Article
Endocrinology & Metabolism
Moritz Weigl, Roland Kocijan, James Ferguson, Gabriele Leinfellner, Patrick Heimel, Xaver Feichtinger, Peter Pietschmann, Johannes Grillari, Jochen Zwerina, Heinz Redl, Matthias Hackl
Summary: MicroRNAs play a regulatory role in bone homeostasis, and circulating microRNAs are considered as potential biomarkers for bone health. This study investigated the impact of anti-osteoporotic treatments on circulating microRNAs in OVX and SHAM rats, revealing that these treatments can reverse bone loss and modulate specific miRNA expressions. The findings suggest that bone-related miRNAs could serve as promising biomarkers for monitoring treatment efficacy in osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Ruxu You, Jinyu Liu, Lei Ke, Guangyi Yu, Yu Zhang, Takahiro Mori
Summary: The study found that sequential teriparatide/zoledronic acid is not cost-effective for Chinese women with postmenopausal osteoporosis, unless the cost of teriparatide is reduced by 50% for participants over the age of 80.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Orthopedics
Peng Wang, Guang-qian Shang, Shuai Xiang, Hai-ning Zhang, Ying-zhen Wang, Hao Xu
Summary: This study confirmed that the combination of zoledronic acid and teriparatide could effectively prevent and treat aseptic loosening of the prosthesis, showing different mechanisms of action for each drug. However, further experiments and clinical research are needed to ensure the safety and feasibility of long-term application in clinical settings.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Junho Jung, Gyu-Jo Shim, Minah Kim, Youngjae Yoon, Jae-Eun Kim, Seong-Suk Jue, Bilal Al-Nawas, Yong-Dae Kwon
Summary: The study demonstrated that preoperative PTH administration significantly reduced the number of empty lacunae and increased the number of blood vessels, suggesting more viable bone tissue in this group. However, postoperative PTH administration showed no significant differences compared to controls. Therefore, preoperative PTH use may represent a better prophylactic regimen for preventing MRONJ.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Endocrinology & Metabolism
A. R. Zullo, Y. Lee, C. Lary, L. A. Daiello, D. P. Kiel, S. D. Berry
Summary: The study found that denosumab and zoledronic acid may be as effective as teriparatide for preventing hip fractures in frail older adults, especially nursing home residents. These non-oral treatments are likely preferable for most frail, older adults due to their lower cost and easier administration.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Amir Qaseem, Lauri J. Hicks, Itziar A. Etxeandia-Ikobaltzeta, Tatyana E. Shamliyan, Thomas Cooney, Amer Coll Phys
Summary: This guideline updates the 2017 ACP recommendations on pharmacologic treatment of primary osteoporosis or low bone mass. The recommendations include the use of bisphosphonates as initial treatment, the use of RANK ligand inhibitor as second-line treatment, and an individualized approach for starting pharmacologic treatment with bisphosphonates. Most recommendations are based on high-certainty evidence.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hamza Rahimi, Ali Guermazi, Frank W. Roemer, Oleg M. Teytelboym, Robert-Yves Carlier, Mohamed Jarraya
Summary: Imaging plays a central role in the diagnosis of axial spondylarthritis (axSpA), with MRI considered the reference standard for early detection of inflammatory changes. Recognizing vertebral involvement patterns can help establish a diagnosis early and initiate therapy before irreversible changes occur. This review aims to present an overview of imaging findings in axSpA with vertebral involvement and detail the current recommendations for diagnosis in patients with isolated vertebral involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Orthopedics
Ihsan Oz, Alauddin Kochai, Yuksel Lacin Avan, Dogan Keskin, Bekir Murat Cinar, Huseyin Cakiroglu, Huseyin Pehlivan
Summary: The study compares the effects of teriparatide, zoledronic acid, and their combination therapy with vitamin K on osteoporotic rats. After four weeks of treatment, histopathological and biomechanical evaluations were performed. The results showed that the group receiving additional vitamin K had advantages in fracture healing. Therefore, combination therapies may yield optimal results in biomechanical and histological examinations.
JOINT DISEASES AND RELATED SURGERY
(2023)
Review
Pharmacology & Pharmacy
Laura P. B. Elbers, Hennie G. Raterman, Willem F. Lems
Summary: Long-term anti-osteoporotic drug therapy requires continuous monitoring and treatment, as discontinuation of therapy may lead to rapid increases in bone turnover markers and significant bone density loss, especially in patients treated with denosumab and romosozumab.
Article
Dentistry, Oral Surgery & Medicine
Dan Zhao, Dexuan Xiao, Mengting Liu, Jiajie Li, Shuanglin Peng, Qing He, Yue Sun, Jingang Xiao, Yunfeng Lin
Summary: In this study, a novel nanoparticle tFNA-KLT was synthesized and shown to effectively prevent the occurrence of BRONJ by accelerating angiogenesis.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Oncology
Christopher Li, Meghan R. Flanagan, Mei-Tzu C. Tang, Peggy L. Porter, Kathleen E. Malone
Summary: This study demonstrates that bisphosphonate use is associated with a lower risk of subsequent invasive breast cancer among women with a history of DCIS, suggesting a potential preventative approach for this high-risk population.
Review
Medicine, General & Internal
Ian R. Reid, Emma O. Billington
Summary: The goal of osteoporosis management is to prevent fractures. Various pharmacological agents, such as bisphosphonates, denosumab, and anabolic drugs, are available to reduce fracture risk by either reducing bone resorption or stimulating bone formation. Anabolic drugs have shown greater anti-fracture efficacy and increase in bone density compared to anti-resorptive drugs, but their effects are transient.
Article
Dentistry, Oral Surgery & Medicine
W-J Wu, L. Zheng, J. Zhang, X-M Lv, M-W Huang, Y. Shi, S-M Liu
Summary: The study evaluated the effectiveness of venous superdrainage using the superficial circumflex iliac vein (SCIV) in the DCIAPF for oromandibular reconstruction. The results showed that superdrainage using the SCIV can reduce the incidence of venous congestion due to relative venous insufficiency.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Endocrinology & Metabolism
Giorgia Dito, Marina Lugaresi, Chiara Degradi, Gregorio Guabello, Matteo Longhi, Sabrina Corbetta
Summary: This study compared the efficacy of two different sequential treatment strategies (TPT + ZOL and TPT + Dmab) in severe osteoporotic patients. The results showed that both treatment strategies had similar effects in increasing bone density at the lumbar and hip levels, as well as reducing the risk of fracture.
Article
Biochemistry & Molecular Biology
George Adrian Ciobanu, Laurentiu Mogoanta, Sanda Mihaela Popescu, Mihaela Ionescu, Cristina Maria Munteanu, Ionela Elisabeta Staicu, Razvan Mercut, Cristian Corneliu Georgescu, Monica Scrieciu, Daniel Vlad, Adrian Camen
Summary: This study investigated the relationship between immune response and etiopathogenic factors in medication-related osteonecrosis of the jaws (MRONJ) caused by zoledronic acid. The duration of treatment, trigger factor, MRONJ location, and healing status significantly influenced the expression of immunohistochemical markers. Prolonged treatment duration was associated with decreased marker scores, indicating an inverse correlation. Marker expression varied based on the trigger factor, MRONJ location, and healing status, and was more pronounced in patients cured per primam compared to those with relapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Stamatia Rokidi, Natalie Bravenboer, Sonja Gamsjaeger, Barbara Misof, Stephane Blouin, Pascale Chavassieux, Klaus Klaushofer, Eleftherios Paschalis, Socrates Papapoulos, Natasha Appelman-Dijkstra
Article
Endocrinology & Metabolism
Johanne Dubail, Perrine Brunelle, Genevieve Baujat, Celine Huber, Mathilde Doyard, Caroline Michot, Pascale Chavassieux, Abdeslam Khairouni, Vicken Topouchian, Sophie Monnot, Eugenie Koumakis, Valerie Cormier-Daire
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Stamatia Rokidi, Natalie Bravenboer, Sonja Gamsjaeger, Pascale Chavassieux, Jochen Zwerina, Eleftherios Paschalis, Socrates Papapoulos, Natasha Appelman-Dijkstra
Article
Endocrinology & Metabolism
Delphine Farlay, Sebastien Rizzo, Louis-Georges Ste-Marie, Laetitia Michou, Suzanne N. Morin, Shijing Qiu, Pascale Chavassieux, Roland D. Chapurlat, Sudhaker D. Rao, Jacques P. Brown, Georges Boivin
Summary: Bisphosphonates are commonly used drugs for treating osteoporosis, but long-term use may increase the risk of atypical femur fracture. Research found that patients with AFF had higher bone mineralization levels compared to non-AFF patients, potentially due to the accumulation of bisphosphonates in bone mineral affecting the osteocyte cytoskeleton.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Pia Rosgaard Jensen, Thomas Levin Andersen, Pascale Chavassieux, Jean-Paul Roux, Jean-Marie Delaisse
Summary: Bisphosphonates not only strongly inhibit bone resorption, but also negatively affect bone formation, limiting the ability to initiate bone formation. This study reveals a possible mechanism for impeding the recruitment of osteoprogenitor cells, which in turn impacts the process of bone formation.
Article
Endocrinology & Metabolism
Erik F. Eriksen, Roland Chapurlat, Rogely Waite Boyce, Yifei Shi, Jacques P. Brown, Stephane Horlait, Donald Betah, Cesar Libanati, Pascale Chavassieux
Summary: The bone-forming agent romosozumab significantly increases modeling-based bone formation on cancellous and endocortical surfaces in the first 2 months of treatment, but not on periosteal surfaces. There was no significant difference in remodeling-based bone formation on all three bone surfaces after 2 months of romosozumab treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Ines Foessl, J. H. Duncan Bassett, Ashild Bjornerem, Bjoern Busse, Angelo Calado, Pascale Chavassieux, Maria Christou, Eleni Douni, Imke A. K. Fiedler, Joao Eurico Fonseca, Eva Hassler, Wolfgang Hoegler, Erika Kague, David Karasik, Patricia Khashayar, Bente L. Langdahl, Victoria D. Leitch, Philippe Lopes, Georgios Markozannes, Fiona E. A. McGuigan, Carolina Medina-Gomez, Evangelia Ntzani, Ling Oei, Claes Ohlsson, Pawel Szulc, Jonathan H. Tobias, Katerina Trajanoska, Sansin Tuzun, Amina Valjevac, Bert van Rietbergen, Graham R. Williams, Tatjana Zekic, Fernando Rivadeneira, Barbara Obermayer-Pietsch
Summary: This expert paper presents a comprehensive overview of state-of-the-art technologies used to investigate bone properties in humans and animals, outlining their strengths and weaknesses. It also introduces new research methodologies and discusses future strategies to integrate phenotypic and rapidly developing -omics data for advancing musculoskeletal research and personalized medicine.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xenia G. Borggaard, Jean-Paul Roux, Jean-Marie Delaisse, Pascale Chavassieux, Christina M. Andreasen, Thomas L. Andersen
Summary: The study found that patients treated with bisphosphonates had fewer quiescent pores/osteons compared to placebo-treated patients, indicating that new cortical remodeling events need to be activated. Additionally, the contribution of eroded pores in the resorption-reversal phase was higher in bisphosphonate-treated patients, while the contribution of mixed eroded-formative pores and formative pores was lower in these patients compared to placebo.
Review
Endocrinology & Metabolism
Pascale Chavassieux, Roland Chapurlat
Summary: Bone histomorphometry is currently the only method to analyze bone at the tissue and cell levels. It has important applications in diagnosing bone diseases and conducting research, providing insights into bone tissue metabolism and the action mechanisms of therapeutic drugs in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
J. Dubail, P. Brunelle, G. Baujat, C. Huber, M. Doyard, C. Michot, P. Chavassieux, A. Khairouni, V. Topouchian, S. Monnot, E. Koumakis, V. Cormier-Daire
EUROPEAN JOURNAL OF HUMAN GENETICS
(2020)
Meeting Abstract
Endocrinology & Metabolism
Xenia G. Borggaard, Jean-Paul Roux, Jean-Marie Delaisse, Pascale Chavassieux, Christina M. Andreasen, Thomas L. Andersen
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Meeting Abstract
Endocrinology & Metabolism
Erik F. Eriksen, Rogely Waite Boyce, Yifei Shi, Jacques P. Brown, Stephane Horlait, Cesar Libanati, Roland Chapurlat, Pascale Chavassieux
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Meeting Abstract
Endocrinology & Metabolism
Stamatia Rokidi, Stephane Blouin, Barbara Misof, Nathalie Bravenboer, Pascale Chavassieux, Klaus Klaushofer, Eleftherios P. Paschalis, Socrates E. Papapoulos, Natasha M. Appelman-Dijkstra
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Meeting Abstract
Endocrinology & Metabolism
Erik F. Eriksen, Roland Chapurlat, Pascale Chavassieux, Rogely Boyce, Stephane Horlait, Yifei Shi, Rachel B. Wagman, Jacques P. Brown, Rogely Boyce, Stephane Horlait, Yifei Shi, Rachel B. Wagman, Cesar Libanati
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Meeting Abstract
Rheumatology
Erik Eriksen, Roland Chapurlat, Rogely Boyce, Jacques Brown, Stephane Horlait, Cesar Libanati, Yifei Shi, Rachel Wagman, Pascale Chavassieux
ARTHRITIS & RHEUMATOLOGY
(2019)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.