Journal
JOURNAL OF CLINICAL PERIODONTOLOGY
Volume 42, Issue 6, Pages 506-512Publisher
WILEY
DOI: 10.1111/jcpe.12418
Keywords
CRP; gestational diabetes; gingivitis; periodontopathogens; pregnancy
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Funding
- NIDCR [RO1 DE019826]
- Ege University Research Foundation [2013 DIS 026]
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AimGestational diabetes mellitus (GDM), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden. Materials and MethodsFour case-control groups (n=117) were recruited, (1) No gingivitis, No GDM (n=27); (2) Gingivitis, No GDM (n=31); (3) No gingivitis, GDM (n=21); and (4) Gingivitis, GDM (n=38). Oral infection with three key periodontal pathogens was determined by PCR. Systemic inflammation was determined by quantification of CRP by EIA. ResultsGingivitis during pregnancy was associated with oral infection with Porphyromonas gingivalis, Filifactor alocis and Treponema denticola and combinations thereof (all p<0.01). GDM was also associated with increased infection with individual and multiple oral pathogens (all p<0.05). Gingivitis during pregnancy led to a 325% increase in systemic CRP (mean, 2495 versus 8116ng/ml, p<0.01). ConclusionsDiabetes and gingivitis act in concert to increase risk biomarkers for poor pregnancy outcome.
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