Assessments of antibody biodistribution

Pharmacokinetic study and Fcγ receptor gene analysis in two patients with rheumatoid arthritis controlled by low-dose infliximab

(2014) Shinichiro Nishio et al.   Modern Rheumatology

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

(2013) Philip R. Cooper et al.   BRAIN RESEARCH

Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies

(2013) Miroslav Dostalek et al.   CLINICAL PHARMACOKINETICS

Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody

(2013) Lubna Abuqayyas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

(2013) Maya K Leabman et al.   mAbs

Antibody biodistribution coefficients

(2013) Dhaval K. Shah et al.   mAbs

89Zr, a Radiometal Nuclide with High Potential for Molecular Imaging with PET: Chemistry, Applications and Remaining Challenges

(2013) Gabriel Fischer et al.   MOLECULES

Simultaneous Analysis of Multiple Monoclonal Antibody Biotherapeutics by LC-MS/MS Method in Rat Plasma Following Cassette-Dosing

(2012) Hongyan Li et al.   AAPS Journal

Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations

(2012) C. Andrew Boswell et al.   AAPS Journal

Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

(2012) Lubna Abuqayyas et al.   AAPS Journal

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

(2012) Yang Chen et al.   AAPS Journal

Application of knockout mouse models to investigate the influence of FcγR on the tissue distribution and elimination of 8C2, a murine IgG1 monoclonal antibody

(2012) Lubna Abuqayyas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis

(2012) Xiaotao Duan et al.   JOURNAL OF CHROMATOGRAPHY A

Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer

(2012) Lubna Abuqayyas et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

Investigation of the Role of FcγR and FcRn in mAb Distribution to the Brain

(2012) Lubna Abuqayyas et al.   MOLECULAR PHARMACEUTICS

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

(2011) S. I. Rudnick et al.   CANCER RESEARCH

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies

(2010) Diane R. Mould et al.   BIODRUGS

Effect of FCGR2A and FCGR3A variants on CLL outcome

(2010) D. Dornan et al.   BLOOD

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Ron J. Keizer et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-  Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys

(2010) R. Deng et al.   DRUG METABOLISM AND DISPOSITION

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Investigation of the Influence of FcRn on the Distribution of IgG to the Brain

(2009) Amit Garg et al.   AAPS Journal

Biodistribution Mechanisms of Therapeutic Monoclonal Antibodies in Health and Disease

(2009) Mohammad Tabrizi et al.   AAPS Journal

In vivo Molecular Imaging of Cancer with a Quenching Near-Infrared Fluorescent Probe Using Conjugates of Monoclonal Antibodies and Indocyanine Green

(2009) Mikako Ogawa et al.   CANCER RESEARCH

Refinement of the Population Pharmacokinetic Model for the Monoclonal Antibody Matuzumab

(2009) Katharina Kuester et al.   CLINICAL PHARMACOKINETICS

Physiologically based pharmacokinetic model for T84.66: A monoclonal anti-CEA antibody

(2009) Shweta R. Urva et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibodies and Antimatter: The Resurgence of Immuno-PET

(2008) A. M. Wu   JOURNAL OF NUCLEAR MEDICINE

Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index

(2008) C. F. McDonagh et al.   MOLECULAR CANCER THERAPEUTICS