Article
Engineering, Biomedical
Dimitrios Karazisis, Lars Rasmusson, Sarunas Petronis, Anders Palmquist, Furqan A. Shah, Hossein Agheli, Lena Emanuelsson, Anna Johansson, Omar Omar, Peter Thomsen
Summary: This study investigated the effects of controlled nanoscale topography and microscale roughness on the development of osseointegration in implants. The results showed that nanotopography promoted implant stability and downregulated the expression of the proinflammatory cytokine TNF-alpha. Nanoscale-driven mechanisms may involve attenuation of the inflammatory response at the titanium implant site.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Jorge Felipe Lima Teixeira, Joao Antonio Chaves de Souza, Fernando Augusto Cintra Magalhaes, Guilherme Jose Pimentel Lopes de Oliveira, Jose Bernardo de Santis, Carlos Alberto de Souza Costa, Pedro Paulo Chaves de Souza
Summary: This study aimed to evaluate the effects of conditioned media from osteoblasts cultured on laser-modified titanium surfaces on the differentiation of bone marrow cells in a paracrine manner and to analyze the expression of Wnt pathway inhibitors. The study found that the conditioned media from osteoblasts cultured on laser-modified titanium surfaces can promote mineralized nodule formation and alkaline phosphatase activity in bone marrow cells, influencing the osteoblastic differentiation of neighboring cells. Among the regulated mediators, Dickkopf-1 (DKK1) is one of them.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yao Ding, Zhang Yuan, Jin-Wei Hu, Kun Xu, Hong Wang, Peng Liu, Kai-Yong Cai
Summary: The fabrication of micro-nano-structured Ti substrates using double acid corrosion and hydrothermal treatment, followed by immobilization of mesoporous polydopamine nanoparticles as photothermal agent, resulted in physical stress on bacteria and enhanced mesenchymal stem cell osteogenic differentiation. In vivo animal experiments confirmed that the modified Ti implants could improve osseointegration.
Article
Chemistry, Physical
Pankaj Chauhan, Veena Koul, Naresh Bhatnagar
Summary: The surface of dental implants is crucial for osseointegration, with SLA representing the most widely accepted surface. Ti6Al4V ELI alloy demonstrates a different surface topography compared to CP-Ti, and optimization of acid etching parameters can achieve micro- and nano-level topography, enhancing surface properties.
Article
Biology
Guya Diletta Marconi, Luigia Fonticoli, Ylenia Della Rocca, Thangavelu Soundara Rajan, Adriano Piattelli, Oriana Trubiani, Jacopo Pizzicannella, Francesca Diomede
Summary: This study focused on the effects of different dental implant surfaces on the expression of extracellular matrix (ECM) components by human periodontal ligament stem cells (hPDLSCs). The results showed that the rough surface of titanium dental implant can enhance the expression of ECM molecules and osteogenic markers in cells, which can positively impact the osseointegration process.
Article
Biochemistry & Molecular Biology
Guya Diletta Marconi, Luigia Fonticoli, Ylenia Della Rocca, Stefano Oliva, Thangavelu Soundara Rajan, Oriana Trubiani, Giovanna Murmura, Francesca Diomede, Jacopo Pizzicannella
Summary: The study focused on the interaction between human periodontal ligament stem cells and two different implant titanium surfaces to evaluate cytotoxicity, cellular adhesion capacity, and improvement in ECM release. Various techniques including microscopic evaluation, viability assays, immunofluorescence, Western blot, and RT-PCR were used to analyze the parameters. Understanding cell/implant interaction is essential for developing more effective surfaces that enhance ECM release and promote osseointegration.
Article
Cell Biology
Caiyun Wang, Shang Gao, Ran Lu, Xin Wang, Su Chen
Summary: The study suggests that hydrogenated superhydrophilic nanotubes modified titanium implants significantly accelerate bone growth and integration, with the Nano group also exhibiting enhanced osteogenesis at later stages, indicating high clinical potential.
Article
Engineering, Biomedical
Paula Gabriela Faciola Pessoa de Oliveira, Mariana Sales de Melo Soares, Adriana Maria Mariano Silveira e Souza, Mario Taba Jr, Daniela Bazan Palioto, Michel Reis Messora, Bruna Ghiraldini, Felipe Anderson de Sousa Nunes, Sergio Luis Scombatti de Souza
Summary: This study evaluated the response of a nano-hydroxyapatite coating implant through gene expression analysis and three-dimensional evaluation in healthy and diabetic rats. The results showed that the NANO surface presented the best results in diabetic rats, promoting increased osteoblast proliferation in the early stages of osseointegration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Kai Li, Xiang Lu, Shiwei Liu, Xiaodong Wu, Youtao Xie, Xuebin Zheng
Summary: The study demonstrated that boron-incorporated CS coatings promoted osteoblastic differentiation and angiogenesis while suppressing inflammatory response. Specifically, the F-BCS coating showed enhanced osseointegration compared to L-BCS and C-CS coatings in in vivo experiments.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rafael Siqueira, Jessica Afonso Ferreira, Fabio Antonio Piola Rizzante, Guilherme Faria Moura, Daniela Baccelli Silveira Mendonca, Denildo de Magalhaes, Renata Cimoes, Gustavo Mendonca
Summary: This study used a mouse osteoporotic model to investigate the influence of hydrophilic titanium surfaces on gene expression and bone formation during the osseointegration process. The results showed that the hydrophilic surface promoted bone formation and activated key genes involved in the bone morphogenetic protein signaling pathway. In situations of osteoporosis, the hydrophilic surface seems to provide additional benefits in the early stages of osseointegration.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Materials Science, Biomaterials
Dimitrios Karazisis, Omar Omar, Sarunas Petronis, Peter Thomsen, Lars Rasmusson
Summary: Nanopatterning on implant surfaces has shown to enhance osseointegration by promoting gene expressions related to early osteogenic differentiation and osteoblastic activity in human jaw bone. Older patient age is associated with increased expression of proinflammatory cytokines on machined implants and decreased expression of proosteogenic factor on nanopatterned implants.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Engineering, Biomedical
Lais Morandini Rodrigues, Elis A. Lima Zutin, Elisa M. Sartori, Fabio A. P. Rizzante, Daniela B. S. Mendonca, Paul H. Krebsbach, Karl J. Jepsen, Lyndon F. Cooper, Luana M. R. Vasconcellos, Gustavo Mendonca
Summary: The study found that nanoscale surface implants promoted more bone formation associated with higher levels of Osterix gene expression. The surface characteristics of these implants can directly influence bone formation by adherent cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Dentistry, Oral Surgery & Medicine
Le Na Lau, Jun-Ho Cho, Ye-Hyeon Jo, In-Sung Luke Yeo
Summary: Selecting the appropriate sterilization method is crucial for the biocompatibility of implant materials. This study evaluated the biocompatibility of gamma-ray irradiated 3Y-TZP compared with unirradiated titanium, 3Y-TZP, and pure gold. The results showed that gamma-ray irradiation increased surface roughness of zirconia and significantly decreased its bioactivity. Further investigation is warranted to understand the effect of this sterilization method on implant materials.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Materials Science, Biomaterials
Ning Gan, Wei Qin, Chunlei Zhang, Ting Jiao
Summary: This study developed an in situ deposition method based on metal-phosphate coordination networks for surface modification of dental implants. The coordination complexes formed by phytic acid and metal cations exhibited excellent antibacterial activity and enhanced osteogenic activity, providing a potential solution for the failure of dental implant surgery. These findings contribute to a better understanding of the importance of surface modification of dental implants.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Vasilii S. Kolmogorov, Alexander S. Erofeev, Emily Woodcock, Yuri M. Efremov, Aleksei P. Iakovlev, Nikita A. Savin, Anna V. Alova, Svetlana V. Lavrushkina, Igor I. Kireev, Alexandra O. Prelovskaya, Elena V. Sviderskaya, Denis Scaini, Natalia L. Klyachko, Peter S. Timashev, Yasufumi Takahashi, Sergey V. Salikhov, Yuri N. Parkhomenko, Alexander G. Majouga, Christopher R. W. Edwards, Pavel Novak, Yuri E. Korchev, Petr V. Gorelkin
Summary: A high-resolution estimation method for mechanical properties and the possibility of qualitative and quantitative analysis of living cells have been demonstrated in this study. Forces applied using a nanopipette are much smaller than those using atomic force microscopy, with no detectable effect on live cells.
Article
Engineering, Biomedical
Bradley Lahens, Christopher D. Lopez, Rodrigo F. Neiva, Michelle M. Bowers, Ryo Jimbo, Estevam A. Bonfante, Jonathan Morcos, Lukasz Witek, Nick Tovar, Paulo G. Coelho
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Engineering, Biomedical
Nick Tovar, Lukasz Witek, Rodrigo Neiva, Heloisa F. Marao, Luiz F. Gil, Pablo Atria, Ryo Jimbo, Eduardo A. Caceres, Paulo G. Coelho
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Surgery
Christopher D. Lopez, J. Rodrigo Diaz-Siso, Lukasz Witek, Jonathan M. Bekisz, Luiz F. Gil, Bruce N. Cronstein, Roberto L. Flores, Andrea Torroni, Eduardo D. Rodriguez, Paulo G. Coelho
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Surgery
Christopher D. Lopez, Paulo G. Coelho, Lukasz Witek, Andrea Torroni, Michael I. Greenberg, Dean L. Cuadrado, Audrey M. Guarino, Jonathan M. Bekisz, Bruce N. Cronstein, Roberto L. Flores
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Engineering, Biomedical
Lukasz Witek, Han Tian, Nick Tovar, Andrea Torroni, Rodrigo Neiva, Luiz F. Gil, Paulo G. Coelho
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Engineering, Biomedical
Ilana S. Ramalho, Edmara T. P. Bergamo, Lukasz Witek, Paulo G. Coelho, Adolfo C. O. Lopes, Estevam A. Bonfante
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Surgery
Samantha G. Maliha, Christopher D. Lopez, Paulo G. Coelho, Lukasz Witek, Madison Cox, Alan Meskin, Sejndi Rusi, Andrea Torroni, Bruce N. Cronstein, Roberto L. Flores
PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Article
Orthopedics
Andrea Torroni, Paulo Eduardo Lima Parente, Lukasz Witek, Jacques Henri Hacquebord, Paulo G. Coelho
Summary: This study compared R and OD osteotomy instrumentation in posterior lumbar fixation using a sheep model, finding that the OD group showed better mechanical stability, while no significant differences were detected in bone histomorphology analysis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Biomedical
E. B. Benalcazar Jalkh, E. T. P. Bergamo, K. N. Monteiro, P. F. Cesar, L. A. Genova, A. C. O. Lopes, P. N. Lisboa Filho, P. G. Coelho, C. F. Santos, F. Bortolin, M. M. T. Piza, E. A. Bonfante
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Jose Carlos Romanini-Junior, Ronaldo Hirata, Estevam A. Bonfante, Dimorvan Bordin, Rose Yakushijin Kumagai, Vinicius P. Fardin, Paulo G. Coelho, Andre F. Reis
Article
Engineering, Biomedical
Fabio C. Lorenzoni, Estevam A. Bonfante, Guilherme B. Valverde, Paulo G. Coelho, Gerson Bonfante, Van P. Thompson, Nelson R. F. A. Silva
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Mitsuaki Furuhata, Tadahiro Takayama, Takanobu Yamamoto, Yasumasa Ozawa, Motoki Senoo, Manami Ozaki, Seiichi Yamano, Shuichi Sato
Summary: This study investigated the bone healing pattern in rat mandibular bone defects with and without RCM containing FGF-2. Real-time assessment revealed that RCM/FGF-2 effectively promoted bone regeneration within the critical-size mandibular defects in rats, with increased volume, BMD, and closure percentage of the NFB area compared to control and RCM groups. Histological evaluation confirmed the presence of osteoblasts, osteocytes, and blood vessels within the newly formed bone.
JOURNAL OF DENTAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lukasz Witek, Nick Tovar, Christopher D. Lopez, Jonathan Morcos, Michelle Bowers, Roumiana S. Petrova, Paulo G. Coelho
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2020)
Meeting Abstract
Medicine, General & Internal
Daniela Oliveira, Sofia Maia, Ines Balaco, Paulo Coelho, Susana Almeida, Margarida Venancio, Jorge Saraiva, Gen Nishimura, Sergio B. Sousa
Article
Medicine, General & Internal
Isabel O. Cruz, Sara Alves Pereira, Bruna Vieira, Ines Chora, Paulo Coelho
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.