Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Rheumatology
Hui-Min Li, Yi Liu, Ren-Jie Zhang, Jing-Yu Ding, Cai-Liang Shen
Summary: Our meta-analysis indicates that VDR BsmI and TaqI polymorphisms are associated with OA susceptibility in the spine and the FokI polymorphism is associated with knee OA susceptibility. However, the ApaI polymorphism is not a significant genetic risk factor for OA. Ethnic stratification also showed no significant association between VDR gene polymorphisms and OA in Caucasians or Asians.
Article
Medicine, General & Internal
Lukasz Oldak, Patrycja Milewska, Sylwia Chludzinska-Kasperuk, Kamil Grubczak, Joanna Reszec, Ewa Gorodkiewicz
Summary: This study focused on quantifying cathepsin B, D, and S in gliomas, exploring their correlation with patient age, tumor size, and each other. The research led to the development of a diagnostic method for distinguishing different grades of glioma and identifying independent markers using cathepsins.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Sarra Bchir, Soumaya Boumiza, Hela ben Nasr, Abdelhamid Garrouch, Imen Kallel, Zouhair Tabka, Karim Chahed
Summary: The study found that patients with chronic obstructive pulmonary disease (COPD) had higher Cathepsin D (CTSD) activity compared to healthy controls, especially in smokers. The increased CTSD activity may be related to elevated levels of MMPs and TNF-alpha, particularly in COPD smokers, but not correlated with oxidative stress parameters.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Review
Medicine, General & Internal
Maoquan Yang, Wansheng Ji, Ning Xu, Chuanju Zong, Jinhua Gu, Xiaojing Guo, Li Zhang
Summary: In this meta-analysis, VDR gene polymorphisms including Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI were found to be significantly associated with colorectal cancer (CRC) risk. Specifically, the BsmI variant was associated with a lower risk of CRC in Caucasian population, the FokI polymorphism was associated with colon cancer risk, and the Cdx-2 polymorphism was associated with decreased CRC risk among Africans.
Review
Nutrition & Dietetics
Liana Najjar, Joshua Sutherland, Ang Zhou, Elina Hyppoenen
Summary: A systematic review and meta-analysis were conducted to assess the association between selected variants affecting 25-hydroxyvitamin D concentrations and T1D risk, revealing no significant correlation. Despite some heterogeneity in one of the genetic variants analyzed, overall results did not show any association with T1D susceptibility. Additionally, subgroup analysis for Caucasians also found no association with T1D.
Article
Endocrinology & Metabolism
Jingzhe Song, Nan Zhu, Xinchen Pan, Lu Guo, Xiang Kong
Summary: This study investigated the expression and significance of Cathepsin C (Cat C) and Cathepsin D (Cat D) in the serum and placenta of nonpregnant women, pregnant women in different trimesters, and patients with preeclampsia (PE). The results showed that the levels of Cat C were significantly lower in the first trimester compared to the nonpregnant group, while Cat D levels were significantly higher. Cat C and D levels increased in the second and third trimesters, with no significant difference between the two trimesters. In patients with PE, Cat C levels were significantly higher and Cat D levels were significantly lower than in the third trimester, and these levels were correlated with the severity of PE.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: The meta-analysis showed no significant association between the ACE I/D polymorphism and lung cancer risk, and subgroup analysis by ethnicity did not yield significant results.
Article
Biochemistry & Molecular Biology
Sandeep Goyal, Ketul V. Patel, Yadav Nagare, Digambar B. Raykar, Santosh S. Raikar, Atul Dolas, Princy Khurana, Rajath Cyriac, Sharad Sarak, Mukesh Gangar, Anil K. Agarwal, Aditya Kulkarni
Summary: This study describes the design, optimization, and evaluation of novel non-peptidic acylguanidine based small molecule inhibitors of Cathepsin D, leading to the identification of an optimized lead 24e with improved microsomal stability and potency. This compound could serve as a potential candidate for further preclinical studies against diseases where Cathepsin D plays a key role.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Qian Li, Wen Li, Menglu Chen, Yihui Chai, Liancheng Guan, Yunzhi Chen
Summary: This study, through a meta-analysis of relevant research, found that VDR Fok I gene polymorphism is closely associated with susceptibility to sepsis, and patients with sepsis have lower levels of 25-hydroxyvitamin D. VDR Fok I gene mutations may change the risk of sepsis.
Review
Medicine, General & Internal
Xiaofeng Li, Xianghai Gan, Junzuo Gong, Tianyi Mou, Hua Zhou, Mengqin Li
Summary: This meta-analysis aims to summarize the association between BsmI, ApaI, TaqI, and FokI polymorphisms and the risk of acute pancreatitis, with results to be submitted to a peer-reviewed journal for publication.
Article
Multidisciplinary Sciences
Fei Ju, Ruonan Zhu
Summary: This meta-analysis found that lower vitamin D levels are associated with allergic rhinitis, and vitamin D supplementation might be beneficial in addition to standard treatment. Furthermore, the VDR gene variant rs2228570 was also found to be associated with the development of rhinitis, requiring further research for confirmation.
Article
Dermatology
Young Ho Lee, Gwan Gyu Song
Summary: This study found a correlation between VDR ApaI and BsmI polymorphisms and vitiligo susceptibility in the Asian population, while no association was observed for TaqI and FokI polymorphisms in European, Asian, Arab, and Latin American populations.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Kayvon Pedram, Nouf N. Laqtom, D. Judy Shon, Alessandro Di Spiezio, Nicholas M. Riley, Paul Saftig, Monther Abu-Remaileh, Carolyn R. Bertozzi
Summary: Mucins play important roles in various human diseases, and studying their biosynthesis and inhibition of glycosylation is significant. Our research challenges the traditional view by showing that heavily O-glycosylated mucin domains can be proteolytically degraded in mammalian tissues without prior deglycosylation. This finding provides insights into the endogenous pathways for glycoprotein catabolism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Obstetrics & Gynecology
Cong Chen, Wan-Fen Wang, Gong-Li Yang, Chong Guo
Summary: The meta-analysis found a significant association between ACE gene I/D polymorphism and PCOS risk, showing that the variations are related to increased susceptibility to PCOS.
REPRODUCTIVE SCIENCES
(2022)
