A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Pathogenic Mechanisms of HIV Disease

(2011) Susan Moir et al.   Annual Review of Pathology-Mechanisms of Disease

The Transcription Factor STAT3 Is Required for T Helper 2 Cell Development

(2011) Gretta L. Stritesky et al.   IMMUNITY

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

High TCR Stimuli Prevent Induced Regulatory T Cell Differentiation in a NF- B-Dependent Manner

(2011) L. L. Molinero et al.   JOURNAL OF IMMUNOLOGY

A Mathematical Model for the Reciprocal Differentiation of T Helper 17 Cells and Induced Regulatory T Cells

(2011) Tian Hong et al.   PLoS Computational Biology

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Functional Motifs in Biochemical Reaction Networks

(2010) John J. Tyson et al.   Annual Review of Physical Chemistry

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

(2010) Ryuta Mukasa et al.   IMMUNITY

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

RORC2 Is Involved in T Cell Polarization through Interaction with the FOXP3 Promoter

(2010) S. Burgler et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3

(2010) Takashi Maruyama et al.   NATURE IMMUNOLOGY

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

The TCR-mediated signaling pathways that control the direction of helper T cell differentiation

(2010) Toshinori Nakayama et al.   SEMINARS IN IMMUNOLOGY

Diversity and Plasticity of Th Cell Types Predicted from Regulatory Network Modelling

(2010) Aurélien Naldi et al.   PLoS Computational Biology

Integration of Distinct Intracellular Signaling Pathways at Distal Regulatory Elements Directs T-bet Expression in Human CD4+ T Cells

(2009) K. Placek et al.   JOURNAL OF IMMUNOLOGY

Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles

(2009) Sara Abromson-Leeman et al.   JOURNAL OF NEUROIMMUNOLOGY

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor ROR t

(2009) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal Organization of the Cell Cycle

(2008) John J. Tyson et al.   CURRENT BIOLOGY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

From the two-dimensional Th1 and Th2 phenotypes to high-dimensional models for gene regulation

(2008) Henk-Jan van den Ham et al.   INTERNATIONAL IMMUNOLOGY

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels

(2008) O. Feinerman et al.   SCIENCE

Multistable Decision Switches for Flexible Control of Epigenetic Differentiation

(2008) Raúl Guantes et al.   PLoS Computational Biology