Review
Public, Environmental & Occupational Health
Maria Olimpia Paz Alvarenga, Giza Hellen Nonato Miranda, Railson Oliveira Ferreira, Miki Taketomi Saito, Nathalia Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues Lima
Summary: Five studies found a significant relationship between the severity of periodontitis and diabetic retinopathy, but the overall quality of evidence was rated as low. Further large-scale studies with proper adjustment for confounders and prospective analysis are needed to clarify this association.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Alaa Aldoss, Rhodanne Lambarte, Fahd Alsalleeh
Summary: Hyperglycemic conditions limit the proliferation and migration of periodontal ligament fibroblasts (PDLFs) and enhance the expression of pro-inflammatory cytokines, leading to the development of periodontitis. The study investigated the effects of different glucose concentrations on PDLFs' viability, cytotoxicity, migration ability, and the expression of interleukins and Toll-like receptor (TLR)-4. The results showed that high glucose concentration (50 mM) decreased PDLFs viability and migration, and increased the expression of IL-6 and TLR-4.
Article
Microbiology
Camilla Pedrosa Vieira Lima, Daniela Correa Grisi, Maria Do Carmo Machado Guimaraes, Loise Pedrosa Salles, Paula de Castro Kruly, Thuy Do, Luiz Gustavo Dos Anjos Borges, Naile Dame-Teixeira
Summary: This study investigated oral microbial signatures associated with hyperglycaemia by correlating the oral microbiome with three glycaemic markers. The results showed that hyperglycaemia was correlated with the proportions of certain bacterial taxa. The salivary microbiome was also found to be influenced by systemic hyperglycaemia and changes in salivary pH.
JOURNAL OF ORAL MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Muhammad H. A. Saleh, Debora R. Dias, Obada Mandil, Ricardo P. de Oliveira, Abdusalam Alrmali, Mauricio G. Araujo, Hom-Lay Wang, Zoltan Barath, Istvan A. Urban
Summary: Patients with RPc >= 5 mm at more than 15% of the sites are at risk for tooth loss. Grading and RPc >= 5 mm displayed very good predictive capability of TLP.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Valeria Fridman D'Alessandro, Atsuro Takeshita, Taro Yasuma, Masaaki Toda, Corina N. D'Alessandro-Gabazza, Yuko Okano, Suphachai Tharavecharak, Chisa Inoue, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Yutaka Yano, Esteban C. Gabazza
Summary: Diabetic nephropathy, a common complication of diabetes mellitus, is the leading cause of end-stage renal disease. The overexpression of transforming growth factor beta 1 is associated with insulin resistance and rapid progression of kidney fibrosis under diabetic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lu Tang, Tingfang Li, Yuqi Chang, Zheng Wang, Yanjing Li, Feng Wang, Lei Sui
Summary: Periodontitis, a common complication of diabetes, is exacerbated by oxidative stress-induced damage to telomeres and senescence of periodontal ligament stem cells (PDLSCs), ultimately leading to impaired bone tissue regeneration and reconstruction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Paula Tegelberg, Tellervo Tervonen, Matti Knuuttila, Jari Jokelainen, Sirkka Keinanen-Kiukaanniemi, Juha Auvinen, Pekka Ylostalo
Summary: The study indicates that impairment in glucose control in non-diabetic individuals is associated with deterioration in periodontal status, suggesting a correlation between blood sugar levels at age 46 and periodontal conditions.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Medicine, Research & Experimental
Pengpeng Zhang, Wei Wei, Xiaohai Zhang, Chaoling Wen, Chitchamai Ovatlarnporn, Opeyemi Joshua Olatunji
Summary: This study found that the ethanolic extract of Krat has significant antidiabetic and antihyperlipidemic effects on type 2 diabetic rats. These results for the first time demonstrated the potential of Mitragyna speciosa in the treatment of diabetes and provide scientific reinforcement for its traditional use.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Diana Vilela Azzi, Andressa Naira de Jesus Pereira, Viviam de Oliveira Silva, Renata de Carvalho Foureaux, Andressa Ribeiro Veiga Lima, Robson Sfaciotti Barducci, Adriana Silva Albuquerque, Gabriel Lasmar Reis, Raphael Ricon de Oliveira, Eric Francelino Andrade, Marcio Gilberto Zangeronimo, Antonio Chalfun-Junior, Luciano Jose Pereira
Summary: The study evaluated the effects of beta-glucans isolated from Saccharomyces cerevisiae on alveolar bone loss and inflammatory/metabolic parameters in normal and diabetic rats with periodontal disease. The results showed that doses above 40 mg/kg could reduce alveolar bone loss and improve inflammatory profile.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Dentistry, Oral Surgery & Medicine
Abid Rahim, Sabreen Hassan, Naeem Ullah, Nawal Noor, Rimsha Rafique, Farhad Ali Khattak, Saima Afaq
Summary: This study explored the association and severity of periodontal clinical parameters and oral hygiene with HbA1c levels in non-diabetics and T2DM patients. The results showed that periodontal status and oral hygiene status were deteriorated in uncontrolled T2DM patients compared to non-diabetic participants and controlled T2DM.
Article
Multidisciplinary Sciences
Saar Shoer, Smadar Shilo, Anastasia Godneva, Orly Ben-Yacov, Michal Rein, Bat Chen Wolf, Maya Lotan-Pompan, Noam Bar, Ervin Weiss, Yael Houri-Haddad, Yitzhak Pilpel, Adina Weinberger, Eran Segal
Summary: Analyzing data from a six-month clinical trial in pre-diabetes, the authors found that 166 out of 2,803 measured features, including oral and gut microbiome, metabolites, and cytokines, significantly changed in response to dietary interventions. This highlights the role of the microbiome in cardiometabolic health and reveals potential therapeutic avenues.
NATURE COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jung-Hyun Park, Sun-Hyun Kim, Sun-Jong Kim, Jin-Woo Kim
Summary: This study investigated the association between the recovery from or development of periodontal disease (PD) and the risk of incident diabetes in a population. The results showed that individuals who recovered from PD had a lower risk of diabetes compared to those who had consistent PD, while individuals who developed PD had a higher risk of diabetes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Medicine, General & Internal
Oliver Laugisch, Thorsten M. Auschill, Christian Heumann, Anton Sculean, Nicole B. Arweiler
Summary: Precise measurements of periodontal parameters are crucial for diagnosing and treating periodontal disease. This study compared the measurements of a manual probe and an electronic pressure-sensitive probe, and found significant differences in pocket depths but not gingival margins. The correlation between the two probes was statistically significant. However, there were no significant differences in pain sensitivity and time needed for measurements.
Review
Dentistry, Oral Surgery & Medicine
Eduardo Montero, Ana Molina, David Palombo, Belen Moron, Guillermo Pradies, Ignacio Sanz-Sanchez
Summary: The study aimed to evaluate the efficacy and effectiveness of tooth-supported fixed prostheses in partially edentulous patients with stage IV periodontitis. Results showed that tooth-supported fixed prostheses appeared to be a valid treatment approach for restoring masticatory function in patients with severe periodontitis. However, the comparative efficacy of this treatment between periodontitis and non-periodontitis patients remains unclear due to the lack of clinical trials.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Tanja Veljovic, Ivana Gusic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Ana Tadic, Snezana Brkic
Summary: Oxidative stress may serve as a link between diabetes mellitus and periodontitis. In this study, the salivary lipid peroxidation (LP) in periodontitis patients with and without type 2 diabetes was evaluated. The results showed that the improvement in clinical periodontal status following nonsurgical periodontal therapy is accompanied by a significant decrease in salivary LP in diabetes mellitus type 2 (DM2) patients, suggesting that periodontitis is the primary driver of the elevated salivary LP in this group.