Article
Pharmacology & Pharmacy
Daniel B. Roquini, Gabriel L. Silva, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Polrat Wilairatana, Josue De Moraes
Summary: Human helminthiasis affects approximately one in five people in the world and disproportionally affects the poorest and most deprived communities. This study aimed to evaluate the antiparasitic and molecular properties of the major available anthelmintic drugs against Angiostrongylus cantonensis. The results showed that macrocyclic lactones, levamisole, pyrantel pamoate, and albendazole are important anthelmintic agents against A. cantonensis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Parasitology
Abdulhakam Dumidae, Kanin Luangsawang, Aunchalee Thanwisai, Apichat Vitta
Summary: Genetic characterization of Angiostrongylus cantonensis recovered from a patient's eye in Thailand showed high similarity to existing sequences in the GenBank database. Phylogenetic analysis revealed close relationship with certain haplotypes and strains from other countries. These findings are important for future research on genetic variation of A. cantonensis causing human angiostrongyliasis.
PARASITOLOGY RESEARCH
(2023)
Article
Immunology
Sofia Delgado-Serra, Jessica Sola, Nieves Negre, Claudia Paredes-Esquivel
Summary: Neural angiostrongyliasis, caused by the rat lungworm, has emerged as a zoonotic disease in Europe. The presence of A. cantonensis worms on the island of Mallorca, Spain, has been confirmed through sentinel surveillance and molecular analysis. Infected animals, particularly hedgehogs, exhibit specific clinical signs, and a single mitochondrial haplotype has been identified on the island.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Helena C. Turck, Mark T. Fox, Robert H. Cowie
Summary: This study provides a synthesis of the knowledge on paratenic hosts of Angiostrongylus cantonensis and investigates their role in causing human neuroangiostrongyliasis worldwide. The review identifies various animals as paratenic hosts, including prawns, crabs, fish, frogs, lizards, and snakes. The potential of these hosts to cause neuroangiostrongyliasis depends on consumption frequency, preparation methods, and infection prevalence. Safe food preparation protocols and public education are crucial for preventing human infections.
Article
Public, Environmental & Occupational Health
Muxin Chen, Dana Huang, Jiaxu Chen, Yalan Huang, Huiwen Zheng, Yijun Tang, Qian Zhang, Shaohong Chen, Lin Ai, Xiaonong Zhou, Renli Zhang
Summary: The detection of Angiostrongylus cantonensis primarily relies on morphology or immunology by detecting the parasite or specific antibodies or DNA in the cerebrospinal fluid; molecular techniques, such as PCR amplification followed by DNA sequence analysis, are proposed for efficient and accurate identification. Larva release from tissue upon pepsin digestion is another method to detect A. cantonensis, but it requires live mollusks, potentially complicating large-scale analysis. Morphological assays are limited, prompting the development of molecular approaches for better detection, management, and study purposes.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2021)
Article
Multidisciplinary Sciences
Benedicte Melot, Gauthier Delvallez, Ann-Claire Gourinat, Nicolas Molko, Cyrille Goarant, Yves-Marie Ducrot, Emilie Huguon, Cecile Cazorla, Martine Chauvet, Antoine Biron, Julien Colot
Summary: Eosinophilic meningitis is a rare disease predominantly caused by parasites, with Angiostrongylus cantonensis identified as the main pathogen in cases in New Caledonia. The study found that the disease primarily affects young adults and non-walking infants, with distinct peaks of incidence during the dry and rainy seasons. Identification of potential reservoirs is crucial for targeted prevention campaigns due to the high and regular incidence of cases.
Letter
Immunology
Maria Teresa Galan-Puchades, Mercedes Gomez-Samblas, Antonio Osuna, Sandra Saez-Duran, Ruben Bueno-Mari, Marius V. Fuentes
Summary: This study examined rats trapped in urban sewers of Valencia, Spain in 2021 to determine their role as potential reservoirs of zoonotic parasites. Morphological and molecular identification and sequencing revealed the presence of autochthonous Angiostrongylus cantonensis nematodes, a common cause of human eosinophilic meningitis, in the pulmonary arteries of Rattus norvegicus and R. rattus rats.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Microbiology
Divakaran Pandian, Tomas Najer, David Modry
Summary: Human angiostrongylosis, caused by larvae of Angiostrongylus nematodes, is an emerging zoonosis worldwide. The disease mainly manifests as eosinophilic meningitis or ocular form in humans. However, there is a lack of comprehensive studies on angiostrongylosis in the Indian subcontinent. Our research highlights the increasing incidence of angiostrongylosis in humans in India, emphasizes the importance of studying potential causes and clinical course of the disease, and suggests the use of monitor lizards as effective sentinels.
Article
Microbiology
William J. Sears, Yvonne Qvarnstrom, Thomas B. Nutman
Summary: A molecular detection method RPAcan3990 targeting Angiostrongylus cantonensis with a detection limit of 1 fg/μl successfully detected all positive clinical samples from various regions. The assay showed optimal performance within a temperature range of 35°C to 40°C.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Sebastia Jaume-Ramis, Alberto Martinez-Orti, Sofia Delgado-Serra, Maria Dolores Bargues, Santiago Mas-Coma, Pilar Foronda, Claudia Paredes-Esquivel
Summary: This study aims to collect evidence about intermediate hosts involved in the transmission of A. cantonensis and identified 398 gastropods belonging to 17 species, of which 11% tested positive for A. cantonensis. The findings of this study have important epidemiological implications, and further measures are discussed to prevent neuroangiostrongylosis cases.
Article
Immunology
Kai-Yuan Jhan, Pi-Kai Chang, Chien-Ju Cheng, Shih-Ming Jung, Lian-Chen Wang
Summary: The impairment of cognitive functions in mice infected with A. cantonensis may be caused by synaptic loss, which occurs before severe immunological and pathological changes in the infected host.
JOURNAL OF NEUROINFLAMMATION
(2022)
Letter
Immunology
Jessica Rizor, Ryan A. Yanez, Tuddow Thaiwong, Matti Kiupel
Summary: A case of Angiostrongylus infection in a red ruffed lemur from a zoo in southeastern United States was reported, indicating the emergence of this parasite as a zoonosis in the region.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Parasitology
David Modry, Barbora Feckova, Barbora Putnova, Sheina Macy Manalo, Domenico Otranto
Summary: Experiments were conducted to elucidate the infection pathways of third stage larvae (L3) of Angiostrongylus cantonensis among different mollusc species. The results showed that infected synanthropic molluscs play a key role in the epidemiology of human infections by A. cantonensis, with the infectivity of larvae demonstrated through intermediate hosts. Control of molluscs living in peri-domestic environment is crucial in preventing human infections.
Article
Food Science & Technology
Argon Steel, Matthew S. Platz, Alyssa-Jade Riglos, Billie Jean Garcia, John Jacob, Susan Jarvi
Summary: This study found that both ozone gas (O3) and ultrasound can effectively kill the larvae of Angiostrongylus cantonensis, the rat lungworm, and the combined use of these methods is more effective. These methods show promise in reducing the risk of rat lungworm infection through accidental consumption.
Article
Immunology
Zongpu Zhou, Tuo Lin, Zhen Liu, Qian Ding, Zhixuan Ma, Wanqi Li, Fukang Xie, Yue Lan, Ying Feng
Summary: IL-17A plays an important role in demyelination induced by Angiostrongylus cantonensis infection via the IL-17RA/STAT3/SOCS3 pathway in A1-type astrocytes, indicating that specific blockage of IL-17A and SOCS3 activity could be a therapeutic strategy for neuroinflammatory demyelinating diseases associated with astrocyte activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dongjing Zhang, Xiaoying Zheng, Zhiyong Xi, Kostas Bourtzis, Jeremie R. L. Gilles
Article
Biochemistry & Molecular Biology
Yanxia Liu, Yanhe Zhou, Jinya Wu, Peiming Zheng, Yiji Li, Xiaoying Zheng, Santhosh Puthiyakunnon, Zhijian Tu, Xiao-Guang Chen
CELL AND BIOSCIENCE
(2015)
Article
Infectious Diseases
Xi Sun, Li-Fu Wang, Ying Feng, Hui Xie, Xiao-Ying Zheng, Ai He, Md Robiul Karim, Zhi-Yue Lv, Zhong-Dao Wu
INFECTIOUS DISEASES OF POVERTY
(2016)
Article
Parasitology
Dongjing Zhang, Meichun Zhang, Yu Wu, Jeremie R. L. Gilles, Hanano Yamada, Zhongdao Wu, Zhiyong Xi, Xiaoying Zheng
PARASITES & VECTORS
(2017)
Article
Infectious Diseases
Thomas L. Schmidt, Gordana Rasic, Dongjing Zhang, Xiaoying Zheng, Zhiyong Xi, Ary A. Hoffmann
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Infectious Diseases
Lan-Gui Song, Xiao-Ying Zheng, Da-Tao Lin, Guang-Xi Wang, Zhong-Dao Wu
INFECTIOUS DISEASES OF POVERTY
(2017)
Article
Parasitology
Dongjing Zhang, Yongjun Li, Qiang Sun, Xiaoying Zheng, Jeremie R. L. Gilles, Hanano Yamada, Zhongdao Wu, Zhiyong Xi, Yu Wu
PARASITES & VECTORS
(2018)
Article
Public, Environmental & Occupational Health
Xiao Yang, Zhenyu Qu, Hualiang He, Xiaoying Zheng, Ai He, Yu Wu, Qian Liu, Dongjing Zhang, Zhongdao Wu, Zhuoya Li, Ximei Zhan
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2012)
Article
Entomology
Yu Wu, Xiaoying Zheng, Meichun Zhang, Ai He, Zhuoya Li, Ximei Zhan
JOURNAL OF INSECT PHYSIOLOGY
(2010)
Article
Infectious Diseases
Kai Li, Ai He, Wei Ping Cai, Xiao Ping Tang, Xiao Ying Zheng, Zhuo Ya Li, Xi Mei Zhan
Article
Parasitology
Xiao Yang, Zhuoya Li, Hualiang He, Mei Cheng, Qian Liu, Dongjing Zhang, Jing Chen, Xiansheng Wu, Ai He, Xiaoying Zheng, Yu Wu, Zhongdao Wu, Ximei Zhan
PARASITOLOGY RESEARCH
(2013)
Article
Parasitology
Dongjing Zhang, Ximei Zhan, Xiansheng Wu, Xiao Yang, Gehao Liang, Zhantu Zheng, Zhuoya Li, Yu Wu, Xiaoying Zheng
PARASITOLOGY RESEARCH
(2014)
Article
Parasitology
Xiansheng Wu, Ximei Zhan, Ming Gan, Dongjing Zhang, Meichun Zhang, Xiaoying Zheng, Yu Wu, Zhuoya Li, Ai He
PARASITOLOGY RESEARCH
(2013)
Article
Virology
Meichun Zhang, Xiaoying Zheng, Yu Wu, Ming Gan, Ai He, Zhuoya Li, Dongjing Zhang, Xiansheng Wu, Ximei Zhan
Article
Entomology
Xue Xia, Chang-Wu Peng, Yi-Jia Lu, Xiao-Ying Zheng, Xiao-Yue Hong
SYSTEMATIC AND APPLIED ACAROLOGY
(2018)