Article
Chemistry, Multidisciplinary
Ling-Feng Zhou, Jun Wu, Shuai Li, Qi Li, Li-Ping Jin, Cai-Ping Yin, Ying-Lao Zhang
Summary: Among the twenty-one strains of termite-associated actinomycetes tested, nine showed bacteriostatic activities, with strain YH01 isolated from the queen of Odontotermes formosanus exhibiting potent antibacterial activity. The metabolite roseoflavin from YH01 demonstrated strong inhibition against Gram-positive bacteria, particularly MRSA, while also displaying no effect on Gram-negative bacteria.
Article
Multidisciplinary Sciences
Noura El-Ahmady El-Naggar, Shimaa I. I. Bashir, Nashwa H. H. Rabei, WesamEldin I. A. Saber
Summary: Microbial-based strategy offers advantages in economic, eco-friendly, and biosafety aspects for nanotechnology compared to traditional chemical and physical protocols. This study presents a novel biosynthesis method for chitosan nanoparticles (CNPs) using Streptomyces microflavus strain NEAE-83 and optimizes the biosynthesis process through artificial intelligence. The CNPs exhibit in-vitro antibacterial activity against Pectobacterium carotovorum and hold potential for controlling potato soft rot diseases.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Cristina Rodriguez-Melcon, Carlos Alonso-Calleja, Camino Garcia-Fernandez, Javier Carballo, Rosa Capita
Summary: This study determined the lethal concentrations of disinfectants and antibiotics for Listeria monocytogenes and found that the surface characteristics of bacterial cells influence resistance to these compounds. Most strains showed resistance to antibiotics, highlighting the concern of antibiotic resistance.
Article
Immunology
Xubin Zheng, Ziwei Bao, Lina Davies Forsman, Yi Hu, Weihua Ren, Yazhou Gao, Xuliang Li, Sven Hoffner, Judith Bruchfeld, Jan-Willem Alffenaar
Summary: This study aimed to identify clinically relevant PK/PD thresholds for tuberculosis treatment optimization. Using CART analysis and LASSO logistic regression, the study found that AUC/MIC values and drug exposure of TB drugs were associated with clinical outcomes and adverse events. Further research is needed to explore the impact of CART-derived thresholds for individualized dosing on treatment outcomes in randomized controlled trials.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Margaret Ming-Chih Ho, Ming-Hui Sun, Wei-Chi Wu, Chi-Chun Lai, Lung-Kun Yeh, Yih-Shiou Hwang, Ching-Hsi Hsiao, Kuan-Jen Chen
Summary: This study evaluated the antibiotic susceptibility and minimum inhibitory concentrations of Stenotrophomonas maltophilia isolates from ocular infections. The results showed higher susceptibility and lower MICs for fluoroquinolones, which can be recommended for treating S. maltophilia ocular infections. Tigecycline and TMP-SMX could be alternative antibiotics.
Article
Microbiology
Tingting Shi, Xin Guo, Jiali Zhu, Lingming Hu, Zhipeng He, Donghua Jiang
Summary: The manuscript highlights the potential role of Streptomyces roseoverticillatus 63 (Sr-63) against Xanthomonas oryzae pv. oryzae (Xoo) in combating bacterial leaf blight disease in rice. One of the key findings is that carbazomycin B isolated from Sr-63 fermentation broth showed antibacterial activity against Xoo. The compound hindered the membrane formation of Xoo, reduced the production of key bacterial components, and negatively impacted Xoo metabolism.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Thankaraj Rajam Jabila Mary, Rajaretinam Rajesh Kannan, Appadurai Muthamil Iniyan, Wilson Alphonse Carlton Ranjith, Soundarapandian Nandhagopal, Vinita Vishwakarma, Samuel Gnana Prakash Vincent
Summary: Kalafungin has potent inhibitory effects on beta-lactamase, leading to cell membrane destruction in Staphylococcus aureus. In vivo studies in zebrafish model demonstrated its effectiveness and safety, suggesting its potential for synergistic antibacterial therapy.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Microbiology
Rundong Tan, Anqi Yu, Ziming Liu, Ziqi Liu, Rongfeng Jiang, Xiaoli Wang, Jialin Liu, Junhui Gao, Xinjun Wang
Summary: MIC is crucial for bacterial detection in infections, and predicting MIC accurately using genome sequencing and machine learning algorithms can improve clinical efficacy and antibiotic use.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Anton P. Tyurin, Vera A. Alferova, Alexander S. Paramonov, Maxim V. Shuvalov, Gulnara K. Kudryakova, Eugene A. Rogozhin, Alexander Y. Zherebker, Vladimir A. Brylev, Alexey A. Chistov, Anna A. Baranova, Mikhail V. Biryukov, Igor A. Ivanov, Igor A. Prokhorenko, Natalia E. Grammatikova, Tatyana V. Kravchenko, Elena B. Isakova, Elena P. Mirchink, Elena G. Gladkikh, Elena V. Svirshchevskaya, Andrey V. Mardanov, Aleksey V. Beletsky, Milita V. Kocharovskaya, Valeriya V. Kulyaeva, Alexander S. Shashkov, Dmitry E. Tsvetkov, Nikolay E. Nifantiev, Alexander S. Apt, Konstantin B. Majorov, Svetlana S. Efimova, Nikolai V. Ravin, Evgeny N. Nikolaev, Olga S. Ostroumova, Genrikh S. Katrukha, Olda A. Lapchinskaya, Olga A. Dontsova, Stanislav S. Terekhov, Ilya A. Osterman, Zakhar O. Shenkarev, Vladimir A. Korshun
Summary: A novel family of natural lipoglycopeptides produced by Streptomyces sp. INA-Ac-5812, including gausemycins A and B, have been reported. These compounds exhibit pronounced activity against Gram-positive bacteria and show significant differences in mechanism compared to known glyco- and lipopeptides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biophysics
Giulia Barzan, Luca Rocchetti, Chiara Portesi, Francesco Pellegrino, Angelo Taglietti, Andrea Mario Rossi, Andrea Mario Giovannozzi
Summary: This study investigated the antimicrobial properties of differently sized AgNPs immobilized on a surface. It was found that an active surface with high antibacterial efficacy could be achieved using a small amount of silver, reducing aggregation phenomena. The research provides a pathway for the development of antibacterial materials with low silver content.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Microbiology
Jielu Yan, Bob Zhang, Mingliang Zhou, Francois-Xavier Campbell-Valois, Shirley W. I. Siu
Summary: Antimicrobial peptides (AMPs) are potential candidates for replacing conventional antibiotics to combat drug resistance in pathogenic bacteria. To accelerate the evaluation process, we develop a deep learning method called MBC-Attention to predict the minimum inhibitory concentration of AMPs against Escherichia coli. The proposed model outperforms traditional machine learning methods.
Article
Microbiology
Dikchha Singh, Malay K. Das, Gyan P. Srivastav, Shaloo Verma, Prassan Choudhary, Sudipta Das, Renu, Arpan Bhowmik, Jyoti P. Singh, Shobit Thapa, Murugan Kumar, Hillol Chakdar, Anil K. Saxena
Summary: The genetic diversity and antioxidant potential of 52 Streptomyces isolates from 26 species collected in Meghalaya, India were analyzed. Significant diversity was observed among the isolates, with different species and strains exhibiting different antioxidant activities. The results provide important insights into the diversity of Streptomyces and its potential biotechnological applications.
CURRENT MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yu-Chung Chuang, Hsin-Yi Lin, Jann-Tay Wang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Yee-Chun Chen, Shan-Chwen Chang
Summary: This retrospective cohort study compares different daptomycin minimum inhibitory concentration (MIC) testing methods for predicting clinical outcome of vancomycin-resistant enterococcus (VRE) bacteremia. The results indicate that the dichotomized threshold for free drug area under the concentration-time curve to MIC ratio (fAUC/MIC) for broth microdilution (BMD) is the best predictor of mortality.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Agriculture, Multidisciplinary
Seong Jong Kim, Charles L. Cantrell, Bharathi Avula, Jian Chen, Kevin K. Schrader, Suikinai N. Santo, Abbas Ali, Ikhlas A. Khan
Summary: Streptomyces distallicus compounds aureothin and allo-aureothin showed larvicidal activity against Aedes aegypti, indicating their potential as microbial larvicides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Genetics & Heredity
Ming-Ren Yang, Shun-Feng Su, Yu-Wei Wu
Summary: By using a machine learning feature selection approach, we accurately predicted the minimum inhibitory concentration (MIC) values of antimicrobial drugs, and found that half of the selected features were annotated as hypothetical proteins with unknown functions, indicating the potential of uncovering novel genes associated with pathogenic antimicrobial resistance through feature selection on the entire gene set.
FRONTIERS IN GENETICS
(2023)
Article
Biotechnology & Applied Microbiology
Anand Nagpure, Bharti Choudhary, Shanti Kumar, Rajinder K. Gupta
ANNALS OF MICROBIOLOGY
(2014)
Article
Mycology
L. S. Singh, S. Mazumder, T. C. Bora
JOURNAL DE MYCOLOGIE MEDICALE
(2009)
Article
Materials Science, Multidisciplinary
Archana Tiwari, Yanku Lama Sherpa, Anand P. Pathak, Laishram Shantikumar Singh, Amlan Gupta, Ajay Tripathi
MATERIALS TODAY COMMUNICATIONS
(2019)
Article
Medicine, General & Internal
Thounaojam Salvia, Karma G. Dolma, Om Prakash Dhakal, Bidita Khandelwal, Laishram Shantikumar Singh
Summary: This study examines the production of ESBLs, AmpC, and MBL in Enterobacteriaceae isolates and their co-occurrence. The results show a high prevalence of beta-lactamases, especially in Klebsiella pneumoniae and Escherichia coli isolates. It highlights the importance of identifying MDR beta-lactamase strains for effective therapy and reducing the risk of MDR in healthcare settings.
JOURNAL OF LABORATORY PHYSICIANS
(2022)