Article
Medical Laboratory Technology
Jan Van Elslande, Samira Hijjit, Katrien De Vusser, Michel Langlois, Bjorn Meijers, Ann Mertens, Bart Van Der Schueren, Glynis Frans, Pieter Vermeersch
Summary: This case highlights the delicate balance between avoiding unreliable results due to lipemia and the risk of delayed diagnosis when results are rejected. Providing an estimate of the degree of hypertriglyceridemia might be preferable to rejecting the result.
Review
Pharmacology & Pharmacy
Melody Hermel, Madison Lieberman, Leandro Slipczuk, Jamal S. Rana, Salim S. Virani
Summary: This article provides an update on the use of monoclonal antibodies, gene silencing therapies, and gene editing techniques for the management of hyperlipidemia. It reviews the cutting-edge pharmaceuticals targeting LDL cholesterol, PCSK9, lipoprotein (a), angiopoietin-like 3, and apolipoprotein C3. The available and upcoming biotechnological lipid therapies are discussed for clinicians managing patients with familial hyperlipidemia, statin intolerance, hypertriglyceridemia, or elevated lipoprotein (a) levels.
Article
Endocrinology & Metabolism
Sang-Ho Jo, Hyewon Nam, Jeongwoo Lee, Sojeong Park, Jungkuk Lee, Dae-Sung Kyoung
Summary: The study showed that the use of fenofibrate was associated with lower rates of total and cardiac mortality and cardiovascular events in patients with type 2 diabetes during a 3-year follow-up in real-world large populations.
Article
Health Care Sciences & Services
Zunaira Ali Baig, Amir Rashid, Asifa Majeed, Zahra Masood, Asma Faryal, Zahra Arshad Khan, Aden Razaq
Summary: This study assessed lipid abnormalities in newly diagnosed diabetics and non-diabetics and found that regardless of type 2 diabetes, lipid levels can independently cause derangement, which serves as an early onset indicator rather than a later-stage complication. These derangements of lipid levels are an independent risk factor for future cardiovascular pathology.
Article
Nutrition & Dietetics
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: This study aimed to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase-mediated VLDL-triglyceride lipolysis, as well as the role of HDL in this process. The results showed that VLDL from patients with hypercholesterolemia and hypertriglyceridemia are more resistant to lipolysis, with HDL helping to enhance the efficiency of lipolysis in these groups.
Article
Veterinary Sciences
Matthew J. L. Munro, Sean E. Hulsebosch, Stanley L. Marks, Chen Gilor
Summary: The study found that the micronized, nanocrystal formulation of fenofibrate was effective in treating hyperlipidemia in dogs, normalizing serum triglyceride concentrations and decreasing serum cholesterol concentrations significantly.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Bai-Hui Zhang, Fan Yin, Ya-Nan Qiao, Shou-Dong Guo
Summary: Cardiovascular disease (CVD) is the leading cause of death globally, with atherosclerosis as its main pathological basis. The causal association between elevated triglyceride levels and atherosclerotic CVD (ASCVD) has been controversial, but recent studies have shown that triglycerides are the main causal risk factors for residual ASCVD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medical Laboratory Technology
Junji Kobayashi, Takuya Minamizuka, Masaya Koshizaka, Yoshiro Maezawa, Hiraku Ono, Koutaro Yokote
Summary: The study found that serum HDL-C is an extremely useful marker for discriminating LPL deficiency from SHTG in the Japanese population, with high sensitivity and specificity, which can serve as an important indicator of the type of disease in patients.
CLINICA CHIMICA ACTA
(2021)
Article
Medical Laboratory Technology
Victoria Higgins, Lawrence A. Leiter, Sarah R. Delaney, Daniel R. Beriault
Summary: The study validated the superiority of the NIH LDL-C equation over the Friedewald equation, particularly in patients with hypertriglyceridemia and/or low LDL-C. The NIH equation showed a stronger correlation with ultracentrifugation LDL-C and improved accuracy after applying restriction criteria, making it a more reliable choice for lipid management in clinical practice.
CLINICAL BIOCHEMISTRY
(2022)
Article
Medical Laboratory Technology
Chuan Zheng, Weiyan Zhou, Ruyi Zhou, He Zhang, Shanshan Liang, Wen Zhang, Guixing Li, Chuanbao Zhang, Wei Gan
Summary: This study found that vitamin C, glycerol fructose, lipoprotein X, and lipemia significantly interfere with serum lipid analysis. Improvements in reagent formulation are necessary to ensure reliable results.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Shuping Wang, Yiping Cheng, Yingzhou Shi, Wanyi Zhao, Ling Gao, Li Fang, Xiaolong Jin, Xiaoyan Han, Qiuying Sun, Guimei Li, Jiajun Zhao, Chao Xu
Summary: This study identified two novel compound heterozygous variants of LPL, which resulted in defects in the expression and function of LPL and caused type I hyperlipoproteinemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Denis Sviridov, Amaury Dasseux, Mart Reimund, Milton Pryor, Steven K. Drake, Zack Jarin, Anna Wolska, Richard W. Pastor, Alan T. Remaley
Summary: A new generation of ApoC2 mimetic peptides based on hydrocarbon stapling and amino acid substitutions have been developed in this study. These peptides effectively lower plasma triglycerides and are shorter and more resistant to proteolysis compared to earlier peptides, which makes them a potential new therapy for hypertriglyceridemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Takaaki Kosugi, Masahiro Eriguchi, Hisako Yoshida, Hikari Tasaki, Fumihiro Fukata, Masatoshi Nishimoto, Masaru Matsui, Ken-Ichi Samejima, Kunitoshi Iseki, Shouichi Fujimoto, Tsuneo Konta, Toshiki Moriyama, Kunihiro Yamagata, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Masahide Kondo, Koichi Asahi, Tsuyoshi Watanabe, Kazuhiko Tsuruya
Summary: Chronic kidney disease (CKD) is associated with a higher risk of new-onset dyslipidemia, including high triglycerides, low high-density lipoprotein cholesterol, and high triglycerides/high-density lipoprotein cholesterol ratios, in the general population. These specific lipid abnormalities in CKD patients may contribute to the increased risk of cardiovascular disease.
Article
Pharmacology & Pharmacy
Jose Rioja, Maria Jose Ariza, Maria Jose Benitez-Toledo, Javier Espildora-Hernandez, Inmaculada Coca-Prieto, Teresa Arrobas-Velilla, Ana Camacho, Gunilla Olivecrona, Miguel Angel Sanchez-Chaparro, Pedro Valdivielso
Summary: This study aimed to establish and validate cut-off points for the diagnosis of familial chylomicronemia syndrome (FCS) based on the ROC curve. The results showed that all FCS patients had post-heparin plasma lipoprotein lipase (LPL) activity below 25.1 mU/mL, with no overlap between FCS and multifactorial chylomicronemia syndrome (MCS) groups. Therefore, in addition to genetic testing, LPL activity in subjects with severe hypertriglyceridemia can serve as a reliable criterion for FCS diagnosis with a cut-off of 25.1 mU/mL.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Multidisciplinary Sciences
Chad A. Brautigam, Ranjit K. Deka, Shih-Chia Tso, Wei Z. Liu, Michael V. Norgard
Summary: The mechanisms of energy generation and carbon-source utilization in Treponema pallidum have been unclear, but recent studies suggest the presence of an acetogenic energy-conservation pathway and confirm the activity of one of the enzymes involved.
Article
Veterinary Sciences
Betty Chow, Steve L. Hill, Keith P. Richter, Sina Marsilio, Mark R. Ackermann, Jonathan A. Lidbury, Jan S. Suchodolski, Sarah Cocker, Jorg M. Steiner
Summary: Integrating IHC and clonality testing increased the number of LSA cases diagnosed, with moderate agreement between USI and LSI samples. LSI samples rarely changed the diagnosis.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Sina Marsilio, Floris C. Droes, Lawrence Dangott, Betty Chow, Steve Hill, Mark Ackermann, J. Scott Estep, Jonathan A. Lidbury, Jan S. Suchodolski, Jorg M. Steiner
Summary: This study characterized the mucosal proteome in cats with lymphoplasmacytic enteritis (LPE) and small cell lymphoma (SCL), identifying differentially expressed proteins but not confirming potential biomarkers. Future research should focus on alternative techniques to identify biomarkers for cats with chronic enteropathies.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Melanie Werner, Jan S. Suchodolski, Jonathan A. Lidbury, Jorg M. Steiner, Katrin Hartmann, Stefan Unterer
Summary: The study found that fecal cultures were ineffective in distinguishing between dogs with chronic diarrhea and healthy dogs, and there was a high level of variability in culture results among different laboratories.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Linda Toresson, Joerg M. Steiner, Eva Spodsberg, Gunilla Olmedal, Jan S. Suchodolski, Jonathan A. Lidbury, Thomas Spillmann
Summary: This study showed that oral cobalamin supplementation is a potential alternative to parenteral supplementation in dogs with exocrine pancreatic insufficiency (EPI), significantly increasing serum cobalamin concentrations.
VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Carolyn E. Arnold, Rachel Pilla, M. Keith Chaffin, Jessica L. Leatherwood, Tryon A. Wickersham, Todd R. Callaway, Sara D. Lawhon, Jonathan A. Lidbury, Joerg M. Steiner, Jan S. Suchodolski
Summary: This study examined the influence of various factors on the fecal microbiota of healthy horses, revealing that the amount of grain in the diet and colitis had significant effects. Horses with AAD showed more severe dysbiosis compared to those with Salmonella infection.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Review
Veterinary Sciences
Jan S. Suchodolski
Summary: The gut microbiome plays a crucial role in maintaining immune and metabolic functions, with impact on intestinal and overall organ health. Dysbiosis concept continues to evolve, with molecular tools becoming the standard for microbiome analysis, though challenges in standardization and result consistency persist. The Dysbiosis Index is a useful tool for assessing microbiome status in clinical patients.
VETERINARY CLINICAL PATHOLOGY
(2022)
Article
Veterinary Sciences
Sarah E. Cocker, Yuri A. Lawrence, Jonathan A. Lidbury, Jan S. Suchodolski, Jorg M. Steiner, Keith P. Richter
Summary: Long-term administration of supraphysiologic doses of GCs significantly increases serum cPLI concentrations in sick dogs, although the change is small and often clinically insignificant, it may pose a clinical interpretation dilemma in some dogs.
VETERINARY CLINICAL PATHOLOGY
(2022)
Article
Veterinary Sciences
I. L. Oikonomidis, K. Theodorou, E. Papaioannou, P. G. Xenoulis, K. K. Adamama-Moraitou, J. M. Steiner, M. Kritsepi-Konstantinou, J. S. Suchodolski, T. Rallis, N. Soubasis
Summary: This study investigated the changes in thyroid hormone concentrations in dogs with canine parvoviral enteritis during hospitalization and found an association between thyroid hormones and prognosis, as well as the development of systemic inflammatory response syndrome.
VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Elisabeth Skotnitzki, Jan S. Suchodolski, Kathrin Busch, Melanie Werner, Yury Zablotski, Bianca D. Ballhausen, Felix Neuerer, Stefan Unterer
Summary: The study reported a higher prevalence of signs of chronic GI disease in dogs after an episode of acute hemorrhagic diarrhea (AHD), possibly due to severe intestinal mucosal damage and associated barrier dysfunction triggering chronic GI disease later in life.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Panagiotis G. Xenoulis, Romy M. Heilmann, Eva M. Stavroulaki, Denise S. Riggers, Laura J. Gneipel, Jan S. Suchodolski, Jorg M. Steiner
Summary: This study investigated the association between HTGL and IR as well as the subclinical inflammatory phenotype in Miniature Schnauzers. It was found that HTGL in these dogs was associated with increased serum calprotectin concentrations, and dietary intervention led to a decrease in serum insulin concentrations.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Chee-Hoon Chang, Jonathan A. Lidbury, Jan S. Suchodolski, Joerg M. Steiner
Summary: This study found that oral supplementation is an alternative to injectable supplementation for cobalamin supplementation in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
F. C. Droes, J. S. Suchodolski, J. M. Steiner, J. A. Lidbury
Summary: This study aimed to estimate the prevalence and describe the clinical and laboratory data of dogs with chronic hepatitis and portal vein thrombosis and splanchnic venous thrombosis. The study found that portal vein and splanchnic venous thrombosis are potentially serious complications that were identified in a relatively low proportion of dogs with chronic hepatitis.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
Article
Veterinary Sciences
Michael Hung, Justin Heinz, Jorg M. Steiner, Jan Suchodolski, Jonathan Lidbury
Summary: This study evaluated serum cobalamin and methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or nonparvoviral acute enteropathy. The results showed that juvenile dogs with parvoviral enteritis or nonparvoviral acute enteropathy had lower serum cobalamin concentrations than healthy juvenile dogs, but cellular cobalamin deficiency was not apparent based on serum MMA concentrations.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Rae Mcatee, Sarah M. Schmid, M. Katherine Tolbert, Scott Hetzel, Jan S. Suchodolski, Jessica C. Pritchard
Summary: In healthy dogs, concurrent administration of a probiotic does not mitigate the adverse effects caused by esomeprazole administration. However, it does lead to an increase in fecal dysbiosis index.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Sharon Kuzi, Soha Zgairy, Barbara A. Byrne, Jan Suchodolski, Sondra C. Turjeman, So Young Park, Itamar Aroch, Mike Hong, Omry Koren, Eran Lavy
Summary: This study investigated the fecal microbiome features in dogs with giardiasis and found that the fecal microbial composition of symptomatic and asymptomatic dogs with giardiasis is similar. Giardiasis is not characterized by prominent dysbiosis based on fecal dysbiosis index (DI).
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)