Article
Infectious Diseases
Briallen Lobb, Matthew C. Lee, Christi L. McElheny, Yohei Doi, Kristin Yahner, Alejandro Hoberman, Judith M. Martin, Jeremy A. Hirota, Andrew C. Doxey, Nader Shaikh
Summary: This study used genomics-based analysis to sequence and analyze 148 bacterial isolates from children, identifying sequence types and antibiotic resistance of Streptococcus pneumoniae and Haemophilus influenzae. The research lays the groundwork for the clinical application of genomics-based workflows in detecting and analyzing these pathogens.
BMC INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Hye-Mi Lee, Hyo-Jin Byon, Namo Kim, Stephen J. Gleich, Randall P. Flick, Jeong-Rim Lee
Summary: Mild upper respiratory tract infection symptoms do not worsen anaesthesia-induced atelectasis in children, but the presence and severity of URI are correlated with perioperative respiratory adverse events in children.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Luanne Hall-Stoodley, Karen S. McCoy
Summary: This review discusses the formation of biofilms in the airway, their role in defending against infection, and the pathophysiology and dysfunctional mechanisms associated with biofilm infections. It also briefly discusses evaluating and treating airway-associated biofilm infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yue Fan, Dongdong Li, Pu Wang, Lili Ren, Xiaowei Chen
Summary: This study found a relationship between acute otitis media (AOM) in children with viral upper respiratory infection (URI) and infection by common respiratory viruses. Among the 255 children examined, 164 (64.1%) tested positive for at least one respiratory virus, with respiratory syncytial virus (RSV) being the most common. The presence of RSV was significantly higher in children with URI + AOM compared to those with URI alone.
Article
Infectious Diseases
Bhavna Samtani, Natasha Gray, Jessica Omand, Charles Keown-Stoneman, Mary Aglipay, Catherine Birken, Jonathon Maguire
Summary: This study found that children who received an antibiotic prescription for upper respiratory tract infection (URTI) before the age of 2 had 1.4 times higher odds of receiving an antibiotic prescription for URTI in later childhood, and this relationship did not appear to differ between acute otitis media (AOM) and non-AOM URTI.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Multidisciplinary Sciences
Lei Xu, Joshua Earl, Michael E. Pichichero
Summary: Analysis of microbiota composition in the nasopharynx of children revealed correlations between certain genera and Streptococcus pneumoniae colonization, with Corynebacterium showing a consistent inverse relationship. Corynebacterium propinquum and C. pseudodiphtheriticum were found to inhibit the growth of Spn serotype 22F strain in vitro.
Article
Immunology
Michael E. Pichichero, Timothy J. Chapman, Peter Bajorski
Summary: The study revealed that otitis-prone children are more susceptible to respiratory infections, showing higher rates of pneumonia, acute sinusitis, and influenza compared to non-otitis-prone children. This increased susceptibility was present from 6 months to 5 years of age, indicating the importance of monitoring and managing respiratory infections in otitis-prone children.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Immunology
Tal Marom, Jacob Pitaro, Udayan K. Shah, Sara Torretta, Paola Marchisio, Ayan T. Kumar, Patrick C. Barth, Sharon Ovnat Tamir
Summary: The global COVID-19 pandemic has had an impact on the management of pediatric infectious diseases, including AOM. The new coronavirus, SARS-CoV-2, is responsible for COVID-19, and previous coronavirus serotypes were rarely detected in AOM cases. Preventive measures and changes in healthcare practices have affected the diagnosis and treatment of AOM during the pandemic.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Mark Edmondson-Jones, Therese Dibbern, Marcus Hultberg, Bengt Anell, Emma Medin, Yang Feng, Carla Talarico
Summary: The introduction of PCVs significantly reduced antibiotic prescribing rates, TTP incidence, healthcare resource utilization and associated costs in children <= 2 years of age in two regions in Sweden.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Pediatrics
Sara Torretta, Pasquale Capaccio, Ilaria Coro, Samantha Bosis, Maria Elisabetta Pace, Pietro Tosi, Lorenzo Pignataro, Paola Marchisio
Summary: During the COVID-19 pandemic lockdown in Italy, otitis-prone children in Milan showed significant clinical improvement, with a decrease in acute otitis media episodes, otorrhea episodes, and antibiotic treatments when compared to the same period in 2019. Telemedicine assessment played a crucial role in maintaining patient care during the lockdown and led to unexpected positive outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, Research & Experimental
Jong-Yeup Kim, Inseok Ko, Dong-Kyu Kim, Myeong Sang Yu
Summary: This study found that adenotonsillectomy does not alter the frequency of upper airway infections in children. There were no significant differences in the incidence of acute pharyngitis, rhinosinusitis, or otitis media between the adenotonsillectomy group and control group from postoperative year 1 to year 9. The hospital visits for these diseases gradually decreased over time in both groups.
Article
Public, Environmental & Occupational Health
Hwi Choe, Tae-Young Pak
Summary: This study examines the longitudinal association between household food insecurity and healthcare utilization and expenditure using data from the Korean Welfare Panel Study. The results show that severe food insecurity is associated with higher rates of outpatient visits, hospitalization days, and inpatient admissions. Moderate food insecurity is associated with reduced personal healthcare expenditure. These findings provide insights for targeting healthcare policies and interventions.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Antonio Della Volpe, Pietro De Luca, Antonietta De Lucia, Francesco Martines, Piera Piroli, Luca D'Ascanio, Angelo Camaioni, Ignazio La Mantia, Arianna Di Stadio
Summary: This study aims to evaluate the effect of a specific oral supplementation in the treatment of pediatric otitis media. The results showed that the supplement can effectively improve the symptoms of upper respiratory tract infection and middle ear disease as a supportive treatment.
Article
Nutrition & Dietetics
Yvan Vandenplas, Marta Zolnowska, Roberto Berni Canani, Sian Ludman, Zsuzsanna Tengelyi, Ana Moreno-alvarez, Anne E. N. Goh, Maria Laura Gosoniu, Bridget-Anne Kirwan, Monika Tadi, Ralf G. Heine
Summary: This clinical trial demonstrates that an extensively hydrolyzed formula supplemented with HMO supports normal growth in infants with CMPA and provides a protective effect against respiratory and ear infections.
Article
Otorhinolaryngology
K. Hathi, C. J. Chin, B. J. A. Hoyt
Summary: This study assessed the impact of the coronavirus disease 2019 pandemic on paediatric bilateral myringotomy and tube insertion rates in New Brunswick, Canada. The study found that during the pandemic, the rate of paediatric bilateral myringotomy and tube insertion significantly decreased, likely due to public health measures reducing the transmission of upper respiratory tract infections and resulting in fewer surgical indications.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2023)
Review
Education, Scientific Disciplines
Christel Grau Canet-Wittkampf, Agnes Diemers, Kristin van den Bogerd, Johanna Schonrock-Adema, Roger Damoiseaux, Dorien Zwart, Debbie Jaarsma, Saskia Mol, Katrien Bombeke, Esther de Groot
Summary: This study examines how healthcare learners and professionals learn patient-centredness through interventions involving standardized patients (SPs) in different healthcare educational contexts. The results reveal that interventions with SPs create a safe learning environment, facilitate reflective practice, and enable collaborative learning. These interventions trigger mechanisms such as confidence, comfort, safety, self-reflection, awareness, comparing & contrasting perspectives, and combining and broadening perspectives. Overall, the study proposes a program theory for learning patient-centredness through interventions with SPs.
Article
Primary Health Care
Karin Smit, Roderick P. Venekamp, Loeke A. Krol, Geert-Jan Geersing, Lisette Schoonhoven, Karin A. H. Kaasjager, Frans H. Rutten, Dorien L. M. Zwart
Summary: This Dutch primary care-based trial assessed the feasibility of home monitoring using pulse oximetry for patients aged >= 40 years with cardiovascular comorbidity and moderate-to-severe COVID-19. The results showed high adherence to monitoring, a high feeling of safety among patients, and similar primary care consultations compared to usual care.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Primary Health Care
Tamara N. Platteel, Marijn Beets, Hendrik A. Teeuwissen, Thijs ten Doesschate, Janneke H. H. M. van de Wijgert, Roderick P. Venekamp, Alma C. van de Pol
Summary: Nitrofurantoin is the recommended antibiotic treatment for uncomplicated urinary tract infections in males according to the Dutch primary care UTI guideline. However, its effectiveness may be compromised by undetected prostate involvement. This study aimed to compare the failure rate of nitrofurantoin with that of other antibiotics and assess GP adherence to the guideline.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Infectious Diseases
Eva L. Koekenbier, Konstantin Fohse, Josephine S. van de Maat, Jan Jelrik Oosterheert, Cees van Nieuwkoop, Jacobien J. Hoogerwerf, Martin P. Grobusch, Maurice A. A. J. van den Bosch, Janneke H. H. van de Wijgert, Mihai G. Netea, Frits R. Rosendaal, Marc J. M. Bonten, C. H. (Henri) van Werkhoven, BCG-PRIME Study Grp
Summary: The objective was to test whether BCG vaccination would reduce the incidence of COVID-19 and RTIs in older adults with comorbidities. The results showed that BCG vaccination does not protect older adults against COVID-19, COVID-19 hospitalization, or clinically relevant RTIs.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Roderick P. Venekamp, Ewoud Schuit, Lotty Hooft, Irene K. Veldhuijzen, Wouter van den Bijllaardt, Suzan D. Pas, Vivian F. Zwart, Esther B. Lodder, Marloes Hellwich, Marco Koppelman, Richard Molenkamp, Constantijn J. H. Wijers, Irene H. Vroom, Leonard C. Smeets, Carla R. S. Nagel-Imming, Wanda G. H. Han, Susan van den Hof, Jan A. J. W. Kluytmans, Janneke H. H. M. van de Wijgert, Karel G. M. Moons
Summary: The performances of three commonly used antigen rapid diagnostic tests used as self-tests in asymptomatic individuals were assessed during the Omicron period. The sensitivities of these tests were found to be very low. Repeated self-testing and testing when symptoms develop are recommended.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Jon Salmanton-Garcia, Pauline Wipfler, Paula Valle-Simon, Christina Merakou, Ioannis Kopsidas, Ullrich Bethe, Angela Steinbach, Orly Spivak, Lenka Souckova, Maria Amelia Mendonca, Markela Koniordou, Margot Hellemans, Jesus Frias-Iniesta, Ruth Joanna Davis, Imre Barta, Anna Maria Azzini, Helena H. Askling, Christos D. Argyropoulos, Elena Alvarez-Barco, Murat Akova, Marc M. J. Bonten, Miriam Cohen-Kandli, Rebecca Jane Cox, Robert Flisiak, Petr Husa, Ligita Jancoriene, Alena Koscalova, Odile Launay, Jens Lundgren, Patrick Mallon, Laura Marques, Pontus Naucler, Jordi Ochando, Zoi-Dorothea Pana, Evelina Tacconelli, Krisztina Toth, Sven Trelle, Pierre van Damme, Theoklis E. Zaoutis, Markus Zeitlinger, Kerstin Albus, Fiona A. Stewart, Sanne H. I. Hofstraat, Patricia Bruijning-Verhagen, Oliver A. Cornely, ACCELERATE Consortium
Summary: The VACCELERATE consortium created a network to accelerate the clinical development of vaccines in Europe. By April 2023, 481 research sites from 39 European countries have registered in the network. The network has been used 21 times for academic and industry trials since its launch in October 2020.
Article
Medicine, General & Internal
Joline L. H. de Sevaux, Roger A. M. J. Damoiseaux, Saskia Hullegie, Elisabeth A. M. Sanders, G. Ardine de Wit, Nicolaas P. A. Zuithoff, Lucy Yardley, Sibyl Anthierens, Paul Little, Alastair D. Hay, Anne G. M. Schilder, Roderick P. Venekamp
Summary: This study aims to investigate whether adding analgesic ear drops to usual care can provide better relief for ear pain in children with acute otitis media (AOM) presenting to primary care. The trial will recruit 300 children aged 1-6 years with a diagnosis of AOM and ear pain. The study will assess outcomes such as ear pain score, antibiotic use, duration of pain, GP reconsultations, adverse events, complications of AOM, and cost-effectiveness over a 4-week follow-up period. The results will be published in medical journals and presented at scientific meetings.
Article
Public, Environmental & Occupational Health
Chiara de Bellegarde de Saint Lary, Louella M. R. Kasbergen, Patricia C. J. L. Bruijning-Verhagen, Henk van der Jeugd, Felicity Chandler, Boris M. Hogema, Hans L. Zaaijer, Fiona R. M. van der Klis, Luisa Barzon, Erwin de Bruin, Quirine ten Bosch, Marion P. G. Koopmans, Reina S. Sikkema, Leo G. Visser
Summary: In 2020, the first cases of Dutch West Nile virus (WNV) infected birds were detected through targeted surveillance. Retrospective testing revealed human WNV infections, indicating the potential risks for bird ringers due to their exposure to mosquito bites and avian excrements. This study found that bird ringers have a higher risk of exposure to WNV and USUV compared to the general population.
Article
Public, Environmental & Occupational Health
Christos Argyropoulos, Janina Leckler, Jon Salmanton-Garcia, Marinos Constantinou, Alexandra Alexandrou, Sophia Themistocleous, Evgenia Noula, George Shiamakkides, Andria Nearchou, Fiona A. Stewart, Kerstin Albus, Markela Koniordou, Ioannis Kopsidas, Orly Spivak, Margot Hellemans, Greet Hendrickx, Ruth Joanna Davis, Anna Maria Azzini, Paula Valle Simon, Antonio Javier Carcas-Sansuan, Helena Hervius Askling, Sirkka Vene, Jana Baranda Prellezo, Elena alvarez-Barco, Alan J. Macken, Romina Di Marzo, Catarina Luis, Ole F. Olesen, Jesus A. Frias Iniesta, Imre Barta, Krisztina Toth, Murat Akova, Marc M. J. Bonten, Miriam Cohen-Kandli, Rebecca Jane Cox, Lenka Souckova, Petr Husa, Ligita Jancoriene, Odile Launay, Jens Lundgren, Patrick Mallon, Charis Armeftis, Laura Marques, Pontus Naucler, Jordi Ochando, Evelina Tacconelli, Pierre van Damme, Theoklis Zaoutis, Sanne Hofstraat, Patricia Bruijning-Verhagen, Markus Zeitlinger, Oliver A. Cornely, Zoi Dorothea Pana
Summary: This study aims to develop a toolkit that provides trustworthy information and promotes positive attitudes towards vaccine trials, with a focus on inclusiveness and equity. The produced materials, including brochures, videos, and puzzles, inform the public about the benefits and risks of trial participation and aim to build confidence in the COVID-19 vaccines.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Public, Environmental & Occupational Health
L. Jonker, K. J. Linde, A. R. de Boer, E. Ding, D. Zhang, M. L. A. de Hoog, S. Herfst, D. J. J. Heederik, P. L. A. Fraaij, P. M. Bluyssen, I. M. Wouters, P. C. J. L. Bruijning-Verhagen
Summary: The study aimed to investigate the impact of COVID-19 measures on SARS-CoV-2 incidence in secondary schools and its association with classroom CO2 concentration and airborne contamination. The findings showed that school-initiated COVID-19 measures had no additional effect on the incidence rate. Furthermore, the study found that the incidence rate decreased during the national lockdown and post-lockdown periods compared to the pre-lockdown period.
Article
Primary Health Care
Karin Smit, Roderick P. Venekamp, Geert-Jan Geersing, Frans H. Rutten, Lisette Schoonhoven, Dorien L. M. Zwart
Summary: This study examines the process of structured home monitoring with a pulse oximeter for patients with COVID-19. The results show that both patients and GPs have a positive attitude towards this method and believe it provides valuable clinical decision support.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Michelle Spek, Roderick P. Venekamp, Daphne C. A. Erkelens, Maarten van Smeden, Loes T. C. M. Wouters, Hester M. den Ruijter, Frans H. Rutten, Dorien L. Zwart
Summary: Patients with chest discomfort and shortness of breath (SOB) who contact the out-of-hours primary care (OHS-PC) more often receive high urgency allocation, but this association is less significant in men when considering the risk of ACS or other life-threatening diseases.
Article
Public, Environmental & Occupational Health
Michelle Spek, Tessa C. van Charldorp, Vera V. Vinck, Roderick P. Venekamp, Frans H. Rutten, Dorien L. Zwart, Esther de Groot
Summary: In the primary care out of hours service, the use of a semi-automatic decision tool may overlook callers' concerns during telephone triage, leading to interactional difficulties. When callers express concerns, it is recommended for triage nurses to briefly explore them before returning to the NTS-assisted triage process.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Otorhinolaryngology
Stephen I. Pelton, Saskia Hullegie, Amanda J. Leach, Paola Marchisio, Tal Marom, Vishakha Sabharwal, Nader Shaikh, Paula A. Tahtinen, Roderick P. Venekamp
Summary: This study aims to identify and synthesize key research advances in the preventative measures and medical and surgical treatment of uncomplicated otitis media (OM), as well as the impact of the COVID-19 pandemic on OM management. The study found that there have been important advances in OM management in recent years, such as the effectiveness of video discharge instructions in reducing symptoms for parents of children with acute otitis media (AOM) and the efficacy of levofloxacin solution for treating chronic suppurative otitis media.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Immunology
Roy P. Zuurbier, Debby Bogaert, Wouter A. A. de Steenhuijsen Piters, Kayleigh Arp, Mei Ling J. N. Chu, Elisabeth A. M. Sanders, Marlies A. van Houten
Summary: Respiratory tract infections in infants are often caused by viruses. A study found that while the presence of rhinovirus in early life is negatively associated with acute respiratory tract infections, it is associated with increased susceptibility to and recurrence of respiratory tract infections later in life.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)