Article
Biochemistry & Molecular Biology
Tijana B. Radovanovic, Branka R. Gavrilovic, Tamara G. Petrovic, Svetlana G. Despotovic, Jelena P. Gavric, Ana Kijanovic, Marko Mirc, Natasa Tomasevic Kolarov, Caterina Faggio, Marko D. Prokic
Summary: Global warming poses a severe threat to existing ecosystems, affecting anuran tadpoles' survival and fitness, while climate change and chemical pollution also impact their adaptation. Pre-exposure to desiccation can modulate biochemical responses to chemical stressors, enhancing antioxidant activity and reducing lipid peroxidation in juveniles. The study suggests that tadpoles exposed to stressful environments may develop adaptive responses to subsequent stressors.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Immunology
Hao Yuan, Si-Xian Wu, Yi-Feng Zhou, Fang Peng
Summary: The study demonstrates that SPD can protect CIA mice by inhibiting the polarization of M1 macrophages, reducing pro-inflammatory cytokines, and promoting the release of anti-inflammatory factors.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Immunology
Anqi Li, Zhanfeng Zhang, Xiaochen Ru, Yanfeng Yi, Xiaoyu Li, Jing Qian, Jue Wang, Xiaobing Yang, Yunliang Yao
Summary: Through gene expression analysis, a total of 1,885 up-regulated and 1,899 down-regulated DEGs were identified in RA samples. The analysis showed significant differences in the infiltration of 25 cells, and 603 immune-related genes were obtained through WGCNA, with 270 DEIRGs identified. Enrichment analysis indicated that DEIRGs were associated with immunity-related biological processes, and 4 candidate biomarkers were identified through the PPI network.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenzhen Zhang, Jin Zhao, Kuan Chen Lai, Laijun Lai
Summary: The study found that TAPBPL protein can significantly ameliorate CII-induced arthritis in mice and reduce the expression of inflammatory cytokines. The results suggest that TAPBPL protein has the potential to be used in the treatment of patients with RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Pan Shen, Weiji Lin, Xin Ba, Yao Huang, Zhe Chen, Liang Han, Kai Qin, Ying Huang, Shenghao Tu
Summary: Herba taxilli, composed of Taxillus chinensis, is used in traditional Chinese medicine to treat inflammation and arthritis. Quercetin, a key component, shows antiarthritic effects and may act through SIRT1 to target mitochondrial biogenesis in rheumatoid arthritis treatment. Further research is needed to fully understand the mechanisms involved.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Mijin Kim, Bongjun Sur, Thea Villa, Seung Yeol Nah, Seikwan Oh
Summary: The study showed that Gintonin has anti-arthritic effects by inhibiting the expression of inflammatory mediators and preventing the nuclear translocation of NF-kappa B/p65. Additionally, it suppressed arthritis symptoms in a mice model of collagen-induced arthritis.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Food Science & Technology
Yuling Zhang, Yufang Gong
Summary: The study investigated the role of Allicin in regulating Treg/Th17 ratio in splenic lymphocytes through the expression of MEKK2 protein in the MAPK signaling pathway. It was found that Allicin treatment reduced arthritis severity, affected collagen fiber proliferation, and modulated Treg/Th17 ratio in CIA mice. Furthermore, Allicin may have therapeutic potential for rheumatoid arthritis by influencing MEKK2 protein expression and Treg/Th17 balance.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Daniel S. Yang, Edward E. Dickerson, Ling X. Zhang, Holly Richendrfer, Padmini N. Karamchedu, Gary J. Badger, Tannin A. Schmidt, Alger M. Fredericks, Khaled A. Elsaid, Gregory D. Jay
Summary: Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is characterized by joint arthropathy and is caused by the absence of lubricin (proteoglycan 4-PRG4). This study used Prg4-deficient mice as a model to investigate the effects of intra-articular injection of recombinant human PRG4 (rhPRG4) on gait changes and mitochondrial dyscrasia. The results showed that rhPRG4 injection improved gait alterations and reduced caspase-3 activation in the cartilage of the mice. RNA-Seq analysis also revealed upregulation of genes involved in cytoskeletal stabilization. This suggests that IA rhPRG4 may mitigate chondrocyte mitochondrial dyscrasias associated with CACP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Chien-Fu Chen, Hsin-Pei Li, Ya-Hsuan Chao, Min-Yu Tu, Chih-Ching Yen, Ying-Wei Lan, Shang-Hsun Yang, Kowit-Yu Chong, Chi-Chien Lin, Chuan-Mu Chen
Summary: Kefir peptides (KPs) can alleviate symptoms of collagen-induced arthritis (CIA) in mice by inhibiting dendritic cell maturation and inflammatory cytokine release. This study demonstrates that KPs attenuate CIA by suppressing DC maturation and inflammatory cytokine releases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Haiyan Liu, Jin Zhao, Min Su, Xiaohong Tian, Laijun Lai
Summary: The CD300c-Ig fusion protein can prevent and treat CIA, reducing arthritis severity, inhibiting immune cell activation and proinflammatory cytokine expression, suppressing T cell proliferation and cytokine production, and decreasing autoantibody production.
Article
Integrative & Complementary Medicine
Ju-Young Kim, Yoon-Hee Cheon, Sung-Jun Ahn, Sung Chul Kwak, Chong Hyuk Chung, Chang Hoon Lee, Myeung Su Lee
Summary: The study demonstrates the beneficial effects of HAR on local symptoms and systemic bone erosion triggered by inflammatory arthritis, showing reduced clinical scores and incidence rates of CIA, localized improvements in bone and cartilage destruction, and inhibition of inflammatory cytokines expression.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Engineering, Biomedical
Yuxiao Zhou, Junlong Dang, Ye Chen, Song Guo Zheng, Jing Du
Summary: Rheumatoid arthritis is a systemic polyarticular arthritis that affects small joints and currently lack curable treatments. The study shows that human gingiva-derived mesenchymal stem cells have the potential to interfere with the progression of autoimmune arthritis, reducing bone erosion and improving bone function.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Jinyu Li, Qi Sun, Chenying Zheng, Chunxiao Bai, Chuyin Liu, Xueqian Zhao, Peiying Deng, Limin Chai, Yusong Jia
Summary: This study found that LXA4 could protect CIA mice by inhibiting p38 MAPK pathway, reducing synoviocyte proliferation, decreasing inflammatory cytokine levels, alleviating oxidative stress, and easing arthritis severity.
BIOCHEMICAL GENETICS
(2021)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Rheumatology
Aki Kohara, Koichi Yanaba, Yoshinao Muro, Hideki Ito, Hidemi Nakagawa, Kentaro Noda, Daitaro Kurosaka
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
Article
Rheumatology
Kentaro Noda, Ken Yoshida, Taro Ukichi, Kazuhiro Furuya, Kenichiro Hirai, Isamu Kingetsu, Daitaro Kurosaka
JOURNAL OF RHEUMATOLOGY
(2017)
Letter
Rheumatology
Kentaro Noda, Taro Ukichi, Kazuhiro Furuya, Ken Yoshida, Isamu Kingetsu, Toshikazu Tanaka, Daitaro Kurosaka
Letter
Rheumatology
Kentaro Noda, Ken Yoshida, Daitaro Kurosaka
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Rheumatology
Kentaro Noda, Miku Tajima, Yohsuke Oto, Moe Saitou, Masayuki Yoshiga, Kazuhiro Otani, Ken Yoshida, Daitaro Kurosaka
MODERN RHEUMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Kentaro Noda, Bianca Dufner, Haruyasu Ito, Ken Yoshida, Gianfranco Balboni, Rainer H. Straub
Summary: The study investigated the role of Prokineticin 2 (PK2) in the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA). PK2 and its receptors were expressed in synovial tissues of both RA and OA patients. The study found that PK2 could suppress the production of IL-6 from OA synovial fibroblasts, but this effect was weaker in RA synovial fibroblasts.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Takayuki Matsushita, Kazuhiro Otani, Masayuki Yoshiga, Masashi Hirano, Kentaro Noda, Daitaro Kurosaka
Summary: In patients with rheumatoid arthritis (RA), baricitinib has been shown to improve both arthritis symptoms and neuropsychological symptoms, such as depression and fatigue. This study investigated the effect of baricitinib on microglia in the brain region with a weak blood-brain barrier (BBB) using a CIA mouse model. The results demonstrated that baricitinib decreased activated microglia levels in the early phase and improved food intake and sucrose preference. However, it did not affect microglial morphology in the late phase.
Article
Multidisciplinary Sciences
Ken Yoshida, Haruyasu Ito, Daisaburo Kurosaka, Ryo Ikeda, Kentaro Noda, Mitsuru Saito, Daitaro Kurosaka
Summary: PAD4 contributes to the production of citrullinated proteins as autoantigens in RA. This study showed that autocitrullinated PAD4 can recruit monocytes and induce inflammation in mouse joints. Higher levels of citrullinated PAD4 were found in the synovial fluid of RA patients compared to osteoarthritis patients.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Masayori Moriyama, Kentaro Noda, Haruyasu Ito, Takayuki Matsushita, Daitaro Kurosaka
Summary: This article reports a case of developing SLE after SARS-CoV-2 vaccination and suggests that patients who develop SLE within 2 weeks of vaccination are more likely to have immunological abnormalities or a family history of autoimmune diseases. The study also implies the involvement of type I interferon in the pathogenesis of SLE after SARS-CoV-2 vaccination.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
Article
Rheumatology
K. Noda, M. Saitou, T. Matsushita, T. Ukichi, D. Kurosaka
Summary: This study investigated central sensitivity syndrome (CSS) in patients with rheumatoid arthritis (RA) and its impact on pain characteristics and evaluator global assessment. The results showed that CSS was associated with evaluator global assessment and PGA minus EGA, and the descriptors of pain differed between disease activity-related pain and CS-related pain in RA patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Letter
Rheumatology
Kentaro Noda, Takashi Shimoyama, Haruyasu Ito, Ken Yoshida, Daitaro Kurosaka
RHEUMATOLOGY ADVANCES IN PRACTICE
(2022)
Article
Rheumatology
M. Saitou, K. Noda, T. Matsushita, T. Ukichi, D. Kurosaka
Summary: This study aims to explore the prevalence, clinical characteristics, and association between central sensitisation syndrome (CSS) and neuropathic pain (NP)-like symptoms in rheumatoid arthritis (RA) patients. The findings suggest that NP-like symptoms might be one of the symptoms of CSS in longstanding RA patients. Detecting CSS using the central sensitisation inventory (CSI) may help to understand the pathogenesis of patients with disproportionately greater NP-like symptoms and/or widespread pain compared with the degree of inflammation.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Taro Ukichi, Ken Yoshida, Satoshi Matsushima, Go Kawakami, Kentaro Noda, Kazuhiro Furuya, Daitaro Kurosaka
Article
Rheumatology
Ken Yoshida, Haruyasu Ito, Kazuhiro Furuya, Taro Ukichi, Kentaro Noda, Daitaro Kurosaka
ARTHRITIS RESEARCH & THERAPY
(2017)
Letter
Rheumatology
Ken Yoshida, Haruyasu Ito, Taro Ukichi, Takayuki Matsushita, Kazuhiro Furuya, Kentro Noda, Yoshinao Muro, Daitaro Kurosaka
RHEUMATOLOGY ADVANCES IN PRACTICE
(2018)
