Article
Urology & Nephrology
Masaki Hatano, Izuru Kitajima, Seizo Yamamoto, Masaki Nakamura, Kazuya Isawa, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Yoshifumi Ubara
Summary: The study findings suggest that improvement in beta 2m clearance through advances in dialysis technology may significantly prolong the time between starting HD and the first surgery for CTS.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Oscar Westin, Emil L. Fosbol, Mathew S. Maurer, Birgitte P. Leicht, Philip Hasbak, Anne Kaersgaard Mylin, Sara Rorvig, Thomas Hartvig Lindkaer, Helle Hjorth Johannesen, Finn Gustafsson
Summary: Screening for early-stage transthyretin cardiac amyloidosis in patients with prior surgery for bilateral carpal tunnel syndrome showed a clinical yield of approximately 5%. The yield was higher (>1 in 5) when focusing on nonobese men aged 70 years or older, suggesting the potential for systematic screening.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Clinical Neurology
Vasudeva G. Iyer
Summary: This article presents a rare case of a common neurological disorder, diagnosed through clinical reasoning and additional investigations.
Article
Multidisciplinary Sciences
Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto
Summary: Amyloid fibrils of beta 2-microglobulin (beta 2m) can cause dialysis-related amyloidosis. Decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited amyloid formation of beta 2m, suggesting that macromolecular crowding protects the onset of amyloidosis.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Seiji Takashio, Teiji Kato, Hikaru Tashima, Hiroki Irie, Yoshihiro Komohara, Tetsuya Oguni, Kei Morikawa, Naoto Kuyama, Noriaki Tabata, Shinsuke Hanatani, Eiichiro Yamamoto, Kenichi Matsushita, Mitsuharu Ueda, Kenichi Tsujita
Summary: Amyloid deposition was frequently observed in the tenosynovium removed during carpal tunnel release (CTR) in elderly men with carpal tunnel syndrome (CTS). Cardiac screening was found to be useful for the early diagnosis of cardiac amyloidosis (CA) in CTR patients with amyloid deposition.
CIRCULATION JOURNAL
(2023)
Article
Clinical Neurology
Daniele Severi, Francesco Aruta, Aniello Iovino, Emanuele Spina, Maria Nolano, Fiore Manganelli, Stefano Tozza
Summary: The study reported a case of two asymptomatic brothers who were diagnosed with ATTRv at a very early stage thanks to the diagnosis of carpal tunnel syndrome, suggesting that screening for carpal tunnel syndrome may help detect ATTRv in pre-symptomatic patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Andreas Thimm, Alexander Carpinteiro, Sara Oubari, Maria Papathanasiou, Peter Luedike, Lukas Kessler, Christoph Rischpler, Tobias Blau, Hans Christian Reinhardt, Tienush Rassaf, Hartmut Schmidt, Christoph Kleinschnitz, Tim Hagenacker
Summary: Neurological involvement is common in systemic AL amyloidosis, particularly in the peripheral nervous system. Male sex and cardiac involvement are independent predictors of peripheral neuropathy. Peripheral neuropathy has no impact on survival.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hiroki Mizuno, Junichi Hoshino, Masatomo So, Yuta Kogure, Takeshi Fujii, Yoshifumi Ubara, Kenmei Takaichi, Tetsuko Nakaniwa, Hideaki Tanaka, Genji Kurisu, Fuyuki Kametani, Mayuko Nakagawa, Tsuneaki Yoshinaga, Yoshiki Sekijima, Keiichi Higuchi, Yuji Goto, Masahide Yazaki
Summary: This study reported a rare case of DRA in a 41-year-old hemodialysis patient with a beta(2)-microglobulin variant (V27M) showing strong amyloidogenic propensity. The findings highlight the unique clinical manifestations and pathomechanical features of this variant compared to previously reported cases.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Bertil Ladefoged, Tor Clemmensen, Anne Dybro, Charlotte Hartig-Andreasen, Lone Kirkeby, Lars Christian Gormsen, Peter Bomholt, Julian Gillmore, Steen Hvitfeldt Poulsen
Summary: The prevalence of ATTRwt was found to be 8.3% in a population of age and gender-selected patients with a recent history of CTS. Patients diagnosed with ATTRwt through screening had less cardiac involvement in terms of structure and function compared to clinical ATTRwt patients.
Article
Medicine, General & Internal
Stahs Pripotnev, Susan E. Mackinnon
Summary: Carpal tunnel release is a commonly performed procedure, with most patients experiencing improvement in their symptoms. However, there is a small subset of patients who may experience failure of the initial surgery. The management of these patients involves thorough clinical examination, electrodiagnostic studies, and step-wise surgical approaches for revision surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Katarzyna Osiak, Agata Mazurek, Mateusz Koziej, Jerzy A. Walocha, Artur Pasternak
Summary: Electrodiagnostic testing plays a crucial role in the diagnosis and surgical treatment of CTS, providing a quantitative assessment of nerve physiological function. It can detect other pathologies and assist in determining reasons for surgical failure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Masaki Hatano, Masato Anno, Kota Miyoshi, Kazuya Isawa, Junichi Hoshino, Naoki Sawa, Yoshifumi Ubara, Masaki Nakamura, Seizo Yamamoto, Izuru Kitajima
Summary: This study developed a new grading system for destructive lumbar spondyloarthropathy (DLSA) and evaluated its interrater reliability and association with lumbar level. The results showed that the new grading system has good interrater reliability and significant correlation with the lumbar level. This classification system may be helpful in surgical decision-making.
Article
Health Care Sciences & Services
Jui-Chien Wang, Chung-Yi Li, Po-Yen Ko, Tung-Tai Wu, Kuo-Chen Wu, Fong-Chin Su, I-Ming Jou, Po-Ting Wu
Summary: This study aimed to evaluate the correlation between carpal tunnel pressure (CTP) and the clinical presentations in patients with carpal tunnel syndrome (CTS), as well as explore the possible predictors for the postoperative recovery pattern. The results showed that preoperative CTP was well correlated with the clinical presentations and could be a useful predictor for the postoperative clinical recovery pattern.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Kyoko Muneshige, Kenji Onuma, Koji Sukegawa, Yuya Otake, Gen Inoue, Masashi Takaso, Kentaro Uchida
Summary: This study found that COL5A1 expression is elevated in patients undergoing hemodialysis and that B2-MG may regulate its expression, suggesting a potential mechanism for the development of carpal tunnel syndrome in these patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Geriatrics & Gerontology
Hsueh-Wen Hsueh, Chi-Chao Chao, Koping Chang, Yung-Ming Jeng, Masahisa Katsuno, Haruki Koike, Sung-Tsang Hsieh
Summary: The study compares the clinical manifestations of A97S and V30M in hereditary transthyretin amyloidosis (ATTRv) and observes differences between the two genotypes. Dysphagia and carpal tunnel syndrome are common in A97S, and the onset age is younger. Autopsy findings in A97S reveal extensive amyloid deposits in the viscera and nerves of the tongue, larynx, and esophagus.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Satoru Mitsuboshi, Ryohei Kaseda, Ichiei Narita
Summary: This study suggests that steroid use may reduce the risk of proton pump inhibitor-induced nephropathy. Factors such as the presence of chronic kidney disease, comorbidities related to nephropathy, male sex, and age >= 80 years are associated with kidney injury.
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Ryohei Kaseda, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Yuki Higuchi, Valentina Kon, Ichiei Narita, Akihiko Saito
Summary: The study found that a rice endosperm protein (REP)-based diet has better efficacy in reducing renal injury-driven atherosclerosis compared to a casein-based diet, potentially due to the anti-inflammatory effects of HDL.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Urology & Nephrology
Yuko Oyama, Yoichi Iwafuchi, Ichiei Narita
Summary: This case study highlights the uncommon occurrence of adrenal insufficiency and hypercalcemia as a result of glucocorticoid withdrawal in a hemodialysis patient. The patient's long-term use of glucocorticoids for nephrotic syndrome led to difficulties in tapering the medication and ultimately resulted in end-stage renal failure. Awareness of these potential complications is crucial for clinicians managing similar cases.
Article
Urology & Nephrology
Shuzo Kaneko, Kunihiro Yamagata, Joichi Usui, Naotake Tsuboi, Hitoshi Sugiyama, Shoichi Maruyama, Ichiei Narita
Summary: This study found that with the passage of time, the survival rates and renal survival rates of RPGN patients have improved. Clinical severity was found to predict prognosis effectively, with anti-glomerular basement membrane disease-RPGN having a poorer renal prognosis compared to other diseases, while the prognostic results for anti-neutrophil cytoplasmic antibody-associated vasculitis-RPGN were similar to overall RPGN.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Urology & Nephrology
Reiko Okubo, Masahide Kondo, Shu-Ling Hoshi, Hirayasu Kai, Chie Saito, Kunitoshi Iseki, Chiho Iseki, Tsuyoshi Watanabe, Ichiei Narita, Seiichi Matsuo, Hirofumi Makino, Akira Hishida, Kunihiro Yamagata
Summary: This study found that incorporating a behavior modification intervention into the practice guidelines for chronic kidney disease is cost-effective. It is estimated that the number of patients with end-stage kidney disease would decrease, leading to a reduction in healthcare expenditure. Providing economic incentives to general physicians and strengthening guideline recommendations are suggested.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Correction
Urology & Nephrology
Reiko Okubo, Shu-Ling Hoshi, Tomokazu Kimura, Masahide Kondo, Koichi Asahi, Chiho Iseki, Shouichi Fujimoto, Ichiei Narita, Hiroyuki Nishiyama, Kunihiro Yamagata, Kunitoshi Iseki
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Correction
Urology & Nephrology
Keiichi Matsuzaki, Ryousuke Aoki, Yoshihito Nihei, Hitoshi Suzuki, Masao Kihara, Takashi Yokoo, Naoki Kashihara, Ichiei Narita, Yusuke Suzuki
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Urology & Nephrology
Reiko Okubo, Shu-Ling Hoshi, Tomokazu Kimura, Masahide Kondo, Koichi Asahi, Chiho Iseki, Shouichi Fujimoto, Ichiei Narita, Hiroyuki Nishiyama, Kunihiro Yamagata, Kunitoshi Iseki
Summary: This study evaluated the cost-effectiveness of mass screening for dipstick hematuria tests in addition to the Specific Health Checkup (SHC) program in Japan. The results showed that adding the dipstick hematuria test to the SHC program is cost-saving and efficient in utilizing healthcare resources. The findings have implications for mass screening programs not only in Japan but worldwide.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Urology & Nephrology
Keiichi Matsuzaki, Ryousuke Aoki, Yoshihito Nihei, Hitoshi Suzuki, Masao Kihara, Takashi Yokoo, Naoki Kashihara, Ichiei Narita, Yusuke Suzuki
Summary: A survey conducted by the Japanese Society of Nephrology revealed that most patients with gross hematuria after receiving the COVID-19 vaccine were already diagnosed with IgAN. Some of these patients developed proteinuria and hematuria after vaccination, but there were no cases of severe renal dysfunction observed.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Letter
Endocrinology & Metabolism
Minako Wakasugi, Akio Yokoseki, Masakazu Wada, Takeshi Momotsu, Kenji Sato, Hiroyuki Kawashima, Kazutoshi Nakamura, Osamu Onodera, Ichiei Narita
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Endocrinology & Metabolism
Minako Wakasugi, Akio Yokoseki, Masakazu Wada, Takeshi Momotsu, Kenji Sato, Hiroyuki Kawashima, Kazutoshi Nakamura, Osamu Onodera, Ichiei Narita
Summary: Polypharmacy is associated with an increased risk of fragility fracture, especially in patients with hyperpolypharmacy. The impact of hyperpolypharmacy on incident fragility fractures is particularly strong in dialysis-dependent CKD patients.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Physiology
Keiko Kabasawa, Ribeka Takachi, Kazutoshi Nakamura, Norie Sawada, Shoichiro Tsugane, Yumi Ito, Junta Tanaka, Ichiei Narita, Kunihiro Matsushita
Summary: This study investigated the association between urinary sodium-to-potassium ratio and albuminuria in a community-dwelling Japanese adult population. The results showed that both spot urinary and dietary sodium-to-potassium ratios were associated with elevated albuminuria. These findings suggest a link between sodium intake and kidney damage.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ichiei Narita, Terumasa Hayashi, Shoichi Maruyama, Takao Masaki, Masaomi Nangaku, Tomoya Nishino, Hiroshi Sato, Tadashi Sofue, Takashi Wada, Enyu Imai, Manabu Iwasaki, Kyoichi Mizuno, Hiroki Hase, Masahiro Kamouchi, Hiroyasu Yamamoto, Tatsuo Kagimura, Kenichiro Tanabe, Hideki Kato, Takehiko Wada, Tomoko Usui, Tadao Akizawa, Hideki Hirakata, Yoshiharu Tsubakihara
Summary: In non-dialysis-dependent chronic kidney disease (ND-CKD) patients, low hematopoietic response to erythropoiesis-stimulating agents (ESAs) is associated with poor renal and cardiovascular outcomes. The responsiveness of ESAs can be evaluated using a specific formula, and it can predict renal and cardiovascular events. Therefore, identifying the causes of poor response and taking appropriate measures are important in such patients.
Article
Genetics & Heredity
Hirofumi Watanabe, Shin Goto, Michihiro Hosojima, Hideyuki Kabasawa, Naofumi Imai, Yumi Ito, Ichiei Narita
Summary: We report a case of Alport syndrome with a family history of impaired glucose tolerance. Whole exome sequencing identified a novel heterozygous variant of the COL4A5 gene and a rare variant of the GCK gene as the causes of Alport syndrome and monogenic diabetes, respectively. Two independent pathogenic variants affected the clinical phenotypes. Clinical next-generation sequencing is helpful for identifying the causes of patients' manifestations.
HUMAN GENOME VARIATION
(2023)
Article
Nutrition & Dietetics
Minako Wakasugi, Akio Yokoseki, Masakazu Wada, Takeshi Momotsu, Kenji Sato, Hiroyuki Kawashima, Kazutoshi Nakamura, Osamu Onodera, Ichiei Narita
Summary: This Japanese hospital-based study found that consuming fewer vegetables and fruits is associated with a higher risk of death, regardless of the presence of chronic kidney disease.
JOURNAL OF RENAL NUTRITION
(2023)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
