Article
Orthopedics
Zhirong Fan, Ping Chen, Xiubing Yu, Xing Li, Haitao Su, Haiyun Chen, Bing Yang, Ji Qi, Haizhou Wang
Summary: This study aimed to evaluate the biomechanical outcomes of FNS internal fixation in the treatment of nonanatomically reduced femoral neck fractures. The results showed that the positive buttress model had lower FNS stress at a Pauwels angle of 30 degrees, but higher FNS stress at a Pauwels angle of 50 degrees. Therefore, the clinical efficacy of FNS internal fixation may be influenced by the fracture angle.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Kai Wang, Dongze Lin, Peisheng Chen, Chaohui Lin, Tianxuan Feng, Jiajie Liu, Shunze Zheng, Yaqian Liang, Jirui Ouyang, Yubo Cui, Fengfei Lin
Summary: This study aimed to investigate the effects of postoperative femoral neck shortening in patients with femoral neck fractures fixed with femoral neck system screws (FNS) and to explore the influencing factors. The data of 113 patients with femoral neck fractures were retrospectively analyzed, and the incidence of femoral neck shortening, postoperative complication rates, and hip Harris scores were compared between the femoral neck shortening group and the femoral neck no shortening group. The results showed that FNS fixation of femoral neck fractures had a high incidence of postoperative neck shortening, and factors such as cortical comminution, fracture type, and fracture reduction quality were significantly correlated with neck shortening. Femoral neck shortening can affect postoperative hip function but does not affect fracture healing.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Xin Guo, Yihui Zeng, Haijun Xu, Xinyuan Zhan
Summary: Osteonecrosis of the femoral head, particularly involving the lateral head-neck junction, was confirmed as a major risk factor for spontaneous femoral neck fractures (SFF). The study also found that steroid use and osteoporosis were significant risk factors for SFF. Different causes of SFF were associated with different fracture types. MRI and pathological examinations showed that osteonecrosis in the SFF group predominantly occurred at the lateral head-neck junction.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
John C. Fisher III, Christopher Gerzina, Kaitlin Rush, Cyrus Caroom
Summary: This case series highlights peri-implant subtrochanteric femur fractures as an unreported complication associated with the use of FNS for femoral neck fractures. These fractures were observed exclusively in patients with incomplete nondisplaced fractures who received FNS fixation. No similar complications were observed in patients treated with other types of fixation. This finding suggests the need for caution and further investigation when considering FNS as a treatment option for this specific fracture pattern.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Guy Romeo Kenmegne, Chang Zou, Yue Fang, Xuanhong He, Yixiang Lin, Yijie Yin
Summary: This study compared the clinical efficacy and outcomes of FNS and CCS in the treatment of femoral neck fractures in adults below 65 years old. The results showed that the FNS group had significantly shorter fracture healing time, fewer fluoroscopies, higher Harris Hip Score, and lower postoperative complications, with no significant differences in other factors.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biotechnology & Applied Microbiology
Shenghui Wu, Wei Wang, Ruiyang Li, Jingyi Guo, Yu Miao, Guangyi Li, Jiong Mei
Summary: A new measurement method was designed to assess the injury degree of the femoral head in patients with FHFs and investigate its association with FNFs. The 2D and 3D parameters were found to be feasible adjunctive diagnostic tools in identifying FNFs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Kyle H. Cichos, Gerald McGwin Jr, Elie S. Arthroplasty Hip Fracture Consortium, Elie S. Ghanem
Summary: For patients with femoral neck fractures, the direct anterior approach (DAA) for total hip arthroplasty (THA) is associated with lower risk of dislocation, reduced need for mechanical revision, and decreased mortality compared to the posterior approach (PA).
JOURNAL OF ARTHROPLASTY
(2023)
Article
Medicine, General & Internal
Hailin Xing, Quanzhou Wu, Shuhua Lan, Chong Wang, Jifei Ye, Fang Ye, Shuming Huang
Summary: Pediatric femoral shaft combined with ipsilateral femoral neck fractures are rare but challenging injuries. In this study, minimally invasive procedures utilizing cannulated screws combined with elastic stable intramedullary nails showed good follow-up results in two cases.
Article
Multidisciplinary Sciences
Celine Allard, Emmanuel Pardo, Christophe de la Jonquiere, Anne Wyniecki, Anne Soulier, Annibal Faddoul, Eileen S. Tsai, Francis Bonnet, Franck Verdonk
Summary: The study compared the efficacy and side effects of PENG block with femoral block in postoperative pain control after hip fracture surgery. While there was no significant difference in postoperative morphine consumption, pain intensity, time to ambulation, incidence of morphine-related side effects, or length of hospital stay between the two groups, the PENG block did result in significantly improved postoperative muscle strength of the quadriceps.
Article
Multidisciplinary Sciences
Zhichao Gao, Mei Wang, Baojie Shen, Xiaodong Chu, Di Ruan
Summary: The study conducted biomechanical tests and clinical retrospective analysis on femoral neck fractures. Results showed that the 3CCS + mFNSS group had better torsion resistance compared to the 3CCS group, but inferior compressive strength and fatigue resistance compared to the DHS group. In clinical application, the 3CCS + mFNSS group had lower screw retreatment and femoral head necrosis rates, and better fracture healing rates than the 3CCS group, indicating the effectiveness of medial support screws in promoting fracture stability and healing.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Interdisciplinary Applications
Daizhu Yuan, Zhanyu Wu, Siwei Luo, Yuhu Zhou, Jianxiang Teng, Chuan Ye
Summary: Intramedullary nails with femoral neck protection in the treatment of femoral shaft fractures improve mechanical strength, prevent secondary hip fractures, and decrease the overall risk of reoperation postoperatively.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Medicine, General & Internal
Hiroaki Kijima, Shin Yamada, Tetsuya Kawano, Motoharu Komatsu, Yosuke Iwamoto, Natsuo Konishi, Hitoshi Kubota, Hiroshi Tazawa, Takayuki Tani, Norio Suzuki, Keiji Kamo, Ken Sasaki, Masashi Fujii, Itsuki Nagahata, Takanori Miura, Shun Igarashi, Naohisa Miyakoshi
Summary: This study aims to classify basicervical and transcervical shear fractures and determine the optimal osteosynthesis method for them. The results showed that basicervical fractures accounted for 0.96% of all proximal femur fractures, with a 0% failure rate, while transcervical shear fractures accounted for 9.6% of all proximal femur fractures, with a 13% failure rate. Finite element analysis demonstrated that transcervical shear fractures have high instability and may require multiple screw insertions and careful postoperative management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Gianpiero Cazzato, Maria Serena Oliva, Giulia Masci, Raffaele Vitiello, Alessandro Smimmo, Maria Rosaria Matrangolo, Osvaldo Palmacci, Stefano D'Adamio, Antonio Ziranu
Summary: This study evaluated the reliability of the 2018 AO/OTA classification, simplified AO/OTA classification, and Garden classification in femoral neck fractures. The results showed that the interobserver reliability of the Garden classification was low, while the AO and simplified AO/OTA classifications had only fair reliability. The experience of the observers did not seem to improve reliability. No classification was shown to be superior in terms of reliability.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Peng Niu, Yongxi Liu, Yanfeng Zhang, Lei Li
Summary: Studies have shown that antioxidants can lower the risk of osteoporosis, which is a factor for femoral neck fracture. However, the connection between blood antioxidant levels and femoral neck strength is still uncertain.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Medicine, General & Internal
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study aimed to investigate the incidence, risk factors and pathogenic microorganisms causing infection in patients with subtrochanteric femoral fractures managed with an intramedullary nail. Deep infection was associated with non-union, open fracture, massive transfusion, post-operative transfusion and prolonged length of stay. Staphylococcus aureus and coliforms were the most common microorganisms identified in superficial and deep infections, respectively, with polymicrobial infection present in a significant proportion of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hou-Feng Zheng, Vincenzo Forgetta, Yi-Hsiang Hsu, Karol Estrada, Alberto Rosello-Diez, Paul J. Leo, Chitra L. Dahia, Kyung Hyun Park-Min, Jonathan H. Tobias, Charles Kooperberg, Aaron Kleinman, Unnur Styrkarsdottir, Ching-Ti Liu, Charlotta Uggla, Daniel S. Evans, Carrie M. Nielson, Klaudia Walter, Ulrika Pettersson-Kymmer, Shane McCarthy, Joel Eriksson, Tony Kwan, Mila Jhamai, Katerina Trajanoska, Yasin Memari, Josine Min, Jie Huang, Petr Danecek, Beth Wilmot, Rui Li, Wen-Chi Chou, Lauren E. Mokry, Alireza Moayyeri, Melina Claussnitzer, Chia-Ho Cheng, Warren Cheung, Carolina Medina-Gomez, Bing Ge, Shu-Huang Chen, Kwangbom Choi, Ling Oei, James Fraser, Robert Kraaij, Matthew A. Hibbs, Celia L. Gregson, Denis Paquette, Albert Hofman, Carl Wibom, Gregory J. Tranah, Mhairi Marshall, Brooke B. Gardiner, Katie Cremin, Paul Auer, Li Hsu, Sue Ring, Joyce Y. Tung, Gudmar Thorleifsson, Anke W. Enneman, Natasja M. van Schoor, Lisette C. P. G. M. de Groot, Nathalie van der Velde, Beatrice Melin, John P. Kemp, Claus Christiansen, Adrian Sayers, Yanhua Zhou, Sophie Calderari, Jeroen van Rooij, Chris Carlson, Ulrike Peters, Soizik Berlivet, Josee Dostie, Andre G. Uitterlinden, Stephen R. Williams, Charles Farber, Daniel Grinberg, Andrea Z. LaCroix, Jeff Haessler, Daniel I. Chasman, Franco Giulianini, Lynda M. Rose, Paul M. Ridker, John A. Eisman, Tuan V. Nguyen, Jacqueline R. Center, Xavier Nogues, Natalia Garcia-Giralt, Lenore L. Launer, Vilmunder Gudnason, Dan Mellstrom, Liesbeth Vandenput, Najaf Amin, Cornelia M. van Duijn, Magnus K. Karlsson, Osten Ljunggren, Olle Svensson, Goran Hallmans, Francois Rousseau, Sylvie Giroux, Johanne Bussiere, Pascal P. Arp, Fjorda Koromani, Richard L. Prince, Joshua R. Lewis, Bente L. Langdahl, A. Pernille Hermann, Jens-Erik B. Jensen, Stephen Kaptoge, Kay-Tee Khaw, Jonathan Reeve, Melissa M. Formosa, Angela Xuereb-Anastasi, Kristina Akesson, Fiona E. McGuigan, Gaurav Garg, Jose M. Olmos, Maria T. Zarrabeitia, Jose A. Riancho, Stuart H. Ralston, Nerea Alonso, Xi Jiang, David Goltzman, Tomi Pastinen, Elin Grundberg, Dominique Gauguier, Eric S. Orwoll, David Karasik, George Davey-Smith, Albert V. Smith, Kristin Siggeirsdottir, Tamara B. Harris, M. Carola Zillikens, Joyce B. J. van Meurs, Unnur Thorsteinsdottir, Matthew T. Maurano, Nicholas J. Timpson, Nicole Soranzo, Richard Durbin, ScottG. Wilson, Evangelia E. Ntzani, Matthew A. Brown, Kari Stefansson, David A. Hinds, Tim Spector, L. Adrienne Cupples, Claes Ohlsson, Celia M. T. Greenwood, Rebecca D. Jackson, David W. Rowe, Cynthia A. Loomis, David M. Evans, Cheryl L. Ackert-Bicknell, Alexandra L. Joyner, Emma L. Duncan, Douglas P. Kiel, Fernando Rivadeneira, J. Brent Richards
Article
Endocrinology & Metabolism
G. Armbrecht, D. Felsenberg, M. Ganswindt, M. Lunt, S. K. Kaptoge, K. Abendroth, A. Aroso, D. Banzer, A. K. Bhalla, J. Dequeker, R. Eastell, K. Hoszowski, G. Lyritis, P. D. Delmas, P. Masaryk, T. Miazgowski, J. Cannata, R. Nuti, L. Oei, G. Poor, I. Redlund-Johnell, D. M. Reid, W. Reisinger, H. Schatz, C. J. Todd, A. D. Woolf, K. Javaid, F. Rivadeneira, A. J. Silman, C. Cooper, T. W. O'Neill, J. Reeve
OSTEOPOROSIS INTERNATIONAL
(2015)
Article
Rheumatology
Gabriele Armbrecht, Dieter Felsenberg, Melanie Ganswindt, Mark Lunt, Stephen K. Kaptoge, Klaus Abendroth, Antonio Aroso Dias, Ashok K. Bhalla, Jorge Cannata Andia, Jan Dequeker, Richard Eastell, Krzysztof Hoszowski, George Lyritis, Pavol Masaryk, Joyce van Meurs, Tomasz Miazgowski, Ranuccio Nuti, Gyula Poor, Inga Redlund-Johnell, David M. Reid, Helmut Schatz, Christopher J. Todd, Anthony D. Woolf, Fernando Rivadeneira, Muhammad K. Javaid, Cyrus Cooper, Alan J. Silman, Terence W. O'Neill, Jonathan Reeve
Article
Endocrinology & Metabolism
Jon Power, Nigel Loveridge, Heikki Kroger, Martyn Parker, Jonathan Reeve
Article
Endocrinology & Metabolism
Ling Oei, Karol Estrada, Emma L. Duncan, Claus Christiansen, Ching-Ti Liu, Bente L. Langdahl, Barbara Obermayer-Pietsch, Jose A. Riancho, Richard L. Prince, Natasja M. van Schoor, Eugene McCloskey, Yi-Hsiang Hsu, Evangelos Evangelou, Evangelia Ntzani, David M. Evans, Nerea Alonso, Lise B. Husted, Carmen Valero, Jose L. Hernandez, Joshua R. Lewis, Stephen K. Kaptoge, Kun Zhu, L. Adrienne Cupples, Carolina Medina-Gomez, Liesbeth Vandenput, Ghi Su Kim, Seung Hun Lee, Martha C. Castano-Betancourt, Edwin H. G. Oei, Josefina Martinez, Anna Daroszewska, Marjolein van der Klift, Dan Mellstrom, Lizbeth Herrera, Magnus K. Karlsson, Albert Hofman, Osten Ljunggren, Huibert A. P. Pols, Lisette Stolk, Joyce B. J. van Meurs, John P. A. Ioannidis, M. Carola Zillikens, Paul Lips, David Karasik, Andre G. Uitterlinden, Unnur Styrkarsdottir, Matthew A. Brown, Jung-Min Koh, J. Brent Richards, Jonathan Reeve, Claes Ohlsson, Stuart H. Ralston, Douglas P. Kiel, Fernando Rivadeneira
Review
Endocrinology & Metabolism
Jonathan Reeve, Nigel Loveridge
Article
Biochemistry & Molecular Biology
J. Power, J. Taggart, M. Parker, J. L. Berry, J. Reeve
CELL BIOCHEMISTRY AND FUNCTION
(2014)
Article
Biochemistry & Molecular Biology
Alireza Moayyeri, Yi-Hsiang Hsu, David Karasik, Karol Estrada, Su-Mei Xiao, Carrie Nielson, Priya Srikanth, Sylvie Giroux, Scott G. Wilson, Hou-Feng Zheng, Albert V. Smith, Stephen R. Pye, Paul J. Leo, Alexander Teumer, Joo-Yeon Hwang, Claes Ohlsson, Fiona McGuigan, Ryan L. Minster, Caroline Hayward, Jose M. Olmos, Leo-Pekka Lyytikaeinen, Joshua R. Lewis, Karin M. A. Swart, Laura Masi, Chris Oldmeadow, Elizabeth G. Holliday, Sulin Cheng, Natasja M. van Schoor, Nicholas C. Harvey, Marcin Kruk, M. Fabiola Del Greco, Wilmar Igl, Olivia Trummer, Efi Grigoriou, Robert Luben, Ching-Ti Liu, Yanhua Zhou, Ling Oei, Carolina Medina-Gomez, Joseph Zmuda, Greg Tranah, Suzanne J. Brown, Frances M. Williams, Nicole Soranzo, Johanna Jakobsdottir, Kristin Siggeirsdottir, Kate L. Holliday, Anke Hannemann, Min Jin Go, Melissa Garcia, Ozren Polasek, Marika Laaksonen, Kun Zhu, Anke W. Enneman, Mark McEvoy, Roseanne Peel, Pak Chung Sham, Maciej Jaworski, Asa Johansson, Andrew A. Hicks, Pawel Pludowski, Rodney Scott, Rosalie A. M. Dhonukshe-Rutten, Nathalie van der Velde, Mika Kaehoenen, Jorma S. Viikari, Harri Sievaenen, Olli T. Raitakari, Jesus Gonzalez-Macias, Jose L. Hernandez, Dan Mellstroem, Oesten Ljunggren, Yoon Shin Cho, Uwe Voelker, Matthias Nauck, Georg Homuth, Henry Voelzke, Robin Haring, Matthew A. Brown, Eugene McCloskey, Geoffrey C. Nicholson, Richard Eastell, John A. Eisman, Graeme Jones, Ian R. Reid, Elaine M. Dennison, John Wark, Steven Boonen, Dirk Vanderschueren, Frederick C. W. Wu, Thor Aspelund, J. Brent Richards, Doug Bauer, Albert Hofman, Kay-Tee Khaw, George Dedoussis, Barbara Obermayer-Pietsch, Ulf Gyllensten, Peter P. Pramstaller, Roman S. Lorenc, Cyrus Cooper, Annie Wai Chee Kung, Paul Lips, Markku Alen, John Attia, Maria Luisa Brandi, Lisette C. P. G. M. de Groot, Terho Lehtimaeki, Jose A. Riancho, Harry Campbell, Yongmei Liu, Tamara B. Harris, Kristina Akesson, Magnus Karlsson, Jong-Young Lee, Henri Wallaschofski, Emma L. Duncan, Terence W. O'Neill, Vilmundur Gudnason, Timothy D. Spector, Francois Rousseau, Eric Orwoll, Steven R. Cummings, Nick J. Wareham, Fernando Rivadeneira, Andre G. Uitterlinden, Richard L. Prince, Douglas P. Kiel, Jonathan Reeve, Stephen K. Kaptoge
HUMAN MOLECULAR GENETICS
(2014)
Article
Endocrinology & Metabolism
Yohann Bala, Roland Chapurlat, Angela M. Cheung, Dieter Felsenberg, Michel LaRoche, Edward Morris, Jonathan Reeve, Thierry Thomas, Jose Zanchetta, Oliver Bock, Ali Ghasem-Zadeh, Roger Martin Zebaze Djoumessi, Ego Seeman, Rene Rizzoli
JOURNAL OF BONE AND MINERAL RESEARCH
(2014)
Article
Genetics & Heredity
Ling Oei, Yi-Hsiang Hsu, Unnur Styrkarsdottir, Bert H. Eussen, Annelies de Klein, Marjolein J. Peters, Bjarni Halldorsson, Ching-Ti Liu, Nerea Alonso, Stephen K. Kaptoge, Gudmar Thorleifsson, Goeran Hallmans, Lynne J. Hocking, Lise Bjerre Husted, Karen A. Jameson, Marcin Kruk, Joshua R. Lewis, Millan S. Patel, Serena Scollen, Olle Svensson, Stella Trompet, Natasja M. van Schoor, Kun Zhu, Brendan M. Buckley, Cyrus Cooper, Ian Ford, David Goltzman, Jesus Gonzalez-Macias, Bente Lomholt Langdahl, William D. Leslie, Paul Lips, Roman S. Lorenc, Jose M. Olmos, Ulrika Pettersson-Kymmer, David M. Reid, Jose A. Riancho, P. Eline Slagboom, Carmen Garcia-Ibarbia, Thorvaldur Ingvarsson, Hrefna Johannsdottir, Robert Luben, Carolina Medina-Gomez, Pascal Arp, Kannabiran Nandakumar, Stefan Th Palsson, Gunnar Sigurdsson, Joyce B. J. van Meurs, Yanhua Zhou, Albert Hofman, J. Wouter Jukema, Huibert A. P. Pols, Richard L. Prince, L. Adrienne Cupples, Christian R. Marshall, Dalila Pinto, Daisuke Sato, Stephen W. Scherer, Jonathan Reeve, Unnur Thorsteinsdottir, David Karasik, J. Brent Richards, Kari Stefansson, Andr G. Uitterlinden, Stuart H. Ralston, John P. A. Ioannidis, Douglas P. Kiel, Fernando Rivadeneira, Karol Estrada
JOURNAL OF MEDICAL GENETICS
(2014)
Article
Medicine, General & Internal
Katerina Trajanoska, John A. Morris, Ling Oei, Hou-Feng Zheng, David M. Evans, Douglas P. Kiel, Claes Ohlsson, J. Brent Richards, Fernando Rivadeneira
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Article
Genetics & Heredity
John A. Morris, John P. Kemp, Scott E. Youlten, Laetitia Laurent, John G. Logan, Ryan C. Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu T. Mohanty, C. Marcelo Sergio, Julian Quinn, Loan Nguyen-Yamamoto, Aimee-Lee Luco, Jinchu Vijay, Marie-Michelle Simon, Albena Pramatarova, Carolina Medina-Gomez, Katerina Trajanoska, Elena J. Ghirardello, Natalie C. Butterfield, Katharine F. Curry, Victoria D. Leitch, Penny C. Sparkes, Anne-Tounsia Adoum, Naila S. Mannan, Davide S. K. Komla-Ebri, Andrea S. Pollard, Hannah F. Dewhurst, Thomas A. D. Hassall, Michael-John G. Beltejar, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, Jennifer C. McCreight, Karen E. Huber, Nadia K. Litterman, Matthew H. McIntyre, Joanna L. Mountain, Elizabeth S. Noblin, Carrie A. M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson, Douglas J. Adams, Suzanne M. Vaillancourt, Stephen Kaptoge, Paul Baldock, Cyrus Cooper, Jonathan Reeve, Evangelia E. Ntzani, Evangelos Evangelou, Claes Ohlsson, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Jonathan H. Tobias, Celia L. Gregson, Nicholas C. Harvey, Elin Grundberg, David Goltzman, David J. Adams, Christopher J. Lelliott, David A. Hinds, Cheryl L. Ackert-Bicknell, Yi-Hsiang Hsu, Matthew T. Maurano, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett, David M. Evans, J. Brent Richards
Correction
Genetics & Heredity
John A. Morris, John P. Kemp, Scott E. Youlten, Laetitia Laurent, John G. Logan, Ryan C. Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu T. Mohanty, C. Marcelo Sergio, Julian Quinn, Loan Nguyen-Yamamoto, Aimee-Lee Luco, Jinchu Vijay, Marie-Michelle Simon, Albena Pramatarova, Carolina Medina-Gomez, Katerina Trajanoska, Elena J. Ghirardello, Natalie C. Butterfield, Katharine F. Curry, Victoria D. Leitch, Penny C. Sparkes, Anne-Tounsia Adoum, Naila S. Mannan, Davide S. K. Komla-Ebri, Andrea S. Pollard, Hannah F. Dewhurst, Thomas A. D. Hassall, Michael-John G. Beltejar, Douglas J. Adams, Suzanne M. Vaillancourt, Stephen Kaptoge, Paul Baldock, Cyrus Cooper, Jonathan Reeve, Evangelia E. Ntzani, Evangelos Evangelou, Claes Ohlsson, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Jonathan H. Tobias, Celia L. Gregson, Nicholas C. Harvey, Elin Grundberg, David Goltzman, David J. Adams, Christopher J. Lelliott, David A. Hinds, Cheryl L. Ackert-Bicknell, Yi-Hsiang Hsu, Matthew T. Maurano, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett, David M. Evans, J. Brent Richards
Meeting Abstract
Endocrinology & Metabolism
John Morris, John Kemp, Scott Youlten, John Logan, Ryan Chai, Nicholas Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu Mohanty, Marcelo Sergio, Carolina Medina-Gomez, Katerina Trajanoska, Julian Quinn, Elena Ghirardello, Natalie Butterfield, Katharine Curry, Victoria Leitch, Penny Sparkes, Laetitia Laurent, Anne-Tounsia Adoum, Naila Mannan, Davide Komla-Ebri, Andrea Pollard, Hannah Dewhurst, Stephen Kaptoge, Paul Baldock, Cyrus Cooper, Jonathan Reeve, Evangelia Ntzani, Evangelos Evangelou, Claes Ohlsson, David Karasik, Fernando Rivadeneira, Cheryl Ackert-Bicknell, Douglas Kiel, Jonathan Tobias, Celia Gregson, Nicholas Harvey, David Adams, Christopher Lelliott, David Hinds, Yi-Hsiang Hsu, Matthew Maurano, Peter Croucher, Graham Williams, Duncan Bassett, David Evans, Brent Richards
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Endocrinology & Metabolism
Kenneth E. S. Poole, Linda Skingle, Andrew H. Gee, Thomas D. Turmezei, Fjola Johannesdottir, Karen Blesic, Collette Rose, Madhavi Vindlacheruvu, Simon Donell, Jan Vaculik, Pavel Dungl, Martin Horak, Jan J. Stepan, Jonathan Reeve, Graham M. Treece
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
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Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
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Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
