Article
Medicine, General & Internal
Habakkuk A. Yumo, Jackson N. Ndenkeh, Isidore Sieleunou, Denis N. Nsame, Pius B. Kuwoh, Marcus Beissner, Thomas Loscher, Christopher Kuaban
Summary: In comparison to children below 18 months, children aged 18 months and above showed higher rates of HIV testing, HIV positivity, and enrollment in ART treatment. This highlights the importance of prioritizing HIV testing for older children in order to achieve an AIDS-free generation.
Article
Infectious Diseases
Andreia De Matos, Sara Brandao Lopes, Jose Eduardo Serra, Eugenia Ferreira, Jose Saraiva da Cunha
Summary: The study found that PLWHIV with BSI had higher 30-day mortality, while three-year survival was influenced by lower CD4 cell counts, hematological tumors, and cardiopulmonary comorbidities.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Theerajet Guayboon, Yingyong Chinthammitr, Sanya Sukpanichnant, Navin Horthongkham, Nasikarn Angkasekwinai
Summary: A case of HHV-8-associated MCD in a patient with advanced HIV infection was reported, presenting with prolonged intermittent fever, urticarial rash, hepatosplenomegaly, and generalized lymphadenopathy. The patient's symptoms improved dramatically after rituximab treatment and has been in remission for almost two years. HHV-8 viral load and lymph node histopathology play important roles in diagnosis and monitoring disease activity.
Article
Multidisciplinary Sciences
Yue Fan, Dongdong Li, Pu Wang, Lili Ren, Xiaowei Chen
Summary: This study found a relationship between acute otitis media (AOM) in children with viral upper respiratory infection (URI) and infection by common respiratory viruses. Among the 255 children examined, 164 (64.1%) tested positive for at least one respiratory virus, with respiratory syncytial virus (RSV) being the most common. The presence of RSV was significantly higher in children with URI + AOM compared to those with URI alone.
Article
Immunology
Dalton Wamalwa, Irene Njuguna, Elizabeth Maleche-Obimbo, Emily Begnel, Daisy J. Chebet, Judith A. Onyango, Lisa Marie Cranmer, Meei-Li Huang, Barbra A. Richardson, Michael Boeckh, Grace John-Stewart, Jennifer Slyker
Summary: CMV viremia is common in hospitalized children with HIV and CMV DNA levels >= 1000 IU/mL are associated with increased risk of mortality and longer hospitalization.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Aleksandra Szczawinska-Poplonyk, Elzbieta Grzesk, Eyal Schwartzmann, Anna Materna-Kiryluk, Jadwiga Maldyk
Summary: ALPS is a disorder characterized by disruptions in lymphocyte apoptosis pathway and immune system homeostasis. This study highlights the challenges in diagnosing ALPS in the presence of CAEBV infection. Further research is needed to explore the role of CAEBV as a triggering and disease-modifying factor in ALPS.
FRONTIERS IN PEDIATRICS
(2021)
Article
Infectious Diseases
Ruth N. Kigozi, JohnBaptist Bwanika, Emily Goodwin, Peter Thomas, Patrick Bukoma, Persis Nabyonga, Fred Isabirye, Paul Oboth, Carol Kyozira, Mame Niang, Kassahun Belay, Gloria Sebikaari, James K. Tibenderana, Sam Siduda Gudoi
Summary: The study in Uganda found that key malaria commodities were widely available, and over 75% of health facilities tested suspected malaria cases. Regular supervision and training health workers in the use of RDTs were predictors of meeting the testing target.
Article
Infectious Diseases
Josselin Brisset, Karl Angendu Baki, Laurence Watier, Elisee Kinkpe, Justine Bailly, Linda Ayedadjou, Maroufou Jules Alao, Ida Dossou-Dagba, Gwladys Bertin, Michel Cot, Farid Boumediene, Daniel Ajzenberg, Agnes Aubouy, Sandrine Houze, Jean-Francois Faucher
Summary: This study aimed to describe the etiology, management, and early outcomes of non-traumatic comas in young children in Benin, and to identify factors associated with death. The study found that infections were the cause of all deaths, with cerebral malaria being the most common cause of non-traumatic coma. Missed opportunities for early effective antimalarial treatment were common.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Medicine, General & Internal
Andrea M. Weckman, Andrea L. Conroy, Mwayiwawo Madanitsa, Bruno Gnaneswaran, Chloe R. Mcdonald, Linda Kalilani-Phiri, Jaya Chandna, Doreen Ali, Victor Mwapasa, Carole Khairallah, Kyaw Lay Thwai, Steven R. Meshnick, Steve M. Taylor, Feiko O. Ter Kuile, Kevin C. Kain, Melissa Gladstone
Summary: Exposure to malaria in pregnancy and maternal immune activation can lead to neurodevelopmental delays in children, particularly in language development. Successful interventions to prevent malaria during pregnancy may reduce the risk of neurocognitive delay in offspring.
Article
Cell Biology
James A. Watson, Sophie Uyoga, Perpetual Wanjiku, Johnstone Makale, Gideon M. Nyutu, Neema Mturi, Elizabeth C. George, Charles J. Woodrow, Nicholas P. J. Day, Philip Bejon, Robert O. Opoka, Arjen M. Dondorp, Chandy C. John, Kathryn Maitland, Thomas N. Williams, Nicholas J. White
Summary: Severe malaria caused by Plasmodium falciparum is difficult to accurately diagnose in children in high-transmission settings. A combination of platelet count and plasma PfHRP2 concentration can be used to identify severe falciparum malaria in severely ill patients. About one-third of children enrolled in clinical studies of severe malaria in high-transmission settings in Africa had other causes of their severe illness.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Moses Ocan, Frances Acheng, Carol Otike, Judith Beinomugisha, David Katete, Celestino Obua
Summary: The study investigated the extent of protective immune response and breakthrough hepatitis B virus infections among adult vaccinated healthcare workers in northern Uganda. The majority of healthcare workers showed protective levels of hepatitis B antibodies and the protective immune response persisted for over ten years.
Article
Medicine, General & Internal
Deborah Omoleye, Muhammad A. Israr, Faria Tazin, Camille Celeste Go, Olanrewaju Saheed
Summary: This is a case report of a 15-year-old girl who presented with seizures and was diagnosed with cerebral malaria. The patient responded well to aggressive treatment with anti-malarial medications and antibiotics, and showed significant improvement after two weeks of treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Microbiology
Hanan A. Al-Nazal, Emily Cooper, Mei Fong Ho, Sharareh Eskandari, Victoria Majam, Ashwini Kumar Giddam, Waleed M. Hussein, Md Tanjir Islam, Mariusz Skwarczynski, Istvan Toth, Sanjai Kumar, Ali Zaid, Michael Batzloff, Danielle Stanisic, Michael F. Good
Summary: Researchers have developed a whole-parasite Babesia vaccine using chemically attenuated B. microti parasitized red blood cells and produced liposomes containing killed parasite material. The vaccine significantly reduces peak parasitemia following challenge.
CELL HOST & MICROBE
(2021)
Article
Immunology
Michelle E. Roh, Issaka Zongo, Alassane Haro, Liusheng Huang, Anyirekun Fabrice Some, Rakiswende Serge Yerbanga, Melissa D. Conrad, Erika Wallender, Jennifer Legac, Francesca Aweeka, Jean-Bosco Ouedraogo, Philip J. Rosenthal
Summary: In this case-control study assessing drug levels and resistance markers for seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine-amodiaquine in children in Burkina Faso, suboptimal drug levels and not increased prevalence of resistance markers was associated with incident malaria in SMC-eligible children.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Rolland Mutumba, Joseph Mbabazi, Hannah Pesu, Eva Greibe, Mette F. Olsen, Andre Briend, Christian Molgaard, Christian Ritz, Ezekiel Mupere, Suzanne Filteau, Henrik Friis, Benedikte Grenov
Summary: Anemia is common among stunted children in eastern Uganda, and micronutrient deficiencies, inflammation, and malaria are associated with low hemoglobin levels.