Article
Medicine, General & Internal
Jinxia Wu, Jing Chen, Rong Huang, Hongwei Zhu, Lin Che, Yanyan Lin, Yajie Chang, Guiping Shen, Jianghua Feng
Summary: This study aimed to screen specific biomarkers of premature thelarche (PT) and central precocious puberty (CPP) and elucidate their underlying pathogenesis. The relationships between clinical phenotype, serum perfluorinated compounds (PFCs), and metabolic characteristics were explored. The results showed a similar disordered trend of pyruvate and butyrate metabolisms in PT and CPP. Specific biomarkers were screened for PT and CPP, and they exhibited good sensitivity for classification diagnosis. PFC exposure is associated with endocrine homeostasis imbalance and drives metabolic changes in CPP and PT.
Article
Endocrinology & Metabolism
Daniela Fava, Andrea Calandrino, Maria Grazia Calevo, Anna Elsa Maria Allegri, Flavia Napoli, Roberto Gastaldi, Giuseppa Patti, Emilio Casalini, Marta Bassi, Andrea Accogli, Abdel Razaq Ahmad A. Alyasin, Antonia Ramaglia, Andrea Rossi, Mohamad Maghnie, Giovanni Morana, Natascia Di Iorgi
Summary: The study investigated the presence of brain abnormalities in girls diagnosed with central precocious puberty (CPP) and explored the relationship between maternal factors, age at diagnosis, clinical signs and symptoms, hormonal profiles, and neuroimaging findings. The results showed that less than half of the girls had a normal brain MRI, and a few had significant intracranial lesions after the age of 6, even without neurological signs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
Summary: The Notch signaling pathway plays a role in regulating cell activities in multiple systems, including the hypothalamus. Recent studies have found that genetic mutations related to the Notch signaling pathway may be associated with central precocious puberty.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mei Li, Dan Lan, Yanfei Chen
Summary: Our study is the first to integrate proteomics and metabolomics to analyze the serum of girls with CPP and we found some key differential proteins and metabolites as well as a potential biomarker for this condition. Lipid metabolism pathways are involved and these may provide a key direction to further explore the molecular mechanisms and pathogenesis of CPP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Shoko Yoshii, Tomozumi Takatani, Tadashi Shiohama, Rieko Takatani, Yutaka Konda, Shinya Hattori, Hajime Yokota, Hiromichi Hamada
Summary: This study examined the structural differences in the brain of patients with central precocious puberty (CPP). The results showed specific morphological differences in the brain scans of patients with CPP compared to control group, which can contribute to understanding the association between CPP and negative psychological outcomes.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Nutrition & Dietetics
Galateia Stathori, Anastasia-Maria Tzounakou, George Mastorakos, Nikolaos F. Vlahos, Evangelia Charmandari, Georgios Valsamakis
Summary: The prevalence of central precocious puberty (CPP) in girls has been increasing worldwide and is often associated with childhood obesity and diet. Evidence suggests that girls with obesity have alterations in appetite-regulating hormones, potentially affecting the onset of puberty. Additionally, diet-induced hypothalamic inflammation may play a role in the pathophysiology of CPP, leading to changes in appetite-regulating hormones in young children.
Article
Medicine, General & Internal
Shin-Hee Kim, Moon Bae Ahn, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Byung-Kyu Suh
Summary: Positive MRI findings were similar in girls with CPP and girls evaluated for headaches, suggesting routine brain MRI may not be necessary in girls with CPP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Hong-Ying Zhao, Ya-Rong Zhang, Ran Zhang, Yu-Ting Li, Rong-Lian Guo, Wen-Sheng Shi
Summary: This study found differences in metabolites and lipids between girls with central precocious puberty and age-matched female controls. Metabolomics analysis showed altered metabolic pathways in girls with central precocious puberty, while lipidomics analysis revealed significant differences in (O-acyl) omega-hydroxy fatty acids (OAHFA). These findings suggest potential roles of antibiotic overuse, increased meat consumption, and obesity in the development of central precocious puberty.
FRONTIERS IN PEDIATRICS
(2023)
Article
Psychiatry
Ozge Gizli Coban, Aynur Bedel, Arif Onder, Asli Surer Adanir, Hale Tuhan, Mesut Parlak
Summary: Girls with central precocious puberty (CPP) have higher rates of psychiatric disorders and social anxiety disorder, and are more likely to be victims of bullying compared to healthy controls. Screening for peer-victimization in girls with CPP is important, and longterm prospective studies are needed to further understand the psychological consequences of CPP.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Endocrinology & Metabolism
Marissa J. Kilberg, Maria G. Vogiatzi
Summary: Central precocious puberty (CPP) refers to early activation of the hypothalamic-pituitary-gonadal axis, with sexual development occurring before the age of 8 in girls and 9 in boys. The onset of thelarche has decreased over the past decades, but the progression of puberty can be slower and may not negatively impact adult height in girls who experience thelarche between 6-8 years. Advances in diagnosis and management include the use of ultrasensitive luteinizing hormone assay for testing and a better understanding of the genetic factors influencing puberty onset. Long-acting formulations of gonadotropin-releasing hormone analogs (GnRHas) have also improved the management of CPP. Limited data in boys and a lack of controlled studies hinder clinical care and clear practice guidelines for CPP.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Patrizia Bruzzi, Lara Valeri, Marcello Sandoni, Simona Filomena Madeo, Barbara Predieri, Laura Lucaccioni, Lorenzo Iughetti
Summary: This study aimed to evaluate the efficacy of GnRHas in the treatment of idiopathic central precocious puberty (ICPP) in girls. The results showed that BMI at diagnosis and transient metabolic complications during treatment did not impact the long-term outcomes of GnRHas therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Francesca Aiello, Grazia Cirillo, Alessandra Cassio, Raffaella Di Mase, Gianluca Tornese, Giuseppina R. Umano, Emanuele Miraglia del Giudice, Anna Grandone
Summary: PROKR2 mutations do not appear to be a common cause of central precocious puberty in girls, as evidenced by the lack of rare variants in a cohort of 31 girls with precocious puberty and the identification of only 5 common polymorphisms, with one showing a higher minor allele frequency than reported in the genome aggregation database (gnomAD).
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Didem Helvacioglu, Serap Demircioglu Turan, Tulay Guran, Zeynep Atay, Adnan Dagcinar, Digdem Bezen, Esin Karakilic Ozturan, Feyza Darendeliler, Aysegul Yuksel, Fatma Dursun, Suna Kilinc, Serap Semiz, Saygin Abali, Metin Yildiz, Asan Onder, Abdullah Bereket
Summary: The study showed that while age and LH/FSH ratio are significant predictors of CNS lesions in girls with central precocious puberty, their predictive power is weak. Therefore, despite the low likelihood of finding a lesion requiring intervention, systematic MRI appears to be the most efficient current approach.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Chunlin Wang, Qingqing Chen, Ke Yuan, Minfei He, Jianfang Zhu, Yanlan Fang, Jianhong Hu, Qingfeng Yan
Summary: Central precocious puberty (CPP) is a disease that seriously affects the development of a child and is increasing year by year, with limited treatment options. An analysis revealed altered members of metabolic signaling pathways in CPP may serve as potential novel therapeutic targets.
Article
Biochemical Research Methods
Tianyi Qiu, Jingxuan Qiu, Jun Feng, Dingfeng Wu, Yiyan Yang, Kailin Tang, Zhiwei Cao, Ruixin Zhu
BRIEFINGS IN BIOINFORMATICS
(2017)
Article
Multidisciplinary Sciences
Tianyi Qiu, Yiyan Yang, Jingxuan Qiu, Yang Huang, Tianlei Xu, Han Xiao, Dingfeng Wu, Qingchen Zhang, Chen Zhou, Xiaoyan Zhang, Kailin Tang, Jianqing Xu, Zhiwei Cao
NATURE COMMUNICATIONS
(2018)
Article
Pharmacology & Pharmacy
Tanyi Qiu, Dingfeng Wu, LinLin Yang, Hao Ye, Qiming Wang, Zhiwei Cao, Kailin Tang
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Biochemical Research Methods
Qingchen Zhang, Lu Zhang, Chen Zhou, Yiyan Yang, Zuojing Yin, Dingfeng Wu, Kailin Tang, Zhiwei Cao
BMC BIOINFORMATICS
(2019)
Article
Biochemistry & Molecular Biology
Chen Zhou, Zikun Chen, Lu Zhang, Deyu Yan, Tiantian Mao, Kailin Tang, Tianyi Qiu, Zhiwei Cao
NUCLEIC ACIDS RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Jian Gao, Qiming Wang, Yuwei Huang, Kailin Tang, Xue Yang, Zhiwei Cao
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Zikun Chen, Xiaoning Wang, Yuanyuan Li, Yahang Wang, Kailin Tang, Dingfeng Wu, Wenyan Zhao, Yueming Ma, Ping Liu, Zhiwei Cao
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Genetics & Heredity
Zuojing Yin, Xinmiao Yan, Qiming Wang, Zeliang Deng, Kailin Tang, Zhiwei Cao, Tianyi Qiu
FRONTIERS IN GENETICS
(2020)
Article
Cell Biology
Zuojing Yin, Qiming Wang, Xinmiao Yan, Lu Zhang, Kailin Tang, Zhiwei Cao, Tianyi Qiu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Kailin Tang, Xuejie Ji, Mengdi Zhou, Zeliang Deng, Yuwei Huang, Genhui Zheng, Zhiwei Cao
Summary: Although transcriptomics technologies have advanced rapidly in the past decades, integrating mixed data from microarray and RNA-seq remains challenging due to inherent variability differences. Rank-In is a novel method proposed to correct nonbiological effects and enable consolidated analysis of blended data. Validated on public cell and tissue samples, Rank-In demonstrated superior classification and prediction accuracy, showing potential for integrative study of cancer profiles.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Jian Gao, Zuojing Yin, Zhuanbin Wu, Zhen Sheng, Chao Ma, Rui Chen, Xiongwen Zhang, Kailin Tang, Jian Fei, Zhiwei Cao
Summary: This study explored the synergistic effects of Berberine and Evodiamine in hepatocellular carcinoma by co-inhibiting NF-kappa B and c-JUN, which showed significant anticancer activity. The in vivo experiments in zebrafish and analysis of HCC individuals revealed promising results, suggesting the potential of natural compounds for developing combination therapies in combating malignant cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Deyu Yan, Genhui Zheng, Caicui Wang, Zikun Chen, Tiantian Mao, Jian Gao, Yu Yan, Xiangyi Chen, Xuejie Ji, Jinyu Yu, Saifeng Mo, Haonan Wen, Wenhao Han, Mengdi Zhou, Yuan Wang, Jun Wang, Kailin Tang, Zhiwei Cao
Summary: HIT 2.0 is a curated dataset focusing on Herbal Ingredients' Targets from PubMed literatures 2000-2020, hosting 10,031 compound-target activity pairs with quality indicators between 2208 targets and 1237 ingredients from more than 1250 reputable herbs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Zikun Chen, Deyu Yan, Mou Zhang, Wenhao Han, Yuan Wang, Shudi Xu, Kailin Tang, Jian Gao, Zhiwei Cao
Summary: This study proposes a method called MetNC for predicting the metabolites of natural compounds (NCs) through simulating in vivo biotransformation. The results show that MetNC performs the best in terms of metabolite coverage and short-listing true products, and it has an additional advantage in recommending microbiota-transformed metabolites.
FRONTIERS IN CHEMISTRY
(2022)
Article
Cell Biology
Xinmiao Yan, Yiyan Yang, Zikun Chen, Zuojing Yin, Zeliang Deng, Tianyi Qiu, Kailin Tang, Zhiwei Cao
Article
Biochemical Research Methods
Zhen Sheng, Yi Sun, Zuojing Yin, Kailin Tang, Zhiwei Cao
BRIEFINGS IN BIOINFORMATICS
(2018)