Article
Clinical Neurology
Chi-Ying R. Lin, Anisha Viswanathan, Tiffany X. Chen, Hiroshi Mitsumoto, Jean P. Vonsattel, Phyllis L. Faust, Sheng-Han Kuo
Summary: This study found that high pyramidal scores in MSA cases are associated with the parkinsonian subtype, laryngeal stridor, and certain autonomic dysfunction.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Oncology
Florence Boissiere-Michot, Ghita Chabab, Caroline Mollevi, Severine Guiu, Evelyne Lopez-Crapez, Jeanne Ramos, Nathalie Bonnefoy, Virginie Lafont, William Jacot
Summary: The study revealed that high gamma delta T cell density was significantly associated with younger age, higher tumor grade, adjuvant chemotherapy, BRCA1 promoter methylation, TIL density, and PD-L1/PD-1 expression in triple-negative breast cancer patients, and served as an independent prognostic factor, especially in those with wild-type PIK3CA tumors.
Article
Endocrinology & Metabolism
Angela De la Hoz Rodriguez, Jose Luis Munoz De Nova, Patricia Munoz Hernandez, Alvaro Valdes de Anca, Rosario Serrano Pardo, Rodrigo Tovar Perez, Elena Martin-Perez
Summary: This study focused on the role of oxyphil cells (OxC) in patients with primary hyperparathyroidism (PHPT), finding that a high content of OxC appears to be exclusive to pathologic glands and may be associated with deterioration of renal function in patients with PHPT.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Dan Wang, Li Peng, Li Hua, Jiaxiang Li, Yifei Liu, Yanhong Zhou
Summary: This study investigated the association between Mapk14 expression and clinicopathological features, tumor-infiltrating immune cells, and DNA methylation in colorectal cancer. The results showed that Mapk14 was upregulated in colorectal tumor tissues and its high expression was associated with poor clinicopathological features and poor prognoses. Additionally, Mapk14 was found to be significantly correlated with immune infiltration, immune checkpoints, tumor mutational load, and drug sensitivity. These findings suggest that Mapk14 could serve as a prognostic biomarker and a potential therapeutic target for colorectal cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengping Long, Chong You, Qianqian Song, Lina X. J. Hu, Zhaorong Guo, Qian Yao, Wei Hou, Wei Sun, Baosheng Liang, Xiaohua Zhou, Yiqiang Liu, Taobo Hu
Summary: This study analyzed the expression of androgen receptor (AR) in both estrogen receptor (ER)-positive and ER-negative breast cancer, and its association with clinicopathological and molecular features. The results showed that AR negativity was associated with different characteristics in ER-positive and ER-negative breast cancer. AR-positive breast cancer had better clinicopathological features, especially in the ER-negative subtype. These findings suggest a distinctive role of AR in ER-negative breast cancer compared to ER-positive breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Anne Gomez-Brouchet, Claire Illac, Adeline Ledoux, Pierre-Yves Fortin, Sandra de Barros, Clementine Vabre, Fabien Despas, Sophie Peries, Christelle Casaroli, Corinne Bouvier, Sebastien Aubert, Gonzague de Pinieux, Frederique Larousserie, Louise Galmiche, Franck Talmont, Stuart Pitson, Marie-Lise Maddelein, Olivier Cuvillier
Summary: The SphK1/S1P signaling pathway is involved in the regulation of HIF-1 alpha expression in osteosarcoma under hypoxia. Inhibiting SphK1 and S1P(1) receptor may be a potential treatment target for osteosarcoma patients. Overexpression of SphK1 and S1P(1) is related to hypoxia marker GLUT-1 in osteosarcoma.
Article
Endocrinology & Metabolism
Nardeen B. Dawood, Chi-Hong Tseng, Dalena T. Nguyen, Kimberly L. Yan, Masha J. Livhits, Angela M. Leung, Michael W. Yeh
Summary: PHPT, a common cause of hypercalcemia and secondary osteoporosis, is often underdiagnosed. A retrospective cohort study revealed that more than half of patients with confirmed hypercalcemia were not assessed for PHPT, leading to missed opportunities to avoid skeletal and other complications. Care gaps in BMD assessment and therapy represent areas for improvement in PHPT management.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Urology & Nephrology
Gabrielle K. Steinl, Jennifer H. Kuo
Summary: Secondary hyperparathyroidism (SHPT) is common in patients with chronic kidney disease, and those who fail medical treatment should be referred to a parathyroid surgeon. Surgical indications, preoperative planning, intraoperative strategies, and postoperative management are crucial.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Nutrition & Dietetics
Maciej Kolodziej, Marek Saracyn, Arkadiusz Lubas, Miroslaw Dziuk, Adam Daniel Durma, Jerzy Smoszna, Grzegorz Zelichowski, Stanislaw Niemczyk, Grzegorz Kaminski
Summary: This study aimed to evaluate the usefulness of positron emission tomography/computed tomography (PET/CT) in the preoperative localization diagnosis of patients with tertiary hyperparathyroidism (tHP). The results showed that PET/CT had a high sensitivity in accurately localizing abnormal parathyroid glands, making it a valuable choice for preoperative imaging in patients with tHP.
Article
Genetics & Heredity
Rui Chen, Xinyang Wang, Jingyue Fu, Mengdi Liang, Tiansong Xia
Summary: The study found that in breast cancer, FLT3 plays a role in predicting prognosis, is related to immune infiltration, and may pave the way for the development of novel immunotherapies.
FRONTIERS IN GENETICS
(2022)
Article
Surgery
Sophie Dream, Herbert Chen, Brenessa Lindeman
Summary: Persistent hyperparathyroidism after renal transplant negatively affects allograft function, but referral for definitive treatment of THPT is often delayed, leading to potential improvement in renal function with earlier referral.
Article
Medicine, General & Internal
Hye Ryeon Choi, Sun Hyung Choi, Namki Hong, Yumie Rhee, Jin Kyong Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung
Summary: Normocalcemic primary hyperparathyroidism (NPHPT) is a heterogeneous disease entity of primary hyperparathyroidism, characterized by high rates of multi-gland disease and mild biochemical abnormalities but symptomatic presentation. Intraoperative PTH monitoring may improve surgical outcomes, and short-term outcomes after surgery are similar to those of typical primary hyperparathyroidism (TPHPT).
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Neurosciences
Shailaja Balakumar, Rekha Pai, Ari G. Chacko, Bimal Patel, Rachel Nancy, Rajesh Balakrishnan, Sauradeep Sarkar, Gowri Sampath, Geeta Chacko
Summary: This study classified molecular subtypes of gliomas by detecting TERT promoter mutations and other molecular alterations, and found that different molecular subtypes were associated with prognosis. TERT promoter mutations occurred frequently in specific subtypes and were associated with shorter survival.
Review
Endocrinology & Metabolism
Li-Xi Zhang, Ben Zhang, Xu-Yao Liu, Zi-Ming Wang, Peng Qi, Tong-Yue Zhang, Qiang Zhang
Summary: Secondary and tertiary hyperparathyroidism are common and complicated endocrine diseases, and their hyperactivity disorder can cause structural alterations in multiple organs and systems. The current treatment for these diseases remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Adrien Latge, Sophie Riehm, Michel Vix, Jacob Bani, Mihaela Ignat, Valentin Pretet, Mehdi Helali, Giorgio Treglia, Alessio Imperiale
Summary: The study evaluated the use of F-18-fluorocholine PET/CT and 4D-CT in patients with primary hyperparathyroidism. Results showed that PET/CT had significantly higher sensitivity than 4D-CT, but the combination of the two techniques did not improve sensitivity or detection rate. This technique seems to be valuable in accurately detecting hyperfunctioning parathyroid tissue before reoperation.
Article
Endocrinology & Metabolism
Hande Turan, Gurkan Tarcin, Ozgur Mete, Ada Bulut Sinoplu, Saadet Olcay Evliyaoglu, Buge Oz, Oya Ercan
Summary: We report a rare case of silent corticotroph tumor coexisting with adrenocortical choristoma in an 11-year-old boy. It is a very rare entity and the underlying mechanism is not fully understood.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Valentina Tassi, Elisa Scarnecchia, Piero Ferolla, Ozgur Mete, Maganti Manjula, Frances Allison, Rossella Potenza, Jacopo Vannucci, Silvia Ceccarelli, Kazuhiro Yasufuku, Marc De Perrot, Andrew Pierre, Gail Darling, Renato Colella, Stefano Ascani, Sandro Mattioli, Shaf Keshavjee, Thomas Kenneth Waddell, Francesco Puma, Niccolo Daddi
Summary: The clinical significance of multifocal pulmonary neuroendocrine proliferation (MNEP) in association with typical carcinoid (TC) is still debated. This study found that MNEP may be a relevant factor in the prognosis of TC patients. Therefore, thorough preoperative evaluation, systematic pathological evaluation, and long-term postoperative follow-up should be recommended for TC patients.
ANNALS OF THORACIC SURGERY
(2022)
Editorial Material
Endocrinology & Metabolism
Sylvia L. Asa, Lori A. Erickson, Ozgur Mete
ENDOCRINE PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Lucy X. Ma, Osvaldo Espin-Garcia, Philippe L. Bedard, Tracy Stockley, Rebecca Prince, Ozgur Mete, Monika K. Krzyzanowska
Summary: This study analyzes the actionability and clinical use of NGS results in advanced thyroid cancer. Most patients had at least one potentially actionable mutation and 57% of patients had at least one Level 1 or 2 alteration, predominantly driven by BRAF V600E and RET alterations. This study rationalizes the need for routine multigene NGS testing or reflex BRAF and RET testing in the management of patients with advanced thyroid cancer.
Article
Genetics & Heredity
Leslie E. Oldfield, Jessica Grzybowski, Sylvie Grenier, Elizabeth Chao, Gregory S. Downs, Kirsten M. Farncombe, Tracy L. Stockley, Ozgur Mete, Raymond H. Kim
Summary: This report highlights the importance of tissue testing in VHL variant negative cases, using a rare case of VHL mosaicism as an example.
NPJ GENOMIC MEDICINE
(2022)
Editorial Material
Endocrinology & Metabolism
Sylvia L. Asa, Ozgur Mete
ENDOCRINE PATHOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Ozgur Mete, Sylvia L. Asa
Article
Endocrinology & Metabolism
Renee Hofstedter, Maria Carolina Sanabria-Salas, Maria Di Jiang, Shereen Ezzat, Ozgur Mete, Raymond H. Kim
Summary: Adrenal cortical carcinoma is a rare and aggressive malignancy that originates from steroidogenic cells of the adrenal gland. It is often sporadic but can be associated with inherited tumor syndromes. There have been very few reports of adrenal cortical neoplasia in patients with BHD syndrome. We present a case of adrenal cortical carcinoma in a 50-year-old female with a germline pathogenic variant in the FLCN gene. Genetic testing revealed the same variant in the tumor, suggesting its contribution to the pathogenesis of adrenal cortical carcinoma. This case expands our understanding of BHD syndrome and highlights the importance of genetic testing for FLCN in patients with adrenal cortical carcinomas.
ENDOCRINE PATHOLOGY
(2023)
Review
Oncology
C. Christofer Juhlin, Ozgur Mete, Zubair W. Baloch
Summary: The World Health Organization has released the fifth edition of the Classification of Endocrine and Neuroendocrine Tumors. This publication includes changes to the nomenclature of thyroid diseases and introduces novel concepts important for patient management. The classification now groups non-neoplastic and benign neoplastic lesions under 'thyroid follicular nodular disease', reflecting their clonal and non-clonal proliferations in multinodular goiter. Thyroid neoplasms originating from follicular cells are categorized into benign, low-risk, and malignant neoplasms, emphasizing the subtyping of papillary thyroid carcinoma based on histomorphologic features and redefining the cribriform-morular variant as cribriform-morular thyroid carcinoma. The review highlights the key changes in the fifth edition and their impact on patient management and future directions in this field.
ENDOCRINE-RELATED CANCER
(2023)
Letter
Endocrinology & Metabolism
Ozgur Mete, C. Christofer Juhlin
ENDOCRINE PATHOLOGY
(2023)
Article
Endocrinology & Metabolism
Sylvia L. Asa, Ozgur Mete, Nicole D. Riddle, Arie Perry
Summary: This study identified a rare type of pituitary neuroendocrine tumors (PitNETs) that express both PIT1 and SF1 transcription factors. These tumors exhibit variable clinical and morphological features, commonly presenting as large tumors with growth hormone excess and occasionally coexisting with other types of PitNETs.
ENDOCRINE PATHOLOGY
(2023)
Article
Endocrinology & Metabolism
Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete
Summary: This review provides an overview of the molecular genetics, pathology, and treatment of medullary thyroid carcinoma (MTC). It emphasizes the importance of distinguishing MTC from other neuroendocrine tumors and recommends routine testing for RET gene mutations in all MTC patients, as well as somatic RET alterations in advanced/progressive or metastatic diseases. Additionally, the option of Lu-177-DOTATATE peptide radionuclide receptor therapy may benefit patients with SSTR-avid metastatic disease. Lastly, the authors call for a change in the nomenclature of MTC to C-cell neuroendocrine neoplasm to align with the IARC/WHO taxonomy.
ENDOCRINE PATHOLOGY
(2023)
Book Review
Endocrinology & Metabolism
Ozgur Mete
ENDOCRINE PATHOLOGY
(2023)
Book Review
Endocrinology & Metabolism
Ozgur Mete
ENDOCRINE PATHOLOGY
(2023)
Article
Pathology
Ozgur Mete, Bruce M. Wenig
Summary: This review article provides a brief overview of the new WHO classification for head and neck neuroendocrine neoplasms. It discusses the spectrum of these neoplasms, diagnostic criteria, and offers insights into the role of biomarkers and molecular immunohistochemistry in accurate diagnosis. The article emphasizes the importance of morphology and immunohistochemical findings in the classification and diagnosis of neuroendocrine neoplasms.
HEAD & NECK PATHOLOGY
(2022)
