Saar Gill, Hany Elmariah, Chetasi Talati, Emma Nunley, Guimin Gao, Aelin Kim, Michael Bishop, Satyajit Kosuri, Soma Das, Deepak Singhal, Parvathy Venugopal, Claire C. Homan, Anna Brown, Hamish S. Scott, Devendra Hiwase, Lucy A. Godley
Summary: There is growing recognition that pathogenic germ line variants play a role in the development of hematopoietic cancers. Patients with myeloid malignancies and deleterious germ line DDX41 variants have a higher incidence of severe acute GVHD. The use of posttransplant cyclophosphamide can reduce the risk of severe acute GVHD in these patients.
Review
Chemistry, Medicinal
Serena Tseng, Mu-En Lee, Pei-Chin Lin
Summary: Acute myeloid leukemia (AML) is the second most common hematologic malignancy in children, and its rarity makes the new genetic abnormality classifications and risk group classifications significant for the management and prognosis prediction in childhood AML. This review focuses on the well-known genetic subtypes in childhood AML and discusses the current treatment algorithms, novel treatment modalities, and indications of hematopoietic stem cell transplantation (HSCT).
Review
Immunology
Nicoletta Caronni, Elisa Montaldo, Luca Mezzanzanica, Francesco Cilenti, Marco Genua, Renato Ostuni
Summary: The development of cancer is influenced by the tumor microenvironment, and advancements in single-cell analysis technologies have helped unravel the contributions of the immune system to cancer progression. Tumor-associated macrophages and neutrophils play crucial roles in disrupting immune homeostasis and providing therapeutic opportunities for reprogramming the tumor microenvironment.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Immunology
Sabrina N. Copsel, Dietlinde Wolf, Brent Pfeiffer, Henry Barreras, Victor L. Perez, Robert B. Levy
Summary: Human and mouse CD4(+)FoxP3(+) T cells, as non-redundant regulatory compartments, play crucial roles in maintaining self-tolerance and have potential therapeutic applications in autoimmune disorders and transplants. Currently, the focus is on using donor-derived Tregs, but manipulating recipient Tregs after transplantation remains challenging. Researchers are exploring strategies to control recipient Tregs and improve post-transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Tianxiao Gao, Ting Liu, Chun-Jung Ko, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun
Summary: The study demonstrates that TBK1 plays a crucial role in regulating proinflammatory macrophage function and protecting against tissue inflammation. It suppresses the induction of proinflammatory cytokines, particularly IL-1 beta, by inhibiting the NF-kappa B and MAP kinase signaling pathways in macrophages. This finding is important for further understanding the pathogenesis of inflammatory diseases and identifying new therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Surgery
Orly Fink, Ehud Even-Or, Batia Avni, Sigal Grisariu, Irina Zaidman, Yael Dinur Schejter, Adeeb NaserEddin, Mohammad Najajreh, Polina Stepensky
Summary: Allogeneic hematopoietic stem cell transplantation is the only curative treatment for the hematological complications of Fanconi anemia. The study analyzed data from 41 patients who underwent this treatment and found significant improvements in outcomes over the past two decades. Peripheral blood stem cell grafts were associated with higher rates of graft-versus-host disease compared to other stem cell sources.
CLINICAL TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Seahyoung Lee, Dong-Sik Chae, Byeong-Wook Song, Soyeon Lim, Sang Woo Kim, Il-Kwon Kim, Ki-Chul Hwang
Summary: Recent clinical trials have shown that one-third of studies on adipose-derived stem cells (ADSCs) focused on musculoskeletal disorders (MSD). These disorders are a major burden to society and conventional treatments are often inadequate, leading to the investigation of ADSC-based cell therapies as more effective alternatives. Categorizing the specific MSDs targeted by ADSC therapy and understanding their mechanisms of action can aid in developing optimized strategies for ADSC-based treatments in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Virology
Bruno Azevedo Randi, Hermes Ryoiti Higashino, Vinicius Ponzio da Silva, Erick Menezes Xavier, Vanderson Rocha, Silvia Figueiredo Costa
Summary: This study analyzed the clinical characteristics and outcomes of COVID-19 in adult hematopoietic stem-cell transplantation (HSCT) recipients through a systematic review and meta-analysis. The findings showed that symptomatic infection of SARS-CoV-2 was common in HSCT patients and the mortality rate was higher compared to the general population. It is crucial to implement measures to mitigate the risk of SARS-CoV-2 infection in this population and carefully evaluate HSCT recipients who develop COVID-19.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Oncology
Michelle Janssen, Anke Bruns, Juergen Kuball, Reinier Raijmakers, Debbie van Baarle
Summary: This review highlights the importance of vaccination post-stem cell transplantation for patients at risk of infection, emphasizing the significance of timing in order to obtain proper immune response. Individualized approaches may be necessary to optimize vaccine responses, as consensus on optimal timing is currently lacking.
Review
Rheumatology
Dinesh Khanna, Nancy Krieger, Keith M. Sullivan
Summary: This narrative review examines the evolving cell therapies for the treatment of diffuse cutaneous scleroderma (dcSSc) and other autoimmune diseases, including mesenchymal stem cells, chimeric antigen receptor-based therapy, tolerogenic dendritic cells, and facilitating cells.
Article
Oncology
Oluwatobiloba Morakinyo, Oliver Bucher, Kristjan Paulson
Summary: This study examined the transplant rates of acute myeloid leukemia (AML) patients in non-Quebec Canada. The results showed that transplant rates were influenced by factors such as time period, province of residence, gender, and age. However, there were no significant differences in transplant rates among indigenous patients, low-income families, and visible minorities. The study also found that Alberta had the highest transplant rates among the provinces in non-Quebec Canada.
Article
Oncology
Saurabh Zanwar, Eapen K. Jacob, Carl Greiner, Kevin Pavelko, Michael Strausbauch, Emilie Anderson, Arini Arsana, Megan Weivoda, Mithun Vinod Shah, Taxiarchis Kourelis
Summary: This study found that the enrichment of abnormal myeloid progenitor cells and immune effector cells in peripheral blood stem cells is associated with a higher risk of relapse and therapy-related myeloid neoplasms in newly diagnosed multiple myeloma patients. These abnormal cell subpopulations are also associated with inferior survival outcomes post-transplant.
BLOOD CANCER JOURNAL
(2023)
Article
Medicine, General & Internal
Phillip C. Nguyen, Kate Manos, Chun Y. Fong, Anthony P. Schwarer, Ing S. Tiong, Andrew H. Wei, David Kliman, David J. Curtis
Summary: The benefits of non-myeloablative stem cell transplant in older patients with acute myeloid leukaemia are unclear. A comparison of long-term outcomes in those aged 55-65 years in first remission showed that while 5-year overall survival and relapse-free survival were similar between transplant and chemotherapy only cohorts, transplantation was associated with increased non-relapse mortality.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wanessa Miranda-Silva, Vinicius Campos de Molla, Franciele Hinterholz Knebel, Tania Regina Tozetto-Mendoza, Celso Arrais-Rodrigues, Anamaria Aranha Camargo, Paulo Henrique Braz-Silva, Eduardo Rodrigues Fregnani
Summary: This study investigated the oral shedding of herpes viruses in patients who underwent alloHSCT and found that the presence of certain herpesviruses in the oral cavity was associated with clinical outcomes such as acute graft-versus-host disease, relapse, and overall survival.
Article
Immunology
Yoon-A Kang, Hyojung Paik, Si Yi Zhang, Jonathan J. Chen, Oakley C. Olson, Carl A. Mitchell, Amelie Collins, James W. Swann, Matthew R. Warr, Rong Fan, Emmanuelle Passegue
Summary: The study reveals the existence of a secretory subset of myeloid-biased multipotent progenitors, MPP3, that plays a crucial role in myeloid lineage differentiation and cytokine production. These cells serve as a reservoir for rapid production of granulocyte/macrophage progenitors and contribute to the amplification of myeloid cell production in stress and disease conditions.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
