Letter
Cardiac & Cardiovascular Systems
Ahmed Sayed, Ann Marie Navar, Leandro Slipczuk, Christie M. Ballantyne, Zainab Samad, Carl J. Lavie, Salim S. Virani
Summary: This cross-sectional study compares the prevalence, awareness, and treatment of elevated low-density lipoprotein (LDL) cholesterol in US adults in 1999-2000 vs 2017-2020.
Article
Medicine, General & Internal
Agnieszka Baranska, Bartlomiej Drop, Urszula Religioni, Joanna Dolar-Szczasny, Maria Malm, Krystian Wdowiak, Magdalena Bogdan, Anna Klak, Piotr Merks, Robert Rejdak
Summary: This research aims to assess the awareness and knowledge about osteoporosis among osteoporosis patients, including risk factors, health condition, supplementation used, socio-demographic factors, and other variables. The results indicate that the more frequent the symptoms associated with the disease, the lower the general self-assessment of the health condition of the respondents. Additionally, almost half of the respondents stated that their knowledge of osteoporosis is negligible. Moreover, the use of dietary supplements significantly differentiated respondents in terms of health self-assessment, and there is a significant relationship between the self-assessment of knowledge about osteoporosis and the use of dietary supplements.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Seung Jae Kim, Oh. Deog Kwon, Kyung-Soo Kim
Summary: The study revealed that most patients with diabetes mellitus have dyslipidemia, but many are unaware or untreated for their condition, resulting in suboptimal control rates. Factors influencing optimal control of dyslipidemia include age, urban living, higher body mass index, lower glycated hemoglobin levels, hypertension, poorer self-rated health status, and receiving regular health check-ups.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Medicine, General & Internal
Xuexue Zhang, Xujie Wang, Miaoran Wang, Hua Qu, Biaoyan Hu, Qiuyan Li
Summary: This study aimed to describe the trend in the prevalence, awareness, and treatment of isolated diastolic hypertension (IDH) in the United States from 2001 to 2018. The results showed that the prevalence of IDH decreased from 2001-2002 to 2017-2018, and although there were increases in awareness and treatment, they remained below 50%.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Y. J. Choi, H. -B. Shin, B. Park, D. J. Kim, Y. -S. Chung
Summary: The management of osteoporosis in South Korea is improving but is still lower compared with diabetes, indicating the need for further efforts to improve diagnosis and treatment rates.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Eung-Joon Lee, Oh Deog Kwon, Seung Jae Kim
Summary: Post-stroke depression (PSD) is prevalent among community-dwelling stroke survivors, but awareness and treatment rates are low, highlighting the need for more active screening and treatment by clinicians.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Prashant Mathur, Sravya Leburu, Vaitheeswaran Kulothungan
Summary: The prevalence of diabetes mellitus (DM) and impaired fasting blood glucose (IFG) is high among adults in India, while the levels of awareness, treatment, and control are still low. There are significant differences in these levels between different age groups. Multifaceted approaches, including improved awareness, adherence to treatment, and better preventive and counseling services, are crucial to halt the development of diabetes in India.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Mahin Amini, Mahdi Moradinazar, Fatemeh Rajati, Moslem Soofi, Sadaf G. Sepanlou, Hossein Poustchi, Sareh Eghtesad, Mahmood Moosazadeh, Javad Harooni, Javad Aghazadeh-Attari, Majid Fallahi, Mohammad Reza Fattahi, Alireza Ansari-Moghaddam, Farhad Moradpour, Azim Nejatizadeh, Mehdi Shahmoradi, Fariborz Mansour-Ghanaei, Alireza Ostadrahimi, Ali Ahmadi, Arsalan Khaledifar, Mohammad Hossien Saghi, Nader Saki, Iraj Mohebbi, Reza Homayounfar, Mojtaba Farjam, Ali Esmaeili Nadimi, Mahmood Kahnooji, Farhad Pourfarzi, Bijan Zamani, Abbas Rezaianzadeh, Masoumeh Ghoddusi Johari, Masoud Mirzaei, Ali Dehghani, Seyed Fazel Zinat Motlagh, Zahra Rahimi, Reza Malekzadeh, Farid Najafi
Summary: This study examined the socioeconomic inequality in prevalence, awareness, treatment, and control of hypertension in Iran. It found that individuals with low socioeconomic status had higher prevalence of hypertension, but treatment and control were more concentrated among those with higher socioeconomic status.
Editorial Material
Medicine, General & Internal
James O'Connell
Summary: The article discusses the importance of using insulin pumps and continuous glucose monitors in diabetes technology, especially for patients with impaired awareness of hypoglycemia.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
So Young Park, Se Hwa Kim, Tae-Young Kim, Young-Kyun Lee, Yong-Chan Ha, Sunmee Jang, Seong Hee Ahn, Ha Young Kim
Summary: In Korean women with osteoporosis, SERMs did not increase the risk of VTE compared to BPs, but old age and estrogen replacement therapy were associated with an increased risk of VTE.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Hyeonji Yoo, Kyong Park
Summary: This study examined the relationship between phytochemical-rich food intake and osteoporosis incidence in premenopausal and postmenopausal women. It found that postmenopausal women with the highest intake of phytochemical-rich foods had a 16% lower risk of osteoporosis. No significant association was observed among premenopausal women. These findings suggest that consuming phytochemical-rich foods may offer protection against osteoporosis in postmenopausal women.
Article
Public, Environmental & Occupational Health
J. S. Thakur, Ria Nangia
Summary: Hypertension and diabetes are major public health problems in certain states of India, particularly in Punjab and Haryana, with low rates of awareness, treatment, and control. The study found that family history is associated with the awareness, treatment, and control of blood glucose and blood pressure levels.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Veterinary Sciences
Hyeshin Hwang, Hee-Jin Dong, Janet Han, Seongbeom Cho, Yongbaek Kim, Inhyung Lee
Summary: This study investigates the prevalence and severity of gastric ulcers in Korean Thoroughbred racehorses, confirming the therapeutic effect of ranitidine and omeprazole, and comparing the efficacy between the two drugs. The study highlights the importance of recognizing gastric ulcers as an important factor and recommends the use of omeprazole as a treatment option in Korea.
JOURNAL OF VETERINARY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Maria Dorobantu, Oana-Florentina Gheorghe-Fronea, Alexandru Scafa-Udriste, Sebastian Onciul, Calin Pop, Lucian Dorobantu, Roxana Darabont
Summary: Gender differences play a significant role in hypertension epidemiology, with clear disparities in prevalence, awareness, treatment, and control between different age groups of men and women, mainly influenced by hormonal status. In high cardiovascular risk European countries like Romania, gender gaps in hypertension prevalence may decrease over time, with females expected to maintain higher awareness and treatment rates than males, while an upward trend in blood pressure control is predicted only for women.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Endocrinology & Metabolism
Ju Hwan Kim, Han Eol Jeong, Yeon-Hee Baek, Sun Wook Cho, Hyuna Lim, Ju-Young Shin
Summary: The study found that oral bisphosphonates are the most commonly used treatment for postmenopausal osteoporosis in an Asian population, with treatment interruptions being most notable in the first year and highest for oral bisphosphonates. Users of intravenous ibandronate, pamidronate, zoledronic acid, and SERMs were less likely to interrupt treatment compared to oral bisphosphonate users. Characteristics such as rheumatoid arthritis and concomitant use of glucocorticoids were associated with increased odds of treatment interruption in specific treatment groups.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Biology
Ho Jun Kim, Seulggie Choi, Kyuwoong Kim, Hyungjun Park, Kyae-Hyung Kim, Sang Min Park
CHRONOBIOLOGY INTERNATIONAL
(2020)
Article
Education, Scientific Disciplines
Kyae Hyung Kim, Hyun-Young Kim, Yong Jin Kwon, Tin Tin Mar, Aye Aye, Ho Young Hwang, Kyung Hwan Kim, Young Jae Im, Kwang-Woong Lee, Jung-Eun Cheon, Seung-Hee Lee
JOURNAL OF SURGICAL EDUCATION
(2020)
Article
Environmental Sciences
Seulggie Choi, Kyae Hyung Kim, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Yoosun Cho, Gyeongsil Lee, Joung Sik Son, Sang Min Park
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Environmental Sciences
Hyeah Park, Seulggie Choi, Kyae Hyung Kim, EunKyo Kang, Ahryoung Ko, Sang Min Park
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Oncology
Kyuwoong Kim, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
Summary: This study found that weight gain in young adults is significantly associated with an increased risk of hepatocellular carcinoma (HCC), especially in individuals with underlying liver diseases. No protective association was observed between weight loss and HCC.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2021)
Article
Environmental Sciences
Seong Rae Kim, Daein Choi, Seulggie Choi, Kyuwoong Kim, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
ENVIRONMENT INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Daein Choi, Seulggie Choi, Hyunho Kim, Kyuwoong Kim, Nakhyun Kim, Ahryoung Ko, Kyae Hyung Kim, Joung Sik Son, Jae Moon Yun, Yoon Kim, Sang Min Park
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Kyae Hyung Kim, Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Yoosun Cho, Yun Hwan Oh, Gyeongsil Lee, Joung Sik Son, Sang Min Park
Summary: The study found that even small amounts of physical activity may help decrease the risk of cardiovascular disease, coronary heart disease, and stroke in breast cancer survivors. However, the benefits of physical activity for obese and overweight breast cancer survivors were smaller compared to those with normal weight. The frequency of moderate-to-vigorous physical activity (MVPA) showed a reverse J-curve association with cardiovascular disease, with the best benefit observed in the group engaging in 3-4 times MVPA per week.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Rheumatology
Jun Seok Park, Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Eun Young Lee, Sang Min Park
Summary: The study found a positive association between fine particulate matter (PM2.5) and the incidence of rheumatoid arthritis (RA), while no adverse effects from particulate matter were found for ankylosing spondylitis (AS) or systemic lupus erythematosus (SLE).
Article
Medicine, General & Internal
Yun Hwan Oh, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
Summary: The study found that increasing relative lean body mass and appendicular skeletal mass can reduce the risk of metabolic syndrome in both men and women, while increasing relative body fat mass index can increase the risk of metabolic syndrome. Particularly, the risk reduction of MetS is more significant in groups with higher baseline BMI and body fat mass index.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Seong Rae Kim, Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Yoosun Cho, Yun Hwan Oh, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
Summary: The study found that reducing physical activity in young adults exposed to low-to-moderate levels of air pollution may increase the risk of cardiovascular disease, while a significant increase in physical activity in a high-pollution environment could have adverse effects on cardiovascular health.
EUROPEAN HEART JOURNAL
(2021)
Article
Health Care Sciences & Services
In Young Hwang, Yohan Han, Min Sun Kim, Kyae Hyung Kim, Belong Cho, Wonho Choi, Yejin Kim, Shin Hye Yoo, Sun Young Lee
Summary: Respecting patients' preference for place of care is crucial in advance care planning for advanced cancer. This retrospective study in South Korea investigated adult cancer patients referred to a palliative care consultation team, recording their preference for place of care and demographic/clinical factors. Among the 891 patients referred, 23.6% preferred home discharge and only 53.8% of them were actually discharged home. Female patients had higher home discharge rates, while those with poor oral intake or dyspnea had lower rates. Additionally, 32.8% of patients discharged home had unintended hospital visits within 2 months. Individualized care planning considering relevant factors is necessary to meet patients' preferences for end-of-life care.
Article
Medicine, General & Internal
EunKyo Kang, Sun Young Lee, Min Sun Kim, Hyemin Jung, Kyae Hyung Kim, Kyoung-Nam Kim, Hye Yoon Park, Yu Jin Lee, Belong Cho, Jee Hoon Sohn
Summary: This study assessed the mental health issues of mild COVID-19 patients admitted to a community treatment center in Korea, finding high prevalence of depression, anxiety, and PTSD during isolation, underscoring the importance of addressing social stigma and providing care for mental health. Somatic symptoms decreased during isolation, but severe depression increased after four weeks of stay.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Psychology, Clinical
EunKyo Kang, Kyae Hyung Kim, Young Min Cho, Sang Min Park, Yong-Jin Kim, Hae-Young Lee, Ye Eun Rhee, Soojeong Kim, Young Ho Yun
Summary: This study found that improvements in self-management strategies are associated with improvements in clinical outcomes among patients with chronic diseases, especially for those with initially poor self-management strategies. For example, diabetic patients who improved their self-management strategies showed a significant change in HbA1c levels.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2021)
Article
Primary Health Care
Min So Kim, Kyae Hyung Kim, Sang Min Park, Jong-Goo Lee, Yeon Seo Ko, A. Ra Cho, Yoon Su Ku
KOREAN JOURNAL OF FAMILY MEDICINE
(2020)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
