Article
Medicine, General & Internal
Masashi Uehara, Shota Ikegami, Hiroshi Horiuchi, Jun Takahashi, Hiroyuki Kato
Summary: This study investigated the prevalence of low back pain and identified subject-specific factors associated with low back pain in a Japanese community-dwelling older adult population. The results showed that the prevalence of low back pain tended to increase with age, and there were similar findings between genders. Multivariate analysis revealed that pelvic incidence minus lumbar lordosis (PI-LL) mismatch was a significant independent factor associated with low back pain.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Silvia Calabria, Giulia Ronconi, Letizia Dondi, Carlo Piccinni, Enrico Cinconze, Antonella Pedrini, Immacolata Esposito, Alice Addesi, Nello Martini, Aldo Pietro Maggioni
Summary: This study analyzed healthcare consumption and costs of CAD patients eligible for secondary prevention in Italy in 2018, revealing a significant burden on patients with comorbidities and frequent hospitalizations. A multidisciplinary healthcare approach is recommended to improve patient outcomes and reduce costs for the Italian National Health Service.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Takashi Waki, Katsuyuki Miura, Sachiko Tanaka-Mizuno, Yusuke Ohya, Koichi Node, Hiroshi Itoh, Hiromi Rakugi, Jumpei Sato, Kazuo Goda, Masaru Kitsuregawa, Tomoki Ishikawa, Naohiro Mitsutake
Summary: This study investigated the prevalence and treatment of hypertensive patients in Japan. The findings revealed that in 2014, approximately 27 million Japanese people were diagnosed with hypertension, and around 90% of them received antihypertensive medication. The prevalence of hypertensive patients varied geographically, but the rates were similar between men and women.
HYPERTENSION RESEARCH
(2022)
Article
Medicine, General & Internal
Masakazu Igarashi, Kotoba Okuyama, Naoya Ueda, Hideki Sano, Kanae Takahashi, Zaina P. Qureshi, Shigeru Tokita, Asao Ogawa, Yasuyuki Okumura, Shoki Okuda
Summary: This retrospective, cross-sectional observational study aimed to assess the incremental medical costs of delirium in hospitalised elderly Japanese patients with cognitive impairment. The study found that medical costs during hospitalisation were significantly higher for patients with delirium compared with those without delirium, regardless of patient subgroups such as age, sex, intensive care unit admission, and most comorbidities.
Article
Clinical Neurology
Fusao Ikawa, Naoyuki Isobe, Nobuaki Michihata, Soichi Oya, Kenji Ohata, Kiyoshi Saito, Kazunari Yoshida, Kiyohide Fushimi, Hideo Yasunaga, Teiji Tominaga, Kaoru Kurisu
Summary: The study identified advanced age, tumor location, diabetes mellitus, and chronic heart disease as risk factors for surgical treatment of AMS in elderly patients. Functional decline at discharge was found to be a significant risk for elderly patients undergoing AMS surgery, highlighting the importance of assessing these factors before surgery.
WORLD NEUROSURGERY
(2021)
Article
Health Care Sciences & Services
Elaine Miyuka Sato, Mauricio Oliveira Magalhaes, Beatriz Coelho Jenkins, Lays da Silva Ferreira, Hallyson Andrey Raposo da Silva, Paulo Renan Farias Furtado, Eder Gabriel Soares Ferreira, Emmanuele Celina Souza dos Santos, Bianca Callegari, Amelia Pasqual Marques
Summary: The study revealed a high prevalence of low back pain among the elderly population (55.7%), which was positively associated with hypertension and negatively associated with education, income, physical activity, and self-perceived health.
Article
Public, Environmental & Occupational Health
Justin M. Chan, Matthew W. Carroll, Matthew Smyth, Zachary Hamilton, Dewey Evans, Kimberlyn McGrail, Eric Benchimol, Kevan Jacobson
Summary: The study compared health administrative data and clinical registry data to evaluate the epidemiology of pediatric IBD in British Columbia, Canada. The findings showed an increasing incidence of IBD in children, with the highest rise among children aged 10-17. However, there were differences in age distribution between the two data sources, with more 10-17-year-olds identified in health administrative data and fewer 6-9-year-olds compared to clinical registry data.
CLINICAL EPIDEMIOLOGY
(2021)
Article
Immunology
Kohei Uemura, Sachiko Ono, Nobuaki Michihata, Hayato Yamana, Hideo Yasunaga
Summary: This study suggests that influenza vaccine has moderate effectiveness in preventing incidence of influenza in the elderly population in Japan, but the protective effect weakens over time. The vaccine can provide protection against influenza for 4 to 5 months after vaccination in individuals aged 65-69 and 80 years and above.
Article
Clinical Neurology
Isabel Torres-Camacho, Maria Camila Pantoja, Luis Alfonso Zarco, Jose Luis Peralta, Carolina Garcia-Alfonso, Diego Rosselli
Summary: This study estimated the prevalence of NMOSD in Colombia between 2017 and 2021 using the official Ministry of Health administrative database. The study found that out of 2,650 diagnosed NMOSD patients, the average age was 44.9 years and the overall unadjusted prevalence rate was 5.3 per 100,000 individuals, with higher rates for females (7.8) than for males (2.8). Further research is needed to understand the contributing factors.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Immunology
Yoshinori Takeuchi, Masao Iwagami, Sachiko Ono, Nobuaki Michihata, Kohei Uemura, Hideo Yasunaga
Summary: This study aimed to evaluate the risk of serious adverse effects after COVID-19 mRNA vaccination. The results showed that the COVID-19 mRNA vaccine was generally safe, but an increased risk of pulmonary embolism was observed in women after the first dose.
Article
Rheumatology
Chong Seng Edwin Lim, Mark Tremelling, Louise Hamilton, Matthew Kim, Alexander Macgregor, Tom Turmezei, Karl Gaffney
Summary: The prevalence of undiagnosed axial spondyloarthritis (RVD-axSpA) in patients with chronic back pain attending routine secondary care IBD clinics is estimated to be 5%. This highlights the significant hidden disease burden among IBD patients and emphasizes the importance of appropriate identification and referral to ensure timely diagnosis and access to appropriate therapy.
Article
Environmental Sciences
Etsuji Okamoto
Summary: Japan's universal health coverage includes dental care in its essential benefits, with services and prices regulated by a uniform fee schedule. Research indicates that this system effectively addresses challenges from population aging and leads to marked improvements in dental health among the elderly population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Koichi Suda, Hiroyuki Yamamoto, Tatsuto Nishigori, Kazutaka Obama, Yukie Yoda, Makoto Hikage, Susumu Shibasaki, Tsuyoshi Tanaka, Yoshihiro Kakeji, Masafumi Inomata, Yuko Kitagawa, Hiroaki Miyata, Masanori Terashima, Hirokazu Noshiro, Ichiro Uyama
Summary: The study findings suggest that insurance-covered robotic gastrectomy has been safely implemented nationwide in Japan. Patients undergoing robotic gastrectomy did not have higher morbidity rates compared to laparoscopic gastrectomy, but had a higher reoperation rate and shorter postoperative hospitalization duration.
Article
Clinical Neurology
Ping-Song Chou, Pi-Shan Sung, Chi-Hung Liu, Yueh-Feng Sung, Ray-Chang Tzeng, Chun-Pai Yang, Chi-Hsun Lien, Helen L. Po, Shang-Chang Ho, Yi-Te Tsai, Tsang-Shan Chen, Shey-Lin Wu, Han-Hwa Hu, A-Ching Chao
Summary: This study found that cerebral small vessel disease (SVD) is common in stroke patients with clinical aspirin treatment failure, and severe white matter lesions are significantly associated with functional outcomes. Therefore, the burden of SVD should be considered when developing future antiplatelet strategies for stroke patients after ATF.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Jiefeng Liu, Yuqian Chen, Chunlin Jin, Duo Chen, Guangfeng Gao, Fen Li
Summary: The prevalence of stroke was high in hypertensive patients aged 60 and above in Jiading District, Shanghai. Dyslipidemia, lack of exercise, atrial fibrillation, and family history of stroke were significantly associated with stroke in hypertensive population. Stroke risk can be increased especially when multiple factors coexisting, and family history of stroke combined with a lack of exercise or dyslipidemia.
Article
Chemistry, Medicinal
Kien Tran, Robin Van den Hauwe, Xavier Sainsily, Pierre Couvineau, Jerome Cote, Louise Simard, Marco Echevarria, Alexandre Murza, Alexandra Serre, Lea Theroux, Sabrina Saibi, Lounes Haroune, Jean-Michel Longpre, Olivier Lesur, Mannix Auger-Messier, Claude Spino, Michel Bouvier, Philippe Sarret, Steven Ballet, Eric Marsault
Summary: Side-chain-constrained amino acids were used to modify apelin-13 (Ape13), resulting in analogues with higher affinity for the apelin receptor (APJ). Substitutions at the Pro12 and Phe13 positions, particularly using 1Nal, Trp, Aia, D-Tic, Db(z)g, and D-alpha-Me-Tyr(OBn) residues, proved to be beneficial in enhancing binding affinity and signaling profile. Compounds 47 and 53 emerged as the most potent Ape13 analogues, with improved pharmacokinetic properties and activation of the G alpha(12) pathway.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Behavioral Sciences
Melanie Vivancos, Roberto Fanelli, Elie Besserer-Offroy, Sabrina Beaulieu, Magali Chartier, Martin Resua-Rojas, Christine E. Mona, Santo Previti, Emmanuelle Remond, Jean-Michel Longpre, Florine Cavelier, Philippe Sarret
Summary: The chemically-modified NT(8-13) analog JMV5296 showed a prolonged plasma half-life, peptide selectivity toward NTS2, and induced a strong antinociceptive effect in acute, tonic, and chronic pain models without inducing hypothermia, suggesting it as a promising avenue for new stable NT agonists development and improvement of pain management.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Oncology
Elora Midavaine, Jerome Cote, Philippe Sarret
Summary: The chemokines CCL2 and CXCL12, along with their receptors CCR2 and CXCR4, play a central role in the formation and development of bone metastases, influencing tumor cell survival, growth, and migration. Understanding the pathophysiology of bone metastases is crucial for reducing the skeletal tumor burden in patients.
CANCER AND METASTASIS REVIEWS
(2021)
Editorial Material
Chemistry, Medicinal
Philippe Sarret
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Christian Comeau, Benjamin Ries, Thomas Stadelmann, Jacob Tremblay, Sylvain Poulet, Ulrike Frohlich, Jerome Cote, Pierre-Luc Boudreault, Rabeb Mouna Derbali, Philippe Sarret, Michel Grandbois, Gregoire Leclair, Sereina Riniker, Eric Marsault
Summary: Small modifications to peptidic macrocycles, such as peptoid substitution and methyl placements, can have a significant impact on permeability. Our study found that changing one peptoid position in the cycle systematically improved permeability, while the influence of methyl substitution varied case by case. Using molecular dynamics simulations and NMR measurements, we provided hypotheses to explain these behaviors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Marc-Andre Dansereau, Elora Midavaine, Valerie Begin-Lavallee, Mounir Belkouch, Nicolas Beaudet, Jean-Michel Longpre, Stephane Melik-Parsadaniantz, Philippe Sarret
Summary: The CCL2/CCR2 axis in the DRG plays a role in peripheral inflammation-induced nociceptor sensitization and pain hypersensitivity, with potential therapeutic implications for painful inflammatory disorders.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Cornelis Immanuel van der Zouwen, Joel Boutin, Maxime Fougere, Aurelie Flaive, Melanie Vivancos, Alessandro Santuz, Turgay Akay, Philippe Sarret, Dimitri Ryczko
Summary: The study found that mice could brake and make sharp turns based on environmental cues during optogenetic stimulation of the MLR, even when increasing laser power to maintain appropriate speed. This indicates that Vglut2-positive neurons of the cuneiform nucleus are a crucial target for increasing locomotor activity while preserving braking and turning capabilities.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Medicine, Research & Experimental
Magali Chartier, Michael Desgagne, Marc Sousbie, Charles Rumsby, Lucie Chevillard, Lea Theroux, Lounes Haroune, Jerome Cote, Jean-Michel Longpre, Pierre-Luc Boudreault, Eric Marsault, Philippe Sarret
Summary: The study discusses a constrained NTS2 macrocyclic NT analog with high selectivity, improved plasma stability, and potent analgesic effects in acute, chronic, and inflammatory pain models. This analog shows strong potential for pain management.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Behavioral Sciences
Elora Midavaine, Jerome Cote, Serge Marchand, Philippe Sarret
Summary: Chronic pain is a major global health issue with limited pharmacological treatment options available. Sex-specific differences in pain conditions are increasingly recognized, highlighting the importance of developing gender-specific pain medications. Research on sexually dimorphic pain responses is vital for advancing pain management strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Nairie Michaelian, Anastasiia Sadybekov, Elie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A. Zamlynny, Xavier Fradera, Phieng Siliphaivanh, Jeremy Presland, Kerrie B. Spencer, Stephen M. Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov
Summary: The leukotriene B4 receptor 1 (BLT1) plays a role in various human diseases and the crystal structure study reveals molecular determinants of ligand binding and selectivity toward different receptor subtypes, providing insights for future structure-based drug design.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Xavier Sainsily, David Coquerel, Hugo Giguere, Lauralyne Dumont, Kien Tran, Christophe Noll, Andrei L. Ionescu, Jerome Cote, Jean-Michel Longpre, Andre Carpentier, Eric Marsault, Olivier Lesur, Philippe Sarret, Mannix Auger-Messier
Summary: The experiment revealed that under high-salt diet conditions, Elabela was more effective than Apelin-13 in reducing high blood pressure, cardiovascular and renal dysfunctions, and displayed better protective effects in salt-induced severe hypertension and cardiorenal failure.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Michael Biet, Marc-Andre Dansereau, Philippe Sarret, Robert Dumaine
Summary: Voltage-gated ion channels, including I-Na, I-CaL, and I-K, play a crucial role in the initiation and propagation of action potentials in sensory neurons. Chronic inflammation induced by CFA alters the activity of these ion channels, resulting in prolonged action potentials and increased nociception. Targeting the transient potassium current I-A may provide a potential therapeutic strategy for reducing pain during inflammation.
PHYSIOLOGICAL REPORTS
(2021)
Article
Health Care Sciences & Services
Lise Dassieu, Emilie Paul-Savoie, Elise Develay, Ana Cecilia Villela Guilhon, Anais Lacasse, Line Guenette, Kadija Perreault, Helene Beaudry, Laurent Dupuis
Summary: This study aimed to understand experiences of people living with chronic pain and community pharmacists regarding the management of analgesic adverse effects. Patients and pharmacists had varying definitions of adverse effects, leading to dilemmas and discrepancies in decision-making. Pharmacists faced barriers in supporting patients due to organizational and financial constraints.
HEALTH EXPECTATIONS
(2022)
Article
Chemistry, Medicinal
Kien Tran, Xavier Sainsily, Jerome Cote, David Coquerel, Pierre Couvineau, Sabrina Saibi, Lounes Haroune, Elie Besserer-Offroy, Joel Flynn-Robitaille, Martin Resua Rojas, Alexandre Murza, Jean-Michel Longpre, Mannix Auger-Messier, Olivier Lesur, Michel Bouvier, Eric Marsault, Pierre-Luc Boudreault, Philippe Sarret
Summary: We have developed novel macrocyclic compounds of Ape13, analogues 39 and 40, which have reduced molecular weight and specific pharmacological profiles.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Santo Previti, Michael Desgagne, Dirk Tourwe, Florine Cavelier, Philippe Sarret, Steven Ballet
Summary: Chronic pain is a global health issue and opioid drugs are commonly used for pain management. However, they come with adverse effects. Neurotensin (NT) ligands have shown promising potential for pain management, without the adverse effects of opioids.
JOURNAL OF PEPTIDE SCIENCE
(2023)