Article
Rheumatology
Esha Abrol, Ester Coutinho, Michael Chou, Melanie Hart, Angela Vincent, Robert Howard, Michael S. Zandi, David Isenberg
Summary: Psychosis in patients with systemic lupus erythematosus is rare but treatable. Certain immunological characteristics may be associated with the development of lupus psychosis. However, no significant biomarkers were found in this small sample, indicating a need for further exploration in a larger multi-centre analysis.
Article
Medicine, Research & Experimental
Edward R. Palmer, Sian Lowri Griffiths, Ben Watkins, Tyler Weetman, Ryan Ottridge, Smitaa Patel, Rebecca Woolley, Sarah Tearne, Pui Au, Eleanor Taylor, Zara Sadiq, Hareth Al-Janabi, Barnaby Major, Charlotte Marriott, Nusrat Husain, Mohammad Zia Ul Haq Katshu, Domenico Giacco, Nicholas M. Barnes, James T. R. Walters, Thomas R. E. Barnes, Max Birchwood, Richard Drake, Rachel Upthegrove
Summary: The ADEPP trial is a clinical trial that aims to investigate the efficacy and cost-effectiveness of sertraline in preventing depression after first-episode psychosis. It will test whether the addition of sertraline following FEP is a clinically useful, acceptable, and cost-effective way of improving outcomes.
Article
Psychiatry
Mario Alvarez-Jimenez, Peter Koval, Lianne Schmaal, Sarah Bendall, Shaunagh O'Sullivan, Daniela Cagliarini, Simon D'Alfonso, Simon Rice, Lee Valentine, David L. Penn, Chris Miles, Penni Russon, Jessica Phillips, Carla McEnery, Reeva Lederman, Eoin Killackey, Cathrine Mihalopoulos, Cesar Gonzalez-Blanch, Tamsyn Gilbertson, Shalini Lal, Sue Maree Cotton, Helen Herrman, Patrick D. McGorry, John F. M. Gleeson
Summary: Although Horyzons did not show a significant effect on social functioning compared to TAU, the intervention was effective in improving vocational or educational attainment and reducing usage of hospital emergency services, which are crucial aspects of social recovery for young people with first-episode psychosis.
Article
Psychology, Clinical
Sandra Vieira, Qiyong Gong, Cristina Scarpazza, Su Lui, Xiaoqi Huang, Benedicto Crespo-Facorro, Diana Tordesillas-Gutierrez, Victor Ortiz-Garcia de la Foz, Esther Setien-Suero, Floor Scheepers, Neeltje E. M. van Haren, Rene Kahn, Tiago Reis Marques, Simone Ciufolini, Marta Di Forti, Robin M. Murray, Anthony David, Paola Dazzan, Philip McGuire, Andrea Mechelli
Summary: This study identified a consistent pattern of neuroanatomical abnormalities in fronto-temporal, insular and occipital regions in five independent samples of individuals with first-episode psychosis. The extent of these alterations was found to be dependent on the severity of symptoms and duration of illness, providing evidence for reliable neuroanatomical changes in first-episode psychosis.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Marina Elisabeth Huurman, Gerdina Hendrika Maria Pijnenborg, Bouwina Esther Sportel, Gerard David van Rijsbergen, Ilanit Hasson-Ohayon, Nynke Boonstra
Summary: This study explores the experiences and needs of individuals after a first episode of psychosis in terms of how information about diagnosis, treatment options, and prognosis is communicated. The study finds that individuals have different needs regarding the timing, content, and delivery of this information. It recommends a tailored process of communication and providing personalized written information.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Clinical
T. Sanchez-Gutierrez, E. Rodriguez-Toscano, L. Roldan, L. Ferraro, M. Parellada, A. Calvo, G. Lopez, M. Rapado-Castro, D. La Barbera, C. La Cascia, G. Tripoli, M. Di Forti, R. M. Murray, D. Quattrone, C. Morgan, J. van Os, P. Garcia-Portilla, S. Al-Halabi, J. Bobes, L. de Haan, M. Bernardo, J. L. Santos, J. Sanjuan, M. Arrojo, A. Ferchiou, A. Szoke, B. P. Rutten, S. Stilo, G. D'Andrea, I. Tarricone, C. M. Diaz-Caneja, C. Arango
Summary: This study analyzed the relationship between tobacco use and first-episode psychosis, age at onset of psychosis, and specific diagnosis of psychosis. The findings showed that patients with first-episode psychosis were more likely to use tobacco and smoke heavily compared to controls. Tobacco use was associated with an earlier age at psychosis onset and a diagnosis of schizophrenia, but these associations were no longer significant after controlling for cannabis use.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
A. Pigoni, D. Dwyer, L. Squarcina, S. Borgwardt, B. Crespo-Facorro, P. Dazzan, S. Smesny, F. Spaniel, G. Spalletta, R. Sanfelici, L. A. Antonucci, A. Reuf, Oe. F. Oeztuerk, A. Schmidt, S. Ciufolini, F. Schonborn-Harrisberger, K. Langbein, A. Gussew, J. R. Reichenbach, Y. Zaytseva, F. Piras, G. Delvecchio, M. Bellani, M. Ruggeri, A. Lasalvia, D. Tordesillas-Gutierrez, V. Ortiz, R. M. Murray, T. Reis-Marques, M. Di Forti, N. Koutsouleris, P. Brambilla
Summary: A large-scale, multi-site analysis of cortical thickness comparing parcellations and vertex-wise approaches in machine learning classifications of first-episode psychosis revealed that vertex-wise thickness maps outperformed parcellation-based methods, with temporal brain areas being the most influential in the classification. The predictive decision scores significantly correlated with age at onset, duration of treatment, and positive symptoms, increasing the generalizability across sites.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Alessandro Pigoni, Giuseppe Delvecchio, Nicola Dusi, Giandomenico Schiena, Angela Andreella, Livio Finos, Filippo Cecchetto, Cinzia Perlini, Maria Gloria Rossetti, Adele Ferro, Marcella Bellani, Antonio Lasalvia, Mirella Ruggeri, Paolo Brambilla
Summary: This longitudinal MRI study found that there are abnormalities in grey matter volume in specific sub-portions of the insular cortex, both in chronic and first-episode patients. These findings suggest that the insula may serve as a key biological marker of psychotic disorders.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Clinical Neurology
Eloi Gine-Serven, Maria Martinez-Ramirez, Ester Boix-Quintana, Eva Davi-Loscos, Nicolau Guanyabens, Virginia Casado, Desiree Muriana, Cristina Torres-Rivas, Benedicto Crespo-Facorro, Javier Labad
Summary: This study found that CSF glucose and LDH levels are associated with early symptoms and phenotypes of psychotic disorders, with lower CSF glucose concentrations being linked to schizophrenia or schizoaffective disorder diagnoses.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Maija Lindgren, Sebastian Therman, Tiina From, Jarmo Hietala, Heikki Laurikainen, Raimo K. R. Salokangas, Jaana Suvisaari
Summary: This study investigated sense of mastery in first-episode psychosis patients and found that they reported lower mastery compared to controls. Lower depressive symptoms and higher perceived social support were positively associated with higher mastery. Sense of mastery was also found to mediate the association between perceived social support and depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Pei Ling Lim, Roselyne Shirley Pat Fong
Summary: This study provides a brief overview of young people presenting with first episode psychosis at a paediatric hospital in Singapore over the course of a year. It highlights the importance of joint initial assessment by paediatricians and child psychiatrists in determining clinical characteristics and guiding treatment decisions. Stigma and cultural beliefs were also identified as factors affecting delay in presentation and adherence to treatment.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Miaomiao Gu, Ni Deng, Wenxi Xia, Lijing Deng, Guopeng Liang
Summary: Previous studies have shown the benefits of lung recruitment in adults with acute hypoxaemic respiratory failure, but there is limited research on its application in paediatric patients, especially after cardiac surgery. This clinical trial aims to investigate whether lung recruitment can reduce the duration of mechanical ventilation in paediatric patients with hypoxaemic respiratory failure after cardiac surgery.
Article
Psychiatry
Xi Chen, Xiaoying Fan, Xiaopeng Song, Margaret Gardner, Fei Du, Dost Ongur
Summary: This study used various imaging techniques to observe abnormalities in metabolite signals in white matter cells during the early and chronic stages of psychosis. These abnormalities suggest specific changes in the pathophysiology of psychosis.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Yi Chian Chua, Edimansyah Abdin, Charmaine Tang
Summary: This study aims to identify and describe possible two-year weight trajectories among patients accepted to the Early Psychosis Intervention Programme (EPIP) in Singapore. The weight change across two years resulted in five different membership categories: super high risk, high risk mitigated, at risk, delayed risk, and low risk.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Jashmina J. Shetty, Christian Nicholas, Barnaby Nelson, Patrick D. McGorry, Suzie Lavoie, Connie Markulev, Miriam R. Schafer, Andrew Thompson, Hok Pan Yuen, Alison R. Yung, Dorien H. Nieman, Lieuwe de Haan, G. Paul Amminger, Jessica A. Hartmann
Summary: Investigating biological processes in at-risk individuals may help elucidate the aetiological mechanisms underlying psychosis development, refine prediction models and improve intervention strategies. The study examined associations between sleep disturbances, chronotype, depressive and psychotic symptoms in ultra-high risk individuals, finding that sleep disturbances were associated with increased depressive and attenuated positive psychotic symptoms, while eveningness preference was linked to increased negative symptoms.
EARLY INTERVENTION IN PSYCHIATRY
(2021)
Review
Psychiatry
Patrick D. McGorry, Cristina Mei, Jessica Hartmann, Alison R. Yung, Barnaby Nelson
Summary: This passage discusses the research findings on the efficacy of interventions for the UHR population and explores the optimal types of interventions, highlighting the clinical benefits of psychosocial treatment.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Maria Jalbrzikowski, Rebecca A. Hayes, Stephen J. Wood, Dorte Nordholm, Juan H. Zhou, Paolo Fusar-Poli, Peter J. Uhlhaas, Tsutomu Takahashi, Gisela Sugranyes, Yoo Bin Kwak, Daniel H. Mathalon, Naoyuki Katagiri, Christine I. Hooker, Lukasz Smigielski, Tiziano Colibazzi, Esther Via, Jinsong Tang, Shinsuke Koike, Paul E. Rasser, Chantal Michel, Irina Lebedeva, Wenche ten Velden Hegelstad, Camilo de la Fuente-Sandoval, James A. Waltz, Romina Mizrahi, Cheryl M. Corcoran, Franz Resch, Christian K. Tamnes, Shalaila S. Haas, Imke L. J. Lemmers-Jansen, Ingrid Agartz, Paul Allen, G. Paul Amminger, Ole A. Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Helen Baldwin, Cali F. Bartholomeusz, Stefan Borgwardt, Sabrina Catalano, Michael W. L. Chee, Xiaogang Chen, Kang Ik K. Cho, Rebecca E. Cooper, Vanessa L. Cropley, Montserrat Dolz, Bjorn H. Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj, Birte Y. Glenthoj, Lieuwe de Haan, Holly K. Hamilton, Mathew A. Harris, Kristen M. Haut, Ying He, Karsten Heekeren, Andreas Heinz, Daniela Hubl, Wu Jeong Hwang, Michael Kaess, Kiyoto Kasai, Minah Kim, Jochen Kindler, Mallory J. Klaunig, Alex Koppel, Tina D. Kristensen, Jun Soo Kwon, Stephen M. Lawrie, Jimmy Lee, Pablo Leon-Ortiz, Ashleigh Lin, Rachel L. Loewy, Xiaoqian Ma, Patrick McGorry, Philip McGuire, Masafumi Mizuno, Paul Moller, Tomas Moncada-Habib, Daniel Munoz-Samons, Barnaby Nelson, Takahiro Nemoto, Merete Nordentoft, Maria A. Omelchenko, Ketil Oppedal, Lijun Ouyang, Christos Pantelis, Jose C. Pariente, Jayachandra M. Raghava, Francisco Reyes-Madrigal, Brian J. Roach, Jan I. Rossberg, Wulf Rossler, Dean F. Salisbury, Daiki Sasabayashi, Ulrich Schall, Jason Schiffman, Florian Schlagenhauf, Andre Schmidt, Mikkel E. Sorensen, Michio Suzuki, Anastasia Theodoridou, Alexander S. Tomyshev, Jordina Tor, Tor G. Vaernes, Dennis Velakoulis, Gloria D. Venegoni, Sophia Vinogradov, Christina Wenneberg, Lars T. Westlye, Hidenori Yamasue, Liu Yuan, Alison R. Yung, Therese A. M. J. van Amelsvoort, Jessica A. Turner, Theo G. M. van Erp, Paul M. Thompson, Dennis Hernaus
Summary: This study investigates baseline structural neuroimaging differences between individuals at clinical high risk and healthy controls, as well as differences between those who later developed a psychotic disorder and those who did not. The findings suggest that lower cortical thickness in individuals at CHR is associated with later psychosis conversion, and certain regions with lower cortical thickness also show abnormal associations with age.
Article
Psychiatry
G. Paul Amminger, Ashleigh Lin, Melissa Kerr, Amber Weller, Jessica Spark, Charlotte Pugh, Sally O'Callaghan, Maximus Berger, Scott R. Clark, James G. Scott, Andrea Baker, Iain McGregor, David Cotter, Zoltan Sarnyai, Andrew Thompson, Alison R. Yung, Brian O'Donoghue, Eoin Killackey, Cathy Mihalopoulos, Hok Pan Yuen, Barnaby Nelson, Patrick D. McGorry
Summary: This study aims to test the efficacy of CBD in treating subthreshold psychotic symptoms in the at-risk stage of psychotic disorder. Through a randomized controlled trial, CBD will be compared to placebo in improving positive psychotic symptoms in UHR patients, with the hypothesis that CBD will be significantly more effective.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Ya Wang, Esmee E. Braam, Cassandra M. J. Wannan, Tamsyn E. Van Rheenen, Raymond C. K. Chan, Barnaby Nelson, Patrick D. McGorry, Alison R. Yung, Ashleigh Lin, Warrick J. Brewer, John Koutsogiannis, Stephen J. Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L. Cropley
Summary: The study found a relationship between severity of neurological soft signs (NSS) and grey matter volume (GMV) in individuals at ultra-high risk for psychosis, particularly those who later transitioned to a psychotic disorder. While NSS showed little overall variation with GMV, sensory integration deficits were associated with lower GMV in specific brain areas in those who later developed psychosis.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Family Studies
Catherine Flynn, Lorana Bartels, Susan Dennison, Helen Taylor, Susy Harrigan
Summary: The majority of carers reported maintaining contact with the imprisoned parent during COVID-19 restrictions, but noted difficulties such as reduced availability, prison-based issues, and suitability of video/telephone visits for young children. While some benefits of videoconferencing were mentioned, respondents typically described the negative impact of restrictions, and lack of physical contact, on children's emotional well-being. Our findings suggest that video visiting should be complementary to in-person visits, tailored to children's needs, with support offered to families.
CHILD & FAMILY SOCIAL WORK
(2022)
Review
Psychiatry
Gemma E. Shields, Deborah Buck, Filippo Varese, Alison R. Yung, Andrew Thompson, Nusrat Husain, Matthew R. Broome, Rachel Upthegrove, Rory Byrne, Linda M. Davies
Summary: This review examines the cost-effectiveness of health and social care interventions for individuals at risk of psychosis and those experiencing first-episode psychosis. The findings suggest that these interventions are generally cost-effective in reducing symptoms and preventing the onset of psychosis.
Article
Immunology
Subash Raj Susai, David Mongan, Colm Healy, Mary Cannon, Barnaby Nelson, Connie Markulev, Miriam R. Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, Patrick D. McGorry, Melanie Focking, David Cotter, G. Paul Amminger
Summary: This study investigated the relationship of erythrocyte omega-3 FAs with plasma immune markers and examined whether the associations between omega-3 FAs and clinical outcomes were mediated via plasma immune markers in CHR individuals. The results indicate a predominantly anti-inflammatory relationship of omega-3 FAs on plasma inflammatory status in CHR individuals, but this did not appear to convey clinical benefits at 6 month and 12 month follow-up. Both immune and non-immune biological effects of omega-3 FAs would be resourceful in understanding the clinical benefits of omega-3 FAs in CHR population.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Health Care Sciences & Services
Andrew Gumley, Simon Bradstreet, John Ainsworth, Stephanie Allan, Mario Alvarez-Jimenez, Maximillian Birchwood, Andrew Briggs, Sandra Bucci, Sue Cotton, Lidia Engel, Paul French, Reeva Lederman, Shon Lewis, Matthew Machin, Graeme MacLennan, Hamish McLeod, Nicola McMeekin, Cathy Mihalopoulos, Emma Morton, John Norrie, Frank Reilly, Matthias Schwannauer, Swaran P. Singh, Suresh Sundram, Andrew Thompson, Chris Williams, Alison Yung, Lorna Aucott, John Farhall, John Gleeson
Summary: The study investigates the feasibility of a digital intervention in recognizing and managing early warning signs of relapse in schizophrenia to prevent relapse.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Clinical Neurology
Gerwyn Morris, Ken Walder, Michael Berk, Andre F. Carvalho, Wolf Marx, Chiara C. Bortolasci, Alison R. Yung, Basant K. Puri, Michael Maes
Summary: The endocannabinoid system plays a crucial role in regulating various bodily functions and is associated with neuropsychiatric disorders. High levels of oxidative stress may impair CB1 and CB2 receptor activity, while upregulation of CB2 can reduce nitrosative stress and neuroinflammation.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Han Xie, Aron Shlonsky, Susy Harrigan
Summary: This study examined the applicability of the Self-Efficacy Questionnaire for Children (SEQ-C) in a Chinese population. The results revealed that a modified Chinese version of the SEQ-C had good reliability and validity, and it was suitable for primary and secondary school children aged between 9 and 18 years.
CURRENT PSYCHOLOGY
(2023)
Review
Clinical Neurology
Seetal Dodd, Luba Sominsky, Dan Siskind, Chiara C. Bortolasci, Andre F. Carvalho, Michael Maes, Adam J. Walker, Ken Walder, Alison R. Yung, Lana J. Williams, Hannah Myles, Tayler Watson, Michael Berk
Summary: Advances in psychopharmacology have been slow, necessitating investigation into new therapeutic approaches. Metformin, a widely used hypoglycemic agent, is being studied for its potential use in mental illness treatment beyond diabetes management.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Psychiatry
Alison R. Yung, Marko Milicevic, Michael Berk
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Michael Berk, Ole Kohler-Forsberg, Megan Turner, Brenda W. J. H. Penninx, Anna Wrobel, Joseph Firth, Amy Loughman, Nicola J. Reavley, John J. Mcgrath, Natalie C. Momen, Oleguer Plana-Ripoll, Adrienne O'Neil, Dan Siskind, Lana J. Williams, Andre F. Carvalho, Lianne Schmaal, Adam J. Walker, Olivia Dean, Ken Walder, Lesley Berk, Seetal Dodd, Alison R. Yung, Wolfgang Marx
Summary: Populations with common physical diseases are more likely to have major depressive disorder (MDD), and people with MDD are at a greater risk for physical diseases. This comorbidity is associated with worse outcomes, reduced treatment adherence, increased mortality, and higher healthcare utilization and costs. Shared genetic and biological pathways, as well as social and lifestyle factors, contribute to the high prevalence of comorbidity. Pharmacotherapies and psychotherapies are effective treatments, and lifestyle interventions and collaborative care models show promise for improving management.
Article
Psychiatry
Andrew Gumley, Simon Bradstreet, John Ainsworth, Stephanie Allan, Mario Alvarez-Jimenez, Lorna Aucott, Maximillian Birchwood, Andrew Briggs, Sandra Bucci, Sue M. Cotton, Lidia Engel, Paul French, Reeva Lederman, Shon Lewis, Matthew Machin, Graeme MacLennan, Hamish McLeod, Nicola McMeekin, Cathy Mihalopoulos, Emma Morton, John Norrie, Matthias Schwannauer, Swaran P. Singh, Suresh Sundram, Andrew Thompson, Chris Williams, Alison R. Yung, John Farhall, John Gleeson
Summary: This study aimed to assess the feasibility of a blended digital intervention for relapse prevention in schizophrenia. The results showed that this intervention was safe, acceptable, and feasible, indicating the need for further main trials.
