Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Biochemistry & Molecular Biology
Yoshihiro Sato, Tomonori Tetsunaga, Kazuki Yamada, Yoshi Kawamura, Aki Yoshida, Toshifumi Ozaki
Summary: The acetabular labrum in the hip joint plays a crucial role in the stability of the joint and the progression of osteoarthritis (OA). The presence of nerve endings in the labrum contributes to hip OA pain, while vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) are associated with pain. This study analyzed the expression levels of VEGF and NGF in the labrum and their roles in OA, finding that their expression is correlated with pain severity and can serve as potential targets for pain management in early OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen
Summary: VEGF is a well-known angiogenic factor that plays a critical role in embryo implantation by enhancing embryo development and facilitating interactions between the embryo and endometrium. Changes in VEGF expression are correlated with reproductive failure, including recurrent implantation failure and recurrent miscarriage. This study aimed to clarify the role of VEGF in embryo implantation by reviewing recent literature and exploring its effects and underlying mechanisms.
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Alayi Bolatai, Yujing He, Na Wu
Summary: This paper summarizes the mechanisms of unbalanced VEGF and receptor expression based on data from relevant literature on GDM and eclampsia. An imbalance in VEGF and its binding receptor is often associated with the occurrence of multiple pregnancy disorders. In recent years, researchers have focused on the potential role of VEGF and its receptors in the development of GDM and eclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yijia Mao, Lingkai Meng, Huayi Liu, Yuting Lu, Kuo Yang, Guangze Ouyang, Yanran Ban, Shuang Chen
Summary: This review summarizes recent research on the influence of traditional Chinese medicine (TCM) on vascular endothelial growth factor (VEGF). It is found that many Chinese medicines and recipes have a regulatory effect on VEGF, providing new treatment ideas and theoretical basis for TCM as a complementary and alternative therapy.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Chemistry, Analytical
Yanli Zhu, Jikai Wang, Haitao Xie, Chengxiao Fu, Jiecan Zhou, Hailing Liu, Pengfei Zeng, Yiyang Sun
Summary: This article presents a new aptasensing platform for sensitive and specific detection of malignancy-associated biomarkers. The platform utilizes alkaline-earth sulfide nanodots as fluorescent labels, which can be excited by near-infrared light, to achieve low detection limits and reliable quantification. Additionally, the platform enables visual analysis and detection of target analytes through color transformation.
ANALYTICAL CHEMISTRY
(2022)
Review
Physiology
Xueli Liu, Bin Zhu, Yujie Li, Xinyue Liu, Sheng Guo, Chenglong Wang, Sen Li, Dingxuan Wang
Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ade Meidian Ambari, Gracia Lilihata, Ervan Zuhri, Elok Ekawati, Shoma Adhi Wijaya, Bambang Dwiputra, Renan Sukmawan, Basuni Radi, Sofia Mubarika Haryana, Suko Adiarto, Dicky A. Hanafy, Dian Zamroni, Elen Elen, Arwin S. Mangkuanom, Anwar Santoso
Summary: The study showed that external counterpulsation improved angiogenesis by preserving VEGF-A and VEGFR-2 levels. Both ECP and sham significantly increased miR-92a levels, with no significant difference in changes between the two groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Ophthalmology
Kenichi Nakamura, Sachi Kojima, Miyuki Inoue-Mochita, Hidenobu Tanihara, Toshihiro Inoue
Summary: We investigated the levels of VEGF, sVEGFR1, and sVEGFR2 in the aqueous humor of glaucoma patients and found correlations among them. sVEGFR1 levels were significantly higher in neovascular glaucoma patients, while sVEGFR2 levels were significantly higher in all glaucoma patients compared to controls. The levels of sVEGFR1 and sVEGFR2 were positively correlated in glaucoma patients, and VEGF levels were negatively correlated with both sVEGFR1 and sVEGFR2 in primary open angle glaucoma patients.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Oncology
Menglu Zhang, Jiaqi Liu, Gang Liu, Zeyu Xing, Ziqi Jia, Jiaxin Li, Wenyan Wang, Jie Wang, Ling Qin, Xin Wang, Xiang Wang
Summary: Breast cancer, the highest incidence of female malignancy, is heavily reliant on neo-vascularization for growth and metastasis, with Vascular Endothelial Growth Factor (VEGF) playing a crucial role. This review focuses on the prognostic value of VEGF in breast cancer, clinical experiences with anti-VEGF therapeutics, and biomarkers for predicting the effectiveness of anti-angiogenic treatment.
Article
Obstetrics & Gynecology
Ikbal Kaygusuz, Nur Semerci Gunduz
Summary: The study found significant associations between VEGF -2578C > A and -1154G > A polymorphisms and the risk of HMB-E, while no significant differences were observed in other polymorphic regions between the patient and control groups.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Chemistry, Medicinal
Yachana Mishra, Aditi Chattaraj, Vijay Mishra, Abhigyan Ranjan, Murtaza M. Tambuwala
Summary: Cancer is a deadly disease characterized by unregulated cell growth that can occur in any part of the body. Detecting ovarian cancer early can help lower the death rate, and aptamers have shown promise as probes for ovarian cancer detection. Compared to other probes, aptamers are more effective in targeting ovarian cancer. Several aptamers have been developed to detect the ovarian tumor marker VEGF, and this review discusses their potential for early-stage ovarian cancer detection and treatment efficacy.
Article
Biotechnology & Applied Microbiology
Youlu Chen, Zuoguan Chen, Jianwei Duan, Liang Gui, Huiyang Li, Xiaoyu Liang, Xinxin Tian, Kaijing Liu, Yongjun Li, Jing Yang
Summary: The research demonstrated that VEGF/NGF-NPs, by co-delivering VEGF and NGF genes, eliminating excessive H2O2, and promoting stable angiogenesis, enhanced the treatment effects of PVD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wanlin Xu, Zhen Zhang, Hao Lu, Yifan Wu, Jia Liu, Shengwen Liu, Wenjun Yang
Summary: The study created a PU/Gel/VEGF conduit which promotes proliferation, migration, and expression of neural markers in nerve cells, aiding in functional recovery of the injured side.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Clinical Neurology
Radek Kaiser, Karel Saur, Andriy Smolanka, Gautham Ullas, Vladimir Benes
Summary: This article reports a rare case of cervical fractures after non-judicial hanging. The patient experienced a Type-III Hangman's fracture combined with occlusion of the right vertebral artery and non-occlusive dissection of both internal carotid arteries. The patient underwent surgical treatment and long-term antiplatelet therapy, resulting in no neurological deficits and no significant restriction of cervical motion.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Chemistry, Physical
Daniel Horak, Karolina Turnovcova, Zdenek Plichta, Dana Marekova, Vladimir Proks, Radek Kaiser, David Netuka, Pavla Jendelova
Summary: In this study, a block copolymer consisting of PHP and PMAH was synthesized and conjugated with Dox and/or RGDS targeting peptide to create nanoparticles that can reduce glioblastoma tumor growth. The nanoparticles were found to effectively decrease tumor size and induce more apoptosis in treated cells compared to untreated cells.
COLLOID AND POLYMER SCIENCE
(2022)
Review
Clinical Neurology
Michal Makel, Andrej Sukop, David Kachlik, Petr Waldauf, Adam Whitley, Radek Kaiser
Summary: Restoring shoulder abduction is a priority in surgical treatment of brachial plexus injuries. This study found no significant difference in abduction strength between the radial nerve and intercostal nerves for axillary nerve reconstruction. However, there was a significant difference in range of motion.
NEUROSURGICAL REVIEW
(2022)
Review
Clinical Neurology
Nora Franziska Dengler, Stefano Ferraresi, Shimon Rochkind, Natalia Denisova, Debora Garozzo, Christian Heinen, Ridvan Alimehmeti, Crescenzo Capone, Damiano Giuseppe Barone, Anna Zdunczyk, Maria Teresa Pedro, Gregor Antoniadis, Radek Kaiser, Annie Dubuisson, Thomas Kretschmer, Lukas Rasulic
Summary: This article systematically reviews the existing literature and reaches a consensus among experienced neurosurgeons on the anatomy, diagnosis, and classification of thoracic outlet syndrome (TOS). The lack of level 1 evidence has led to controversy in this field, but the consensus statements developed by the experts provide valuable insights and guidance for future research in TOS.
Article
Anatomy & Morphology
Michal Benes, David Kachlik, Miroslav Belbl, Sarlota Havlikova, Vladimir Kunc, Adam Whitley, Radek Kaiser, Vojtech Kunc
Summary: This study aimed to analyze the anatomy of the infraclavicular part of the brachial plexus using meta-analytic techniques. The results showed a wide spectrum of possible origins for the nerves in this area, but the usual patterns were the most common types. Clinicians can benefit from this enhanced understanding of the brachial plexus anatomy when dealing with anatomically challenging pathologies in this specific area.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Cell Biology
Karolina Bretova, Viktorie Svobodova, Petr Dubovy
Summary: This study aimed to investigate the reactivity of GLS astrocytes in response to sciatic nerve compression in rats. The results demonstrated that sciatic nerve compression induced activation of GLS astrocytes, characterized by increased GFAP-IF intensity and longer cytoplasmic processes extending into the laminal region. The reactivity of GLS astrocytes was independent of cell proliferation.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Clinical Neurology
Aneta Krajcova, Michal Makel, Gautham Ullas, Veronika Nemcova, Radek Kaiser
Summary: This study demonstrates the anatomical feasibility of reconstructing the infraspinatus branch of the suprascapular nerve (IB-SSN) by transferring the lower subscapular nerve (LSN) in the adult population.
NEUROLOGICAL RESEARCH
(2023)
Review
Clinical Neurology
Michal Makel, Andrej Sukop, David Kachlik, Petr Waldauf, Adam Whitley, Radek Kaiser
Summary: Dual nerve transfer of the spinal accessory nerve to the suprascapular nerve (SAN-SSN) is an effective method for restoring shoulder abduction in brachial plexus injuries. The choice between the anterior and posterior approach for the SAN-SSN transfer does not significantly affect the outcomes of the surgery.
NEUROLOGICAL RESEARCH
(2023)
Review
Clinical Neurology
Shimon Rochkind, Stefano Ferraresi, Natalia Denisova, Debora Garozzo, Christian Heinen, Ridvan Alimehmeti, Crescenzo Capone, Damiano G. Barone, Anna Zdunczyk, Maria T. Pedro, Gregor Antoniadis, Radek Kaiser, Annie Dubuisson, Willem Pondaag, Thomas Kretschmer, Lukas Rasulic, Nora F. Dengler
Summary: This study conducted a systematic literature review and consensus statements on the management of neurogenic thoracic outlet syndrome (nTOS). Through screening and classification of literature, an online meeting was held to develop 14 recommendations on nTOS management. This work is important for guiding clinical decision-making and patient counseling in the neurosurgical field.
Review
Clinical Neurology
Radek Kaiser, Lucia Kantorova, Alena Langaufova, Simona Slezakova, Dagmar Tuckova, Miloslav Klugar, Zdenek Klezl, Pavel Barsa, Jan Cienciala, Richard Hajduk, Lumir Hrabalek, Roman Kucera, David Netuka, Martin Prymek, Martin Repko, Martin Smrcka, Jan Stulik
Summary: This systematic review and meta-analysis found no benefits of adding instrumented spinal fusion to decompression for treating degenerative spondylolisthesis (DS). Isolated decompression seems sufficient for most patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
Michal Varga, Lucia Kantorova, Alena Langaufova, Jan Stulik, Lucie Lancova, Nisaharan Srikandarajah, Radek Kaiser
Summary: This systematic review examines the diagnostic and therapeutic evidence on chronic neck or back pain using hybrid single-photon emission computed tomography (SPECT). It found that a positive finding on SPECT in facet arthropathy is associated with a significantly higher facet blockade effect, and surgical treatment of positive findings has a good effect. Therefore, SPECT/CT may be a useful method in evaluating patients with neck or back pain.
WORLD NEUROSURGERY
(2023)
Article
Anatomy & Morphology
Anhelina Khadanovich, Tomas Herma, Azzat Al-Redouan, Radek Kaiser, David Kachlik
Summary: This study aimed to investigate the communication pattern and overlap of the superficial branch of the radial nerve (SBRN) and the lateral antebrachial cutaneous nerve (LACN) in the forearm. The findings revealed that simultaneous lesion of these nerves is highly probable, emphasizing the clinical importance of their close relationship and connection.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2023)
Article
Clinical Neurology
P. Vanek, N. Svoboda, O. Bradac, J. Malik, R. Kaiser, D. Netuka
Summary: The clinical outcomes and fusion rates after 2 years of surgery were not significantly different between polyetheretherketone (PEEK) and titanium-coated PEEK (Ti-PEEK) cages.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
R. Kaiser, L. Kantorova, A. Langaufova, S. Slezakova, D. Tuckova, M. Klugar, Z. Klezl, P. Barsa, J. Cienciala, R. Hajduk, L. Hrabalek, R. Kucera, D. Netuka, M. Prymek, M. Repko, M. Smrcka, J. Stulik
Summary: This study aims to provide recommendations for surgical treatment of degenerative lumbar stenosis (DLS) and spondylolisthesis. The results suggest that surgical decompression can improve function and leg pain in DLS patients. For unstable spondylolisthesis, simple decompression is recommended.
ACTA CHIRURGIAE ORTHOPAEDICAE ET TRAUMATOLOGIAE CECHOSLOVACA
(2023)
Article
Clinical Neurology
Radek Kaiser, Michal Varga, Otto Lang, Petr Waldauf, Petr Vanek, Karel Saur, Vladimir Benes, David Netuka
Summary: The study investigated the effectiveness of posterior interbody fusion on patients with SPECT/CT positive lumbar degenerative disc disease. The results showed that fusion surgery led to significant clinical improvement and high satisfaction with the treatment. SPECT/CT imaging could be a useful tool for assessing patients with chronic low back pain, especially when MRI findings are inconclusive.
ACTA NEUROCHIRURGICA
(2023)