Journal
BMC PUBLIC HEALTH
Volume 11, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2458-11-345
Keywords
Cardiovascular disease; inflammation; sex; China; developing country; white blood cell count; childhood nutrition
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Funding
- University of Hong Kong Foundation for Development and Research, Hong Kong
- University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong
- Guangzhou Public Health Bureau
- Guangzhou Science and Technology Committee, Guangzhou, China
- University of Birmingham, Birmingham, UK
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Background: We hypothesized that socio-economic development could, via nutritionally driven levels of pubertal sex-steroids, promote a pro-inflammatory state among men but not women in developing countries. We tested this hypothesis, using recalled childhood meat eating as a proxy for childhood nutrition, in southern China. Methods: We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (= 50 years) men (n = 2,498) and women (n = 7,369). Results: Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 10(9)/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 10(9)/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations. Conclusion: If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development.
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