Article
Medicine, General & Internal
Shasha Yu, Bo Wang, Xiaofan Guo, Guangxiao Li, Hongmei Yang, Yingxian Sun
Summary: This study aimed to explore the association between the weight-adjusted waist index (WWI) and the incidence of newly diagnosed type 2 diabetes (T2D) among participants in rural areas of China. A total of 9205 non-diabetic individuals were included at baseline, and followed up for a median of 4.6 years. The study found that increasing WWI was significantly associated with a higher incidence of newly diagnosed T2D among rural Chinese adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Nana Wang, Yuying Li, Chuanji Guo
Summary: This study demonstrates that waist-corrected body mass index (wBMI), combining BMI and waist circumference measurements, is superior in predicting obesity and diabetes mellitus (DM). The study found a significant association between wBMI and the incidence of DM, with wBMI being a more reliable predictor compared to waist circumference, BMI, and waist-to-height ratio.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Na Lu, Gang Cheng, Chun-Ming Ma, Xiao-Li Liu
Summary: This study evaluated the relationship between hypertriglyceridemic waist (HW) phenotype, hypertriglyceridemic waist-to-height ratio (HWHtR) phenotype, and abnormal glucose metabolism in adolescents. The study found that the HWHtR phenotype was closely associated with abnormal glucose metabolism in adolescents, leading to increased insulin resistance and compensatory insulin secretion.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Xiao-Jiao Jia, Jia-Xin Wang, Li-Wei Bai, Tian-Shu Hua, Zhong-Hou Han, Qiang Lu
Summary: The study found a significant correlation between the hypertriglyceridemic waist circumference phenotype and gestational diabetes mellitus, with a higher prevalence of GDM in the HTWC group. This suggests that the HTWC phenotype could serve as a simple marker for identifying GDM risk factors.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ranran Qie, Quanman Li, Yang Zhao, Minghui Han, Dechen Liu, Chunmei Guo, Qionggui Zhou, Gang Tian, Shengbing Huang, Xiaoyan Wu, Yanyan Zhang, Pei Qin, Honghui Li, Jian Wang, Ruirong Cheng, Jinchun Lin, Xizhuo Sun, Yuying Wu, Yang Li, Xingjin Yang, Yang Zhao, Yifei Feng, Ming Zhang, Dongsheng Hu
Summary: The study found that high HWHtR is associated with an increased risk of T2DM, and individuals with stable high triglyceride levels and high WHtR have a higher risk of developing T2DM compared to those with stable normal levels.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Peripheral Vascular Disease
Qiligeer Bao, Yun Li, Shouyuan Ma, Jiaojiao Qiu, Jin Sun, Yongkang Su, Anhang Zhang, Shuang Cai, Bokai Cheng, Man Li, Yan Zhang, Shuxia Wang, Ping Zhu
Summary: This study found an association between the hypertriglyceridemic waist phenotype (HTHW) and left ventricular hypertrophy (LVH) in middle-aged and older Chinese patients with hypertension. Patients with HTHW phenotype were 1.52 times more likely to experience LVH than those with normal triglyceride levels and normal waist circumference. This association was independent of age, sex, and other potential confounding factors. Stratified analysis showed a stronger correlation among women, people aged at least 70, and people with hyperuricemia. These results suggest that distinguishing the HTHW phenotype can serve as a simple and effective screening strategy for identifying people at higher risk of developing LVH.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Ming Yang, Yaqin Xu, Chong Hu, Shuhua Zhang, Maobin Kuang, Yang Zou
Summary: This study revealed that individuals with the Hypertriglyceridemic-waist (HTGW) phenotype have a higher prevalence of non-alcoholic fatty liver disease (NAFLD). Compared to those with normal triglyceride (TG) and waist circumference levels, individuals with abnormal TG or waist circumference, as well as those with the HTGW phenotype, had significantly increased risk of developing NAFLD.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Luana Cupertino Milagres, Mariana De Santis Filgueiras, Naruna Pereira Rocha, Leidjaira Lopes Juvanhol, Sylvia do Carmo Castro Franceschini, Juliana Farias de Novaes
Summary: This study found that vitamin D insufficiency and deficiency were significantly associated with a higher prevalence of hypertriglyceridemic waist phenotype (HWP) in children, indicating an additional risk of inadequate vitamin D status to cardiometabolic health in childhood, even when considering other cardiometabolic risk factors.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Yinfei Chen, Weiheng Wen, Zhiliang Mai, Ming Wang, Hong Chen, Jia Sun
Summary: This study aims to evaluate the relationship between creatinine to cystatin C to waist circumference ratio (CCR/WC ratios) and the development of type 2 diabetes mellitus (T2DM). The results showed a negative correlation between CCR/WC and the risk of T2DM in Chinese adults. Early detection is necessary to control the development of T2DM in Chinese with low CCR/WC levels.
JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Yuan Ren, Zi-Han Qiu, Wei-Hua Wu, Xiao-Guang Dong, Shuang Han, Fu-Liang Zhang, Fan-Li Kong, Feng-E Li
Summary: This study found an association between the hypertriglyceridemic waist phenotype (HTWP) and the initial neurological severity and etiologic subtypes in patients with acute ischemic stroke. Patients with HTWP had less severe initial neurological impairment and an increased risk of small-artery occlusion stroke.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Yan Xuan, Ying Shen, Sujie Wang, Ping Gao, Xi Gu, Dou Tang, Xun Wang, Fanfan Zhu, Leiqun Lu, Ling Chen
Summary: This study aimed to evaluate the relationship between the hypertriglyceridemic waist (HTGW) phenotype and hypertension. It was found that individuals with the HTGW phenotype had a significantly higher prevalence of hypertension compared to those with the normal waist normal triglyceride (NWNT) phenotype. The HTGW phenotype was still found to be significantly associated with hypertension even after adjusting for potential confounders, suggesting the importance of monitoring blood pressure in individuals with this phenotype and identifying those at high risk of hypertension.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Urology & Nephrology
Ruping Chen, Guangshan Sun, Rui Liu, Ao Sun, Yujie Cao, Xiaojie Zhou, Sha Zhang
Summary: The HTGW phenotype was found to be independently associated with an increased risk of prevalent and incident chronic kidney disease in older adults aged 60 years and above in Tianjin, China, based on a community-based cohort study. The study observed statistically significant associations between the HTGW phenotype and CKD in both cross-sectional surveys and retrospective analyses.
Article
Clinical Neurology
Meizhen Gu, Weijun Huang, Xinyi Li, Yupu Liu, Fan Wang, Chao Fang, Ting Chen
Summary: The study revealed a positive association between the Hypertriglyceridemic waist (HTGW) phenotype and obstructive sleep apnea (OSA) risk, which remained significant across different age, gender, and body mass index subgroups. Further longitudinal follow-up studies are required to establish the causal link and prognostic role of these metabolic factors.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Endocrinology & Metabolism
Yan Xuan, Wen Zhang, Yuying Wang, Bin Wang, Yi Chen, Fangzhen Xia, Kun Zhang, Qing Li, Ningjian Wang, Yingli Lu
Summary: This study measured the association between the hypertriglyceridemic-waist (HTGW) phenotype and chronic kidney disease (CKD) in a large type 2 diabetes population in China. The results showed a positive association between HTGW phenotype and CKD, with the strongest association found in participants with hypertension. Further prospective studies are needed to confirm the findings and investigate the underlying biological mechanisms.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Environmental Sciences
Ge Chen, Qian Yi, Leying Hou, Shenghan Peng, Mengya Fan, Peige Song, Yimin Zhu
Summary: The study found that hypertriglyceridemic-waist (HTW) and its dynamic transitions were associated with an increased risk of incident type 2 diabetes mellitus (T2DM) among middle-aged and older Chinese. Individuals with abnormal HTW phenotypes, such as NTEW/ETNW and ETEW, had a significantly higher risk of developing T2DM compared to those with normal HTW phenotype (NTNW). Transitioning to adverse metabolic states from normal or less severe states was also found to be a risk factor for T2DM.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)