Review
Urology & Nephrology
Marc G. Vervloet
Summary: Abnormalities in mineral metabolism in chronic kidney disease contribute to cardiovascular complications and may promote arterial stiffness, which can affect treatment choices.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Transplantation
Lorenza Magagnoli, Mario Cozzolino, Fergus J. Caskey, Marie Evans, Claudia Torino, Gaetana Porto, Maciej Szymczak, Magdalena Krajewska, Christiane Drechsler, Peter Stenvinkel, Maria Pippias, Friedo W. Dekker, Esther N. M. de Rooij, Christoph Wanner, Nicholas C. Chesnaye, Kitty J. Jager
Summary: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is common in older non-dialysis patients with advanced CKD. PTH and phosphate are independently associated with all-cause mortality, while only PTH is associated with cardiovascular mortality. Calcium does not have an independent association with mortality but modifies the effect of phosphate.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Sijia Zhou, Xiaoxiao Wang, Junbao Shi, Qingfeng Han, Lian He, Wen Tang, Aihua Zhang
Summary: The study found that serum FABP4 levels in PD patients are positively associated with abdominal aortic calcification score and serve as an independent marker for AAC in PD patients.
Article
Urology & Nephrology
Limeng Chen, Xueqing Tang, Hua Zheng, Haiyun Wang, Peng Xia, Ying Wang, Xue Zhao, Zijuan Zhou, Ling Qiu, Xuemei Li
Summary: In this single-center retrospective cohort study, 491 PD patients were included. The study found that the levels of CKD-MBD markers in the first year of PD were independent predictors of all-cause mortality, and PTH 100-300 pg/mL might be the best target for Chinese PD patients.
Article
Urology & Nephrology
Yuxi Wang, Quanquan Shen, Junni Wang, Shilong Xiang, Yaomin Wang, Xiaohui Zhang, Jianghua Chen, Fei Han
Summary: This study aimed to construct a nomogram model for predicting cardiac valve calcification in maintenance peritoneal dialysis (MPD) patients. The model utilized independent risk factors such as age, sex, systolic blood pressure, calcium-phosphorus product, Charlson comorbidity index, and dialysis time. The model showed high efficiency in predicting cardiac valve calcification.
Review
Biochemistry & Molecular Biology
Ting Sun, Xijie Yu
Summary: FGF23 is a new endocrine product that has been discovered in the past decade. It is not only related to bone diseases, but also plays a role in kidney and parathyroid metabolism, particularly as a biomarker and key factor in kidney diseases. FGF23 is upregulated in the early stages of chronic kidney disease (CKD), in response to excessive phosphorus levels. However, as kidney function declines, the protective effect of FGF23 weakens and can lead to various complications. Monoclonal antibodies targeting FGF23 are currently used to treat genetic diseases and CKD. This article reviews the role of FGF23 in CKD and discusses the interaction between FGF23 and various organs in CKD conditions, highlighting the importance of studying the effect of hyperphosphatemia on different organs. The potential of FGF23 for therapy is also discussed.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Urology & Nephrology
Si-Jia Zhou, Xiao-Xiao Wang, Wen Tang, Qing-Feng Han, Lian He, Ai-Hua Zhang
Summary: This study evaluated serum irisin levels of peritoneal dialysis (PD) patients and their relationship with vascular calcification, finding a significant association between serum irisin levels and abdominal aortic calcification in PD patients. Lower irisin levels, diabetic mellitus, higher serum ultrasensitive C reactive protein, and older age could be potential predictive factors for vascular calcification in PD patients.
Article
Transplantation
Sevcan A. Bakkaloglu, Justine Bacchetta, Alexander D. Lalayiannis, Maren Leifheit-Nestler, Stella Stabouli, Mathias Haarhaus, George Reusz, Jaap Groothoff, Claus Peter Schmitt, Pieter Evenepoel, Rukshana Shroff, Dieter Haffner
Summary: Mineral and bone disorder (MBD) is common in children with chronic kidney disease (CKD), leading to challenges in clinical diagnosis and management due to the lack of high-quality evidence and wide variations in clinical practice. Assessing bone disease in children with CKD requires careful consideration of clinical practice points (CPPs) and further research in this area is recommended.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Elizabeth R. Stremke, Gretchen N. Wiese, Sharon M. Moe, Meryl E. Wastney, Ranjani N. Moorthi, Kathleen M. Hill Gallant
Summary: This study showed that there was no significant difference in fractional intestinal phosphorus absorption between patients with moderate CKD and healthy adults, despite lower levels of serum 1,25D. Additionally, the relationship between fractional intestinal phosphorus absorption and 24-hour urine phosphorus was not evident.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Dogan-Firat Bozman, Dorothee Bazin, Frederic Lavainne, Aghiles Hamroun, Cecile Couchoud, Thierry Hannedouche
Summary: The study found that continuous exposure to loop diuretics in the year before dialysis was associated with improved conditions at the start of dialysis and possibly lower mortality rates in the three months after inception.
JOURNAL OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Tomohiro Saito, Masahide Mizobuchi, Tadashi Kato, Taihei Suzuki, Yasuro Fujiwara, Naoaki Kanamori, Mikio Makuuchi, Hirokazu Honda
Summary: This study aimed to investigate the use of ROMO in the treatment of osteoporosis in hemodialysis patients. The findings suggest that ROMO treatment is effective in improving bone density and reducing the risk of fractures, with no fatal events occurring during the treatment.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Urology & Nephrology
Chelsea Xu, Edward R. Smith, Mark K. Tiong, Irene Ruderman, Nigel D. Toussaint
Summary: Vascular calcification is associated with cardiovascular morbidity and mortality in people with CKD. Therapy involving magnesium or sodium thiosulfate appears most promising in attenuating the progression of vascular calcification, but the existing studies are small and of short duration. There is insufficient or conflicting data regarding other interventions, highlighting the need for more definitive trials in evaluating interventions targeting vascular calcification in people with CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marcela Avila, Ma del Carmen Prado, Renata Romero, Ricardo Cordova, Ma del Carmen Rigo, Miguel Trejo, Carmen Mora, Ramon Paniagua
Summary: The purpose of this study was to compare the value of vascular calcification (VC), serum osteoprotegerin (OPG) levels, and other biochemical markers as predictors of all-cause and cardiovascular mortality in patients on peritoneal dialysis (PD). The study found that OPG was a significant predictor for all-cause and cardiovascular mortality, performing better than VC. In addition, albumin and calcium levels were associated with the risk of mortality.
Review
Peripheral Vascular Disease
Shunsuke Yamada, Toshiaki Nakano
Summary: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Traditional risk factors as well as specific CKD-related factors contribute to the increased incidence of CVD in CKD patients. CKD-mineral and bone disorder (CKD-MBD) has emerged as a key player in the development of CVD in CKD patients, involving factors such as hypocalcemia, hyperphosphatemia, and increased fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) levels. Understanding and targeting CKD-MBD is crucial for the prevention and treatment of cardiovascular events in CKD patients.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Urology & Nephrology
Ho-Kwan Sin, Ping-Nam Wong, Kin-Yee Lo, Man-Wai Lo, Shuk-Fan Chan, Kwok-Chi Lo, Yuk-Yi Wong, Lo-Yi Ho, Wing-Tung Kwok, Kai-Chun Chan, Andrew Kui-Man Wong, Siu-Ka Mak
Summary: In this study, we found that ECS is an independent predictor of MACE in PD patients, regardless of DM and pre-existing CVD.
Article
Hematology
Anna Lorenzin, Massimo de Cal, Matteo Marcello, David Sorbo, Sabrina Copelli, Claudio Ronco, Silvia de Rosa, Monica Zanella
Summary: Sepsis is a common complication in critically ill patients, and extracorporeal therapies such as hemoperfusion can be used to control infection and provide organ support. This study aimed to determine the amount of vancomycin adsorbed by a sorbent cartridge during hemoperfusion and to establish strategies for maintaining effective plasma levels in critically ill patients.
BLOOD PURIFICATION
(2023)
Review
Urology & Nephrology
Rajiv Agarwal, James Burton, Maurizio Gallieni, Kamyar Kalantar-Zadeh, Gert Mayer, Carol Pollock, Jacek C. Szepietowski
Summary: Despite the limited increase in life expectancy for patients with end-stage kidney disease after the breakthrough of kidney replacement therapy, the quality of life and relief of symptoms have become increasingly important to patients. Currently, most dialysis-associated symptoms and adverse effects do not have approved treatments, and the few available treatments may add further adverse effects. This article demonstrates how understanding the pathophysiology of a particular symptom (chronic kidney disease-associated pruritus) in dialysis led to the development and regulatory approval of a treatment for that symptom. This approach can be applied to other dialysis-associated symptoms, improving the remaining years of patients' lives.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Hematology
Thiago Reis, Colin Hutchison, Francisco de Assis Rocha Neves, Bruno Zawadzki, Monica Zanella, Claudio Ronco, Mitchell H. Rosner
Summary: A hallmark of chronic kidney disease is the retention of solutes that normally are eliminated by the kidneys. The current classification of uremic toxins based on molecular weight and protein affinity is poorly understood in terms of the role of therapies to reduce uremic toxins in chronic kidney disease patients. Most of the research on lowering serum concentrations of toxic compounds is carried out in patients with kidney failure undergoing kidney replacement therapy. The classification of uremic toxins needs to be updated and the relationship between specific solutes and clinical outcomes needs to be established to develop targeted therapies and improve understanding of the pathogenesis of chronic kidney disease.
BLOOD PURIFICATION
(2023)
Review
Hematology
Faeq Husain-Syed, Raymond Vanholder, Mitchell H. Rosner, Hideki Kawanishi, Tammy Lisa Sirich, Claudio Ronco
Summary: Progress in the identification and characterization of uremic retention solutes has enhanced our understanding of the uremic syndrome. The consensus report recommends improving the definition and classification of uremic toxins and suggests personalized dialysis prescriptions to improve outcomes for CKD patients.
BLOOD PURIFICATION
(2023)
Editorial Material
Hematology
Mitchell H. Rosner, Claudio Ronco
BLOOD PURIFICATION
(2023)
Editorial Material
Hematology
Thiago Reis, Francisco de Assis Rocha Neves, Antonio Fagundes Jr., Emily See, Rogerio da Hora Passos, Bruno Zawadzki, Rinaldo Bellomo, Claudio Ronco
BLOOD PURIFICATION
(2023)
Review
Hematology
Kianoush Kashani, Mario G. G. Cozzolino, Ziad A. A. Massy, Peter J. J. Blankestijn, Peter Stenvinkel, Mitchell H. H. Rosner, Claudio Ronco
Summary: Uremic toxins contribute to clinical manifestations of kidney dysfunction, and their classification should be more clinically focused.
BLOOD PURIFICATION
(2023)
Editorial Material
Urology & Nephrology
Gianmarco Sabiu, Maurizio Gallieni
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Peripheral Vascular Disease
Arianna Bartoli, Maurizio Gallieni, Chiara Cogliati, Francesco Casella, Maria Calloni, Chiara Melchionda, Marco Heidempergher, Antonella Foschi, Antonio Luca Brucato, Giulia Rizzi, Massimiliano Quici, Antonio Gidaro
Summary: The study assessed the 2-year mortality rate in patients with PICCs or Midlines using Charlson Comorbidity Index (CCI) and Beclap score. The findings showed that CCI and Beclap score were good predictors of mortality at 2 years. The study suggests that physicians and nurses should consider using these tools in evaluating patients at risk for future dialysis.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Rheumatology
Manuel Alfredo Podesta, Federica Mescia, Anna Ricchiuto, Rona Smith, Martina Tedesco, Matthias Arnaldo Cassia, Julia Holle, Renato Alberto Sinico, Annette Bruchfeld, Iva Gunnarsson, Sophie Ohlsson, Bo Baslund, Zdenka Hruskova, Vladimir Tesar, Gianmarco Sabiu, Maurizio Gallieni, Maria C. Cid, Augusto Vaglio, Lorraine Harper, Mario Cozzolino, Francesco Scolari, David Jayne, Federico Alberici
Summary: This study aims to assess factors associated with hypogammaglobulinemia in AAV patients treated with rituximab, and the results showed that hypogammaglobulinemia is common in AAV patients treated with rituximab, and lower IgG levels are associated with severe infections. Age and higher glucocorticoid doses increase the risk of hypogammaglobulinemia in these patients.
Article
Urology & Nephrology
Maurizio Gallieni, Umberto G. Rossi, Massimo Tonolini, Andrea Ianniello, Roberta Miglio, Gianmarco Sabiu, Maurizio Cariati
Summary: This study evaluated the performance of the self-locating peritoneal dialysis catheter in magnetic resonance imaging (MRI) and found that the catheter had good visibility but created visual interference, limiting the accurate study of the surrounding tissues. The catheter was stable and did not cause any heating effects during MRI.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2023)
Editorial Material
Peripheral Vascular Disease
Raquel Barba Teba, Lide Lopez Arsuaga, Louis Firket, Filipa Ferreira, Wouter Moest, Sinead Stoneman, Georgia Andriana Georgopoulou, Adamantia Bratsiakou, Maurizio Gallieni
Summary: Chronic kidney disease is a significant public health issue with a high prevalence rate. Vascular access is crucial for hemodialysis treatment and has a significant impact on patients' prognosis. The N-PATH program aims to train young European nephrologists in theoretical and practical aspects of Interventional Nephrology to improve their skills and promote a strong network in the field.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Hematology
Thiago Reis, Claudio Ronco, Danielle E. Soranno, William Clark, Silvia De Rosa, Lui G. Forni, Anna Lorenzin, Zaccaria Ricci, Gianluca Villa, John A. Kellum, Ravindra Mehta, Mitchell H. Rosner
Summary: A consensus expert conference was convened to develop standardized nomenclature for mechanisms and materials used in extracorporeal blood purification. Standardized nomenclature is crucial for research, education, and innovation coordination.
BLOOD PURIFICATION
(2023)
Article
Urology & Nephrology
Simonetta Genovesi, Luca Porcu, Paola Rebora, Giorgio Slaviero, Gavino Casu, Silvio Bertoli, Flavio Airoldi, Monique Buskermolen, Maurizio Gallieni, Federico Pieruzzi, Giovanni Rovaris, Alberto Montoli, Emanuela Piccaluga, Giulio Molon, Federico Alberici, Marianna Adamo, Achille Gaspardone, Giuseppe D'Angelo, Pierluigi Merella, Giuseppe Vezzoli, Barbara Trezzi, Patrizio Mazzone
Summary: The study found that as children start attending college, the labor supply of mothers decreased while the labor supply of fathers remained unchanged. The decline in labor supply was mainly driven by high-income, married, more educated, and white mothers.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Amir Kazory, Claudio Ronco
Summary: Symptoms and signs of congestion are the main reasons for hospitalization of acute heart failure patients. Loop diuretics are recommended, but their response is variable. Blockade of nephron has been proposed as a more effective strategy. Two large-scale trials examined this hypothesis, targeting the proximal and distal tubules respectively. Results were discussed in the context of previous studies and ultrafiltration.
CARDIORENAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
