Article
Public, Environmental & Occupational Health
Marilou Kiely, Fazia Tadount, Ernest Lo, Manish Sadarangani, Shu Qin Wei, Ellen Rafferty, Caroline Quach, Shannon E. Macdonald
Summary: This study found that females have a higher risk of adverse reactions following influenza vaccines compared to males, regardless of age and vaccine type. Transparent communication of this risk could increase trust in vaccines and reduce vaccine hesitancy.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Immunology
Antonios Douros, Zharmaine Ante, Samy Suissa, Paul Brassard
Summary: The findings of a large population-based cohort study suggest that common vaccines do not have a protective effect on the risk of dementia, contradicting previous observational data.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
C. Degeling, J. Williams, S. M. Carter, R. Moss, P. Massey, G. L. Gilbert, P. Shih, A. Braunack-Mayer, K. Crooks, D. Brown, J. McVernon
Summary: In the context of an influenza pandemic, community juries in Australia tend to support prioritizing influenza vaccination for primary school students to indirectly protect the general population, as this approach may benefit more people and be more publicly acceptable.
Editorial Material
Multidisciplinary Sciences
Dennis R. Burton, Eric J. Topol
Summary: The evolution of COVID emphasizes the importance of rational vaccine design based on broadly neutralizing antibodies.
Article
Veterinary Sciences
Pru Hobson-West
Summary: This article examines the discourse of a UK campaign group questioning aspects of companion animal vaccine policy and finds similarities to discourses in the human vaccine domain, including discussions of risk, trust in expertise, and imagining science. The article argues that these discourses align with broader social and cultural developments in healthcare.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Public, Environmental & Occupational Health
Chalapati Rao, Kanitta Bundhamcharoen, Matthew Kelly, Viroj Tangcharoensathien
Summary: Comparisons between Global Burden of Disease and WHO Global Health Estimates for cause-specific mortality rates in 11 countries in the WHO South East Asia Region show significant differences, highlighting the need for customized national strategies to improve mortality statistics systems. Analysis of national mortality statistics systems reveals varying limitations in structure, organization, and implementation across countries, requiring tailored approaches to strengthen data quality and reduce reliance on unreliable modelled estimates.
Article
Public, Environmental & Occupational Health
Ann M. Weber, Ribhav Gupta, Safa Abdalla, Beniamino Cislaghi, Valerie Meausoone, Gary L. Darmstadt
Summary: Global surveys have gender-related biases due to missing data, incomplete representation of population groups, and biased ways of using gender information. While efforts are being made to integrate sex-disaggregated statistics into national programs, there is still a lack of data to understand gender disparities and design effective intervention programs. Approaches such as separating gender identification from biological sex, using qualitative research to rephrase questions, and learning from non-health disciplines can help address these challenges. Collaboration across disciplines is essential to advance the field and establish standards for measuring gender in all its forms.
Article
Health Care Sciences & Services
Vageesh Jain, Paula Lorgelly
Summary: This viewpoint proposes a new conceptual framework (COVID-NEEDS) for the global allocation of COVID-19 vaccines, aiming to identify countries most in need of vaccines. The framework takes into account the health, social, and economic impacts of COVID-19 and integrates with existing needs assessment methods.
JOURNAL OF PUBLIC HEALTH POLICY
(2022)
Article
Public, Environmental & Occupational Health
Dede Anwar Musadad, Tri Juni Angkasawati, Yuslely Usman, Matthew Kelly, Chalapati Rao
Summary: Civil Registration and Vital Statistics (CRVS) systems are crucial for obtaining reliable data on births, deaths, and causes of death. However, the CRVS system in Indonesia currently faces challenges in producing accurate vital statistics for evidence-based health action. This study conducted a detailed assessment and gap analysis of the CRVS system and implemented revised death reporting procedures at the local level, demonstrating feasibility and sustainability.
Article
Public, Environmental & Occupational Health
Sharifah Sekalala, Katrina Perehudoff, Michael Parker, Lisa Forman, Belinda Rawson, Maxwell Smith
Summary: This paper discusses the practical implementation of human rights law in COVID-19 vaccine allocation, highlighting the need for broader consideration of intersectional needs in society and prioritization of vulnerable groups. It suggests that vaccines should be allocated based on infection risk, social vulnerabilities, and potential impact of illness.
Article
Medicine, General & Internal
Xue-yan Zheng, Qian Yi, Yan-jun Xu, Xin-ying Zeng, Xiao-jun Xu, Ge Chen, Shu-li Ma, Si-li Tang, Li-feng Lin
Summary: The study reveals a significant decline in overall mortality and cause-specific mortality in Guangdong province between 2005 and 2015, with the burden of non-communicable diseases remaining a key healthcare issue. Variations across geographic regions and shifts in injury patterns by age were also observed, highlighting the need for refined healthcare services to address these disparities.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Sera Kim, Garam Byun, Garam Jo, Dahyun Park, Sung-Il Cho, Hannah Oh, Rockli Kim, S. Subramanian, Sungha Yun, Kyungwon Oh, Jong-Tae Lee, Min-Jeong Shin
Summary: The study found gender-specific age and birth cohort effects on smoking prevalence in South Korea. While smoking prevalence peaked in men in their mid-20s and specific birth cohorts, it consistently increased in women until their mid-40s and in recent birth cohort groups. Period effects declined from 1998-2002 to 2003-2007, following increasing fluctuations in both genders.
Review
Immunology
Cheryl Lin, Pikuei Tu, Leslie M. Beitsch
Summary: While COVID-19 continues to spread globally, there is a decrease in vaccine acceptance rates, with significant demographic, socioeconomic, and partisan differences. Perceived risk, concerns over vaccine safety and effectiveness, and doctors' recommendations are key factors influencing vaccination decisions. Unique COVID-19 factors include political orientation, doubts about the expedited vaccine development process, and perceived political interference.
Article
Medicine, General & Internal
Ben Wamamili, Sheleigh Lawler, Mark Wallace-Bell, Coral Gartner, David Sellars, Randolph C. Grace, Ryan Courtney, Pat Coope
Summary: The study revealed significant differences in smoking and vaping patterns among university students in Australia and New Zealand, with men having higher odds for smoking, vaping, or dual use. Men were also more likely to believe that e-cigarettes are less harmful than tobacco cigarettes.
Article
Medicine, General & Internal
Carley Riley, Jeph Herrin, Veronica Lam, Brent Hamar, Dan Witters, Diana Liu, Harlan M. Krumholz, Brita Roy
Summary: From 2008 to 2017, the percentage of the US population reporting thriving increased, while the percentage suffering remained unchanged. Marked geographical variations indicate priority areas for intervention.
Article
Cardiac & Cardiovascular Systems
Rosalind Hollingsworth, Arto Palmu, Stephanie Pepin, Martin Dupuy, Anju Shrestha, Jukka Jokinen, Ritva Syrjanen, Joshua Nealon, Sandrine Samson, Iris De Bruijn
Summary: This study aims to evaluate the relative effectiveness of high-dose quadrivalent influenza vaccine compared to standard-dose quadrivalent influenza vaccine in preventing cardio-respiratory hospitalizations in adults aged 65 years and older. The study is conducted by the Finnish Institute for Health and Welfare, enrolling over 120,000 participants over multiple influenza seasons for randomized allocation and follow-up for up to 11 months post-vaccination.
AMERICAN HEART JOURNAL
(2021)
Editorial Material
Immunology
Mia Diaco, Lee-Jah Chang, Bruce Seet, Corey A. Robertson, Ayman Chit, Monica Mercer, David P. Greenberg, Rosalind Hollingsworth, Sandrine I. Samson
Summary: The high-dose influenza vaccine is significant for older adults, providing a more effective prevention measure against influenza and promoting healthy aging.
Letter
Infectious Diseases
J. Kevin Yin, Sandrine I. Samson, Joshua Nealon
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Critical Care Medicine
Ruvim Izikson, Daniel Brune, Jean-Sebastien Bolduc, Pierre Bourron, Marion Fournier, Tamala Mallett Moore, Aseem Pandey, Lucia Perez, Nessryne Sater, Anju Shrestha, Sophie Wague, Sandrine Samson
Summary: This study assessed the safety and immunogenicity of concomitant administration of high-dose quadrivalent influenza vaccine (QIV-HD) and mRNA-1273 vaccine booster in older adults. The results showed no safety concerns or immune interference in the coadministration group, supporting the recommendations for co-administration. The antibody responses to influenza and SARS-CoV-2 were similar between the coadministration and QIV-HD groups.
LANCET RESPIRATORY MEDICINE
(2022)
Letter
Biotechnology & Applied Microbiology
J. Kevin Yin, Stephanie Pepin, Robertus van Aalst, Matthew M. Loiacono, Sandrine I. Samson
Summary: The article challenges the recommendation of high-dose influenza vaccine and criticizes the authors of inaccurate numbers-needed-to-vaccinate (NNV) calculation. It emphasizes the importance of preferential recommendation for vaccines preventing influenza/complications and considering the impact of vaccination within the context of disease burden. To address the threat of the COVID-19 pandemic, the article suggests implementing concomitant influenza/COVID-19 vaccination to reduce the burden of co-circulation of influenza and SARS-CoV-2 viruses and increase vaccine coverage as per the WHO mandate.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Health Care Sciences & Services
Nell J. Marshall, Jennifer L. Lee, Jessica Schroeder, Wei-Nchih Lee, Jermyn See, Mohammad Madjid, Mrudula R. Munagala, John D. Piette, Litjen Tan, Orly Vardeny, Michael Greenberg, Jan Liska, Monica Mercer, Sandrine Samson
Summary: This personalized, evidence-based digital intervention proved effective in increasing vaccination rates among individuals with high-risk cardiovascular diseases. White and Asian individuals were more likely to get vaccinated, while the intervention had less impact on people of color.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Immunology
Jau-Yuan Chen, Szu-Min Hsieh, Shinn-Jang Hwang, Chiu-Shong Liu, Xiaoling Li, Marion Fournier, Ting-Yu Yeh, J. Kevin Yin, Sandrine Samson
Summary: This study evaluated the immunogenicity and safety of high-dose and standard-dose influenza vaccines in older adults in Taiwan. The results showed that the high-dose vaccine had higher immunogenicity for all four influenza strains compared to the standard-dose vaccine, and both vaccines had similar safety profiles.
Article
Biotechnology & Applied Microbiology
Xiaoqiang Liu, Juliana Park, Shengli Xia, Bin Liang, Shuangmin Yang, Yanxia Wang, Olga Syrkina, Nathalie Lavis, Shuzhen Liu, Chenyan Zhao, Jian Ding, Jieqiong Hu, Sandrine Samson, Iris A. de Bruijn
Summary: The safety and immunogenicity of the quadrivalent, split-virion influenza vaccine (Shz QIV) developed in China were assessed. The vaccine showed good tolerability and induced immune responses in different age groups, demonstrating non-inferiority against various strains of influenza virus.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Letter
Immunology
J. Kevin Yin, Rebecca C. Harris, Matthew M. Loiacono, Ayman Chit, Sandrine I. Samson
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: The NUDGE-FLU trial aims to investigate the effectiveness of digitally delivered behavioral nudges in increasing influenza vaccination uptake among older adults. It has randomized 964,870 Danish citizens aged 65 years and above to receive either no nudge or one of 9 electronic letters leveraging different behavioral science strategies. The trial will provide important insights into effective communication strategies to maximize vaccination uptake among high-risk groups.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Modin, Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Brian L. Claggett, Erica L. Dueger, Sandrine I. Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: Digital behavioral nudges, such as electronic letters, emphasizing the potential cardiovascular benefits of influenza vaccination and using a reminder letter strategy, were found to be effective in increasing influenza vaccine uptake among older adults both with and without cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Rebecca C. Harris, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study analyzed the effects of two behavioral nudging letter strategies on influenza vaccination rates in patients with heart failure (HF). The results showed that the vaccination rate in HF patients was relatively low, but the behavioral nudging letter strategies were effective in increasing the vaccination rate and had no negative impact on the use of guideline-directed medical therapy (GDMT) in the long term.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study investigated whether behavioural nudges delivered via a governmental electronic letter system could increase influenza vaccination uptake among older adults in Denmark. The results showed that sending an electronic letter highlighting potential cardiovascular benefits of vaccination or sending repeated letters at randomisation and at day 14 significantly improved vaccination rates.
Review
Immunology
Jason K. H. Lee, Gary K. L. Lam, J. Kevin Yin, Matthew M. Loiacono, Sandrine I. Samson
Summary: This updated systematic review and meta-analysis assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adults (& GE;65 years). The analysis included studies conducted over 12 influenza seasons and showed that HD-IIV provided significantly better protection than SD-IIV against influenza-related outcomes. Subgroup analyses further demonstrated the consistent superiority of HD-IIV across different age groups and strains of influenza.
Article
Medicine, Research & Experimental
Niklas Dyrby Johansen, Daniel Modin, Joshua Nealon, Sandrine Samson, Camille Salamand, Carsten Schade Larsen, Brian L. Claggett, Scott D. Solomon, Martin J. Landray, Gunnar H. Gislason, Lars Kober, Jens Ulrik Staehr Jensen, Pradeesh Sivapalan, Lasse Skafte Vestergaard, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study aims to investigate the feasibility of a pragmatic clinical trial in Denmark comparing high-dose and standard-dose influenza vaccines. The study utilizes existing vaccination infrastructure and the Danish nationwide health registries for data collection. The results will provide valuable insights for future vaccine trials and other interventions.
PILOT AND FEASIBILITY STUDIES
(2022)