Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration

Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

(2012) Jessica L. Wittnam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

(2012) Dagmar Schlenzig et al.   JOURNAL OF NEUROCHEMISTRY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A  Is Induced by Pyroglutamate-A  Formation

(2011) A. Alexandru et al.   JOURNAL OF NEUROSCIENCE

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

(2010) H. S. Bateup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

(2009) Oliver Wirths et al.   ACTA NEUROPATHOLOGICA

Glutaminyl Cyclases Display Significant Catalytic Proficiency for Glutamyl Substrates

(2009) Franziska Seifert et al.   BIOCHEMISTRY

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

(2009) Dagmar Schlenzig et al.   BIOCHEMISTRY

N-terminal truncated pyroglutamyl β amyloid peptide Aβpy3-42 shows a faster aggregation kinetics than the full-length Aβ1-42

(2009) Cristina D'Arrigo et al.   BIOPOLYMERS

Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease

(2009) Benjamin R. Miller et al.   NEUROBIOLOGY OF DISEASE

Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery

(2008) Holger Cynis et al.   JOURNAL OF MOLECULAR BIOLOGY