Article
Cell Biology
Nicola L. Stevenson, Dylan J. M. Bergen, Yinhui Lu, M. Esther Prada-Sanchez, Karl E. Kadler, Chrissy L. Hammond, David J. Stephens
Summary: Knockout of the golgin giantin leads to skeletal and craniofacial defects due to changes in glycosylation and extracellular matrix deposition. Our study reveals a conserved role for giantin in collagen biosynthesis and extracellular matrix assembly, as well as a giantin-dependent pathway for intracellular procollagen processing.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Genetics & Heredity
Chris Rorden, Marilee C. Griswold, Nan Moses, Clifford R. Berry, G. Gregory Keller, Rudy Rivas, Helen Flores-Smith, Lisa G. Shaffer, Richard Malik
Summary: The unique appearance of Scottish Fold cats is caused by a single gene variant impacting cartilage development. Breeding programs aim to balance fold and nonfolded offspring. Recent studies show potential health issues in heterozygous cats, but new research suggests milder radiological signs compared to previous findings.
Article
Endocrinology & Metabolism
Riikka E. Maekitie, Sanna Toiviainen-Salo, Ilkka Kaitila, Outi Maekitie
Summary: This study reports a rare form of osteochondrodysplasia in a Finnish family, characterized by abnormal codfish-shaped vertebrae, severe early-onset osteoarthritis, and empty sella syndrome, associated with a mutation in the TBX2 gene.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Brianna Peskin, James Norman, Jennifer Bagwell, Adam Lin, Priyom Adhyapok, Stefano Di Talia, Michel Bagnat
Summary: The vertebrate spine is composed of alternating vertebral bodies and intervertebral discs. Recent studies in zebrafish have found that the sheath surrounding the notochord differentiates into cartilage-like and mineralizing segments, which serve as a blueprint for vertebral body formation. The activation of Notch signaling is essential for sequential notochord segmentation, but the mechanism of activation and the molecular components involved remain unclear. This study reveals that BMP signaling precedes Notch activation and plays a role in segment growth and spine morphogenesis.
Article
Cell Biology
Yang Li, Shuting Yang, Ling Qin, Shuying Yang
Summary: Chondrogenesis is regulated by the transcriptional coactivator TAZ, whose expression increases during chondrogenic differentiation. TAZ deletion impairs skeletal development, joint maintenance, and fracture healing by affecting chondrocyte proliferation and differentiation, and interacting with Sox5.
Article
Pathology
Gerard Frigola, Olga Gomez del Rincon, Virginia Borobio Florian, Anna Vallmajo Fita, Berta Campos, Montse Pauta, Maria Segura Puimedon, Rafael Oliva, Antoni Borrell, Alfons Nadal
Summary: Steel syndrome (STLS) is a rare genetic disorder caused by COL27A1 mutations, characterized by distinctive facial features, dwarfism, hip and radial head dislocations, and carpal bone fusion. This study identified two fetuses with STLS through exome sequencing and histological examination, confirming the genetic basis of the disease and expanding the spectrum of mutations associated with STLS.
Article
Cell Biology
Ziji Zhang, Guangxin Huang, Guping Mao, Shu Hu
Summary: The study investigated the expression profile of exosomal lncRNAs in chondrogenesis of human adipose derived stem cells, identifying a significant number of upregulated and downregulated lncRNAs and mRNAs in exosomes derived from chondrogenic hADSCs. RNA sequencing and KEGG pathway analysis revealed differentially regulated processes, laying a foundation for future research on the cartilage recovery mechanism of exosomes derived from chondrogenic stem cells.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biophysics
Sajedeh Khorshidi, Reza Karimi-Soflou, Akbar Karkhaneh
Summary: A hydrogel/particle scaffold with a gradient of oxygen releasing microparticles was developed in the study, showing significant improvements in cell viability and density. The gradient oxygen releasing composite exhibited different impacts on osteogenesis and chondrogenesis of mesenchymal stem cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Tuhe Shi, Dongyang Niu, Jiahui You, Shuang Li, Guifei Li, Kaixuan Ren, Shifeng Yan, Guohua Xu, Jingbo Yin
Summary: Injectable macro-porous hydrogels with interconnected structure were fabricated using smashed gels recombination strategy. These hydrogels promote cell and tissue infiltration and support the proliferation and chondrogenic differentiation of bone marrow mesenchymal stem cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Cristina Duarte-Olivenza, Juan M. Hurle, Juan A. Montero, Carlos I. Lorda-Diez
Summary: This study aimed to analyze whether regulated cell degeneration accompanies the differentiation of embryonic limb skeletal progenitors. The results showed that the formation of primary cartilage nodules involves a patterned process of cell death and cell senescence. Furthermore, FGF signaling was found to modulate the response of progenitors to cell death pathways through the positive regulation of apoptosis and cell senescence.
Article
Cell & Tissue Engineering
Guping Mao, Yiyang Xu, Dianbo Long, Hong Sun, Hongyi Li, Ruobin Xin, Ziji Zhang, Zhiwen Li, Zhi Yang, Yan Kang
Summary: This study identified a significant role for exosomal circRNA_0001236 in chondrogenic differentiation, promoting cartilage-specific gene and protein expression through the miR-3677-3p/Sox9 axis. Overexpression of exosomal circRNA_0001236 may alleviate cartilage degradation, suppress OA progression, and enhance cartilage repair, suggesting a potentially effective therapeutic strategy for treating OA.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Psychiatry
Fa-rong Liu, Yunqiang Zhou, Yong Wang, Ling-ling Huang, Xian Zhang, Hong Luo, Su-ying Wu, Hai-yan Lyu, Li-huan Huang, Huaxi Xu, Yun-wu Zhang
Summary: In this study, we identified a possible mutation in the GOLGB1 gene that is associated with bipolar disorder (BD) in a Chinese family. By downregulating Golgb1 expression in mice, we found that Golgb1 deficiency may result in BD phenotypes, possibly through affecting PSD93 and PI3K/Akt signaling.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Charindu K. I. Ranmuthu, Chanuka D. S. Ranmuthu, Chalukya K. Wijewardena, Matthew K. T. Seah, Wasim S. Khan
Summary: This systematic review explores the effect of hypoxia on chondrogenic differentiation of human adult mesenchymal stromal cells (MSCs). Most studies suggest that hypoxia during the expansion or differentiation phase enhances some markers of chondrogenic differentiation in adult MSCs. However, results are inconsistent and not always confirmed at the protein level. Factors such as MSC source, donor variability, hypoxia level, exposure time, and culture methodology contribute to these inconsistent findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Fong Chen, Yi-Chun Chen, Yu-Show Fu, Shang-Wen Tsai, Po-Kuei Wu, Chao-Ming Chen, Ming-Chau Chang, Wei-Ming Chen
Summary: This study explored the potential of revitalizing human decellularized allogeneic bone with human mesenchymal stem cells for osteochondral regeneration. Results showed that bone marrow and adipose tissue-derived MSCs exhibited higher osteogenic potential, while Wharton's jelly-derived MSCs had higher chondrogenic potential. Chondrogenic MSCs-seeded allogeneic bone may serve as potential osteochondral constructs for regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Clark T. Hung, Jennifer Racine-Avila, Matthew J. Pellicore, Roy Aaron
Summary: The skeleton has the ability to remodel and repair itself in response to biophysical stimuli, allowing it to adapt to its physiological roles. Cells in the skeleton sense and respond to these stimuli to meet the demands of the organism. Mechanical strain is the most recognized stimulus, but other signals such as fluid flow and ion movements also play a role. The application of electrical and electromagnetic fields can be used to study the effects of these stimuli on cell differentiation and extracellular matrix formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Azumi Hirata, Kentaro Katayama, Takehito Tsuji, Hideto Imura, Nagato Natsume, Toshio Sugahara, Tetsuo Kunieda, Hiroaki Nakamura, Yoshinori Otsuki
CONGENITAL ANOMALIES
(2016)
Article
Pediatrics
Azumi Hirata, Kentaro Katayama, Takehito Tsuji, Hideto Imura, Nagato Natsume, Toshio Sugahara, Tetsuo Kunieda, Hiroaki Nakamura, Yoshinori Otsuki
CONGENITAL ANOMALIES
(2016)
Article
Pathology
Hidenori Yasuda, Yuki Tochigi, Kentaro Katayama, Hiroetsu Suzuki
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Kentaro Katayama, Mao Kuriki, Tomoyo Kamiya, Yuki Tochigi, Hiroetsu Suzuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Veterinary Sciences
Kouyou Akiyama, Kentaro Katayama, Takehito Tsuji, Tetsuo Kunieda
EXPERIMENTAL ANIMALS
(2014)
Article
Biochemistry & Molecular Biology
Kouyou Akiyama, Junko Noguchi, Michiko Hirose, Shimpei Kajita, Kentaro Katayama, Maryam Khalaj, Takehito Tsuji, Heather Fairfield, Candice Byers, Laura Reinholdt, Atsuo Ogura, Tetsuo Kunieda
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Cell Biology
David Asante, Lucy MacCarthy-Morrogh, Anna K. Townley, Matthew A. Weiss, Kentaro Katayama, Krysten J. Palmer, Hiroetsu Suzuki, Chris J. Westlake, David J. Stephens
JOURNAL OF CELL SCIENCE
(2013)
Article
Veterinary Sciences
Junko Chiba, Hiroetsu Suzuki, Hiroaki Aoyama, Kentaro Katayama, Katsushi Suzuki
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2011)
Article
Veterinary Sciences
Kohei Amakasu, Katsushi Suzuki, Kentaro Katayama, Hiroetsu Suzuki
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2011)
Article
Andrology
K. Katayama, H. Yasuda, Y. Tochigi, H. Suzuki
Article
Biotechnology & Applied Microbiology
Azumi Hirata, Kentaro Katayama, Takehito Tsuji, Nagato Natsume, Toshio Sugahara, Yuichi Koga, Kazufumi Takano, Yoshinori Otsuki, Hiroaki Nakamura
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Biology
Ayaka Domon, Kentaro Katayama, Takashi Yamada, Yuki Tochigi, Hiroetsu Suzuki
Summary: The study highlights the important role of kidneys in the development of type 2 diabetes (T2D) by regulating systemic glucose metabolism. SGLT2 inhibitors are a novel class of anti-diabetic drugs that act independently of insulin by inhibiting renal glucose reabsorption, thereby reducing blood glucose levels.
Article
Biochemistry & Molecular Biology
Yuki Tochigi, Yuka Iwasaki, Masanori Sano, Hidenori Yasuda, Kentaro Katayama, Hiroetsu Suzuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Veterinary Sciences
Hidenori Yasuda, Kohei Amakasu, Yuki Tochigi, Kentaro Katayama, Hiroetsu Suzuki
COMPARATIVE MEDICINE
(2016)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.