Article
Endocrinology & Metabolism
XinChao Lin, HongTao Guo, YiGang Lian, Jiajing Kou, GuangLei Wang, YiYun Chen, Juan Wang, Xu Han, Miao Jiang, QiaoHui Yang
Summary: Identifying the high-risk population for osteoporosis is crucial for timely prevention. A study was conducted among elderly urban residents in Beijing to investigate the characteristics and risk factors of osteoporosis. The results showed that the prevalence of osteoporosis in women was higher than in men and increased with aging, while the prevalence of osteopenia was higher in men. A cost-effective method combining grip strength, height loss, and medical history was recommended for identifying high-risk subjects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Urology & Nephrology
Andrew Davenport
Summary: The pattern of chronic kidney disease mineral bone disorder (CKD-MBD) is changing with increasing numbers of elderly patients now treated by dialysis. The risk of falls and bone fractures increases with frailty and sarcopenia. Osteoporosis is increasing with the numbers of elderly dialysis patients.
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Andrew Davenport
Summary: The pattern of chronic kidney disease-mineral bone disease has changed following the increase in elderly patients receiving dialysis, with escalating likelihood of osteoporosis, with associated increased fracture risk and mortality.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Celia L. Gregson, Tafadzwa Madanhire, Andrea Rehman, Rashida A. Ferrand, Anne R. Cappola, Steven Tollman, Tshepiso Mokoena, Lisa K. Micklesfield, Alisha N. Wade, June Fabian
Summary: The study found that osteoporosis is more common than sarcopenia among aging individuals in rural South Africa, with older women living with HIV experiencing greater bone loss. This raises concerns over future fracture risk in Southern Africa, highlighting the importance of routine bone health assessments in HIV clinics, especially for aging women.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Caterina Mosca, Fanney Thorsteinsdottir, Bo Abrahamsen, Juri Johannes Rumessen, Mina Nicole Handel
Summary: Newly diagnosed young adults with celiac disease are at risk of low bone mineral density. A strict gluten-free diet may improve bone density over time, but there is a lack of robust evidence for the effectiveness of nutritional supplements or antiresorptive medications in preventing fragile bones in this age group.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Allergy
Ayelet Makovoz, Jing Wang, Gloria Oshegbo, Young Hwan Park, Jonathan J. Lyons, A. Robin Eisch, Linda M. Scott, James C. Reynolds, Ana M. Ortega-Villa, Dean D. Metcalfe, Hirsh D. Komarow
Summary: This study investigated fracture prevalence and risk predictors in North American patients with systemic mastocytosis (SM), finding a 74% fracture history rate among the cohort. Factors such as age, body mass index, bone density, and alkaline phosphatase levels were consistent with European studies on individuals with SM and bone disease. The study also developed a predictive model for fracture risk based on DXA spine T-scores, alkaline phosphatase, and age.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Clinical Neurology
Mohaddeseh Azadvari, Omid Mirmosayyeb, Maryam Hosseini, Saeed Vaheb, Seyede Zahra Emami Razavi
Summary: Based on the meta-analysis of multiple studies, the pooled prevalence of osteoporosis and osteopenia in patients with multiple sclerosis was found to be 17% and 43% respectively. This highlights the importance of considering bone health status in the management of multiple sclerosis.
NEUROLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Noushin Fahimfar, Sima Noorali, Shakiba Yousefi, Safoora Gharibzadeh, Gita Shafiee, Nekoo Panahi, Mahnaz Sanjari, Ramin Heshmat, Farshad Sharifi, Neda Mehrdad, Alireza Raeisi, Iraj Nabipour, Bagher Larijani, Afshin Ostovar
Summary: A large population-based study in Iran found a high prevalence of osteoporosis among the elderly, with negative associations with body mass index, diabetes in men, and hypertriglyceridemia in women. The study highlights the need for comprehensive interventions due to the severe complications, especially fractures, associated with osteoporosis in the elderly population.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Gastroenterology & Hepatology
Phil A. Hart, Dhiraj Yadav, Liang Li, Savi Appana, William Fisher, Evan Fogel, Chris E. Forsmark, Walter G. Park, Stephen Pandol, Mark D. Topazian, Stephen K. Van den Eden, Santhi Swaroop Vege, David Bradley, Jose Serrano, Darwin L. Conwell
Summary: Chronic pancreatitis patients have a high prevalence of osteopathy, with older age, female sex, white race, and underweight body mass index category being associated with a higher probability of osteopathy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Endocrinology & Metabolism
M. M. Delsmann, A. Strahl, M. Muhlenfeld, N. M. Jandl, F. T. Beil, C. Ries, T. Rolvien
Summary: The study found a high prevalence of low bone mineral density in elderly patients with end-stage osteoarthritis scheduled for total hip arthroplasty. Routine DXA measurements should be considered in these patients to prevent undiagnosed and untreated osteoporosis, which could impact the success of osseointegration and other clinical outcomes.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Health Care Sciences & Services
Kyujin Lee, Ji Young Lee, Yong Hwan Kim
Summary: The study reveals a connection between grip strength, muscle mass, and bone health in elderly women. Low grip strength and muscle mass are associated with increased prevalence of osteoporosis and osteopenia in this population.
Article
Medicine, General & Internal
Do-Youn Lee, Sunghoon Shin
Summary: Sarcopenia is significantly associated with bone disorders, such as osteopenia and osteoporosis, especially in older Korean men.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lin Zhang, Xiaoying Luo, Hao Liu, Wei Zhu, Xupeng Zhang, Shijie Zhu, Xiaowei Zhang, Gaichan Zhao, Tianzhou Li, Fengyu Xiao, Faxue Zhang, Fang Zhou, Yanluan Wan
Summary: This is the first study to estimate and characterize the prevalence of osteoporosis in Hubei province, China. The prevalence of osteoporosis was 12.19%, with 3.69% for males and 18.94% for females. 56.6% of the participants were diagnosed with osteopenia, with 44.96% for males and 65.84% for females.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Nutrition & Dietetics
Yuhe Wang, Xu Han, Jingru Shi, Zeqi Liao, Yuanyue Zhang, Yuanyuan Li, Miao Jiang, Meijie Liu
Summary: This systematic review and meta-analysis investigated the distinct metabolites in patients with osteopenia (ON) and osteoporosis (OP). The results show that certain metabolites were associated with ON and OP, indicating their potential as predictors for OP.
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Marcia S. Brose, Yury Panaseykin, Bhavana Konda, Christelle de la Fouchardiere, Brett G. M. Hughes, Andrew G. Gianoukakis, Young Joo Park, Ilia Romanov, Monika K. Krzyzanowska, Sophie Leboulleux, Terri A. Binder, Corina Dutcus, Ran Xie, Matthew H. Taylor
Summary: This study compared the efficacy and toxicity of lenvatinib starting at doses of 24 mg/day and 18 mg/day in patients with RR-DTC. The results showed that the objective response rate was 57.3% in the 24 mg/day arm and 40.3% in the 18 mg/day arm, indicating that the starting dose of 18 mg/day did not demonstrate noninferiority. However, there was no clinically relevant difference in the safety profile between the two arms.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
Summary: Among the general adult population of Korea, both Pb and Hg exposures were associated with an increased risk of obesity, while both Hg and Cd exposures were associated with increased odds of NAFLD. However, these metals were not associated with an increased risk of DM.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Inae Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Min Kyong Moon
Summary: Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) are associated with an increased risk of obesity and diabetes mellitus. In the Korean adult population, urinary biomarkers for PAHs and VOCs are positively associated with body mass index (BMI).
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Eu Jeong Ku, Bo-Rahm Kim, Jee-In Lee, Yun Kyung Lee, Tae Jung Oh, Hak C. Jang, Sung Hee Choi
Summary: Anakinra, a recombinant human IL-1 receptor antagonist, has been found to have inhibitory effects on the progression of atherosclerosis. It reduces plaque size and serum triglyceride levels, and suppresses inflammatory gene expressions and cell migration. In animal experiments, it also decreases macrophage infiltration and monocyte chemoattractant protein-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kyungsik Kim, June Young Choi, Su-jin Kim, Eun Kyung Lee, Young Ki Lee, Jun Sun Ryu, Kyu Eun Lee, Jae Hoon Moon, Young Joo Park, Sun Wook Cho, Sue K. Park
Summary: Cumulative costs of active surveillance and immediate surgery are similar in low-risk PTMC patients for 10 years, but surgery could be more economical for patients with a longer life expectancy in long-term follow-up.
Review
Oncology
Shinje Moon, Ka Hee Yi, Young Joo Park
Summary: This meta-analysis found that thyroid cancer treatment (including RAIT) does not increase the risk of adverse pregnancy outcomes for patients, and the results regarding miscarriage, preterm labor, and congenital anomalies are similar to those in the general population.
Review
Oncology
Ho-Ryun Won, Eonju Jeon, Jae Won Chang, Yea Eun Kang, Kunho Song, Sun Wook Kim, Dong Mee Lim, Tae Kwun Ha, Ki-Wook Chung, Hyo-Jeong Kim, Young Joo Park, Bon Seok Koo
Summary: There is insufficient evidence to support the effectiveness of post-operative maintenance of thyroid-stimulating hormone (TSH) levels below 2 mU/L in reducing recurrence in patients undergoing thyroid lobectomy for low-risk differentiated thyroid cancer (DTC). Further research is needed to clarify the impact of TSH maintenance in this patient population.
Letter
Endocrinology & Metabolism
Yoo Hyung Kim, Hyo-Cheol Kim, Yun Bin Lee, Samina Park, Eun-Jae Chung, Jin Chul Paeng, Young Joo Park
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Min Joo Kim, Sun Wook Cho, Ye An Kim, Hoon Sung Choi, Young Joo Park, Do Joon Park, Bo Youn Cho
Summary: This study investigated the clinical outcomes of repeated RAI therapy for Graves' disease. The results showed that the remission rate after second RAI therapy was higher and the response was faster. Smaller goiter size, longer time intervals between the first and second RAI therapies, and longer ATD discontinuation period predicted remission after the second RAI therapy.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Environmental Sciences
Min Joo Kim, Sohyeon Choi, Sunmi Kim, Inae Lee, Min Kyong Moon, Kyungho Choi, Jeongim Park, Yoon Hee Cho, Young Min Kwon, Jiyoung Yoo, Gi Jeong Cheon, Young Joo Park
Summary: This study examined the associations between persistent organic pollutants (POPs) and thyroid hormone levels in humans, and found that these associations are influenced by sex, menopausal status, and age. Different POPs had different effects on different hormones, and the associations varied in different population groups. Furthermore, the study also suggested that thyroxine-binding globulin (TBG) and peripheral deiodinase activity (G(D)) may play important roles in explaining the changes in total T4 and total T3.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
Summary: This study suggests that higher postpartum muscle mass is associated with a lower risk of prediabetes and type 2 diabetes in Korean women with gestational diabetes mellitus. This association was observed in normal weight women but not in overweight women.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyobin Seo, Kwang Nam Jin, Ji Sang Park, Koung Mi Kang, Eun Kyung Lee, Ji Ye Lee, Roh-Eul Yoo, Young Joo Park, Ji-hoon Kim
Summary: This study evaluated the risk of thyroid cancer in a lung cancer screening population based on the presence of incidental thyroid nodules detected on low-dose chest computed tomography (LDCT). The results showed that the incidence of thyroid cancer was higher in the ITN-positive group compared to the ITN-negative group, but all cancers were papillary thyroid microcarcinomas (PTMCs). Therefore, thorough screening for thyroid incidentalomas may not be necessary in patients with a heavy smoking history.
Article
Endocrinology & Metabolism
Shinje Moon, Eun Kyung Lee, Hoonsung Choi, Sue K. Park, Young Joo Park
Summary: This study investigates the impact of ultra-sound screening on thyroid cancer outcomes. The findings suggest that early detection of thyroid cancer leads to better survival outcomes compared to symptomatic thyroid cancer.
ENDOCRINOLOGY AND METABOLISM
(2023)
Correction
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Sung Hye Kong, Jung Hee Kim, Man Young Park, Sang Wan Kim, Chan Soo Shin
Summary: The incidence of primary hyperparathyroidism patients who underwent parathyroidectomy has been increasing in Korea. Patients with complications, especially mood disorder, have an increased risk of mortality and cardiovascular and cerebrovascular events.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.