Article
Neurosciences
Bin Wu, Xiaolin Su, Wentong Zhang, Yi-Hong Zhang, Xinghua Feng, Yong-Hua Ji, Zhi-Yong Tan
Summary: This study found that oxaliplatin depolarizes IB4(-) neurons through TRPM8 channels to drive the development of neuropathic pain, and targeting the initial drives of TRPM8 and/or membrane depolarization may prevent oxaliplatin-induced neuropathic pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Gabriela I. Aparicio, Antonella Leon, Rocio Gutierrez Fuster, Baylen Ravenscraft, Paula V. Monje, Camila Scorticati
Summary: The peripheral nervous system can repair itself, and DRG neurons play a role in promoting axon regeneration after injury. The membrane glycoprotein GPM6a is present in DRG neurons and is required for neurite elongation. This suggests that GPM6a could contribute to axon regeneration in the peripheral nervous system.
Article
Cell Biology
Ewa Mrowczynska, Antonina Joanna Mazur
Summary: This study confirms the expression of ILK in chicken DRG and its regulatory role in DRG development, demonstrating its crucial functions in DRG neurons and SCPs through functional experiments.
Article
Neurosciences
Markus Leo, Linda-Isabell Schmitt, Andrea Kutritz, Christoph Kleinschnitz, Tim Hagenacker
Summary: Cisplatin has a significant impact on satellite glial cells (SGCs) and dorsal root ganglion (DRG) neurons, affecting the expression of various proteins and potentially contributing to the neurotoxic side effects. Furthermore, SGC-secreted factors play a role in modulating the excitability of sensory neurons, suggesting that targeting SGCs could be a potential strategy in managing chemotherapy-induced neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Diego N. Messina, Emanuel D. Peralta, Alicia M. Seltzer, Sean I. Patterson, Cristian G. Acosta
Summary: This study investigated the effects of Nav1.8, ASIC3, P2X3, and TRPM8 on sensitivity to non-noxious stimuli during healthy aging. The results suggest that these functional markers are involved in mechanical and cold sensitivity, with changes in their expression levels in the dorsal root ganglia. The findings support the inclusion of aged rodents in pre-clinical studies evaluating pain treatments.
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Chemistry, Multidisciplinary
Yingqiao Wang, Raghav Garg, Jane E. Hartung, Adam Goad, Dipna A. Patel, Flavia Vitale, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: Utilizing nanomaterial-assisted photothermal stimulation, Ti3C2Tx (MXene) demonstrates excellent potential as a candidate for remote, non-genetic, optical modulation of neuronal electrical activity with high spatiotemporal resolution. The material's photothermal response, low cytotoxicity, and ease of large-scale synthesis make it a promising tool for modulating electrophysiology at various scales.
Article
Biochemistry & Molecular Biology
Amira Elfarnawany, Faramarz Dehghani
Summary: Research suggests that PEA may have protective effects against Paclitaxel-induced toxicity on DRG neurons, as evidenced by improved neuronal cell survival, neurite outgrowth, and reduced soma size in vitro.
Article
Multidisciplinary Sciences
Haohao Wu, Charles Petitpre, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, Francois Lallemend
Summary: The study identified three main types of proprioceptive neurons (Ia, Ib and II PNs) and found that they segregate into eight distinct subgroups. Importantly, Ia-PN subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Bing Wang, Longfei Ma, Xinying Guo, Shibin Du, Xiaozhou Feng, Yingping Liang, Gokulapriya Govindarajalu, Shaogen Wu, Tong Liu, Hong Li, Shivam Patel, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Summary: This study identifies a sensory neuron-specific long non-coding RNA, SS-lncRNA, which is predominantly expressed in small neurons of the dorsal root ganglion and contributes to the development and maintenance of neuropathic pain by regulating KCNN1 expression. The downregulation of SS-lncRNA leads to a decrease in KCNN1 expression and the development of neuropathic pain symptoms.
Review
Biochemistry & Molecular Biology
Jonathan H. P. Dawes, Robert N. Kelsh
Summary: The neural crest demonstrates remarkable multipotency, generating various cell types including pigment cells and skeletogenic cells. The control mechanism of this process has been debated for over 35 years. A new dynamic model based on zebrafish pigment cell development has been proposed, potentially resolving the controversy and changing our understanding of fate specification, differentiation, and commitment processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Adam J. Dourson, Zachary K. Ford, Kathryn J. Green, Carolyn E. McCrossan, Megan C. Hofmann, Renita C. Hudgins, Michael P. Jankowski
Summary: The study found that growth hormone (GH) plays an important regulatory role in neonatal pain processing, inhibiting peripheral hypersensitivity through GH receptor (GHr) signaling in primary afferents. After injury, a macrophage-dependent displacement of GH at the injury site was found to regulate neuronal transcription through SRF regulation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Valentina Dzreyan, Moez Eid, Stanislav Rodkin, Maria Pitinova, Svetlana Demyanenko
Summary: This study investigated the expression and localization of E2F1 after axonal injury and found that axotomy increased the expression of E2F1 in neurons. The study also suggested that E2F1 and downstream targets could be potential molecular targets for the development of neuroprotective agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Eliza Grlickova-Duzevik, Thomas M. Reimonn, Merilla Michael, Tina Tian, Jordan Owyoung, Aidan McGrath-Conwell, Peter Neufeld, Madison Mueth, Derek C. Molliver, Patricia Jillian Ward, Benjamin J. Harrison
Summary: By analyzing single-cell RNA-sequencing data from adult mice, researchers found that CELF4, a member of the CUGBP Elav-like family, was enriched in nociceptive neurons. Further experiments confirmed its expression in small-diameter C fibers and medium-diameter myelinated fibers, as well as its distribution in peripheral termini. The findings suggest that CELF proteins may play a role in regulating mRNA fate in nociceptors.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Wen-Long Qiao, Qing Li, Jia-Wei Hao, Shuang Wei, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: This study found a functional interaction between LPA and P2X3 receptors in rat sensory neurons. LPA enhanced the activity of P2X3 receptors through activation of the LPA(1) receptor and PKC pathway, exacerbating nociceptive behaviors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Lisa Barrett, Staci N. Stapleton, Neva J. Fudge, Michael D. Grant
Article
Endocrinology & Metabolism
Neva J. Fudge, Christopher S. Kovacs
Article
Virology
Jacqueline Hesson, Neva Fudge, Michael Grant
Summary: Although no significant differences were observed in markers of inflammation or measures of cognitive ability between CMV-seropositive and -seronegative sub-groups, the study found significant correlations between markers of inflammation and cognitive scores, as well as interconnections between anti-CMV antibody levels, fractalkine, cognitive ability, and depression scores. This suggests potential areas of focus for future studies.
Article
Endocrinology & Metabolism
Janine P. Woodrow, Christopher J. Sharpe, Neva J. Fudge, Ana O. Hoff, Robert F. Gagel, Christopher S. Kovacs
Article
Endocrinology & Metabolism
CS Kovacs, ML Woodland, NJ Fudge, JK Friel
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2005)
Article
Endocrinology & Metabolism
KR McDonald, NJ Fudge, JP Woodrow, JK Friel, AO Hoff, RF Gagel, CS Kovacs
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2004)
Article
Oncology
G Brasier, C Tikellis, L Xuereb, J Craigie, D Casley, CS Kovacs, NJ Fudge, R Kalnins, ME Cooper, PJ Wookey
EXPERIMENTAL CELL RESEARCH
(2004)
Article
Endocrinology & Metabolism
CS Kovacs, LL Chafe, NJ Fudge, JK Friel, NR Manley
Article
Endocrinology & Metabolism
CS Kovacs, LL Chafe, ML Woodland, KR McDonald, NJ Fudge, PJ Wookey
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2002)