Article
Endocrinology & Metabolism
R. M. Y. Wong, R. W. K. Ng, W. W. Chau, W. H. Liu, S. K. H. Chow, C. Y. Tso, N. Tang, W. -H. Cheung
Summary: The prevalence of cognitive impairment in hip fractures is 86.5%, and a MoCA score of less than 15 is associated with an 11.71-fold increased risk of mortality within one year after a hip fracture. Early attention and caution should be given to these patients for appropriate intervention to decrease mortality rates.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Kilian Rapp, Clemens Becker, Chris Todd, Martin Rehm, Dietrich Rothenbacher, Claudia Konnopka, Hans-Helmut Koenig, Thomas Friess, Gisela Buechele
Summary: In Germany, geriatricians provide acute and subacute care for hip fracture patients. The study found that high rates of acute geriatric care were associated with lower mortality, while high rates of subacute rehabilitation were associated with lower care home admission and mortality.
Article
Clinical Neurology
Kirsten Hall Long, Carin Smith, Ronald Petersen, Jane Emerson, Jeanine Ransom, Michelle M. Mielke, Steven Hass, Cynthia Leibson
Summary: This study examined the cost-effectiveness of managing cognitive impairment in Olmsted County, MN residents aged 70-89 years. Results showed significant differences in cost distributions across cognitive categories, with higher medical and medical + nursing home costs for MCI patients compared to cognitively unimpaired individuals.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Wen-Yu Kuo, Min-Chi Chen, Ya-Chi Lin, Shu-Fang Yan, Yea-Ing Lotus Shyu
Summary: This study identified different trajectories of adherence to home rehabilitation for older adults with hip fracture and cognitive impairment. The high adherence group showed better postoperative recovery outcomes. Developing exercise habits and consulting a physical therapist were important factors in promoting high adherence among participants.
Article
Geriatrics & Gerontology
Bjarke Viberg, Lars Uldum Erlandsen Claville, Lis R. Andersen, Lisbeth Fredholm, Dorte Dall-Hansen, Heidi Grejsen
Summary: Enhanced standardized interdisciplinary cooperation between hospital, nursing home facility teams, and visiting acute team nurses can lower readmission rates and potentially reduce mortality in patients with hip fracture.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Jarl E. Strange, Caroline Sindet-Pedersen, Anders Holt, Mikkel P. Andersen, Christian Torp-Pedersen, Lars Kober, Gunnar H. Gislason, Jonas B. Olesen, Emil L. Fosbol
Summary: This study investigated the incidence and factors associated with nursing home admission (NHA) following transcatheter aortic valve replacement (TAVR) compared with the general population, and found that TAVR was not associated with an increased incidence of NHA.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Geriatrics & Gerontology
Brian Nguyen, William James Deardorff, Ying Shi, Bocheng Jing, Alexandra K. Lee, Sei J. Lee
Summary: NH residents receive frequent fingersticks regardless of level of cognitive impairment, suggesting that cognitive status is a minor consideration in monitoring decisions.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Geriatrics & Gerontology
Yiyang Yuan, Kate L. Lapane, Jennifer Tjia, Jonggyu Baek, Shao-Hsien Liu, Christine M. Ulbricht
Summary: The study identified three physical frailty subgroups in older nursing home residents: mild, moderate, and severe. Those with moderate or severe physical frailty were more likely to have cognitive impairment and need assistance in daily activities. The findings suggest a complex interplay between physical frailty and cognitive impairment in this population.
Article
Geriatrics & Gerontology
Heather L. Mutchie, Jennifer S. Albrecht, Denise L. Orwig, Yi Huang, W. John Boscardin, Marc C. Hochberg, Jay S. Magaziner, Ann L. Gruber-Baldini
Summary: Male hip fracture patients are more likely to be diagnosed with cognitive impairment, especially when direct cognitive testing is used. This could impact recovery outcomes after hip fracture, suggesting the need for cognitive testing in these patients to reduce differential misclassification by patient sex.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Geriatrics & Gerontology
Sileno De Queiroz Fortes-Filho, Marlon Juliano Romero Aliberti, Juliana de Araujo Melo, Daniel Apolinario, Maria do Carmo Sitta, Itiro Suzuki, Luiz Eugenio Garcez-Leme
Summary: The study shows that the 10-point Cognitive Screener (10-CS) is a strong predictor of functional recovery and survival after hip fracture repair. Patients with probable cognitive impairment upon admission had lower rates of recovery and higher risk of death compared to those with normal cognition.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Enrique Gonzalez-Marcos, Enrique Gonzalez-Garcia, Paula Rodriguez-Fernandez, Jeronimo J. Gonzalez-Bernal, Esteban Sanchez-Gonzalez, Josefa Gonzalez-Santos
Summary: This study aimed to investigate the relationship between moderate or severe cognitive impairment and hip fractures. The results showed that factors such as age, initial cognitive impairment, discharge status, cognitive worsening at six months, moderate dependence at admission and six months, poor ambulation at discharge, and institutionalization before or after fracture were associated with cognitive decline at the sixth month.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Pei-Chia Yen, Yu-Tai Lo, Chih-Cheng Lai, Ching-Chi Lee, Ching-Ju Fang, Chia-Ming Chang, Yi-Ching Yang
Summary: This study aimed to update the research evidence regarding the effect of outpatient geriatric evaluation and management (GEM) on survival and nursing-home admission compared to conventional care. The results showed that outpatient GEM led by a geriatrician with a multidisciplinary team improved overall survival, particularly during the 24-month follow-up period, with a trivial effect on nursing-home admission.
Article
Nursing
Annamaria Pakai, Emese Havasi-Santha, Erzsebet Mak, Orsolya Mate, Dorina Pusztai, Noemi Fuller, Miklos Zrinyi, Andras Olah
Summary: The study found that cognitive function, self-care capacity, and nurse support can influence the risk of malnutrition in older residents. Older adults with better cognitive function and more independent self-feeding had lower risk of malnutrition. Self-care capacity and appetite were key predictors in predicting malnutrition risk.
Article
Geriatrics & Gerontology
John N. Morris, Elizabeth P. Howard, Erez Schachter, Sharran Burney, Anna Laytham, Daniela Fialova, Emiel O. Hoogendijk, Rosa Liperoti, Hein P. J. van Hout Mpsy, Davide Liborio Vetrano
Summary: This study examined cognitive changes among nursing home residents and developed a risk model for predicting cognitive decline. The results showed that residents with milder impairment had higher rates of cognitive decline, and the CogRisk-NH scale was able to predict the risk of cognitive decline.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Medicine, General & Internal
Alexander Fisher, Wichat Srikusalanukul, Leon Fisher, Paul N. Smith
Summary: This study aimed to evaluate the impact of 10 biochemical indices on predicting postoperative myocardial injury (PMI) and/or hospital death in hip fracture patients. The results showed that age ≥80 years and ischemic heart disease were the most prominent factors associated with both PMI and in-hospital death. Several biochemical markers were identified as accurate predictors, including parathyroid hormone, urea, 25(OH)vitamin D, albumin, and various ratios. These easily accessible biochemical indices substantially improved the prediction of hospital outcomes in hip fracture patients, especially in elderly patients over 80 years old with ischemic heart disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Heike A. Bischoff-Ferrari, Gregor Freystatter, Bruno Vellas, Bess Dawson-Hughes, Reto W. Kressig, John A. Kanis, Walter C. Willett, JoAnn E. Manson, Rene Rizzoli, Robert Theiler, Lorenz C. Hofbauer, Gabriele Armbrecht, Jose A. P. da Silva, Michael Blauth, Caroline de Godoi Rezende Costa Molino, Wei Lang, Uwe Siebert, Andreas Egli, Endel J. Orav, Maud Wieczorek
Summary: Supplementing with omega-3 fatty acids may reduce the incidence of total falls among generally healthy and physically active older adults, while daily high doses of vitamin D or a home exercise program have no benefit.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Rheumatology
James M. Gwinnutt, Maud Wieczorek, Andra Balanescu, Heike A. Bischoff-Ferrari, Annelies Boonen, Giulio Cavalli, Savia de Souza, Annette de Thurah, Thomas E. Dorner, Rikke Helene Moe, Polina Putrik, Javier Rodriguez-Carrio, Lucia Silva-Fernandez, Tanja Stamm, Karen Walker-Bone, Joep Welling, Mirjana Zlatkovic-Svenda, Francis Guillemin, Suzanne M. M. Verstappen
Summary: A taskforce in Europe has reviewed the literature and developed recommendations on lifestyle behaviors for rheumatic and musculoskeletal diseases. They have identified five overarching principles and 18 specific recommendations based on available evidence. The recommendations cover various lifestyle factors such as exercise, diet, weight, alcohol, smoking, and work participation.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Geriatrics & Gerontology
Virginia Ghisla, Patricia O. Chocano-Bedoya, Endel John Orav, Lauren A. Abderhalden, Angelique Sadlon, Andreas Egli, Jan Kruetzfeldt, John A. Kanis, Heike A. Bischoff-Ferrari
Summary: This study evaluated the prevalence and prospective change of health states among European older adults, and found that the likelihood of transitioning to a healthier state decreased with advancing age and among women.
Review
Endocrinology & Metabolism
L. Vandenput, H. Johansson, E. V. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -C. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -P. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, B. Schei, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, N. C. Harvey, M. Lorentzon, W. D. Leslie, J. A. Kanis
Summary: This study describes the collection of cohorts and the analysis plan for updating the fracture risk prediction tool FRAX. The aim is to optimize the current algorithms with respect to current and novel risk factors. The resource includes over 2 million participants and documented incident major osteoporotic fractures. The assembled cohorts and models will provide an updated FRAX tool for enhanced assessment of fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Caroline de Godoi Rezende Costa Molino, Laurence Woll, Maud Wieczorek, Lauren A. Abderhalden, Patricia Lanz, Dominik J. Schaer, Donat R. Spahn, E. John Orav, Andreas Egli, Heike A. Bischoff-Ferrari
Summary: This study found that iron deficiency is associated with an increased number of hospitalizations in older adults, but not with the length of hospital stay. Iron deficiency is a factor in the health of older adults and efforts should be made to reduce iron deficiency to improve overall health outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Lisa Ceglia, Donato A. Rivas, Mathias Schloegl, Grace B. Fielding, Andreas Egli, Heike A. Bischoff-Ferrari, Bess Dawson-Hughes
Summary: This study compared the effect of different forms of vitamin D on intramyonuclear vitamin D receptor concentration, muscle fiber cross-sectional area, and muscle satellite cell activation. The results showed that although calcifediol resulted in the highest serum 25-hydroxyvitamin D levels, no skeletal muscle benefits were observed at these high levels.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Geriatrics & Gerontology
Sarah Huberty, Gregor Freystatter, Maud Wieczorek, Bess Dawson-Hughes, John A. Kanis, Rene Rizzoli, Reto W. Kressig, Bruno Vellas, Jose A. P. Da Silva, Gabriele Armbrecht, Robert Theiler, Andreas Egli, Endel J. Orav, Heike A. Bischoff-Ferrari
Summary: This study investigated the association between the baseline number of chronic diseases and multimorbidity, and the incidence of all and injurious falls over 3 years among European community-dwelling older adults. The results showed that both the presence of chronic diseases and multimorbidity were associated with an increased incidence of falls, even in generally healthy and active older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Endocrinology & Metabolism
Isabelle Hoffmann, Matthias Kohl, Simon von Stengel, Franz Jakob, Katharina Kerschan-Schindl, Uwe Lange, Stefan Peters, Daniel Schoene, Cornel Sieber, Friederike Thomasius, Heike A. Bischoff-Ferrari, Michael Uder, Wolfgang Kemmler
Summary: This study provides positive evidence for the effects of exercise on the number of osteoporotic fractures in adults, although there is no significant relevance found between intensity progression or study duration. However, there is still uncertainty in identifying the most effective exercise protocol for reducing fractures.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Rheumatology
Maud Wieczorek, Suzanne MM. Verstappen, Polina Putrik, James M. Gwinnutt, Andra Balanescu, Heike A. Bischoff-Ferrari, Annelies Boonen, Giulio Cavalli, Savia de Souza, Annette de Thurah, Thomas E. Dorner, Rikke Helene Moe, Javier Rodriguez-Carrio, Lucia Silva-Fernandezu, Tanja Stamm, Karen Walker-Bone, Joep Welling, Mirjana Zlatkovic-Svenda, Francis Guillemin
Summary: This paper reviews the impact of work-related factors on disease-specific outcomes for individuals with rheumatic and musculoskeletal diseases. The findings suggest that work participation may be beneficial for RMD-specific outcomes and should be addressed in healthcare consultations.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Geriatrics & Gerontology
Anna K. K. Stuck, Giacomo Basile, Gregor Freystaetter, Caroline de Godoi Rezende Costa Molino, Wei Lang, Heike A. A. Bischoff-Ferrari
Summary: In the past 3 years, new definitions of sarcopenia have been proposed by the SARCOPENIA Definition and Outcome Consortium, European Working Group on Sarcopenia in Older People, and Asian Working Group on Sarcopenia. This scoping review aimed to explore the predictive validity of these definitions for clinical outcomes. The results showed limited studies on the predictive validity of these definitions and a lack of data for the SDOC and AWGS2 definitions.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Michael Gagesch, Andreas Huni, Heike Geschwindner, Lauren A. Abderhalden, Wei Lang, Gaby Bieri-Bruning, Heike A. Bischoff-Ferrari
Summary: This study investigated the feasibility of a 12-month follow-up after post-acute care (PAC) in Swiss nursing homes and examined factors influencing participation rate. The overall mortality at 12 months was 25%, with 25% participating in the follow-up, and 50% declining participation. Participants had significantly higher Mini-Mental State Examination (MMSE) scores compared to non-participants, and higher cognitive function was associated with a greater willingness to participate.
Article
Pharmacology & Pharmacy
Caroline de Godoi Rezende Costa Molino, Lisa Rubel, Noemi Mantegazza, Heike A. Bischoff-Ferrari, Gregor Freystaetter
Summary: This study examined the association between polypharmacy and cognitive impairment in trauma patients aged 70 years and older. The results showed that polypharmacy was not significantly associated with cognitive impairment, but excessive polypharmacy and the number of medications were associated with a higher risk of cognitive impairment in older trauma patients.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Endocrinology & Metabolism
J. A. Kanis, H. Johansson, E. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -c. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -p. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, L. Vandenput, N. C. Harvey, M. Lorentzon, W. D. Leslie
Summary: A large international meta-analysis finds that a previous history of fracture is associated with an increased risk of future fractures, regardless of age, sex, and bone mineral density. The study highlights the importance of considering previous fracture history as a risk factor for fracture prevention strategies.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Heike A. Bischoff-Ferrari, Sirka Nitschmann
Article
Geriatrics & Gerontology
Michael Gagesch, M. Wieczorek, B. Vellas, R. W. Kressig, R. Rizzoli, J. Kanis, W. C. Willett, A. Egli, W. Lang, E. J. Orav, H. A. Bischoff-Ferrari
Summary: Robust, generally healthy and active older adults without major comorbidities may benefit from a combination of high-dose supplemental vitamin D3, marine omega-3s, and a simple home exercise program (SHEP) with regard to the risk of becoming pre-frail over 3 years.
JOURNAL OF FRAILTY & AGING
(2023)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.