Article
Neurosciences
Nils Schroeter, Ganna Blazhenets, Lars Frings, Wolfgang H. Jost, Cornelius Weiller, Michel Rijntjes, Philipp T. Meyer, Joachim Brumberg
Summary: This study used [F-18]FDG PET to assess glucose metabolism in the substantia nigra (SN) of patients with Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP), and found that it can be used as a marker to distinguish neurodegenerative parkinsonian syndromes (NP) from controls. The method showed good diagnostic accuracy, especially for PD patients without the expression of a specific metabolic pattern.
NPJ PARKINSONS DISEASE
(2022)
Article
Medicine, General & Internal
Cecile Cuvilliers, Xavier Palard-Novello, Clemence Pontoizeau, Pierre Meneret, Anne Devillers, Florence Le Jeune, Antoine Girard
Summary: Adding bloodpool SPECT/CT to standard three-phase bone scintigraphy significantly improved diagnostic accuracy for lower extremity pain, particularly in identifying tendonitis. This additional imaging modality increased confidence in diagnostic conclusions without impacting inter-reader agreement.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Skye Hsin-Hsien Yeh, Chuang-Hsin Chiu, Hung-Wen Kao, Ching-Po Lin, Yu-Hus Lai, Wen-Sheng Huang
Summary: This study examined the relationship between dopamine transporter (DAT) loss and globus pallidus necrosis in patients with delayed neuropsychiatric syndrome (DNS) after acute carbon monoxide (CO) poisoning. The results showed that Tc-99m TRODAT-1 SPECT and MRI could assist in evaluating the risk of Parkinsonism and indicating DAT availability after hyperbaric oxygen therapy (HBOT) in CO-poisoned patients with DNS.
Article
Multidisciplinary Sciences
Mingnan Lin, Size Wu
Summary: The purpose of this study was to investigate the positive predictive value of ultrasound classification of non-mass breast lesions (NMLs) following the breast imaging reporting and data system (BI-RADS), and to enhance understanding of NMLs. The results showed that stratifying the malignancy risk of breast NMLs using the BI-RADS has the potential to improve sensitivity and positive predictive value, but malignant NMLs are underestimated in terms of malignancy likelihood, while benign NMLs are overestimated. The solution may be to separate NMLs from breast masses and use different malignancy risk stratification protocols.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmood Nazari, Andreas Kluge, Ivayla Apostolova, Susanne Klutmann, Sharok Kimiaei, Michael Schroeder, Ralph Buchert
Summary: This study tested layer-wise relevance propagation (LRP) to explain the CNN-based classification of dopamine transporter (DAT) SPECT images in patients with clinically uncertain parkinsonian syndromes. The results showed that LRP provided relevant maps that were easy to interpret and highlighted the key brain regions for CNN-based classification. Overall, LRP is recommended to support CNN-based classification of DAT-SPECT in clinical routine, with a total computation time of 3 seconds which is compatible with busy clinical workflow. The utility of inconsistent relevance maps to identify misclassified cases requires further investigation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Clinical Neurology
Ryoji Goto, Masanori Kurihara, Masashi Kameyama, Hiroki Komatsu, Masashi Higashino, Keiko Hatano, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Tomoyasu Matsubara, Kazutomi Kanemaru, Yuko Saito, Shigeo Murayama, Atsushi Iwata
Summary: This study found a significant correlation between cerebrospinal fluid homovanillic acid (HVA) concentration and striatal dopamine transporter (DAT) binding in patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). The reduction of striatal DAT binding was more advanced in PSP patients compared to PD patients.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Kathryn Busch, Andrew Davidson, Antonio Di Ieva, Nazih Assaad, Mark Butlin, Alberto Avolio, Hosen Kiat
Summary: This study used non-invasive monitoring methods to evaluate the hemodynamic measurements of bAVM patients before and after surgery, and found significant venous changes after surgery. The velocity and pulsatility of the middle cerebral veins increased postoperatively and stabilized within 14 days.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Basil C. Preisig, Alexis Hervais-Adelman
Summary: There is individual variability in the effectiveness of non-invasive brain stimulation. This study found evidence for a dose-response relationship between individual differences in electric fields and tACS-induced activity and connectivity changes, particularly in the right hemisphere.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Stephanie Klinzing, Federica Stretti, Alberto Pagnamenta, Markus Bechir, Giovanna Brandi
Summary: This study used TCCD to investigate CO2-CVR in different groups of individuals, with results showing no significant differences in CO2-CVR among volunteers, sedated and mechanically ventilated patients without TBI, and sedated and mechanically ventilated patients in the acute phase after TBI.
Article
Integrative & Complementary Medicine
Zhen Liu, Yan Pan, Qingdong Zhang, Xiaofei Wang
Summary: This study aimed to investigate the predictive value of quantitative analysis of results from the Doppler ultrasound examination in evaluating restenosis after carotid artery stenting (CAS). Results showed that the peak systolic velocity (PSV) and peak systolic velocity of the internal carotid artery/peak systolic velocity of the common carotid artery (PSVICA/PSVCCA) can be used as reference indicators for evaluating restenosis severity >50% and >80%.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yuan Liang, Yunyou Duan, Changyang Xing, Jinglan Jin, Lingjuan Yan, Xi Liu, Jia Wang
Summary: This study found that the cerebral hemodynamic parameters detected by transcranial colorcoded duplex sonography (TCCD), combined with age, can help predict the prognosis of patients with severe traumatic brain injury (sTBI) at 6 months after large decompressive craniectomy (DC). The findings suggest that TCCD is a noninvasive method with the potential to assess the prognosis of these patients.
ADVANCES IN THERAPY
(2022)
Article
Medicine, General & Internal
Eun-Chong Yoon, Jong-Sun Kim, Chae Hong Lim, Soo Bin Park, Suyeon Park, Kyung-Ann Lee, Hyun-Sook Kim
Summary: This study reassessed the diagnostic utility of sacroiliac joint/sacrum (SIS) ratios of single-photon emission computed tomography/computed tomography (SPECT/CT) for identifying sacroiliitis. The visual scoring method of SPECT/CT showed high sensitivity and negative predictive value in diagnosing axial spondyloarthritis (axSpA).
Article
Psychiatry
Ruiyang Ge, Afifa Humaira, Elizabeth Gregory, Golnoush Alamian, Erin L. MacMillan, Laura Barlow, Rebecca Todd, Sean Nestor, Sophia Frangou, Fidel Vila-Rodriguez
Summary: The study investigated the predictive value of functional connectivity changes induced by acute repetitive transcranial magnetic stimulation (rTMS) for clinical response in treatment-resistant depression. The findings suggest that these connectivity changes may serve as predictors of treatment response and can inform prospective clinical trials.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mercedes Riveira-Martin, Azadeh Akhavanallaf, Zahra Mansouri, Nicola Bianchetto Wolf, Yazdan Salimi, Alexis Ricoeur, Ismini Mainta, Valentina Garibotto, Antonio Lopez Medina, Habib Zaidi
Summary: This study found a strong correlation between absorbed dose metrics from Tc-99m-MAA simulation and Y-90 therapy dosimetry based on SPECT/CT. Although the simulation tended to overestimate tumour absorbed doses, it highlights the predictive ability of Tc-99m-MAA not only in terms of mean absorbed dose but also of the dose distribution.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinghong Ma, Lin Guo, Hailong Zhang, Kai Han, Lei Wang, Wei Fang
Summary: Objective data on the association between myocardial ischemia and outcomes for untreated coronary chronic total occlusion (CTO) patients are limited. This study found that ischemia detected by SPECT myocardial perfusion imaging (MPI) can independently predict adverse events in unrevascularized CTO patients, with CTO-related ischemia being a significant predictor of outcomes. SPECT MPI can help identify high-risk patients who may benefit from subsequent CTO percutaneous coronary intervention.
ANNALS OF NUCLEAR MEDICINE
(2022)