Article
Immunology
Julio Cesar Garcia de Alencar, Claudia de Lucena Moreira, Alicia Dudy Muller, Cleuber Esteves Chaves, Marina Akemi Fukuhara, Elizabeth Aparecida da Silva, Maria de Fatima Silva Miyamoto, Vanusa Barbosa Pinto, Caue Gasparotto Bueno, Felippe Lazar Neto, Luz Marina Gomez Gomez, Maria Clara Saad Menezes, Julio Flavio Meirelles Marchini, Lucas Oliveira Marino, Rodrigo Antonio Brandao Neto, Heraldo Possolo Souza
Summary: The study found that high-dose NAC did not affect the progression of severe COVID-19 in patients. There were no significant differences observed between the group receiving NAC and the placebo group.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Respiratory System
Claudine A. Blum, Eva A. Roethlisberger, Nicole Cesana-Nigro, Bettina Winzeler, Nicolas Rodondi, Manuel R. Blum, Matthias Briel, Beat Mueller, Mirjam Christ-Crain, Philipp Schuetz
Summary: In patients with community-acquired pneumonia, long-term use of corticosteroids is associated with an increased risk of recurrent pneumonia, secondary infections, and new insulin dependence.
BMC PULMONARY MEDICINE
(2023)
Article
Clinical Neurology
Ahmad Shamabadi, Farnaz Kafi, Melika Arab Bafrani, Hassan Asadigandomani, Fatemeh A. Basti, Shahin Akhondzadeh
Summary: This study found that adjunctive L-theanine, when combined with sertraline, showed better efficacy in treating major depressive disorder (MDD) compared to placebo. The L-theanine group demonstrated significant improvement in depression symptoms and a greater reduction in depression scores compared to the placebo group at weeks 2, 4, and 6. Furthermore, the L-theanine group had higher remission and response rates at week 6. These findings suggest that L-theanine is a safe and effective adjunctive therapy for MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
B. Fredrik Lindberg, Ida Nelson, Jonas Ranstam, Donald K. K. Riker
Summary: The study confirmed the efficacy of a glycerol throat spray containing ColdZyme in treating common cold viruses. It demonstrated that ColdZyme can create a protective mucosal barrier and decrease viral load. The use of ColdZyme resulted in a faster recovery from symptoms, with a noticeable effect on the fifth day of the cold.
Article
Biochemistry & Molecular Biology
Jennifer M. Mitchell, Michael Bogenschutz, Alia Lilienstein, Charlotte Harrison, Sarah Kleiman, Kelly Parker-Guilbert, Marcela G. Ot'alora, Wael Garas, Casey Paleos, Ingmar Gorman, Christopher Nicholas, Michael Mithoefer, Shannon Carlin, Bruce Poulter, Ann Mithoefer, Sylvestre Quevedo, Gregory Wells, Sukhpreet S. Klaire, Bessel van der Kolk, Keren Tzarfaty, Revital Amiaz, Ray Worthy, Scott Shannon, Joshua D. Woolley, Cole Marta, Yevgeniy Gelfand, Emma Hapke, Simon Amar, Yair Wallach, Randall Brown, Scott Hamilton, Julie B. Wang, Allison Coker, Rebecca Matthews, Alberdina de Boer, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin
Summary: The results demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder. Compared with placebo, MDMA significantly reduces CAPS-5 scores and improves functional impairment.
Article
Food Science & Technology
Elham Roohelhami, Seyed Hossein Ardehali, Elham Makiabadi, Zahra Vahdat Shariatpanahi
Summary: In this study, the possibility of using bovine colostrum supplementation for managing hospital-acquired infections in critically ill patients was investigated. The results showed that patients in the colostrum group had higher serum levels of CD4 and CD8 proteins and an increase in lymphocytes compared to the control group. Additionally, the incidence of ventilator-associated pneumonia and clostridium difficile diarrhea was significantly lower in the colostrum group.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, General & Internal
Patricia R. M. Rocco, Pedro L. Silva, Fernanda F. Cruz, Paulo F. G. M. M. Tierno, Eucir Rabello, Jefiton Cordeiro Junior, Firmino Haag, Renata E. de avila, Joana D. G. da Silva, Mariana M. S. Mamede, Konrad S. Buchele, Luiz C. V. Barbosa, Anna C. Cabral, Antonio A. F. Junqueira, Joao A. Araujo-Filho, Lucianna A. T. J. da Costa, Pedro P. M. Alvarenga, Alexandre S. Moura, Ricardo Carajeleascow, Mirella C. de Oliveira, Roberta G. F. Silva, Cynthia R. P. Soares, Ana Paula S. M. Fernandes, Flavio Guimaraes Fonseca, Vidyleison Neves Camargos, Julia de Souza Reis, Kleber G. Franchini, Ronir R. Luiz, Sirlei Morais, Carlos Sverdloff, Camila Marinelli Martins, Nathane S. Felix, Paula Mattos-Silva, Caroline M. B. Nogueira, Dayene A. F. Caldeira, Paolo Pelosi, Jose R. Lapa-e-Silva
Summary: Nitazoxanide does not prevent admission to the intensive care unit for patients hospitalized with COVID-19 pneumonia, but it can improve clinical outcomes, reduce hospital stay, and decrease oxygen requirements.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ryan W. W. Dellinger, Holly E. E. Holmes, Tina Hu-Seliger, Rodney W. W. Butt, Stephen A. A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente
Summary: This study demonstrates that NRPT at the recommended dose is safe and may hold promise in lowering markers of hepatic inflammation in patients with NAFLD.
Article
Immunology
Amir Hossein Faghfouri, Behzad Baradaran, Alireza Khabbazi, Mahdi Abdoli Shadbad, Shahab Papi, Elnaz Faghfuri, Yaser Khajebishak, Shima Rahmani, Parastoo Tolou Hayat, Beitullah Alipour
Summary: Supplementation of zinc gluconate can be considered as an adjuvant therapy in alleviating inflammation and genital ulcer among Behcet's disease patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Helen Tang, Lauren Bohannon, Meagan Lew, David Jensen, Sin-Ho Jung, Aaron Zhao, Anthony D. Sung, Paul E. Wischmeyer
Summary: This study aims to evaluate the effects of Lactobacillus rhamnosus GG (LGG) probiotic on COVID-19 infection status and the gut microbiome in subjects with a household contact who has tested positive for COVID-19. A double-blinded, randomised, placebo-controlled trial will be conducted to investigate how LGG impacts the susceptibility to COVID-19 and disease severity, as well as its potential beneficial changes in the gut microbiome.
Article
Critical Care Medicine
Jurjan Aman, Erik Duijvelaar, Liza Botros, Azar Kianzad, Job R. Schippers, Patrick J. Smeele, Sara Azhang, Imke H. Bartelink, Ahmed A. Bayoumy, Pierre M. Bet, Wim Boersma, Peter Bonta, Karin A. T. Boomars, Lieuwe D. J. Bos, Job J. M. H. van Bragt, Gert-Jan Braunstahl, Lucas R. Celant, Katrien A. B. Eger, J. J. Miranda Geelhoed, Yurika L. E. van Glabbeek, Hans P. Grotjohan, Laura A. Hagens, Chris M. Happe, Boaz D. Hazes, Leo M. A. Heunks, Michel van den Heuvel, Wouter Hoefsloot, Rianne J. A. Hoek, Romke Hoekstra, Herman M. A. Hofstee, Nicole P. Juffermans, E. Marleen Kemper, Renate Kos, Peter W. A. Kunst, Ariana Lammers, Ivo van der Lee, E. Laurien van der Lee, Anke-Hilse Maitland-van der Zee, Pearl F. M. Mau Asam, Adinda Mieras, Mirte Muller, Elisabeth C. W. Neefjes, Esther J. Nossent, Laurien M. A. Oswald, Maria J. Overbeek, Carolina C. Pamplona, Nienke Paternotte, Niels Pronk, Michiel A. de Raaf, Bas F. M. van Raaij, Merlijn Reijrink, Marcus J. Schultz, Ary Serpa Neto, Elise M. A. Slob, Frank W. J. M. Smeenk, Marry R. Smit, A. Josien Smits, Janneke E. Stalenhoef, Pieter R. Tuinman, Arthur L. E. M. Vanhove, Jeroen N. Wessels, Jessie C. C. van Wezenbeek, Anton Vonk Noordegraaf, Frances S. de Man, Harm J. Bogaard
Summary: The study showed that imatinib did not significantly reduce the time to discontinuation of oxygen in COVID-19 patients, but may improve survival rates and reduce the duration of invasive mechanical ventilation. Safety evaluation revealed no significant adverse events associated with imatinib.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Vincent C. Marconi, Athimalaipet Ramanan, Stephanie de Bono, Cynthia E. Kartman, Venkatesh Krishnan, Ran Liao, Maria Lucia B. Piruzeli, Jason D. Goldman, Jorge Alatorre-Alexander, Rita de Cassia Pellegrini, Vicente Estrada, Mousumi Som, Anabela Cardoso, Sujatro Chakladar, Brenda Crowe, Paulo Reis, Xin Zhang, David H. Adams, E. Wesley Ely
Summary: Although there was no significant reduction in the frequency of disease progression overall, treatment with baricitinib in addition to standard of care (including dexamethasone) had a similar safety profile to that of standard care alone, and was associated with reduced mortality in hospitalised adults with COVID-19.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Respiratory System
Julie Mankikian, Agnes Caille, Martine Reynaud-Gaubert, Marie-Sara Agier, Julien Bermudez, Philippe Bonniaud, Raphael Borie, Pierre-Yves Brillet, Jacques Cadranel, Isabelle Court-Fortune, Bruno Crestani, Marie-Pierre Debray, Emmanuel Gomez, Anne Gondouin, Sandrine Hirschi-Santelmo, Dominique Israel-Biet, Stephane Jouneau, Karine Juvin, Julie Leger, Mallorie Kerjouan, Charles-Hugo Marquette, Jean-Marc Naccache, Hilario Nunes, Laurent Plantier, Gregoire Prevot, Sebastien Quetant, Julie Traclet, Victor Valentin, Yurdagul Uzunhan, Lidwine Wemeau-Stervinou, Theodora Bejan-Angoulvant, Vincent Cottin, Sylvain Marchand-Adam
Summary: The combination of rituximab and MMF was found to be more effective than MMF alone in the treatment of ILD with a NSIP pattern. However, the use of this combination should be cautious due to the risk of viral infection.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Susumu Yoshino, Takashi Tagawa, Riyo Awa, Jun Ogasawara, Hiroshige Kuwahara, Ikuo Fukuhara
Summary: The study indicates that polymethoxyflavone purified from K. parviflora significantly reduces visceral fat in Japanese overweight adults, with noticeable effects observed within 8-12 weeks.
Article
Cardiac & Cardiovascular Systems
Lotta Ulander, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen, Riitta Paakkanen, Jouni Kuusisto, Olli Anttonen, Tuomo Nieminen, Jaana Yrjola, Ransu Ryysy, Teemu Drews, Seppo Utriainen, Pasi Karjalainen, Ismo Anttila, Katariina Nurmi, Kristiina Silventoinen, Miika Koskinen, Petri T. Kovanen, Jukka Lehtonen, Kari K. Eklund, Juha Sinisalo
Summary: Hydroxychloroquine significantly reduces IL-6 levels in myocardial infarction patients without causing clinically significant adverse events. Larger randomized clinical trials are needed to confirm the potential impact on cardiovascular endpoints after myocardial infarction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Victoria Nankabirwa, James K. Tumwine, Proscovia M. Mugaba, Thorkild Tylleskar, Halvor Sommerfelt
Article
Dentistry, Oral Surgery & Medicine
Nancy Birungi, Lars Thore Fadnes, Victoria Nankabirwa, James Kashugyera Tumwine, Anne Nordrehaug Astrom
ACTA ODONTOLOGICA SCANDINAVICA
(2016)
Article
Public, Environmental & Occupational Health
Lars T. Fadnes, Victoria Nankabirwa, Ingunn M. Engebretsen, Halvor Sommerfelt, Nancy Birungi, Carl Lombard, Sonja Swanevelder, Jan Van den Broeck, Thorkild Tylleskar, James K. Tumwine
Article
Obstetrics & Gynecology
Vicki Flenady, Aleena M. Wojcieszek, Ingvild Fjeldheim, Ingrid K. Friberg, Victoria Nankabirwa, Jagrati V. Jani, Sonja Myhre, Philippa Middleton, Caroline Crowther, David Ellwood, David Tudehope, Robert Pattinson, Jacqueline Ho, Jiji Matthews, Aurora Bermudez Ortega, Mahima Venkateswaran, Doris Chou, Lale Say, Garret Mehl, J. Frederik Froen
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Obstetrics & Gynecology
J. Frederik Froen, Sonja L. Myhre, Michael J. Frost, Doris Chou, Garrett Mehl, Lale Say, Socheat Cheng, Ingvild Fjeldheim, Ingrid K. Friberg, Steve French, Jagrati V. Jani, Jane Kaye, John Lewis, Ane Lunde, Kjersti Morkrid, Victoria Nankabirwa, Linda Nyanchoka, Hollie Stone, Mahima Venkateswaran, Aleena M. Wojcieszek, Marleen Temmerman, Vicki J. Flenady
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Infectious Diseases
David W. Oguttu, Joseph K. B. Matovu, David C. Okumu, Alex R. Ario, Allen E. Okullo, Jimmy Opigo, Victoria Nankabirwa
Article
Medicine, Research & Experimental
Victoria Nankabirwa, Thorkild Tylleskar, Josephine Tumuhamye, James K. Tumwine, Grace Ndeezi, Jose C. Martines, Halvor Sommerfelt
Article
Medicine, Research & Experimental
Victoria Nankabirwa, James K. Tumwine, Olive Namugga, Thorkild Tylleskar, Grace Ndeezi, Bjarne Robberstad, Mihai G. Netea, Halvor Sommerfelt
Article
Public, Environmental & Occupational Health
David Mukunya, James K. Tumwine, Victoria Nankabirwa, Grace Ndeezi, Isaac Odongo, Josephine Tumuhamye, Justin Bruno Tongun, Samuel Kizito, Agnes Napyo, Vincentina Achora, Beatrice Odongkara, Thorkild Tylleskar
GLOBAL HEALTH ACTION
(2017)
Article
Multidisciplinary Sciences
Anselme Simeon Sanou, Abdoulaye Hama Diallo, Penny Holding, Victoria Nankabirwa, Ingunn Marie S. Engebretsen, Grace Ndeezi, James K. Tumwine, Nicolas Meda, Thorkild Tylleskar, Esperance Kashala-Abotnes
Article
Multidisciplinary Sciences
James K. Tumwine, Victoria Nankabirwa, Hama Abdoulaye Diallo, Ingunn Marie Stadskleiv Engebretsen, Grace Ndeezi, Paul Bangirana, Anselme Simeon Sanou, Esperance Kashala-Abotnes, Michael Boivin, Bruno Giordani, Irene Bircow Elgen, Penny Holding, Angelina Kakooza-Mwesige, Vilde Skylstad, Joyce Nalugya, Thorkild Tylleskar, Nicolas Meda
Proceedings Paper
Health Care Sciences & Services
Alice Mugisha, Ankica Babic, Peter Wakholi, Victoria Nankabirwa, Thorkild Tylleskar
INFORMATICS EMPOWERS HEALTHCARE TRANSFORMATION
(2017)
Article
Dentistry, Oral Surgery & Medicine
Nancy Birungi, Lars T. Fadnes, Arabat Kasangaki, Victoria Nankabirwa, Isaac Okullo, Stein A. Lie, James K. Tumwine, Anne N. Astrom
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2017)
Article
Infectious Diseases
Lilian Bulage, Ben Masiira, Alex R. Ario, Joseph K. B. Matovu, Peter Nsubuga, Frank Kaharuza, Victoria Nankabirwa, Janell Routh, Bao-Ping Zhu
BMC INFECTIOUS DISEASES
(2017)
Article
Infectious Diseases
Lilian Bulage, Isaac Ssewanyana, Victoria Nankabirwa, Fred Nsubuga, Christine Kihembo, Gerald Pande, Alex R. Ario, Joseph K. B. Matovu, Rhoda K. Wanyenze, Charles Kiyaga
BMC INFECTIOUS DISEASES
(2017)