Article
Biochemical Research Methods
Julia Akesson, Zelmina Lubovac-Pilav, Rasmus Magnusson, Mika Gustafsson
Summary: ComHub is a tool for predicting hubs in GRNs by averaging predictions from a compendium of network inference methods. Benchmarking against DREAM5 challenge data and independent gene expression datasets showed robust performance. ComHub consistently scored among the top performing methods on data from different sources, and can work with both predefined networks and perform stand-alone network inference, making it generally applicable.
BMC BIOINFORMATICS
(2021)
Article
Cell Biology
Damion Demeter, Evan M. Gordon, Tehila Nugiel, AnnaCarolina Garza, Tyler L. Larguinho, Jessica A. Church
Summary: During childhood, neural systems supporting high-level cognitive processes undergo rapid growth and refinement, relying on successful coordination of activation across the brain. We identified four distinct hub categories in a large youth sample, each exhibiting more diverse connectivity profiles than adults. The split in youth hubs suggests a need for segregating sensory stimuli during rapid development of functional networks.
Article
Multidisciplinary Sciences
Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
Summary: The thalamus plays a critical role as an integrative functional hub in the brain, having extensive connections to multiple resting-state networks. Regions in the anterior and medial parts of the thalamus are associated with core neurocognitive networks, while connections to the sensorimotor network are more limited and distinctively located around the lateral pulvinar nucleus. Prominent connector hubs in the thalamus include the anteroventral, ventral lateral, and mediodorsal nuclei, which have functional connections to various resting-state networks. These findings highlight the importance of the thalamus in facilitating functional integration for brain functions related to primary processing and higher cognition.
Article
Neurosciences
Ruiqi Wu, Feng Wang, Pai-Feng Yang, John C. Gore, Li Min Chen
Summary: Pain perception involves multiple brain regions and networks. Nonhuman primates (NHP) offer an ideal model system to study these pain-related brain networks. By using heat nociceptive stimulation and high-resolution fMRI, researchers successfully parcellated and characterized the pain functional networks, identified key network hubs, and understood the network-wise temporal dynamics.
Article
Green & Sustainable Science & Technology
Ian McShane, Brian Coffey
Summary: This article discusses the role of community hubs and their importance in major events and disasters, emphasizing the criticality of social infrastructure in community building and resilience. The article highlights the need to rethink the concept and policy challenges of community hubs to achieve more socially and environmentally just development.
CURRENT OPINION IN ENVIRONMENTAL SUSTAINABILITY
(2022)
Article
Neurosciences
Kazuya Kawabata, Epifanio Bagarinaob, Hirohisa Watanabe, Satoshi Maesawab, Daisuke Mori, Kazuhiro Hara, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
Summary: Accumulating evidence suggests that the cerebellum is involved in various motor and cognitive tasks. This study used functional connectivity overlap ratio to identify connector hubs in the cerebellum, and found that several regions in the posterior cerebellum exhibited strong connectivity with multiple functional networks, especially the core neurocognitive networks.
Article
Multidisciplinary Sciences
Jordan P. Hamm, Yuriy Shymkiv, Shuting Han, Weijian Yang, Rafael Yuste
Summary: Neural processing of sensory information is strongly influenced by context, with stimulus-evoked responses being reduced or increased depending on contextual regularities. Deviance-augmented responses are limited to specific neurons in the supragranular layers of the visual cortex, forming a neuronal ensemble. Higher cortical areas modulate these context-selective ensembles in the primary sensory cortex, which play a crucial role in the brain's construction and selection of prediction errors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Behavioral Sciences
Lada Zelinski, Ibai Diez, David L. Perez, Sonja A. Kotz, Jorg Wellmer, Uwe Schlegel, Stoyan Popkirov, Johannes Jungilligens
Summary: This study investigates gray matter variations and their relationship with clinical features in patients with dissociative seizures. The results show that the duration of illness and seizure duration are inversely correlated with cortical thickness in specific areas of the brain. Further research is needed to understand the etiological factors contributing to these neuroanatomical variations related to self-referential processing in patients with dissociative seizures.
EPILEPSY & BEHAVIOR
(2022)
Article
Neurosciences
Sara Hernandez-Recio, Ricardo Munoz-Arnaiz, Victor Lopez-Madrona, Julia Makarova, Oscar Herreras
Summary: This study investigated the role of interhemispheric connections in the cortico-hippocampal circuits in anesthetized rats. The results showed varying bilateral correlation and coherence in different frequency bands and time scales. The CA1 region and the Schafer segment exhibited high bilateral coherence, while the Dentate Gyrus showed low coherence. Granger causality testing revealed strong bidirectional relationships between most homonymous bilateral generators.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Fuu-Jiun Hwang, Richard H. Roth, Yu-Wei Wu, Yue Sun, Destany K. Kwon, Yu Liu, Jun B. Ding
Summary: This study reveals that synaptic changes in the motor cortex and striatum play a crucial role in learning and consolidating new motor skills. The formation of long-lasting motor memory traces is associated with reactivation of specific neurons in the motor cortex and an increase in their output strength onto striatal projection neurons.
Review
Clinical Neurology
Jessica Royer, Boris C. Bernhardt, Sara Lariviere, Ezequiel Gleichgerrcht, Bernd J. Vorderwuelbecke, Serge Vulliemoz, Leonardo Bonilha
Summary: Hubs, as key regions connecting different parts of the brain, play a critical role in brain network organization and related disorders.
Article
Energy & Fuels
Nima Tarahomi, Mahdi Samadi, Mohammad Hasan Nikkhah
Summary: Energy decision-makers are exploring the use of energy hubs, which optimize systems with multiple energy carriers, to meet the growing demand for affordable and reliable energy. This paper proposes a novel framework to evaluate and compare series and parallel connections of energy hubs, considering cost and reliability aspects. New indices are introduced to assess the amount of energy not supplied and the energy input for each hub. Simulations are conducted to validate the proposed model and investigate different connection types. The results demonstrate that the total cost of energy carriers is lower in the series mode compared to the parallel mode.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2023)
Article
Neurosciences
Yuan Zhang, Srikanth Ryali, Weidong Cai, Kaustubh Supekar, Ramkrishna Pasumarthy, Aarthi Padmanabhan, Bea Luna, Vinod Menon
Summary: The ability to adaptively respond to behaviorally relevant cues in the environment undergoes significant maturation from childhood to adulthood, and it influences the developmental trajectories of several key cognitive domains. However, little is known about the underlying causal functional circuit mechanisms. This study investigates the maturation of causal signaling mechanisms underlying voluntary control over saccades using state-space and control-theoretic modeling. The results show that directed causal interactions in a saccade network undergo significant maturation between childhood and adulthood, with the frontal eye field being an immature causal signaling hub in children. Control-theoretic analysis demonstrates that the saccade network is less controllable in children compared to adults.
Article
Multidisciplinary Sciences
Koun Onodera, Hiroyuki K. Kato
Summary: The authors demonstrate that translaminar feedback projections from layer 5 suppress activity in superficial layers and enhance feature selectivity in the primary auditory cortex.
NATURE COMMUNICATIONS
(2022)
Article
Automation & Control Systems
Ming Qu, Tao Ding, Wenhao Jia, Shanying Zhu, Yongheng Yang, Frede Blaabjerg
Summary: This article proposes a dual-decomposition-based distributed algorithm to address the confidentiality issue in integrated energy systems, with the convergence rate proven. Numerical results validate the effectiveness of the algorithm.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2021)
