Article
Oncology
Jinghang Xie, Meghan A. Rice, Zixin Chen, Yunfeng Cheng, En-Chi Hsu, Min Chen, Guosheng Song, Liyang Cui, Kaixiang Zhou, Jessa B. Castillo, Chiyuan Amy Zhang, Bin Shen, Frederick T. Chin, Christian A. Kunder, James D. Brooks, Tanya Stoyanova, Jianghong Rao
Summary: Prostate cancer is a common malignancy with limited tools for prognostic risk stratification. This study identified MetAP2 as a potential early-risk stratifier and developed a novel MetAP2-activated PET imaging tracer for monitoring MetAP2 activity in vivo, which may offer new opportunities for noninvasive risk assessment and therapeutic monitoring in prostate cancer patients.
Article
Oncology
Shota Shimizu, Ryota Kawahara, Siro Simizu
Summary: This study investigated the role of methionine aminopeptidase-2 (MetAP2) in vasculogenic mimicry (VM) and found that it is critical for VM in human cancer cells. Inhibiting MetAP2 can effectively suppress VM, suggesting its potential as a target for VM inhibition.
Review
Cell & Tissue Engineering
Qianli Ma, Zahra Miri, Havard Jostein Haugen, Amirhossein Moghanian, Dagnjia Loca
Summary: In 1892, J.L. Wolff proposed that bone could respond to mechanical and biophysical stimuli as a dynamic organ, providing an opportunity for investigations on bone and its potential for tissue repair. Mechanical stimulation through activities like exercise or machinery application can affect the differentiation and development of mesenchymal tissue. The review aims to clarify the extent to which mechanical stimulation can aid in bone tissue repair and regeneration, the underlying mechanisms, and the importance of vascularization in nutrient supply for bone healing and regeneration.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Computer Science, Interdisciplinary Applications
Enhao Zhang, Saeed Miramini, Lihai Zhang
Summary: This study investigates the combined effects of osteoporosis and diabetes on fracture healing process by developing numerical models. The results show that osteoporotic fractures have higher instability and disruption in mesenchymal stem cells' proliferation and differentiation compared to non-osteoporotic fractures. Moreover, when osteoporosis coexists with diabetes, the healing process of fractures can be severely impaired.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2024)
Article
Medicine, Research & Experimental
Maximilian M. Menger, Michelle Bleimehl, David Bauer, Claudia Scheuer, Sandra Hans, Dominik Saul, Sabrina Ehnert, Michael D. Menger, Tina Histing, Matthias W. Laschke
Summary: This study investigated the effects of cilostazol on bone regeneration in an atrophic non-union model in mice. The results showed that cilostazol promoted bone formation and vascularization, as well as increased the number of osteoclasts and macrophages. These findings suggest that cilostazol may be a promising drug candidate for the adjuvant treatment of atrophic non-unions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Mechanical
Zhenjun Wang, Zhongyuan Wang, Yong Liu, Changchun Cai, Bowen Xiong, Zhitai Wang, Zhifeng Xu, Huan Yu
Summary: The study found that during the initial tension process, the warp yarn interface and neighboring matrix were damaged. The accumulation and interaction of these damage zones led to successive failures of the warp, weft, and warp yarns.
FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES
(2021)
Article
Engineering, Multidisciplinary
U. A. Khashaba
Summary: A new drilling approach using controllable force for clamping the specimen was implemented to investigate the influence of cutting and support conditions on thrust force, delaminations, and burr factor in drilling woven GFRP composites. A series of ASTM tests were conducted to determine mechanical properties and predict the critical thrust force for delamination initiation. Accurate measurement of delamination and burr areas was achieved using an inexpensive image processing technique.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Helen Rinderknecht, Andreas K. Nussler, Konrad Steinestel, Tina Histing, Sabrina Ehnert
Summary: Angiogenesis plays a crucial role in the early healing process of bone fractures. This study developed an in vitro model to simulate smoking conditions and investigate the impact of smoking on angiogenesis and fracture repair.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Chengyu Yang, Yang Liu, Ziyan Wang, Minmin Lin, Chao Liu
Summary: Controlled anabolic mechanical loading enhances bone formation mainly through Type H vessels in a S1Pr1-dependent manner.
Article
Materials Science, Composites
Amit Ramji, Yigeng Xu, Marzio Grasso, Mehdi Yasaee, Philip Webb
Summary: The experimental study found that the delamination resistance of 5-harness satin woven laminates is influenced by both interfacial fiber orientation and veil density, with the 90/45 fiber orientation bias exhibiting the greatest resistance, while increasing veil density has limited additional benefits on resistance enhancement.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jasna Nambiar, Sonali Jana, Samit Kumar Nandi
Summary: This review highlights the latest strategies to promote biomaterial-based scaffold vascularization, including the incorporation of cells, growth factors, inorganic ions, etc., as well as structural modifications, biophysical stimuli, and natural molecules.
Article
Materials Science, Ceramics
Yanfeng Zhang, Zhengong Zhou, Shidong Pan, Zhiyong Tan
Summary: This paper presents an experimental approach of three-dimensional woven carbon/carbon composites arranged in various geometrical configurations. Seven types of samples were tested under pin-loading to determine the effects of width-to-hole diameter ratio (W/D), edge distance -to-hole diameter ratio (E/D) and hole diameter -to-thickness ratio (D/t) on the failure mode. The experimental results and observations indicated that net-tension failure and shearing-out failure switched to bearing failure with the increasing ratio of W/D and E/D, respectively.
CERAMICS INTERNATIONAL
(2021)
Article
Biophysics
Ajay Goyal, Jitendra Prasad
Summary: This study aims to develop an in silico bone-adaptation model for woven bone at cellular and tissue levels. The model predicts woven bone growth based on ion diffusion and strain energy density. The results demonstrate that the model accurately predicts woven bone growth under different loading conditions, making it the first model to do so.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Engineering, Biomedical
Jianhua Zhang, Julia Griesbach, Marsel Ganeyev, Anna-Katharina Zehnder, Peng Zeng, Gian Nutal Schaedli, Anke de Leeuw, Yuxiao Lai, Marina Rubert, Ralph Mueller
Summary: The study reveals that mechanical stimulation can promote the formation of 3D bioprinted bone organoids, and long-term mechanical loading is necessary for increasing the density and stiffness of the organoids, as well as promoting osteoblast differentiation.
Article
Orthopedics
Xiao Yang, Yong-xin Mai, Lan Wei, Li-yang Peng, Feng-xiang Pang, Ling-jun Wang, Zhi-peng Li, Jin-fang Zhang, An-min Jin
Summary: This study found that loss of MLK3 inhibits osteoblast differentiation and bone formation, and delays fracture healing by affecting metabolism and disrupting MAPK signaling.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Endocrinology & Metabolism
Brandon A. Coates, Jennifer A. McKenzie, Susumu Yoneda, Matthew J. Silva
Summary: IL-6 plays a role in the inflammatory phase of fracture repair, but its impact on successful repair is not fully understood. In experiments using IL-6 KO mice, it was found that IL-6 knockout enhanced callus formation and bone response after stress fracture injury, possibly through direct action on osteoblast function.
Article
Endocrinology & Metabolism
Pei Hu, Jennifer A. McKenzie, Evan G. Buettmann, Nicole Migotsky, Michael J. Gardner, Matthew J. Silva
Summary: Type 1 diabetes impairs bone formation and fracture healing in humans. Akita mice, with a mutation in the insulin-2 gene, showed reduced bone mass and weaker bones, as well as impaired fracture healing. Akita mice exhibited osteopenia and decreased bone mechanical properties, mimicking some skeletal features of T1DM in humans.
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: Using Laser Capture Microdissection, osteocytes enriched intracortical bone tissues were analyzed for gene expression, revealing differential regulation of genes like Ngf, Wnt1, and MMP13 under mechanical loading. This method provided insights into the molecular changes in osteocytes in response to mechanical stimuli.
Article
Endocrinology & Metabolism
Lisa Y. Lawson, Michael D. Brodt, Nicole Migotsky, Christopher J. Chermside-Scabbo, Ramya Palaniappan, Matthew J. Silva
Summary: The secretion of Wnt ligands is essential for adult bone homeostasis, and inhibiting their secretion results in decreased bone formation and increased resorption. Additionally, osteoblast-derived Wnts play a crucial role in mediating the bone anabolic response to tibial loading.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Katherine R. Hixon, Jennifer A. McKenzie, David A. W. Sykes, Susumu Yoneda, Austin Hensley, Evan G. Buettmann, Hongjun Zheng, Dimitrios Skouteris, Audrey McAlinden, Anna N. Miller, Matthew J. Silva
Summary: A new murine model of atrophic nonunion was established by suppressing the proliferation of osteoblast-lineage cells after fracture, leading to reduced formation and remodeling of the mineralized callus at the fracture site. This resulted in delayed bone bridging, reduced callus size, and failed union with residual bone fragments and fibrous tissue in the mice. Biomechanical testing showed a failure to recover torsional strength in the model mice compared to the wild-type controls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Mingming Yan, Xin Duan, Lei Cai, Weili Zhang, Matthew J. Silva, Robert H. Brophy, Muhammad Farooq Rai
Summary: The study revealed that KIF26B plays a crucial role in injury-induced ectopic calcification. It was found that KIF26B represses osteogenesis by modulating Wnt/β-catenin signaling, making it a potential target for mitigating ectopic calcification.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Physics, Multidisciplinary
Wenbin Zhang, Fahad Alghannam, Yingchao Zhu, Jianfei Zhang, Gregory R. Wohl, Harold K. Haugen, Zhipeng Qin, Guoqiang Xie, Qiyin Fang, Steve Guofang Shen
Summary: The study suggests that using femtosecond laser ablation for implant site preparation can significantly improve the lateral pull-out strength of mini-implants in thinner cortical bone samples (1.0 and 0.5 mm).
FRONTIERS IN PHYSICS
(2021)
Article
Biotechnology & Applied Microbiology
Katherine R. Hixon, Dakota B. Katz, Jennifer A. McKenzie, Anna N. Miller, Farshid Guilak, Matthew J. Silva
Summary: This study demonstrates the potential of cellularized cryogel scaffolds to enhance the healing of non-unions, particularly through the addition of BMP-2 to promote endochondral ossification.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jennifer A. McKenzie, Ian M. Galbreath, Andre F. Coello, Katherine R. Hixon, Matthew J. Silva
Summary: The relationship between osteogenesis and angiogenesis is complex. While angiogenesis is necessary for normal bone development, the role of vascular endothelial growth factor A (VEGFA) in supporting bone formation is still being studied. It has been suggested that VEGFA may have a direct role in bone formation, independent of angiogenesis.
Article
Physiology
Evan G. Buettmann, Susumu Yoneda, Pei Hu, Jennifer A. McKenzie, Matthew J. Silva
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Joseph Deering, Jianyu Chen, Dalia Mahmoud, Tengteng Tang, Yujing Lin, Qiyin Fang, Gregory R. Wohl, Mohamed Elbestawi, Kathryn Grandfield
Summary: The newly formed bone structure contains disorder within an ordered multiscale structure from macro to nanoscale. The heterogeneity in mineral ellipsoid packing at the interface of porous titanium implants is characterized using electron microscopy. The ellipsoids within the bone tissue exhibit alternating orientations corresponding to unique lamellar packets near the titanium implant interface, with short-order ellipsoid orientation shifts observed in the 3D probe.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: This study assessed the contribution of osteoblast lineage cells to bone formation induced by mechanical loading. Preexisting Osx and Dmp1 lineage cells were found to play a predominant role in lamellar bone formation, while recruitment of earlier osteoprogenitors and increased cell proliferation supported robust woven bone formation.
Meeting Abstract
Endocrinology & Metabolism
Taylor deVet, Roshan Bashar, Hubert Debruin, Gregory Wohl
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.